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1. 发明授权

US08784354B2 Positioning tools and methods for implanting medical devices 有权
标题翻译：用于植入医疗器械的定位工具和方法
公开(公告)号：US08784354B2
公开(公告)日：2014-07-22
申请号：US13032569
申请日：2011-02-22
申请人： Richard S. Stack , Richard A. Glenn , Daniel Balbierz , John Lunsford , William L. Athas
发明人： Richard S. Stack , Richard A. Glenn , Daniel Balbierz , John Lunsford , William L. Athas
IPC分类号： A61M5/00 , A61F2/04
CPC分类号： A61F5/0089 , A61F5/0079
摘要： Described herein is a positioning tool having an elongate portion for carrying a medical implant. Also described is a method of positioning a medical implant using an elongate positioning tool. One form of the method includes positioning a medical implant on a distal portion of an elongate positioning tool, inserting the positioning tool with the implant thereon into a body cavity manipulating the positioning tool to position the implant into contact with tissue at an attachment location, attaching the implant to surrounding tissue at the attachment location, separating the implant from the positioning tool, and withdrawing the positioning tool from the body. In a preferred embodiment, the position of the implant is visually confirmed using an endoscope before the implant is attached to surrounding tissue. In one embodiment, the implant is a satiation device and the body cavity is the esophagus and/or stomach. In an alternative embodiment, an expansion structure on the distal end of the elongate portion expands and/or contracts the medical implant to facilitate positioning.
摘要翻译：本文描述的是具有用于承载医用植入物的细长部分的定位工具。还描述了使用细长定位工具定位医疗植入物的方法。该方法的一种形式包括将医疗植入物定位在细长定位工具的远侧部分上，将其上的植入物插入定位工具进入体腔以操纵定位工具以将植入物定位在附着位置处与组织接触植入到附接位置处的周围组织，将植入物与定位工具分离，并将定位工具从身体上取出。在优选实施例中，在植入物附接到周围组织之前，使用内窥镜在视觉上确认植入物的位置。在一个实施例中，植入物是饱食装置，并且体腔是食道和/或胃。在替代实施例中，细长部分的远端上的膨胀结构膨胀和/或收缩医疗植入物以便于定位。

2. 发明授权

US06235023B1 Cell necrosis apparatus 有权
标题翻译：细胞坏死装置
公开(公告)号：US06235023B1
公开(公告)日：2001-05-22
申请号：US09148571
申请日：1998-09-04
申请人： Kee S. Lee , Daniel Balbierz
发明人： Kee S. Lee , Daniel Balbierz
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/1815 , A61B2017/00101 , A61B2018/00011 , A61B2018/00023 , A61B2018/00196 , A61B2018/00273 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00744 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1472 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N1/06 , A61N1/403 , A61N5/04
摘要： A cell necrosis apparatus includes an introducer with a distal end sufficiently sharp to penetrate tissue. An energy delivery device has a first set of RF electrodes, a second set of RF electrodes and a third RF electrode. Each of electrodes has a tissue piercing distal end and is positionable in the introducer as the introducer is advanced through tissue. The first and second sets of RF electrodes are deployable with curvature from the introducer. The third RF electrode is deployable from the introducer with less curvature than the first and second sets of RF electrodes. The second set of RF electrodes is deployable a greater distance from the introducer than the first set of RF electrodes.
摘要翻译：细胞坏死装置包括具有足够锋利以穿透组织的远端的导引器。能量输送装置具有第一组RF电极，第二组RF电极和第三RF电极。每个电极具有组织穿刺的远端，并且当导引器穿过组织时可定位在导引器中。第一组和第二组RF电极可以从导引器以曲率展开。第三RF电极可以从导引器以比第一和第二组RF电极少的曲率展开。与第一组RF电极相比，第二组RF电极与导入器相比可展开更大的距离。

