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1. 发明申请

US20140186871A1 COMPOSITIONS AND METHODS FOR OPTIMIZING DRUG HYDROPHOBICITY AND DRUG DELIVERY TO CELLS 有权
标题翻译：用于优化药物的疏水性和药物递送至细胞的组合物和方法
公开(公告)号：US20140186871A1
公开(公告)日：2014-07-03
申请号：US14092639
申请日：2013-11-27
申请人： Dan W. Urry , Kelley D. Urry
发明人： Dan W. Urry , Kelley D. Urry
IPC分类号： G01N33/50
CPC分类号： G01N33/502 , A61K9/5169 , A61K31/555 , A61K47/6935 , Y02A50/481 , Y02A90/26
摘要： Methods to determine drug hydrophobicity and to quantify changes in drug hydrophobicity that optimize drug function by means of differential scanning calorimetry of an endothermic phase transition of a base protein-based polymer, specifically of an elastic-contractile model protein, to which is attached the drug to be evaluated for its hydrophobicity in terms of the change in Gibbs free energy for hydrophobic association, ΔGHA have been developed. Also described herein is the preparation of nanoparticles comprised of protein-based polymers, specifically of elastic-contractile model proteins, designed for the binding and desired release rate of a specific drug or class of drugs. Further described herein is a means of targeting the drug-laden nanoparticle to a cell by means of decorating the nanoparticle surface with a molecular entity that selectively binds to the diseased cell or disease causing organism, e.g., by decorating the drug-laden nanoparticle surface with synthetic antigen-binding fragment to an up-regulated receptor characteristic of the diseased cell.
摘要翻译：确定药物疏水性并通过基于蛋白质的聚合物（特别是弹性 - 收缩模型蛋白）的吸热相变的差示扫描量热法来测定药物疏水性的变化并量化药物疏水性的变化的方法，其中附着有药物根据疏水缔合的吉布斯自由能的变化来评估其疏水性，已经开发了＆Dgr; GHA。本文还描述了由针对特定药物或一类药物的结合和期望的释放速率设计的基于蛋白质的聚合物，特别是弹性收缩模型蛋白质的纳米颗粒的制备。本文进一步描述的方法是通过用选择性结合患病细胞或引起疾病的生物体的分子实体装饰纳米颗粒表面，将药物负载的纳米颗粒靶向细胞，例如通过用载体载体纳米颗粒表面装饰合成抗原结合片段与病变细胞特征性的上调受体。

2. 发明申请

US20100330606A1 COMPOSITIONS AND METHODS FOR OPTIMIZING DRUG HYDROPHOBICITY AND DRUG DELIVERY TO CELLS 有权
标题翻译：用于优化药物的疏水性和药物递送至细胞的组合物和方法
公开(公告)号：US20100330606A1
公开(公告)日：2010-12-30
申请号：US12797465
申请日：2010-06-09
申请人： DAN W. URRY , KELLEY D. URRY
发明人： DAN W. URRY , KELLEY D. URRY
IPC分类号： C12Q1/02 , C07F15/00
CPC分类号： G01N33/502 , A61K9/5169 , A61K31/555 , A61K47/6935 , Y02A50/481 , Y02A90/26
摘要： Methods to determine drug hydrophobicity and to quantify changes in drug hydrophobicity that optimize drug function by means of differential scanning calorimetry of an endothermic phase transition of a base protein-based polymer, specifically of an elastic-contractile model protein, to which is attached the drug to be evaluated for its hydrophobicity in terms of the change in Gibbs free energy for hydrophobic association, ΔGHA have been developed. Also described herein is the preparation of nanoparticles comprised of protein-based polymers, specifically of elastic-contractile model proteins, designed for the binding and desired release rate of a specific drug or class of drugs. Further described herein is a means of targeting the drug-laden nanoparticle to a cell by means of decorating the nanoparticle surface with a molecular entity that selectively binds to the diseased cell or disease causing organism, e.g., by decorating the drug-laden nanoparticle surface with synthetic antigen-binding fragment to an up-regulated receptor characteristic of the diseased cell.
摘要翻译：确定药物疏水性并通过基于蛋白质的聚合物（特别是弹性 - 收缩模型蛋白）的吸热相变的差示扫描量热法来测定药物疏水性的变化并量化药物疏水性的变化的方法，其中附着有药物根据疏水缔合的吉布斯自由能的变化来评估其疏水性，已经开发了＆Dgr; GHA。本文还描述了由针对特定药物或一类药物的结合和期望的释放速率设计的基于蛋白质的聚合物，特别是弹性收缩模型蛋白质的纳米颗粒的制备。本文进一步描述的方法是通过用选择性结合患病细胞或引起疾病的生物体的分子实体装饰纳米颗粒表面，将药物负载的纳米颗粒靶向细胞，例如通过用载体载体纳米颗粒表面装饰合成抗原结合片段与病变细胞特征性的上调受体。

