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1. 发明授权

US08507520B2 Polysubstituted 2-aryl-6-phenylimidazo[1,2-A]pyridine derivatives, and preparation and therapeutic use thereof 有权
标题翻译：多取代2-芳基-6-苯基咪唑并[1,2-A]吡啶衍生物及其制备和治疗用途
公开(公告)号：US08507520B2
公开(公告)日：2013-08-13
申请号：US12881827
申请日：2010-09-14
申请人： Danielle De Peretti , Yannick Evanno , Patrick Lardenois , Nathalie Rakotoarisoa , Antonio Almario Garcia , André Malanda
发明人： Danielle De Peretti , Yannick Evanno , Patrick Lardenois , Nathalie Rakotoarisoa , Antonio Almario Garcia , André Malanda
IPC分类号： C07D491/02 , C07D498/02 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , C07D213/73 , C07F7/1804
摘要： Compounds of formula (I): wherein R, R1, R2, R3, R4, and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）化合物：其中R，R 1，R 2，R 3，R 4和X如本公开内容所定义，或其酸加成盐，及其合成方法及其应用。

2. 发明授权

US08148370B2 Polysubstituted derivatives of 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, and preparation and therapeutic use thereof 有权
标题翻译： 2-芳基-6-苯基 - 咪唑并[1,2-a]吡啶的多取代衍生物及其制备和治疗用途
公开(公告)号：US08148370B2
公开(公告)日：2012-04-03
申请号：US12881805
申请日：2010-09-14
申请人： Danielle De Peretti , Yannick Evanno
发明人： Danielle De Peretti , Yannick Evanno
IPC分类号： A61K31/44 , C07D491/02 , C07D498/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Compounds of formula (I): wherein R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）化合物：其中R 1，R 2，R 3，R 4和X如本发明所定义，或其酸加成盐，及其合成方法及其应用。

3. 发明申请

US20120053202A1 POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF 有权
标题翻译： 6-取代二咪唑并[1,2-a]吡啶的多异构体衍生物及其制备和治疗用途
公开(公告)号：US20120053202A1
公开(公告)日：2012-03-01
申请号：US13291660
申请日：2011-11-08
申请人： Danielle DE PERETTI , Yannick EVANNO , David MACHNIK , Nathalie RAKOTOARISOA
发明人： Danielle DE PERETTI , Yannick EVANNO , David MACHNIK , Nathalie RAKOTOARISOA
IPC分类号： A61K31/437 , C07F5/02 , C07F7/18 , A61P25/28 , A61P25/08 , A61P25/30 , A61P25/18 , A61P29/00 , A61P19/10 , A61P35/00 , A61P25/16 , A61P25/24 , C07D471/04 , A61P25/00
CPC分类号： C07D471/04 , C07F5/025 , C07F7/1804
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）化合物：其中R 1，R 2，R 3，R 4，Het和X如本公开内容所定义，或其酸加成盐，及其合成用途及其合成方法。

4. 发明授权

US08618301B2 5-phenylpyrazolopyridine derivatives, preparation and therapeutic use thereof 有权
标题翻译： 5-苯基吡唑并吡啶衍生物，其制备和治疗用途
公开(公告)号：US08618301B2
公开(公告)日：2013-12-31
申请号：US13496118
申请日：2010-09-17
申请人： Florian Auger , Danielle De Peretti , Luc Even
发明人： Florian Auger , Danielle De Peretti , Luc Even
IPC分类号： C07D491/02 , C07F5/02
CPC分类号： C07D471/06
摘要： The present invention relates to compounds of formula (I).
摘要翻译：本发明涉及式（I）化合物。