3. 发明申请

US20070276432A1 Devices and Methods for Retaining a Gastro-Esophageal Implant 有权
标题翻译：用于保留胃食管植入物的装置和方法
公开(公告)号：US20070276432A1
公开(公告)日：2007-11-29
申请号：US10575222
申请日：2004-10-08
申请人： Richard Stack , Daniel Balbierz , John Lunsford , Kevin van Bladel , William Eubanks , William Athas , Richard Glenn , Richard Kouri
发明人： Richard Stack , Daniel Balbierz , John Lunsford , Kevin van Bladel , William Eubanks , William Athas , Richard Glenn , Richard Kouri
IPC分类号： A61B17/08
CPC分类号： A61F5/0079 , A61B1/00 , A61B17/0469 , A61B17/0644 , A61B17/0686 , A61B17/072 , A61B17/07292 , A61B17/08 , A61B2017/0417 , A61B2017/0419 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0641 , A61B2017/0647 , A61B2017/301 , A61B2017/306 , A61F2/848 , A61F5/0076 , A61F5/0083 , A61M29/00
摘要： Various methods and devices are described for retaining a medical implant within a body cavity. According to one aspect, at least a portion of a medical implant is positioned within a body cavity, and a wall of the body cavity is re-shaped such that the re-shaped wall prevents migration of the medical implant out of the body cavity. The re-shaped body wall may form a tissue pocket, tunnel, or other barrier against migration of the implant.
摘要翻译：描述了用于将医疗植入物保持在体腔内的各种方法和装置。根据一个方面，医疗植入物的至少一部分定位在体腔内，并且体腔的壁被重新成形，使得重新形成的壁阻止医疗植入物离开体腔的迁移。重塑体壁可以形成组织袋，隧道或抵抗植入物迁移的其它屏障。

4. 发明申请

US20070219571A1 Endoscopic plication devices and methods 有权
标题翻译：内镜矫治装置及方法
公开(公告)号：US20070219571A1
公开(公告)日：2007-09-20
申请号：US11542457
申请日：2006-10-03
申请人： Daniel Balbierz , Dave Cole , Samuel Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
发明人： Daniel Balbierz , Dave Cole , Samuel Crews , Brett Swope , Andrew Smith , John Lunsford , Fiona Sander
IPC分类号： A61B17/08
CPC分类号： A61B17/1155 , A61B17/0218 , A61B17/068 , A61B17/072 , A61B17/07292 , A61B17/1114 , A61B17/115 , A61B17/1285 , A61B2017/00535 , A61B2017/00827 , A61B2017/07214 , A61B2017/07228 , A61B2017/1139 , A61B2017/1157 , A61B2017/306 , A61F5/0036
摘要： Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.
摘要翻译：这里描述的是内窥镜检查器，其通过经腹部通过胃并用于通过从胃内部接合组织并将其向内抽吸来摧毁胃组织。在所公开的实施例中，将组织向内拉入真空室，使得胃外部的浆膜组织的部分彼此相对定位。所公开的调节器允许组织的相对部分彼此移动接触，并且优选地递送缝合线，缝钉或其它装置，用于保持组织切片之间的接触，至少在它们之间形成浆膜粘结。这些步骤中的每一个可以完全从胃内进行，因此可以消除对任何手术或腹腔镜干预的需要。在形成一个或多个脓肿之后，医疗装置可以连接到脓液以保持在胃中。

5. 发明申请

US20070112342A1 Tissue ablation apparatus and method 审中-公开
标题翻译：组织消融装置及方法
公开(公告)号：US20070112342A1
公开(公告)日：2007-05-17
申请号：US11651123
申请日：2007-01-08
申请人： Rob Pearson , Steve Daniel , Daniel Balbierz , Kee Lee , Jessica Liang , Martha Getaneh
发明人： Rob Pearson , Steve Daniel , Daniel Balbierz , Kee Lee , Jessica Liang , Martha Getaneh
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B2018/0016 , A61B2018/00577 , A61B2018/00654 , A61B2018/00702 , A61B2018/00714 , A61B2018/00791 , A61B2018/00797 , A61B2018/00875 , A61B2018/143 , A61B2018/1472 , A61B2018/1475
摘要： A method and apparatus for controlling the extent of tissue ablation are disclosed. The method utilizes delivering energy from an energy deliver device to a plurality of deployed electrodes and regulating energy delivered to the electrodes based on the temperature sensed by at least one remote elongate sensor element. A control device may be used to supply energy to the electrodes, to produce tissue ablation that advances from individual-electrode ablation regions to fill a combined-electrode ablation volume. Information from the sensor element(s) is used for determining the extent of ablation in the regions of the sensor elements. The supply of energy to the electrodes can thus be regulated to control the level and extent of tissue ablation throughout the combined-electrode volume.
摘要翻译：公开了一种用于控制组织消融程度的方法和装置。该方法利用将能量从能量传递装置传送到多个展开的电极，并且基于由至少一个远程细长传感器元件感测的温度来调节传递到电极的能量。可以使用控制装置向电极提供能量，以产生从单个电极消融区域前进以填充组合电极消融体积的组织消融。来自传感器元件的信息用于确定传感器元件区域中的消融程度。因此，可以调节对电极的能量供应以控制整个组合电极体积中的组织消融的水平和程度。

