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1. 发明授权

US08304388B2 Imaging agents 失效
标题翻译：成像剂
公开(公告)号：US08304388B2
公开(公告)日：2012-11-06
申请号：US12302290
申请日：2007-05-25
申请人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
发明人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
IPC分类号： A61K38/39 , A61K38/10 , A61K38/08
CPC分类号： A61K51/088 , A61K49/0002
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.
摘要翻译：本发明提供了适用于纤维化的非侵入性可视化的新型成像剂。本发明还提供了用于制备显影剂的前体，以及包含显影剂和用于制备药物组合物的试剂盒的药物组合物。在另一方面，提供了用于体内成像和用于诊断包括纤维化的病症的药物的制备的成像剂的用途。

2. 发明申请

US20090012991A1 SYSTEM AND METHOD FOR PROVIDING INFORMATION TAGGING IN A NETWORKED SYSTEM 有权
标题翻译：在网络系统中提供信息标签的系统和方法
公开(公告)号：US20090012991A1
公开(公告)日：2009-01-08
申请号：US11964181
申请日：2007-12-26
申请人： Brian Scott Johnson , Brian M. Johnson , Badrul M. Sarwar , Benny Soetarman , Rajyashree Mukherjee , Venkat Sundaranatha , Neelakantan Sundaresan , Randall Scott Shoup , Daniel Kramer , Jason M. Heidema , Musaab At-Taras , Alvaro Bolivar , Jean-David Ruvini
发明人： Brian Scott Johnson , Brian M. Johnson , Badrul M. Sarwar , Benny Soetarman , Rajyashree Mukherjee , Venkat Sundaranatha , Neelakantan Sundaresan , Randall Scott Shoup , Daniel Kramer , Jason M. Heidema , Musaab At-Taras , Alvaro Bolivar , Jean-David Ruvini
IPC分类号： G06F7/00
CPC分类号： G06Q30/0623 , G06F17/30525 , G06F17/30867 , G06Q30/02 , G06Q30/0603 , G06Q30/0621 , G06Q30/0631
摘要： A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.
摘要翻译：公开了一种用于在联网系统中提供信息标签的计算机实现的系统和方法。示例性实施例中的装置包括被配置为处理分类产品列表的数据库的标签引擎; 接收与所述产品列表中的至少一个相关联的用户提供的标签; 保留用户提供的标签; 并且向用户查看至少一个产品列表来服务于用户提供的标签。

3. 发明申请

US20070009428A1 Compounds and methods for enhanced delivery to disease targets 审中-公开
标题翻译：用于增强输送到疾病目标的化合物和方法
公开(公告)号：US20070009428A1
公开(公告)日：2007-01-11
申请号：US11175668
申请日：2005-07-06
申请人： Faisal Syud , Nichole Wood , Andrew Torres , Mark Baillie , Dinko Trotter , Cristina Hehir , Ming Zhao , Daniel Kramer
发明人： Faisal Syud , Nichole Wood , Andrew Torres , Mark Baillie , Dinko Trotter , Cristina Hehir , Ming Zhao , Daniel Kramer
IPC分类号： A61K51/00
CPC分类号： A61K51/04 , A61K47/6899 , B82Y5/00
摘要： A set of compounds that includes an active-agent labeled species and a pretargeting conjugate is disclosed. The active agent-labeled species includes a ligand coupled to an active agent. The pretargeting conjugate includes a protein conjugated to a targeting species having a targeting moiety capable of binding to an in-vivo target or a biomarker produced by or associated with the target. The protein is substantially free of a cofactor. Also disclosed are methods of administering the pretargeting species and the active-agent labeled species to a subject for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.
摘要翻译：公开了一组包含活性剂标记的物质和预靶向缀合物的化合物。活性剂标记的物质包括与活性剂偶联的配体。预靶向缀合物包括与靶向物质缀合的蛋白质，其具有能够结合体内靶标的靶向部分或由靶产生或与靶标相关的生物标志物。蛋白质基本上不含辅因子。还公开了将预靶向物种和活性剂标记物种施用于受试者以诊断或治疗疾病状况或评估治疗疾病状况的有效性的方法。

