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1. 发明授权

US07973037B2 Cathepsin cysteine protease inhibitors 有权
标题翻译：组织蛋白酶半胱氨酸蛋白酶抑制剂
公开(公告)号：US07973037B2
公开(公告)日：2011-07-05
申请号：US12082104
申请日：2008-04-08
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/535 , A61K31/497 , A61K31/435 , A61K31/385 , C07D265/30 , C07D241/04 , C07D211/08 , C07D333/02 , C07D255/03
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译：本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如骨质疏松症

2. 发明申请

US20080178554A1 Concrete Reinforcement Support Chair 失效
标题翻译：混凝土加固支撑椅
公开(公告)号：US20080178554A1
公开(公告)日：2008-07-31
申请号：US12022143
申请日：2008-01-29
申请人： Gary Dan McKay
发明人： Gary Dan McKay
IPC分类号： E04C5/16
CPC分类号： E04C5/20
摘要： An apparatus (“chair”) for supporting one or more reinforcement bars or post-tension cables (“bars/cables”) in a concrete structure includes a base member having a centered opening, a pair of opposing first leg members extending upward from the base member at a first angle, a pair of opposing second leg members extending upward from the base member at a second angle, and a strap-shaped locking cradle. The strap-shaped locking cradle includes an arc-shaped receiving portion attached to the first and second leg members, a flexible portion suitable for wrapping over the bars/cables and a fastener to affix the flexible portion to the arc-shaped receiving portion or one of the first leg members such that transverse and vertical movement of the bars/cables is limited and longitudinal movement of the bars/cables is allowed.
摘要翻译：用于在混凝土结构中支撑一个或多个加强筋或后拉电缆（“杆/电缆”）的装置（“椅子”）包括具有中心开口的基部构件，从第一支撑构件向上延伸的一对相对的第一腿构件第一角度的基部构件，以第二角度从基部构件向上延伸的一对相对的第二腿部构件和带状锁定支架。带状锁定支架包括附接到第一和第二腿部构件的弧形接收部分，适于缠绕在杆/电缆上的柔性部分和紧固件以将柔性部分固定到弧形接收部分或一个的第一腿构件，使得杆/电缆的横向和垂直运动受到限制，并且允许杆/电缆的纵向移动。

3. 发明授权

US07375134B2 Cathepsin cysteine protease inhibitors 有权
公开(公告)号：US07375134B2
公开(公告)日：2008-05-20
申请号：US10505796
申请日：2003-02-28
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien
IPC分类号： A01N37/34
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

4. 发明授权

US08318748B2 Cathepsin cysteine protease inhibitors 有权
标题翻译：组织蛋白酶半胱氨酸蛋白酶抑制剂
公开(公告)号：US08318748B2
公开(公告)日：2012-11-27
申请号：US13115462
申请日：2011-05-25
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Christophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/4965 , A61K31/66 , A61K31/44 , A61K31/445 , A61K31/425 , A61K31/415
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译：本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如骨质疏松症

5. 发明授权

US07870702B2 Concrete reinforcement support chair 失效
标题翻译：混凝土加固支撑椅
公开(公告)号：US07870702B2
公开(公告)日：2011-01-18
申请号：US12022143
申请日：2008-01-29
申请人： Gary Dan McKay
发明人： Gary Dan McKay
IPC分类号： E04C5/16
CPC分类号： E04C5/20
摘要： An apparatus (“chair”) for supporting one or more reinforcement bars or post-tension cables (“bars/cables”) in a concrete structure includes a base member having a centered opening, a pair of opposing first leg members extending upward from the base member at a first angle, a pair of opposing second leg members extending upward from the base member at a second angle, and a strap-shaped locking cradle. The strap-shaped locking cradle includes an arc-shaped receiving portion attached to the first and second leg members, a flexible portion suitable for wrapping over the bars/cables and a fastener to affix the flexible portion to the arc-shaped receiving portion or one of the first leg members such that transverse and vertical movement of the bars/cables is limited and longitudinal movement of the bars/cables is allowed.
摘要翻译：用于在混凝土结构中支撑一个或多个加强筋或后拉电缆（“杆/电缆”）的装置（“椅子”）包括具有中心开口的基部构件，从第一支撑构件向上延伸的一对相对的第一腿构件第一角度的基部构件，以第二角度从基部构件向上延伸的一对相对的第二腿部构件和带状锁定支架。带状锁定支架包括附接到第一和第二腿部构件的弧形接收部分，适于缠绕在杆/电缆上的柔性部分和紧固件以将柔性部分固定到弧形接收部分或一个的第一腿构件，使得杆/电缆的横向和垂直运动受到限制，并且允许杆/电缆的纵向移动。