5. 发明申请

US20130023554A1 5-PHENYLPYRAZOLOPYRIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF 有权
公开(公告)号：US20130023554A1
公开(公告)日：2013-01-24
申请号：US13496118
申请日：2010-09-17
申请人： Florian Auger , Danielle De Peretti , Luc Even
发明人： Florian Auger , Danielle De Peretti , Luc Even
IPC分类号： C07D471/04 , C07F5/02 , A61P25/28 , A61P25/08 , A61P29/00 , A61P25/30 , A61P19/10 , A61P35/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61K31/437 , A61P25/00
CPC分类号： C07D471/06
摘要： Compounds of formula (I): in which:R1 represents a phenyl group or naphthyl group, optionally substituted by one or more atoms or groups chosen, independently of one another, from: halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C6)thioalkyl, —S(O)(C1-C6)alkyl, —S(O)2(C1-C6)alkyl, hydroxyl, hydroxy(C1-C6)alkylene, CHO, COOH, (C1-C6)alkoxy(C1-C6)alkyleneoxy, NRaRb, CONRaRb, SO2NRaRb, NRcCORd, OC(O)NRaRb, OCO(C1-C6)alkyl, NRcC(O)ORe or NRcSO2Re; X represents from 1 to 4 substituents which are identical to or different from one another and which are chosen from hydrogen, halogen, (C1-C6)alkyl or (C1-C6)alkoxy, it being possible for the (C1-C6)alkyl to be optionally substituted by one or more groups chosen from a halogen, (C1-C6)alkoxy or hydroxyl; R2 and R3 represent, independently of one another, a hydrogen atom, a (C1-C6)alkyl group optionally substituted by an Rf group, or a CHO or COOH group; X and R3 can together form, with the carbon atoms which carry them, a carbocycle of 5 to 7 carbon atoms; R4 represents a hydrogen atom or a (C1-C6)alkyl group; Ra and Rb represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl, aryl(C1-C6)alkylene or aryl group; or Ra and Rb together form, with the nitrogen atom which carries them, an azetidine, pyrrolidine, piperidine, azepine, morpholine, thiomorpholine, piperazine or homopiperazine group, this group being optionally substituted by a (C1-C6)alkyl, aryl or aryl(C1-C6)alkylene group; Rc and Rd represent, independently of one another, a hydrogen atom or a (C1-C6)alkyl, aryl(C1-C6)alkylene or aryl group; or Rc and Rd together form a (C2-C5)alkylene group; Re represents a (C1-C6)alkyl, aryl(C1-C6)alkylene or aryl group; or Rc and Re together form a (C2-C5)alkylene group; Rf represents a hydroxyl, oxo, CHO or COOH group, in the form of the base or of an addition salt with an acid.Therapeutic use and synthetic process.

6. 发明申请

US20110065745A1 POLYSUBSTITUTED 2-ARYL-6-PHENYLIMIDAZO[1,2-A]PYRIDINE DERIVATIVES, AND PREPARATION AND THERAPEUTIC USE THEREOF 有权
标题翻译：多取代的2-芳基-6-苯基咪唑并[1,2-A]吡啶衍生物及其制备和治疗用途
公开(公告)号：US20110065745A1
公开(公告)日：2011-03-17
申请号：US12881827
申请日：2010-09-14
申请人： Danielle DE PERETTI , Yannick EVANNO , Patrick LARDENOIS , Nathalie RAKOTOARISOA , Antonio ALMARIO GARCIA , Andre MALANDA
发明人： Danielle DE PERETTI , Yannick EVANNO , Patrick LARDENOIS , Nathalie RAKOTOARISOA , Antonio ALMARIO GARCIA , Andre MALANDA
IPC分类号： A61K31/437 , C07D471/04 , A61P25/08 , A61P29/00 , A61P35/00 , A61P19/10 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/16 , A61P25/18 , C07D213/73 , C07F7/18
CPC分类号： C07D471/04 , C07D213/73 , C07F7/1804
摘要： Compounds of formula (I): wherein R, R1, R2, R3, R4, and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）化合物：其中R，R 1，R 2，R 3，R 4和X如本公开内容所定义，或其酸加成盐，及其合成方法及其应用。