4. 发明申请

US20060203991A1 System for managing employee performance in a complex environment 审中-公开
标题翻译：用于在复杂环境中管理员工绩效的系统
公开(公告)号：US20060203991A1
公开(公告)日：2006-09-14
申请号：US11200840
申请日：2005-08-10
申请人： Daniel Kramer , Patrick Beasley , David Nti-Berko
发明人： Daniel Kramer , Patrick Beasley , David Nti-Berko
IPC分类号： H04M3/00
CPC分类号： H04M3/5175
摘要： Employee performance in a call center or similar complex work environment is managed by selecting a controlled number of performance criteria from among numerous possible performance criteria, establishing performance goals for the selected performance criteria, communicating the goals to the call center employees, monitoring the actual performance of the employees in relation to the performance goals, and reporting the performance of the employees in relation to the performance goals to the employees, management or both.
摘要翻译：呼叫中心或类似复杂工作环境中的员工绩效是通过从众多可能的绩效标准中选择受控数量的绩效标准来管理的，为所选绩效标准确定绩效目标，将目标传达给呼叫中心员工，监控实际绩效员工的绩效目标，并向雇员，管理层或两者报告与员工绩效有关的绩效目标。

5. 发明申请

US20060085049A1 Active electrode, bio-impedance based, tissue discrimination system and methods of use 失效
标题翻译：活性电极，基于生物阻抗，组织鉴别系统和使用方法
公开(公告)号：US20060085049A1
公开(公告)日：2006-04-20
申请号：US11252568
申请日：2005-10-19
申请人： Phillip Cory , Joan Cory , Waldean Schulz , Daniel Kramer , Paul Ray
发明人： Phillip Cory , Joan Cory , Waldean Schulz , Daniel Kramer , Paul Ray
IPC分类号： A61N1/08 , A61B5/05
CPC分类号： A61B5/4893 , A61B5/0536 , A61B5/4041 , A61B5/4519 , A61B2562/0209 , A61B2562/046
摘要： Systems and methods for discriminating and locating tissues within a body involve applying a waveform signal to tissue between two electrodes and measuring the electrical characteristics of the signal transmitted through the tissue. At least one of the electrodes is constrained in area so that localized electrical characteristics of the tissue are measured. Such localized electrical characteristics are determined over a portion of a body of the subject by using an array of electrodes or electrodes that can be moved over the body. A controller may implement the process and perform calculations on the measured data to identify tissue types and locations within the measured area, and to present results in graphical form. Results may be combined with other tissue imaging technologies and with image-guided systems.
摘要翻译：用于区分和定位身体内的组织的系统和方法包括将波形信号施加到两个电极之间的组织并测量透过组织的信号的电特性。电极中的至少一个被限制在区域中，使得测量组织的局部电特性。通过使用能够在身体上移动的电极阵列或电极来确定这种局部电特性，使其在身体的一部分上被确定。控制器可以实施该过程并且对所测量的数据执行计算以识别测量区域内的组织类型和位置，并以图形形式呈现结果。结果可能与其他组织成像技术和图像引导系统相结合。

