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1. 发明授权

US08721669B2 Systems and methods for surgical removal of brain tumors 有权
标题翻译：手术切除脑肿瘤的系统和方法
公开(公告)号：US08721669B2
公开(公告)日：2014-05-13
申请号：US13311725
申请日：2011-12-06
申请人： Dana A. Oliver , Louis M. Shadeck , Robert F. Spetzler
发明人： Dana A. Oliver , Louis M. Shadeck , Robert F. Spetzler
IPC分类号： A61B17/32 , A61B17/20 , A61M31/00
CPC分类号： A61B17/320783 , A61B10/0275 , A61B10/0283 , A61B17/32002 , A61B2017/32004 , A61B2017/320775
摘要： A method for treating a brain tumor includes providing a surgical instrument having an inner member and an outer member. The outer member has a distal region forming a cutting window. The inner member is rotatably received within the outer member, and has a cutting tip that is exposed at the window. The cutting tip and the distal region of the outer member combine to define a cutting implement. An opening is created through the patient's skull to provide access to a brain tumor target site. The cutting implement is delivered through the opening to the target site. The cutting tip is placed into contact with the tumor and operated to cut the tumor. The target site is selectively aspirated to remove cut tumor tissue.
摘要翻译：治疗脑肿瘤的方法包括提供具有内部构件和外部构件的外科器械。外部构件具有形成切割窗的远侧区域。内部构件可旋转地容纳在外部构件内，并且具有暴露在窗口处的切割尖端。外部构件的切割尖端和远侧区域组合以限定切割工具。通过患者的头骨创建一个开口，以提供对脑肿瘤靶点的访问。切割工具通过开口传送到目标位置。切割尖端与肿瘤接触并操作以切割肿瘤。选择性地吸出靶位点以去除切割的肿瘤组织。

2. 发明授权

US08313762B2 Flexible bioresorbable hemostatic packing and stent 有权
标题翻译：柔性生物可吸收止血包装和支架
公开(公告)号：US08313762B2
公开(公告)日：2012-11-20
申请号：US11482234
申请日：2006-07-05
申请人： Dana A. Oliver , Matthew J. Halvorsen , Aimee Hodge
发明人： Dana A. Oliver , Matthew J. Halvorsen , Aimee Hodge
IPC分类号： A61F2/02 , A61K31/17
CPC分类号： A61L24/08 , A61F2/04 , A61L24/0036 , A61L24/0042 , A61L2400/04 , C08L1/26
摘要： The invention provides a flexible bioresorbable foam having hemostatic properties. The foam is formed from a carboxymethylcellulose suspension.
摘要翻译：本发明提供具有止血性能的柔性生物可再吸收泡沫。泡沫由羧甲基纤维素悬浮液形成。

3. 发明申请

US20120184926A1 POLYMERIC SEALANT FOR MEDICAL USE 有权
标题翻译：聚合物用于医疗用途的密封剂
公开(公告)号：US20120184926A1
公开(公告)日：2012-07-19
申请号：US13323636
申请日：2011-12-12
申请人： James Britton Hissong , Dana A. Oliver , Cecil O. Lewis , Janis Saunier , Matthew F. Myntti
发明人： James Britton Hissong , Dana A. Oliver , Cecil O. Lewis , Janis Saunier , Matthew F. Myntti
IPC分类号： A61M35/00 , A61B17/03 , A61L24/04
CPC分类号： A61L26/0047 , A61L24/0015 , A61L24/0042 , A61L24/108 , A61L26/0014 , A61L26/0019 , A61L26/0023 , A61L26/0066 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2400/04 , C09J133/14 , C09J139/06 , C09J167/00 , C09J167/04 , C09J169/00 , C09J175/04 , C09J177/00 , C09J179/02 , C09J185/02
摘要： The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.
摘要翻译：本发明提供一种聚合物医用密封剂。医用密封剂可用于扁桃体和腺样体，其中密封剂具有以下功能中的至少一个：a）抑制细菌的定居，b）抑制细菌与组织的结合，c）减少组织发病率， d）止血，e）愈合过程中涂层和保护组织。 f）促进愈合，g）减轻疼痛。