3. 发明授权

US06699294B2 Injectable implants for tissue augmentation and restoration 失效
标题翻译：注射植入物用于组织增大和恢复
公开(公告)号：US06699294B2
公开(公告)日：2004-03-02
申请号：US09837969
申请日：2001-04-18
申请人： Dan W. Urry
发明人： Dan W. Urry
IPC分类号： A61F202
CPC分类号： C08F293/00 , A61F2/442 , A61F2/4601 , A61F2002/2817 , A61F2002/30678 , A61K38/16 , A61L27/227 , A61L2400/06 , A61L2430/38
摘要： A method for tissue augmentation in a mammal is provided comprising injecting a polymer at a tissue site in need of augmentation and having a tissue temperature, the polymer comprising repeating peptide monomeric units selected from the group consisting of nonapeptide, pentapeptide and tetrapeptide monomeric units, wherein the monomeric units form a series of &bgr;-turns separated by dynamic bridging segments suspended between the &bgr;-turns, wherein the polymer has an inverse temperature transition Tt less than the tissue temperature, and wherein the polymer is injected as a water solution at coacervate concentration in the substantial absence of additional water. A kit containing the injectable bioelastic polymer and a syringe is also provided.
摘要翻译：提供哺乳动物组织增加的方法，包括在需要增加并具有组织温度的组织部位注射聚合物，所述聚合物包含选自非肽，五肽和四肽单体单元的重复肽单体单元，其中单体单元形成一系列β-匝间隔开的悬浮在β-匝间的动态桥连段，其中聚合物具有小于组织温度的反向温度转变Tt，并且其中聚合物以凝集浓度作为水溶液注入在实质上没有额外的水。还提供了包含可注射生物弹性聚合物和注射器的试剂盒。

4. 发明授权

US06533819B1 Injectable implants for tissue augmentation and restoration 失效
标题翻译：注射植入物用于组织增大和恢复
公开(公告)号：US06533819B1
公开(公告)日：2003-03-18
申请号：US09841334
申请日：2001-04-23
申请人： Dan W. Urry , Timothy M. Parker , Paul A. Glazer
发明人： Dan W. Urry , Timothy M. Parker , Paul A. Glazer
IPC分类号： A61F244
CPC分类号： C08F293/00 , A61F2/442 , A61F2/4601 , A61F2002/2817 , A61F2002/30678 , A61K38/16 , A61L27/227 , A61L2400/06 , A61L2430/38
摘要： A method for tissue augmentation in a mammal is provided having injecting a polymer at a tissue site in need of augmentation and having a tissue temperature, the polymer having repeating peptide monomeric units selected from the group consisting of nonapeptide, pentapeptide and tetrapeptide monomeric units, wherein the monomeric units form a series of &bgr;-turns separated by dynamic bridging segments suspended between the &bgr;-turns, wherein the polymer has an inverse temperature transition Tt less than the tissue temperature, and wherein the polymer is injected as a water solution at coacervate concentration in the substantial absence of additional water. A kit containing the injectable bioelastic polymer and a syringe is also provided.
摘要翻译：提供哺乳动物组织增加的方法，其中在需要增加并具有组织温度的组织部位注入聚合物，所述聚合物具有选自单肽，五肽和四肽单体单元的重复肽单体单元，其中单体单元形成一系列β-匝间隔开的悬浮在β-匝间的动态桥连段，其中聚合物具有小于组织温度的反向温度转变Tt，并且其中聚合物以凝集浓度作为水溶液注入在实质上没有额外的水。还提供了包含可注射生物弹性聚合物和注射器的试剂盒。

