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1. 发明申请

US20080281409A1 STENTS WITH DRUG ELUTING COATINGS 审中-公开
标题翻译：带药液涂层的手套
公开(公告)号：US20080281409A1
公开(公告)日：2008-11-13
申请号：US11933517
申请日：2007-11-01
申请人： Anthony Malone , Tim O'Connor , Dave McMorrow , Aiden Flanagan
发明人： Anthony Malone , Tim O'Connor , Dave McMorrow , Aiden Flanagan
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/622
摘要： Provided is a coated medical device (e.g., a stent) comprising one or more surfaces having dispersed thereon a plurality of microparticles comprising an active pharmaceutical ingredient (API) and a polymer. Specifically, the microparticles are disposed on a device surface in a microparticulate phase coating, i.e., as discrete microparticles in the absence of a continuous phase coating. The medical device effectively adheres one or more APIs to its surface, and allows controlled release of the APIs from the device surface to a desired treatment area by using a minimal amount of polymer. The medical device is suitable for insertion or implantation into a subject, preferably a human. Also provided are methods for preparing and using the coated medical device.
摘要翻译：提供了包含一个或多个在其上分散有多个包含活性药物成分（API）和聚合物的微粒的表面的涂覆医疗装置（例如支架）。具体地，微粒在微粒相涂层中的器件表面上，即在不存在连续相涂覆的情况下作为离散微粒布置。医疗设备有效地将一个或多个API粘附到其表面，并且允许通过使用最少量的聚合物将API从设备表面控制释放到期望的治疗区域。医疗装置适于插入或植入受试者，优选人。还提供了制备和使用涂覆的医疗装置的方法。

2. 发明申请

US20080071351A1 ENDOPROSTHESIS WITH ADJUSTABLE SURFACE FEATURES 有权
标题翻译：具有可调节表面特征的内窥镜
公开(公告)号：US20080071351A1
公开(公告)日：2008-03-20
申请号：US11855541
申请日：2007-09-14
申请人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
发明人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
IPC分类号： A61F2/06
CPC分类号： A61L31/146 , A61F2/82 , A61F2/91 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/626
摘要： Endoprostheses (e.g., stents) containing adjustable surfaces are disclosed.
摘要翻译：公开了包含可调表面的内假体（例如，支架）。

3. 发明申请

US20080280026A1 METHODS AND SYSTEMS FOR DEPOSITING COATING ON A MEDICAL DEVICE 失效
标题翻译：用于在医疗设备上沉积涂层的方法和系统
公开(公告)号：US20080280026A1
公开(公告)日：2008-11-13
申请号：US12117100
申请日：2008-05-08
申请人： Tim O,Connor , Dave McMorrow
发明人： Tim O,Connor , Dave McMorrow
IPC分类号： A61L33/00 , B05C11/00
CPC分类号： B05D1/28 , B05D1/002 , B05D3/12
摘要： The present invention is directed to methods and systems for aligning and coating a medical device during a single coating cycle. A first section of an applicator may apply a contact force to surfaces of the medical device. The contact force may align and remove surface irregularities from the medical device prior to coating the medical device with coating. The coating may be resident on a second section of the applicator.
摘要翻译：本发明涉及在单次涂覆循环期间对准和涂覆医疗装置的方法和系统。施加器的第一部分可以对医疗装置的表面施加接触力。在用涂层涂覆医疗装置之前，接触力可以对准和去除医疗装置的表面凹凸。涂层可以驻留在施用器的第二部分上。

4. 发明申请

US20080015674A1 Medical devices and related systems and methods 有权
标题翻译：医疗器械及相关系统及方法
公开(公告)号：US20080015674A1
公开(公告)日：2008-01-17
申请号：US11484528
申请日：2006-07-11
申请人： Michael Austin , Aiden Flanagan , Dave McMorrow , Gabriel Sobrino Serrano
发明人： Michael Austin , Aiden Flanagan , Dave McMorrow , Gabriel Sobrino Serrano
IPC分类号： A61F2/06
CPC分类号： A61F2/966 , A61F2/95 , A61F2002/9511 , A61F2002/9517 , A61F2002/9522 , A61F2002/9665
摘要： Medical devices and related systems and methods.
摘要翻译：医疗器械及相关系统及方法。

5. 发明授权

US07913642B2 Film coating medical devices 有权
标题翻译：薄膜包衣医疗器械
公开(公告)号：US07913642B2
公开(公告)日：2011-03-29
申请号：US11858347
申请日：2007-09-20
申请人： Tim O'Connor , Dave McMorrow , Gabriel Sobrino , Liam Ward , Noel Hynes
发明人： Tim O'Connor , Dave McMorrow , Gabriel Sobrino , Liam Ward , Noel Hynes
IPC分类号： B05C1/00
CPC分类号： B05C1/022 , A61L2420/02
摘要： The present invention relates to a coating assembly and methods that employ the coating assembly to control the thickness of therapeutic or other coatings delivered to a medical device during a coating process. In one embodiment the coating assembly may include a coating plate having a coating transfer surface and a shoulder having a first height, a mandrel moveable over the coating transfer surface, and a coating dispenser positioned in fluid communication with the coating transfer surface. The invention also includes a method of coating a medical device. This method may include placing a medical device on a mandrel, dispensing coating onto a coating transfer surface of a coating plate, moving the mandrel and the medical device over the coating transfer surface of the coating plate so that coating resident on the coating transfer surface transfers to an exposed surface of the medical device, and removing the medical device from the mandrel.
摘要翻译：本发明涉及涂覆组件和方法，其使用涂层组件来控制在涂覆过程期间递送到医疗装置的治疗剂或其它涂层的厚度。在一个实施方案中，涂层组件可以包括具有涂层转移表面和具有第一高度的肩部，可在涂层转移表面上移动的芯棒的涂布板和与涂层转移表面流体连通的涂布分配器。本发明还包括涂覆医疗装置的方法。该方法可以包括将医疗装置放置在心轴上，将涂层分配到涂布板的涂层转移表面上，将心轴和医疗装置移动到涂布板的涂层转移表面上，使得驻留在涂层转移表面上的涂层转移到医疗装置的暴露表面，并且从心轴移除医疗装置。