7. 发明申请

US20110065727A1 POLYSUBSTITUTED DERIVATIVES OF 2-HETEROARYL-6-PHENYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF 有权
标题翻译： 2-异丙基-6-苯基咪唑并[1,2-a]吡啶的多取代衍生物及其制备及其治疗用途
公开(公告)号：US20110065727A1
公开(公告)日：2011-03-17
申请号：US12881815
申请日：2010-09-14
申请人： Danielle DE PERETTI , Yannick EVANNO , Patrick LARDENOIS , David MACHNIK , Nathalie RAKOTOARISOA , Antonio ALMARIO GARCIA
发明人： Danielle DE PERETTI , Yannick EVANNO , Patrick LARDENOIS , David MACHNIK , Nathalie RAKOTOARISOA , Antonio ALMARIO GARCIA
IPC分类号： A61K31/444 , C07D471/04 , A61K31/4709 , A61K31/4725 , A61K31/506 , C07F7/18 , C07F5/04 , C07D213/73 , A61P25/00 , A61P25/30 , A61P25/18 , A61P25/24 , A61P35/00 , A61P19/10 , A61P29/00 , A61P25/28 , A61P25/16
CPC分类号： C07D471/04 , C07D213/73 , C07F7/1804
摘要： Compounds of formula (I): wherein R, R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）的化合物：其中R，R 1，R 2，R 3，R 4和X如本发明所定义，或其酸加成盐，以及其合成用途和方法。

8. 发明授权

US08598166B2 Polysubstituted derivatives of 6-heteroarylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof 有权
标题翻译： 6-杂芳基咪唑并[1,2-a]吡啶的多取代衍生物及其制备和治疗用途
公开(公告)号：US08598166B2
公开(公告)日：2013-12-03
申请号：US13291660
申请日：2011-11-08
申请人： Danielle De Peretti , Yannick Evanno , David Machnik , Nathalie Rakotoarisoa
发明人： Danielle De Peretti , Yannick Evanno , David Machnik , Nathalie Rakotoarisoa
IPC分类号： A61K31/535 , A01N43/42 , A61K31/44
CPC分类号： C07D471/04 , C07F5/025 , C07F7/1804
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）化合物：其中R 1，R 2，R 3，R 4，Het和X如本公开内容所定义，或其酸加成盐，及其合成用途及其合成方法。

9. 发明授权

US08338451B2 Polysubstituted derivatives of 2-heteroaryl-6-phenylimidazo[1,2-a]pyridines, and preparation and therapeutic use thereof 有权
标题翻译： 2-杂芳基-6-苯基咪唑并[1,2-a]吡啶的多取代衍生物及其制备和治疗用途
公开(公告)号：US08338451B2
公开(公告)日：2012-12-25
申请号：US12881815
申请日：2010-09-14
申请人： Danielle De Peretti , Yannick Evanno , Patrick Lardenois , David Machnik , Nathalie Rakotoarisoa , Antonio Almario Garcia
发明人： Danielle De Peretti , Yannick Evanno , Patrick Lardenois , David Machnik , Nathalie Rakotoarisoa , Antonio Almario Garcia
IPC分类号： A61K31/44 , C07D513/02
CPC分类号： C07D471/04 , C07D213/73 , C07F7/1804
摘要： Compounds of formula (I): wherein R, R1, R2, R3, R4 and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）的化合物：其中R，R 1，R 2，R 3，R 4和X如本公开内容所定义，或其酸加成盐，及其合成用途及其合成方法。

10. 发明申请

US20110065700A1 POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYLIMIDAZO[1,2-a]PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF 有权
标题翻译： 6-取代二咪唑并[1,2-a]吡啶的多异构体衍生物及其制备和治疗用途
公开(公告)号：US20110065700A1
公开(公告)日：2011-03-17
申请号：US12881820
申请日：2010-09-14
申请人： Danielle DE PERETTI , Yannick EVANNO , David MACHNIK , Nathalie RAKOTOARISOA
发明人： Danielle DE PERETTI , Yannick EVANNO , David MACHNIK , Nathalie RAKOTOARISOA
IPC分类号： A61K31/437 , C07D471/04 , C07D413/14 , A61K31/5377 , A61P25/28 , A61P25/08 , A61P25/18 , A61P29/00 , A61P19/10 , A61P35/00 , A61P25/16 , A61P25/00 , A61P25/24 , A61P25/30 , C07F5/02 , C07F7/18
CPC分类号： C07D471/04 , C07F5/025 , C07F7/1804
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, Het and X are as defined in the disclosure, or an acid addition salt thereof, and the therapeutic use and process of synthesis thereof.
摘要翻译：式（I）化合物：其中R 1，R 2，R 3，R 4，Het和X如本公开内容所定义，或其酸加成盐，及其合成用途及其合成方法。

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