6. 发明授权

US09324082B2 System and method for providing information tagging in a networked system 有权
标题翻译：在网络系统中提供信息标签的系统和方法
公开(公告)号：US09324082B2
公开(公告)日：2016-04-26
申请号：US11964181
申请日：2007-12-26
申请人： Brian Scott Johnson , Brian M. Johnson , Badrul M. Sarwar , Benny Soetarman , Rajyashree Mukherjee , Venkat Sundaranatha , Neelakantan Sundaresan , Randall Scott Shoup , Daniel Kramer , Jason M. Heidema , Musaab At-Taras , Alvaro Bolivar , Jean-David Ruvini
发明人： Brian Scott Johnson , Brian M. Johnson , Badrul M. Sarwar , Benny Soetarman , Rajyashree Mukherjee , Venkat Sundaranatha , Neelakantan Sundaresan , Randall Scott Shoup , Daniel Kramer , Jason M. Heidema , Musaab At-Taras , Alvaro Bolivar , Jean-David Ruvini
IPC分类号： G06Q30/02 , G06Q30/06 , G06F17/30
CPC分类号： G06Q30/0623 , G06F17/30525 , G06F17/30867 , G06Q30/02 , G06Q30/0603 , G06Q30/0621 , G06Q30/0631
摘要： A computer-implemented system and method for providing information tagging in a networked system is disclosed. The apparatus in an example embodiment includes a tag engine configured to process a database of categorized product listings; to receive a user-provided tag associated with at least one of the product listings; to retain the user-provided tag; and to serve the user-provided tag to a user viewing at least one of the product listings.
摘要翻译：公开了一种用于在联网系统中提供信息标签的计算机实现的系统和方法。示例性实施例中的装置包括被配置为处理分类产品列表的数据库的标签引擎; 接收与所述产品列表中的至少一个相关联的用户提供的标签; 保留用户提供的标签; 并且向用户查看至少一个产品列表来服务于用户提供的标签。

7. 发明申请

US20090191123A1 NOVEL IMAGING AGENTS 失效
标题翻译：新型成像剂
公开(公告)号：US20090191123A1
公开(公告)日：2009-07-30
申请号：US12302290
申请日：2007-05-25
申请人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
发明人： Salah Chettibi , Ben Newton , Mette Husbyn , Magne Solbakken , Peter Brian Iveson , Rajiv Bhalla , Daniel Kramer , Jane Brown
IPC分类号： A61K51/08 , C07K7/06 , C07K7/08
CPC分类号： A61K51/088 , A61K49/0002
摘要： The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.
摘要翻译：本发明提供了适用于纤维化的非侵入性可视化的新型成像剂。本发明还提供了用于制备显影剂的前体，以及包含显影剂和用于制备药物组合物的试剂盒的药物组合物。在另一方面，提供了用于体内成像和用于诊断包括纤维化的病症的药物的制备的成像剂的用途。

8. 发明申请

US20070148756A1 Tissue dissociation device 有权
标题翻译：组织解离装置
公开(公告)号：US20070148756A1
公开(公告)日：2007-06-28
申请号：US10572495
申请日：2004-09-21
申请人： Lawrence Bullen , Herbert Bresler , Daniel Kramer
发明人： Lawrence Bullen , Herbert Bresler , Daniel Kramer
IPC分类号： C12N1/02 , B02B5/02
CPC分类号： C12M45/02
摘要： A tissue dissociation device (10) includes a container (12) having a sterile interior for holding the tissue to be dissociated and a liquid medium. The device (10) also includes a dissociation element (54), inside the container (12), for engaging the tissue to cause dissociation of the tissue. The device (10) also includes a resistive element (81), inside the container (12), for resisting movement of the tissue in response to the engagement by the dissociation element (54). Relative motion between and the resulting resistance provided by the resistive element (81) allows the dissociation element (54) to effectively dissociate the tissue. A powered tissue dissociation device includes a power source operatively connected to the dissociation element (54) for causing the dissociation element (54) to move into engagement with the tissue
摘要翻译：组织解离装置（10）包括具有用于保持要解离的组织的无菌内部的容器（12）和液体介质。装置（10）还包括在容器（12）内部的解离元件（54），用于接合组织以引起组织的解离。装置（10）还包括在容器（12）内部的电阻元件（81），用于响应于解离元件（54）的接合而抵抗组织的移动。由电阻元件（81）提供的相对运动和由此产生的电阻允许解离元件（54）有效地解离组织。动力组织解离装置包括可操作地连接到解离元件（54）的电源，用于使解离元件（54）移动成与组织接合