6. 发明申请

US20100008970A1 Drug-Eluting Endoprosthesis 审中-公开
标题翻译：药物洗脱内假体
公开(公告)号：US20100008970A1
公开(公告)日：2010-01-14
申请号：US12334113
申请日：2008-12-12
申请人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
发明人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
IPC分类号： A61K31/337 , A61F2/00 , B05D1/02
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

7. 发明申请

US20080097569A1 REDUCTION OF BURST RELEASE FROM THERAPEUTICALLY TREATED MEDICAL DEVICES 审中-公开
标题翻译：从治疗医疗器械减少爆发
公开(公告)号：US20080097569A1
公开(公告)日：2008-04-24
申请号：US11857849
申请日：2007-09-19
申请人： Tim O'Connor , Aiden Flanagan , Dave McMorrow , Anthony Malone
发明人： Tim O'Connor , Aiden Flanagan , Dave McMorrow , Anthony Malone
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2250/0067 , A61L31/08 , A61L2300/602
摘要： The present invention generally relates to the conditioning of coated medical devices such as stents. More specifically, the present invention relates to methods for positioning a medical device within an elution media for a predetermined time period to eliminate a burst release from the coating. Under methods and processes of the invention, a medical device target surface may be identified and coated with therapeutic. The coated surface of the medical device may then be positioned within an elution media for a predetermined period of time to release a predetermined amount of coating.
摘要翻译：本发明一般涉及诸如支架之类的涂覆的医疗装置的调理。更具体地，本发明涉及用于将洗涤介质中的医疗装置定位在预定时间段内以消除从涂层中爆发释放的方法。在本发明的方法和方法下，可以鉴定医疗器械靶表面并用治疗剂涂覆。然后可以将医疗装置的涂覆表面定位在洗脱介质中预定的时间段以释放预定量的涂层。

8. 发明授权

US08043651B2 System and method for coating a medical device 失效
标题翻译：用于涂覆医疗装置的系统和方法
公开(公告)号：US08043651B2
公开(公告)日：2011-10-25
申请号：US11876377
申请日：2007-10-22
申请人： Tim O'Connor , LiJuan He , Aiden Flanagan , Anthony Malone , Barry Heaney , Dave McMorrow
发明人： Tim O'Connor , LiJuan He , Aiden Flanagan , Anthony Malone , Barry Heaney , Dave McMorrow
IPC分类号： A61L33/00
CPC分类号： B05D1/28 , B05D1/002 , B05D1/32 , Y10T29/49927
摘要： A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.
摘要翻译：一种用于涂覆诸如支架的医疗装置的方法和装置，包括将支架滚压到浸渍有涂层材料的带或凹版辊上。带和凹版辊可以包括与支架的支柱图案相匹配的凹陷图案。支架也可以滚动抵靠板或圆柱体，同时通过与支架的支柱图案匹配的板或圆筒中的孔或开口的图案将涂层材料压在支架上。

9. 发明授权

US07955382B2 Endoprosthesis with adjustable surface features 有权
标题翻译：具有可调表面特征的内假体
公开(公告)号：US07955382B2
公开(公告)日：2011-06-07
申请号：US11855541
申请日：2007-09-14
申请人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
发明人： Aiden Flanagan , Dave McMorrow , Anthony Malone , Tim O'Connor , Barry Heaney
IPC分类号： A61F2/06
CPC分类号： A61L31/146 , A61F2/82 , A61F2/91 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/626
摘要： Endoprostheses (e.g., stents) containing adjustable surfaces are disclosed.
摘要翻译：公开了包含可调表面的内假体（例如，支架）。

10. 发明申请

US20080107794A1 SYSTEM AND METHOD FOR COATING A MEDICAL DEVICE 失效
标题翻译：用于涂敷医疗装置的系统和方法
公开(公告)号：US20080107794A1
公开(公告)日：2008-05-08
申请号：US11876377
申请日：2007-10-22
申请人： Tim O'Connor , LiJuan He , Aiden Flanagan , Anthony Malone , Barry Heaney , Dave McMorrow
发明人： Tim O'Connor , LiJuan He , Aiden Flanagan , Anthony Malone , Barry Heaney , Dave McMorrow
IPC分类号： B05D1/00
CPC分类号： B05D1/28 , B05D1/002 , B05D1/32 , Y10T29/49927
摘要： A method and device for coating a medical device, such as a stent, including rolling the stent against a ribbon or gravure roll impregnated with coating material. The ribbon and gravure roll may include a recessed pattern matching a strut pattern of the stent. The stent may also be rolled against a plate or cylinder while coating material is forced onto the stent through a pattern of holes or openings in the plate or cylinder matching a strut pattern of the stent.
摘要翻译：一种用于涂覆诸如支架的医疗装置的方法和装置，包括将支架滚压到浸渍有涂层材料的带或凹版辊上。带和凹版辊可以包括与支架的支柱图案相匹配的凹陷图案。支架也可以滚动抵靠板或圆柱体，同时通过与支架的支柱图案匹配的板或圆筒中的孔或开口的图案将涂层材料压在支架上。

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