6. 发明申请

US20060241577A1 Tissue biopsy and treatment apparatus and method 审中-公开
公开(公告)号：US20060241577A1
公开(公告)日：2006-10-26
申请号：US11338109
申请日：2006-01-23
申请人： Daniel Balbierz , Theodore Johnson
发明人： Daniel Balbierz , Theodore Johnson
IPC分类号： A61B18/18
CPC分类号： A61B18/1206 , A61B5/0071 , A61B10/02 , A61B10/0283 , A61B18/00 , A61B18/1477 , A61B18/1482 , A61B18/1815 , A61B90/39 , A61B2017/00022 , A61B2017/00061 , A61B2017/003 , A61B2017/00849 , A61B2017/00867 , A61B2017/22082 , A61B2018/00029 , A61B2018/00083 , A61B2018/00142 , A61B2018/00577 , A61B2018/00642 , A61B2018/00654 , A61B2018/0069 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/143 , A61B2018/1432 , A61B2018/1472 , A61B2018/1861 , A61B2090/064 , A61B2090/3782 , A61B2090/3941 , A61B2090/3966 , A61B2218/002 , A61N7/02 , C08L2201/12
摘要： A method of treating a tumor includes providing a tissue biopsy and treatment apparatus that includes an elongated delivery device that has a lumen and is maneuverable in tissue. A sensor array having a plurality of resilient members is deployable from the elongated delivery device. At least one of the plurality of resilient members is positionable in the elongated delivery device in a compacted state and deployable with curvature into tissue from the elongated delivery device in a deployed state. At least one of the plurality of resilient members includes at least one of a sensor, a tissue piercing distal end or a lumen. The sensor array has a geometric configuration adapted to volumetrically sample tissue at a tissue site to differentiate or identify tissue at the tissue site. At least one energy delivery device is coupled to one of the sensor array, at least one of the plurality of resilient members or the elongated delivery device. The apparatus is then introduced into a target tissue site. The sensor array is then utilized to distinguish a tissue type. The tissue type information derived from the sensor array is utilized to position the energy delivery device to ablate a tumor volume. Energy is then delivered from the energy delivery device to ablate or necrose at least a portion of the tumor volume. The sensor array is then utilized to determine an amount of tumor volume ablation.

7. 发明申请

US20050261712A1 Restrictive and/or obstructive implant for inducing weight loss 有权
标题翻译：用于诱导体重减轻的限制性和/或阻塞性植入物
公开(公告)号：US20050261712A1
公开(公告)日：2005-11-24
申请号：US11114400
申请日：2005-04-26
申请人： Daniel Balbierz , William Athas , John Lunsford , William Eubanks , Kevin Bladel
发明人： Daniel Balbierz , William Athas , John Lunsford , William Eubanks , Kevin Bladel
IPC分类号： A61B17/08 , A61B17/12 , A61F5/00
CPC分类号： A61F5/0086 , A61B17/12009 , A61B2017/12018 , A61F5/003 , A61F5/0036
摘要： Described herein is a system for inducing weight loss in a patient, which comprises an extragastric space occupier positionable in contact with an exterior surface of a stomach wall to form an inward protrusion of wall into the stomach, and a retention device positionable in contact with the wall to retain the inward protrusion and to thereby capture the extragastric space occupier within the protrusion.
摘要翻译：本文描述了一种用于在患者体内引起体重减轻的系统，该系统包括可与胃壁的外表面接触定位的胃内空间占据器，以形成壁向胃内的向内突出部，以及可定位成与胃壁接触的保持装置壁以保持向内的突出部，从而捕获突出部内的胃内空间占据。