5. 发明授权

US5226292A Polymers capable of baromechanical and barochemical transduction 失效
标题翻译：聚合物能够进行硼和化学传输
公开(公告)号：US5226292A
公开(公告)日：1993-07-13
申请号：US688324
申请日：1991-04-22
申请人： Dan W. Urry
发明人： Dan W. Urry
IPC分类号： A61F2/30 , A61K9/20 , A61L27/14 , A61L27/50
CPC分类号： A61L27/14 , A61K9/2045 , A61L27/50 , A61F2/30756
摘要： A composition that expands against an exerted pressure, which comprises a polymeric material having an inverse temperature transition in the range of liquid water, wherein at least a fraction of the monomers in the polymer contain a hydrophobic group that is present in an amount sufficient to provide PdV/dS for the polymer of at least 0.2.degree. K. The composition can be used in a variety of different application to produce mechanical work or cause chemical changes in a sealed environment by varying the pressure on the composition, with the degree of mechanical or chemical change being controlled by selection of the number, hydrophobicity, and size of the hydrophobic group and the presence or absence of reactive functional groups in the polymer.
摘要翻译：一种针对施加的压力膨胀的组合物，其包含在液体水范围内具有反向温度转变的聚合物材料，其中聚合物中至少一部分单体含有疏水基团，其以足以提供聚合物的PdV / dS为至少0.2°K。该组合物可用于各种不同的应用中以通过改变组合物的压力来产生机械作业或在密封环境中引起化学变化，其机械或通过选择疏水基团的数量，疏水性和尺寸以及聚合物中反应性官能团的存在或不存在来控制化学变化。

6. 发明授权

US4589882A Enzymatically crosslinked bioelastomers 失效
标题翻译：酶交联生物弹性体
公开(公告)号：US4589882A
公开(公告)日：1986-05-20
申请号：US533524
申请日：1983-09-19
申请人： Dan W. Urry
发明人： Dan W. Urry
IPC分类号： A61L17/00 , A61L27/22 , A61L27/40 , C08G69/10 , D01F8/00 , A61F2/02 , A61F2/06 , A61K37/00
CPC分类号： D01F8/00 , A61L17/00 , A61L27/227 , A61L27/40 , C08G69/10 , Y10S930/31
摘要： A method of repairing a natural elastic system in a human or animal body, which comprises replacing a damaged portion of the system with a shaped artificial elastomeric copolymer comprising an elastomeric component selected from the group consisting of tetrapeptide and pentapeptide repeating units or mixtures thereof wherein the repeating units comprise amino acid residues selected from the group consisting of hydrophobic amino acid and glycine residues and the repeating units exist in a conformation having a .beta.-turn and a crosslinking component selected from the group consisting of amino acid and peptide residues of the formula ##STR1## wherein .alpha. represents a covalent bond or a peptide fragment containing 1-10 .alpha.-helix-forming amino acid residues, B represents a covalent bond or a petide fragment containing 1-10 amino acid residues, and n is an integer from 2 to 6; wherein the copolymer optionally comprises a chemotactic component selected from the group consisting of -Ala-Pro-Gly-Val-Gly-Val-, -Pro-Gly-Val-Gly-Val-Ala-, -Gly-Val-Gly-Val-Ala-Pro-, -Val-Gly-Val-Ala-Pro-Gly-, -Gly-Val-Ala-Pro-Gly-Val-, and -Val-Ala-Pro-Gly-Val-Gly- and is essentially devoid of peptide fragments which occur in natural elastin other than these elastomeric, crosslinking, and chemotactic components, is disclosed along with elastomeric copolymers suitable for use in the method of the invention and methods of synthesizing such bioelastomers.
摘要翻译：一种修复人或动物体内的天然弹性体系的方法，其包括用成形的人造弹性体共聚物代替系统的损坏部分，所述成形人造弹性体共聚物包含选自四肽和五肽重复单元或其混合物的弹性组分，其中重复单元包括选自疏水性氨基酸和甘氨酸残基的氨基酸残基，并且重复单元以具有β转角和交联成分的构型存在，所述结构选自下列化学式的氨基酸和肽残基： IMAGE>其中α表示共价键或含有1-10个α-螺旋形成氨基酸残基的肽片段，B表示共价键或含有1-10个氨基酸残基的petide片段，n为2- 6; 其中所述共聚物任选地包含选自以下的趋化成分：-Ala-Pro-Gly-Val-Gly-Val-，-Pro-Gly-Val-Gly-Val-Ala-，-Gly-Val-Gly-Val -Ala-Pro-，-Val-Gly-Val-Ala-Pro-Gly-，-Gly-Val-Ala-Pro-Gly-Val-和-Val-Ala-Pro-Gly-Val-Gly- 基本上没有发生在除了这些弹性体，交联和趋化性组分之外的天然弹性蛋白中发生的肽片段以及适用于本发明方法的弹性体共聚物和合成这种生物弹性体的方法。

