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    • 10. 发明授权
    • Bio-interventional therapeutic treatments for cardiovascular diseases
    • 生物介入治疗心血管疾病
    • US07736346B2
    • 2010-06-15
    • US11253177
    • 2005-10-18
    • Aaron MillerLoren BentleyDaniel C. RosenmanPeter A. Altman
    • Aaron MillerLoren BentleyDaniel C. RosenmanPeter A. Altman
    • A61M5/00
    • A61B17/3478A61B2017/00243A61B2017/00247A61B2018/00392A61M25/0084
    • Catheter-based systems are disclosed for geometrically and temporally controlled deliveries of fluid agents to the heart. Each system includes an elongate catheter shaft, a tissue penetration element at the shaft distal end, and a handle at the shaft proximal end for manipulating the penetrating element. The penetrating element and a proximate conductive coil provide bipolar sensing electrodes. One version of the system includes a fluid lumen through the penetrating element and a contrast fluid lumen open at the catheter shaft distal end. In other versions, the penetrating element contains two fluid lumens. These systems facilitate tissue mapping and therapeutic agent delivery protocols in which several agents can be simultaneously delivered at a depth within heart tissue, prevented from intermingling until they reach the tissue. Treatment and contrast agents can be delivered simultaneously or temporally spaced, directed to the same region or to different regions separated by intervening tissue.
    • 公开了基于导管的系统,用于几何和时间上控制向心脏传递流体剂。 每个系统包括细长的导管轴,在轴远端处的组织穿透元件,以及在轴近端的用于操纵穿透元件的手柄。 穿透元件和邻近的导电线圈提供双极感测电极。 系统的一个版本包括通过穿透元件的流体腔和在导管轴远端开口的造影液腔。 在其他版本中,穿透元件包含两个流体流明。 这些系统促进组织图和治疗剂递送方案,其中可以在心脏组织内的深度同时递送多种试剂,防止混合直到它们到达组织。 治疗和造影剂可以同时或时间间隔地递送,指向相同的区域或由介入组织分开的不同区域。