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    • 1. 发明授权
    • Thieno [3,2-c] pyridine derivatives and their therapeutic application
    • 噻吩并[3,2-c]吡啶衍生物及其治疗应用
    • US4529596A
    • 1985-07-16
    • US510582
    • 1983-07-05
    • Daniel AubertClaude FerrandJean-Pierre Maffrand
    • Daniel AubertClaude FerrandJean-Pierre Maffrand
    • A61K31/435A61P7/02C07D495/04
    • C07D495/04
    • This invention relates to new thieno [3,2-c] pyridine derivatives having the formula: ##STR1## in which: Y represents the OH group or an OR group in which R is a straight or branched lower alkyl radical, or Y represents a group ##STR2## in which R.sub.1 and R.sub.2 are each independently of each other, hydrogen or a straight or branched lower alkyl group; or R.sub.1 and R.sub.2 form together and with the nitrogen atom to which they are attached a heterocycle which may include a second heteroatom such as oxygen or nitrogen, wherein the latter may be substituted by a lower alkyl or benzyl radical which may be substituted; and X represents hydrogen, a halogen or a lower alkyl radical; and their addition salts with pharmaceutically acceptable mineral or organic acids if Y represents the group OR or ##STR3## or with mineral bases if Y represents OH, as well as the two enantiomers or their mixture.The invention also relates to the preparation process of new thieno [3,2-c] pyridine derivatives and to their therapeutic application as blood-platelet aggregation inhibiting agents and antithrombotics.
    • 本发明涉及具有下式的新的噻吩并[3,2-c]吡啶衍生物:其中:Y表示OH基或OR基,其中R是直链或支链低级烷基,或 Y表示其中R 1和R 2各自独立地为氢或直链或支链低级烷基的基团 或者R 1和R 2与它们所连接的氮原子一起形成杂环,其可以包括第二杂原子如氧或氮,其中后者可以被可被取代的低级烷基或苄基取代; X表示氢,卤素或低级烷基; 如果Y代表基团OR或或者与Y表示OH的矿物碱,以及它们的两种对映异构体或它们的混合物,则它们与药学上可接受的矿物或有机酸的加成盐。 本发明还涉及新的噻吩并[3,2-c]吡啶衍生物的制备方法及其作为血小板聚集抑制剂和抗血栓形成剂的治疗应用。