8. 发明申请

US20050137662A1 Tissue surface treatment apparatus and method 失效
标题翻译：组织表面处理装置及方法
公开(公告)号：US20050137662A1
公开(公告)日：2005-06-23
申请号：US11034435
申请日：2005-01-11
申请人： David Morris , Steven Daniel , Daniel Balbierz
发明人： David Morris , Steven Daniel , Daniel Balbierz
IPC分类号： A61B18/14 , A61F2/00
CPC分类号： A61M25/1002 , A61B18/1477 , A61B2018/00011 , A61B2018/00017 , A61B2018/00029 , A61B2018/00291 , A61B2018/143 , A61B2018/1475 , A61M2025/0085
摘要： A tissue surface treatment apparatus includes a housing having a proximal end, a distal end including a tissue contacting surface, an interior defined by the housing and a handpiece coupled to the housing. The contactinc surface has a plurality of apertures. An energy delivery device including an electrode is positionable in the housing interior. The electrode includes a tissue penetrating distal end in substantial alignment with an aperture. The electrode is configured to be advanced from the housing interior through the aperture and into a target tissue site to define an ablation volume at least partly bounded by a tissue surface. An advancement device is coupled to the energy delivery device and is at least partly positionable within at least one of the housing or the handpiece. The advancement device is configured to advance the electrode from the housing interior into the target tissue site and withdrawal the electrode into the housing interior. A cable is coupled to the housing or the energy delivery device and is configured to be coupled to an energy source.
摘要翻译：组织表面处理设备包括具有近端，远端包括组织接触表面的壳体，由壳体限定的内部和联接到壳体的手持件。触点表面具有多个孔。包括电极的能量输送装置可定位在壳体内部。电极包括与孔基本对准的穿透远端的组织。电极被配置为从壳体内部通过孔推进到目标组织部位以限定至少部分地由组织表面限定的消融体积。进给装置联接到能量输送装置，并且至少部分地可定位在壳体或手持件中的至少一个中。推进装置被配置为将电极从壳体内部推进到目标组织部位并将电极抽出到壳体内部。电缆耦合到壳体或能量输送装置，并且被配置为耦合到能量源。

9. 发明授权

US06551311B2 Cell necrosis apparatus and method 失效
标题翻译：细胞坏死装置及方法
公开(公告)号：US06551311B2
公开(公告)日：2003-04-22
申请号：US09758326
申请日：2001-01-10
申请人： Kee S. Lee , Daniel Balbierz
发明人： Kee S. Lee , Daniel Balbierz
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/1815 , A61B2017/00101 , A61B2018/00011 , A61B2018/00023 , A61B2018/00196 , A61B2018/00273 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00744 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1472 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N1/06 , A61N1/403 , A61N5/04
摘要： A cell necrosis apparatus includes an introducer with a distal end sufficiently sharp to penetrate tissue, an energy delivery including a plurality of electrodes and a slidable sensing member. Each electrode of the plurality of electrodes has a tissue piercing distal end and is positionable in the introducer as the introducer is advanced through tissue. At least one electrode of the plurality of electrodes is deployable with curvature from the introducer. The slidable sensing member is positionable within the introducer and electrically coupled to the energy delivery device. The sensing member is configured to measure a property of the energy delivery device or at least one electrode of the plurality of electrodes.
摘要翻译：细胞坏死装置包括具有足够锐利以穿透组织的远端的导引器，包括多个电极的能量传递和可滑动的感测构件。多个电极中的每个电极具有组织穿刺的远端，并且当导引器前进穿过组织时可定位在导引器中。多个电极中的至少一个电极可以从导引器以曲率展开。可滑动感测构件可定位在导引器内并电耦合到能量输送装置。感测构件被配置成测量能量输送装置或多个电极中的至少一个电极的性质。

10. 发明授权

US06330478B1 Cell necrosis apparatus 有权
标题翻译：细胞坏死装置
公开(公告)号：US06330478B1
公开(公告)日：2001-12-11
申请号：US09148529
申请日：1998-09-04
申请人： Kee S. Lee , Daniel Balbierz , Edward J. Gough
发明人： Kee S. Lee , Daniel Balbierz , Edward J. Gough
IPC分类号： A61F200
CPC分类号： A61B18/1482 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00101 , A61B2018/00011 , A61B2018/00023 , A61B2018/00083 , A61B2018/00196 , A61B2018/00273 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00744 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1472 , A61B2018/1475 , A61B2018/162 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N1/06 , A61N1/403 , A61N5/04
摘要： A cell necrosis apparatus includes an introducer with a distal end sufficiently sharp to penetrate tissue. An energy delivery device has a first set of RF electrodes and a second set of RF electrodes. Each RF electrode of the first and second sets has a tissue piercing distal end and is positionable in the introducer as the introducer is advanced through tissue. The first and second sets of RF electrodes are deployable with curvature from the introducer. The second set of RF electrodes is deployable a greater distance from the introducer than the first set of RF electrodes.
摘要翻译：细胞坏死装置包括具有足够锋利以穿透组织的远端的导引器。能量输送装置具有第一组RF电极和第二组RF电极。第一组和第二组的每个RF电极具有组织穿刺远端，并且当导引器前进穿过组织时可定位在导引器中。第一组和第二组RF电极可以从导引器以曲率展开。与第一组RF电极相比，第二组RF电极与导入器相比可展开更大的距离。

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