4. 发明授权

US07927361B2 Method and apparatus for removing material from an intervertebral disc space, such as in performing a nucleotomy 有权
标题翻译：用于从椎间盘空间中去除材料的方法和装置，例如进行核切开术
公开(公告)号：US07927361B2
公开(公告)日：2011-04-19
申请号：US11289266
申请日：2005-11-29
申请人： Dana A. Oliver , Kenneth M. Adams , Tom J. Francis
发明人： Dana A. Oliver , Kenneth M. Adams , Tom J. Francis
IPC分类号： A61B17/88
CPC分类号： A61B17/32002 , A61B2017/00261 , A61B2017/2904
摘要： Instrument and method for removing material from an intervertebral disc. The instrument includes outer and inner tubular members. The outer tubular member defines a passage and a cutting window. The inner tubular member is coaxially disposed within the passage, and defines a central lumen and a cutting tip. The cutting tip forms an open mouth having a plurality of teeth. Upon assembly, the cutting tip is exposed within the cutting window combining to define a shaving head. A powered handpiece is coupled to the inner tubular member, and the shaving head is inserted into an intervertebral disc and positioned such that the cutting tip contacts targeted material (e.g., nucleus, annulus and/or end plate). The handpiece is activated to rotate the cutting tip relative to the cutting window. Contacted material is sheared between an edge of the cutting window and the teeth of the cutting tip.
摘要翻译：用于从椎间盘去除材料的仪器和方法。该仪器包括外部和内部管状构件。外管状构件限定通道和切割窗。内部管状构件同轴地设置在通道内，并且限定中心腔和切割尖端。切割尖端形成具有多个齿的开口。在组装时，切割尖端暴露在切割窗内组合以限定剃须头。动力手持件联接到内部管状构件，并且剃削头被插入到椎间盘中并且被定位成使得切割尖端接触目标材料（例如，细胞核，环带和/或端板）。激活手柄以相对于切割窗口旋转切割尖端。在切割窗口的边缘和切割尖端的齿之间剪切接触材料。

5. 发明授权

US07858107B2 Flexible bioresorbable hemostatic packing and stent having a preselectable in-vivo residence time 有权
标题翻译：柔性生物可吸收的止血包装和支架具有预选的体内停留时间
公开(公告)号：US07858107B2
公开(公告)日：2010-12-28
申请号：US10938999
申请日：2004-09-10
申请人： Dana A. Oliver , Matthew J. Halvorsen , Leah Kavanagh
发明人： Dana A. Oliver , Matthew J. Halvorsen , Leah Kavanagh
IPC分类号： A61K31/728 , A61F2/00
CPC分类号： A61L24/043 , A61K31/728 , A61L2/0035 , A61L24/0036 , A61L24/0042 , A61L2202/21 , A61L2400/04
摘要： The invention provides a flexible bioresorbable foam having hemostatic properties and a preselectable in-vivo residence time. The foam includes a blend of collagen and a hyaluronic acid component such as hyaluronic acid or a derivative thereof, typically, the hyaluronic acid component is present in a range of from about 70 to about 90 percent.
摘要翻译：本发明提供具有止血性质和可预选的体内停留时间的柔性生物可再吸收泡沫。泡沫包括胶原蛋白和透明质酸组分如透明质酸或其衍生物的混合物，通常，透明质酸组分存在于约70至约90％的范围内。