7. 发明授权

US5527610A Elastomeric polypeptide matrices for preventing adhesion of biological materials 失效
标题翻译：用于防止生物材料粘附的弹性多肽基质
公开(公告)号：US5527610A
公开(公告)日：1996-06-18
申请号：US246874
申请日：1994-05-20
申请人： Dan W. Urry
发明人： Dan W. Urry
IPC分类号： A61L31/04 , C07K5/103 , C07K7/06 , C07K14/00 , C12N5/00 , C08G69/10
CPC分类号： C07K7/06 , A61L31/047 , C07K14/001 , C07K5/1008 , C12N5/0068 , C12N2533/30 , C12N2533/50 , Y10T428/2929 , Y10T428/2931 , Y10T428/2967 , Y10T428/2969 , Y10T428/31725
摘要： The invention provides a bioelastomer comprising tetrapeptide and/or pentapeptide monomeric units of the formula:R.sub.1 PGR.sub.2 G.sub.nwherein R.sub.2 is a peptide-producing residue of alanine or glycine; P is a peptide-producing residue of proline; G is a peptide-producing residue of glycine; R.sub.2 is a peptide-producing residue of glycine or alanine; and n is 0 or 1. In a further aspect of the invention, a method is provided for preventing adhesion of biological materials, such as protein, cells, and tissues, by forming a protective layer between a first surface and a second surface using the bioelastomer.
摘要翻译：本发明提供生物弹性体，其包含下式的四肽和/或五肽单体单元：R1PGR2Gn，其中R2是丙氨酸或甘氨酸的产肽残基; P是脯氨酸的肽产生残基; G是甘氨酸的肽产生残基; R2是甘氨酸或丙氨酸的肽产生残基; 在本发明的另一方面，提供了一种通过在第一表面和第二表面之间形成保护层来防止生物材料如蛋白质，细胞和组织的粘附的方法，其使用生物弹性体。

8. 发明授权

US5520672A Superabsorbent materials and uses thereof 失效
公开(公告)号：US5520672A
公开(公告)日：1996-05-28
申请号：US384566
申请日：1995-02-06
申请人： Dan W. Urry
发明人： Dan W. Urry
IPC分类号： A61F13/53 , A61F5/44 , A61F13/00 , A61F13/15 , A61F13/20 , A61F13/49 , A61L15/00 , A61L15/32 , A61L15/60 , C08G69/10 , C08L101/16 , G02B1/04 , B32B9/00
CPC分类号： G02B1/043 , A61F13/15203 , A61L15/32 , A61L15/60 , C08G69/10 , A61F2013/530773 , Y10T442/2484
摘要： Polymeric materials having an inverse temperature transition, particularly bioelastic polymers comprising monomeric units selected from the group consisting of bioelastic pentapeptides, tetrapeptides, and nonapeptides, have been found to have controllable absorbent properties that can be varied with temperature or contact with liquids. The materials are selected to be in a contracted or swollen state initially, depending on the specific use. When the material is located under different conditions (such as a different temperature resulting from being either in contact with or at distance from human skin), the material undergoes swelling or contraction to switch to the other state.