9. 发明申请

US20060135884A1 Application devices, systems and methods for use with medical devices 有权
标题翻译：用于医疗设备的应用设备，系统和方法
公开(公告)号：US20060135884A1
公开(公告)日：2006-06-22
申请号：US11223792
申请日：2005-09-09
申请人： Dennis Hack , Francis Sciulli , Charles Mutschler , R. Harpham , Daniel Kramer , Felicia Ruggeri , Jan Yates , William Atterbury , Joseph Juratovac , Jeffery Held , Chad Bouton , James Gleeson
发明人： Dennis Hack , Francis Sciulli , Charles Mutschler , R. Harpham , Daniel Kramer , Felicia Ruggeri , Jan Yates , William Atterbury , Joseph Juratovac , Jeffery Held , Chad Bouton , James Gleeson
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0507 , A61B5/4869 , A61B5/4878 , A61B5/6839 , A61B5/6841 , A61B2562/143 , A61M5/16836 , A61M2005/1416 , A61M2005/1588
摘要： An application or an attachment device for attaching a medical device includes a base layer and an adhesive layer on a rearward side of the base layer. The adhesive layer is adapted to removably attach the base layer. The adhesive layer can be adapted to removably attach the base layer to a patient (either a human patient or a lower animal patient). The device also includes a medical device attachment mechanism on a forward side of the base layer, The attachment mechanism is adapted to attach the medical device to the base layer. The medical device can, for example, be a sensor. The medical device attachment mechanism can, for example, include a mechanical attachment mechanism. The medical device attachment mechanism can additionally or alternatively include at least one adhesive layer on the base layer. The adhesive layer can, for example, be positioned on the base layer so that it does not extend beyond a footprint of the medical device when the medical device is attached to the base layer.
摘要翻译：用于附接医疗装置的应用或附着装置包括在基层的后侧上的基层和粘合剂层。粘合剂层适于可移除地附接基底层。粘合剂层可以适于将基层可拆卸地附接到患者（人类患者或下部动物患者）。该装置还包括在基层的前侧上的医疗装置附接机构。附接机构适于将医疗装置附接到基层。医疗装置例如可以是传感器。医疗装置附接机构例如可以包括机械附接机构。医疗装置附接机构可附加地或可选地在基层上包括至少一个粘合剂层。例如，当医疗装置附接到基底层时，粘合剂层可以例如位于基底层上，使得其不会延伸超过医疗装置的覆盖区。

10. 发明申请

US20050260131A1 Pharmaceuticals for enhanced delivery to disease targets 审中-公开
标题翻译：用于增强输送到疾病目标的药物
公开(公告)号：US20050260131A1
公开(公告)日：2005-11-24
申请号：US10851359
申请日：2004-05-20
申请人： Mohan Amaratunga , Bahram Moasser , Faisal Syud , John Brogan , Daniel Kramer
发明人： Mohan Amaratunga , Bahram Moasser , Faisal Syud , John Brogan , Daniel Kramer
IPC分类号： C07H21/00 , C07K14/00 , A61K51/00 , A61K48/00 , A61K49/00 , C07K14/52 , C07K16/46
CPC分类号： C07H21/00
摘要： Pharmaceuticals for enhanced delivery to a disease target comprises a pair of compounds. The first compound comprises a first oligopeptide conjugated to a first moiety for coupling with a diagnostic or therapeutic active agent. The second compound comprises a second oligopeptide conjugated to a targeting species having a targeting moiety capable of binding to a target. The second oligopeptide has a sequence that is complementary to a sequence of the first oligopeptide. The first and second oligopeptides can be complementary PNA sequences. The pharmaceuticals are administered into a subject in methods for diagnosing or treating a disease condition, or assessing the effectiveness of a treatment of the disease condition.
摘要翻译：用于增强递送至疾病靶标的药物包含一对化合物。第一化合物包含与第一部分缀合的第一寡肽，用于与诊断或治疗活性剂偶联。第二化合物包含与具有能与靶标结合的靶向部分的靶向物质缀合的第二寡肽。第二寡肽具有与第一寡肽的序列互补的序列。第一和第二寡肽可以是互补的PNA序列。药物在用于诊断或治疗疾病状况的方法或评估治疗疾病状况的有效性的方法中施用于受试者。

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