6. 发明申请

US20090285897A1 REHYDRATABLE THIOLATED POLYSACCHARIDE PARTICLES AND SPONGE 有权
标题翻译：可再结晶的多糖多糖颗粒和海绵
公开(公告)号：US20090285897A1
公开(公告)日：2009-11-19
申请号：US12429120
申请日：2009-04-23
申请人： Matthew Franco Myntti , Dana A. Oliver , Brian J. Vaccaro
发明人： Matthew Franco Myntti , Dana A. Oliver , Brian J. Vaccaro
IPC分类号： A61K9/16 , A61K9/14 , A61K31/715 , A61K47/36
CPC分类号： A61L24/0031 , A61L24/0036 , A61L24/08 , A61L26/0023 , A61L26/008 , C08B37/003 , C08G2210/00 , C08L1/286 , C08L3/02 , C08L5/00 , C08L5/02 , C08L5/04 , C08L5/08 , C08L5/12 , C08L101/02
摘要： Tissue and other body structures may be protected using a hydrated composition made from free-flowing rehydratable particles or a rehydratable sponge comprising substantially collagen-free dehydrothermally crosslinked thiolated polysaccharide. Rehydration of crosslinked or uncrosslinked polysaccharide particles may be carried out without clumping by dispersing the particles in a biocompatible water-miscible polar dispersant such as ethanol and combining the dispersion with sufficient aqueous solvent for the particles to convert them to a cohesive hydrogel. The hydrated particles or sponge may assist in returning an injured, inflamed or surgically repaired surface to a normal state, e.g., through one or more healing mechanisms such as modulation of an inflammatory response, phagocytosis, mucosal remodeling, reciliation or other full or partial restoration of normal function.
摘要翻译：可以使用由自由流动的可再水化颗粒制成的水合组合物或包含基本上无胶原的脱水热交联的硫醇化多糖的可再水化海绵来保护组织和其它身体结构。交联或未交联的多糖颗粒的再水化可以通过将颗粒分散在生物相容性的水混溶性极性分散剂如乙醇中而不凝结地进行，并将该分散体与足够的含水溶剂混合以使颗粒转化为粘性水凝胶。水合颗粒或海绵可以帮助将损伤的，发炎的或手术修复的表面恢复到正常状态，例如通过一种或多种愈合机制，例如调节炎症反应，吞噬作用，粘膜重塑，复发或其他完全或部分恢复的正常功能。

7. 发明申请

US20070264353A1 EXTRACELLULAR POLYSACCHARIDE SOLVATING SYSTEM FOR TREATMENT OF BACTERIAL EAR CONDITIONS 有权
标题翻译：用于治疗细菌性耳朵的细胞多糖溶解系统
公开(公告)号：US20070264353A1
公开(公告)日：2007-11-15
申请号：US11739508
申请日：2007-04-24
申请人： Matthew F. Myntti , Dana A. Oliver , Cecil O. Lewis
发明人： Matthew F. Myntti , Dana A. Oliver , Cecil O. Lewis
IPC分类号： A61K33/00 , A61K33/06 , A61K33/26
CPC分类号： A61K45/06 , A61K31/10 , A61K31/19 , A61K33/22 , A61K33/24 , A61K33/40
摘要： Chronic otitis media and other bacterial ear conditions may be treated by applying a solvating system containing a metal ion sequestering agent and surfactant to a bacterial biofilm in the middle or inner ear. The solvating system disrupts the biofilm and aids in its removal.
摘要翻译：可以通过将含有金属离子螯合剂和表面活性剂的溶剂化体系应用于中耳或内耳的细菌生物膜来治疗慢性中耳炎和其它细菌耳朵病症。溶剂化系统破坏生物膜并有助于其去除。

8. 发明授权

US06607512B2 Device for delivery of liquid and gel-like surgical materials and methods for use thereof 失效
标题翻译：用于输送液体和凝胶状手术材料的装置及其使用方法
公开(公告)号：US06607512B2
公开(公告)日：2003-08-19
申请号：US09757278
申请日：2001-01-09
申请人： Dana A. Oliver , Lawrence F. Travers
发明人： Dana A. Oliver , Lawrence F. Travers
IPC分类号： A61K3100
CPC分类号： A61M31/00 , A61M5/31581
摘要： The present invention provides a novel apparatus for delivering a liquid or gel-like surgical material to a target site within a body cavity. The apparatus is characterized in part by an elongated structural member adapted for engagement with a conventional syringe and cannula assembly. In preferred embodiments of the present invention, devices of the invention further comprise a highly flexible applicator tip which permits application of the surgical material at variable delivery angles and even against gravity. Methods also are disclosed for applying the surgical material to the target site using. devices of the present invention.
摘要翻译：本发明提供了一种用于将液体或凝胶状外科材料输送到体腔内的靶部位的新型装置。该装置的特征在于部分由适于与常规注射器和插管组件接合的细长结构构件。在本发明的优选实施例中，本发明的装置还包括高度灵活的施用器尖端，其允许外科材料以可变的输送角度甚至反重力施加。公开了将外科手术材料应用于目标部位的方法。本发明的装置。