9. 发明授权

US4870055A Segmented polypeptide bioelastomers to modulate elastic modulus 失效
标题翻译：分段多肽生物弹性体调节弹性模量
公开(公告)号：US4870055A
公开(公告)日：1989-09-26
申请号：US180677
申请日：1988-04-08
申请人： Dan W. Urry , U. Prasad Kari
发明人： Dan W. Urry , U. Prasad Kari
IPC分类号： A61L27/22 , A61L27/50 , C07K1/107 , C07K14/46 , C07K14/78
CPC分类号： C07K1/1075 , A61L27/227 , A61L27/507 , C07K14/46 , C07K14/78 , Y10S530/849 , Y10S623/924 , Y10S930/29
摘要： A method of increasing the modulus of elasticity of a biopolymer is disclosed, which comprises incorporating a hexameric unit of the formula--X--(APGVGV).sub.n --Y--whereinA is a peptide-forming residue of L-alanine;P is a peptide-forming residue of L-proline;G is a peptide-forming residue of glycine;V is a peptide-forming residue of L-valine;X is PGVGV, GVGV, VGV, GV, V, or a covalent bond;Y is APGVG, APGV, APG, AP, A, or a covalent bond; andn is an integer from 2 to 200, wherein said hexameric unit comprises at least 18 amino acid residues, into an elastomeric polypeptide chain.
摘要翻译：公开了增加生物聚合物弹性模量的方法，其包括掺入式-X-（APGVGV）n-Y-的六聚体单元，其中A是L-丙氨酸的肽形成残基; P是L-脯氨酸的肽形成残基; G是甘氨酸的肽形成残基; V是L-缬氨酸的肽形成残基; X是PGVGV，GVGV，VGV，GV，V或共价键; Y是APGVG，APGV，APG，AP，A或共价键; 并且n是2至200的整数，其中所述六聚体单元包含至少18个氨基酸残基进入弹性体多肽链。

10. 发明授权

US5972406A Bioelastomers suitable as food product additives 失效
标题翻译：生物弹性体适合作为食品添加剂
公开(公告)号：US5972406A
公开(公告)日：1999-10-26
申请号：US735692
申请日：1995-10-16
申请人： Dan W. Urry , Peter R. Shewry , Umamaheswara Prasad Kari
发明人： Dan W. Urry , Peter R. Shewry , Umamaheswara Prasad Kari
IPC分类号： A21D2/26 , A23G4/00 , A23G4/08 , A23G4/14 , A23J1/00 , A23J1/12 , A23L1/0562 , A23L1/22 , A23L1/305 , A21D10/00
CPC分类号： A23G4/14 , A21D2/26 , A23G4/08 , A23J1/007 , A23J1/008 , A23J1/12 , A23L27/70 , A23L29/281 , A23L33/17
摘要： The invention provides a method for improving the texture of a food product by incorporating in the food product or a precursor of the food product a bioelastic polypeptide in an amount sufficient to increase the elasticity of the food product, the bioelastic polypeptide having tetrapeptide or pentapeptide repeating units or mixtures thereof and the repeating units existing in a conformation having a .beta.-turn. The invention also provides a method for binding a food product precursor by adding a bioelastic polypeptide in an amount sufficient to bind the food product precursor, the bioelastomer having tetrapeptide or pentapeptide repeating units or mixtures thereof and the repeating units existing in a conformation having a .beta.-turn. The present invention further provides a food adjunct containing a bioelastic polypeptide having tetrapeptide or pentapeptide repeating units or mixtures thereof where the repeating units exist in a conformation having a .beta.-turn, and an edible material suitable for human or animal consumption.
摘要翻译：本发明提供了一种通过在食物产品或食品前体中掺入足以增加食品弹性的量的生物弹性多肽来改善食品的质地的方法，所述生物弹性多肽具有四肽或五肽重复单元或其混合物，并且存在具有β-折点的构象的重复单元。本发明还提供了通过添加足以结合食品前体的量的生物弹性多肽来结合食品前体的方法，所述生物弹性体具有四肽或五肽重复单元或其混合物，并且存在于具有β -转。本发明进一步提供了一种含有具有四肽或五肽重复单元或其混合物的生物弹性多肽的食品添加剂，其中重复单元以具有β转角的构象存在，以及适用于人或动物消费的可食用材料。

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