9. 发明授权

US09119896B2 Polymeric sealant for medical use 有权
标题翻译：用于医疗用途的聚合物密封剂
公开(公告)号：US09119896B2
公开(公告)日：2015-09-01
申请号：US13323636
申请日：2011-12-12
申请人： James Britton Hissong , Dana A. Oliver , Cecil O. Lewis , Janis Saunier , Matthew F. Myntti
发明人： James Britton Hissong , Dana A. Oliver , Cecil O. Lewis , Janis Saunier , Matthew F. Myntti
IPC分类号： A61M35/00 , A61L24/00 , A61L24/10 , A61L31/04 , A61L31/14 , A61L31/16
CPC分类号： A61L26/0047 , A61L24/0015 , A61L24/0042 , A61L24/108 , A61L26/0014 , A61L26/0019 , A61L26/0023 , A61L26/0066 , A61L31/047 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2400/04 , C09J133/14 , C09J139/06 , C09J167/00 , C09J167/04 , C09J169/00 , C09J175/04 , C09J177/00 , C09J179/02 , C09J185/02
摘要： The invention provides a polymeric medical sealant. The medical sealant is useful for application to the tonsils and adenoids, wherein the sealant performs at least one of the following functions, a) inhibit the colonization of bacteria, b) inhibit the binding of bacteria to tissue, c) reduction of tissue morbidity, d) hemostasis, e) coating and protection of tissue during healing. f) promotion of healing, and g) reduction of pain.
摘要翻译：本发明提供一种聚合物医用密封剂。医用密封剂可用于扁桃体和腺样体，其中密封剂具有以下功能中的至少一个：a）抑制细菌的定居，b）抑制细菌与组织的结合，c）减少组织发病率， d）止血，e）愈合过程中涂层和保护组织。 f）促进愈合，g）减轻疼痛。

10. 发明授权

US08172846B2 Method for performing high speed surgical procedures 有权
标题翻译：执行高速外科手术的方法
公开(公告)号：US08172846B2
公开(公告)日：2012-05-08
申请号：US12356173
申请日：2009-01-20
申请人： William Charles Brunnett , Dana A. Oliver , Cecil O. Lewis , Kenneth M. Adams
发明人： William Charles Brunnett , Dana A. Oliver , Cecil O. Lewis , Kenneth M. Adams
IPC分类号： A61B17/32
CPC分类号： A61B17/1633 , A61B17/1624 , A61B17/1631 , A61B17/1662 , A61B17/1679 , A61B17/32002 , A61B2017/00477 , A61B2017/00845 , A61B2017/2904 , A61B2017/320032 , A61B2018/00005
摘要： A method for performing a surgical procedure on tissue at a target site of a patient includes providing a surgical cutting instrument including an outer tube, inner wire assembly and a cutting tip. The outer tube defines a curved segment. The inner wire assembly is rotatably disposed within the outer tube. The cutting tip is connected to the inner wire assembly and positioned at a distal end of the outer tube. The tissue at the target site is exposed and the cutting tip is deployed against the tissue. The method further includes rotating the inner wire assembly relative to the outer tube at speeds in excess of 50,000 RPM such that the cutting tip removes contacted tissue.
摘要翻译：在患者的目标部位的组织上执行外科手术的方法包括提供包括外管，内线组件和切割尖端的外科切割仪器。外管限定弯曲段。内线组件可旋转地设置在外管内。切割尖端连接到内部线组件并且定位在外部管的远端。目标部位的组织被暴露，并且切割尖端相对于组织展开。该方法还包括以超过50,000RPM的速度相对于外管旋转内部线组件，使得切割尖端移除接触的组织。

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