6. 发明授权

US06225288B1 Gamma-ketoacid dipeptides as inhibitors of caspase-3 失效
标题翻译：伽马酮酸二肽作为半胱天冬酶-3的抑制剂
公开(公告)号：US06225288B1
公开(公告)日：2001-05-01
申请号：US09526840
申请日：2000-03-16
申请人： Yongxin Han , Andre Giroux , Erich Grimm , Renee Aspiotis , Sebastien Francoeur , Robert Zamboni , Petpiboon Prasit , Christopher Bayly , Dan McKay , Cameron Black
发明人： Yongxin Han , Andre Giroux , Erich Grimm , Renee Aspiotis , Sebastien Francoeur , Robert Zamboni , Petpiboon Prasit , Christopher Bayly , Dan McKay , Cameron Black
IPC分类号： C07K506
CPC分类号： C07D239/34 , C07C323/59
摘要： Compounds represented by formula I: as well as pharmaceutically acceptable salts, esters and hydrates thereof are disclosed along with pharmaceutical compositions and methods of treatment. The compounds are useful as inhibitors of caspase-3, which is implicated in modulating apoptosis.
摘要翻译：由式I表示的化合物及其药学上可接受的盐，酯和水合物与药物组合物和治疗方法一起公开。该化合物可用作半胱天冬酶-3的抑制剂，其涉及调节凋亡。

7. 发明申请

US20110230446A1 CATHEPSIN CYSTEINE PROTEASE INHIBITORS 有权
公开(公告)号：US20110230446A1
公开(公告)日：2011-09-22
申请号：US13115462
申请日：2011-05-25
申请人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
发明人： Christopher I. Bayly , Cameron Black , Serge Leger , Chun Sing Li , Dan McKay , Chirstophe Mellon , Jacques Yves Gauthier , Vouy-Linh Truong , Cheuk Lau , Michel Therien , Michael J. Green , Bernard L. Hirschbein , James William Janc , James T. Palmer , Chitra Baskaran
IPC分类号： A61K31/277 , A61K31/495 , A61K31/4418 , A61K31/426 , A61K31/4174 , A61K31/663 , A61P19/08 , A61P19/10 , A61P1/02 , A61P19/02 , A61P35/00 , A61P19/00
CPC分类号： C07C237/20 , A61K31/165 , A61K31/18 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4418 , A61K31/495 , C07C255/25 , C07C255/29 , C07C255/46 , C07C255/58 , C07C259/10 , C07C311/37 , C07C317/32 , C07C2601/02 , C07C2601/14 , C07D209/08 , C07D213/38 , C07D213/57 , C07D213/64 , C07D213/70 , C07D213/89 , C07D215/12 , C07D231/12 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D271/06 , C07D277/28 , C07D277/30 , C07D295/135 , C07D295/155 , C07D307/52 , C07D333/20 , C07D401/04 , C07D417/04
摘要： This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.
摘要翻译：本发明涉及一类新的化合物，它们是半胱氨酸蛋白酶抑制剂，包括但不限于组织蛋白酶K，L，S和B的抑制剂。这些化合物可用于治疗其中指示抑制骨吸收的疾病，例如骨质疏松症

8. 发明授权

US07968720B2 Secondary amines as renin inhibitors 失效
标题翻译：仲胺作为肾素抑制剂
公开(公告)号：US07968720B2
公开(公告)日：2011-06-28
申请号：US12223597
申请日：2007-01-31
申请人： Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
发明人： Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
IPC分类号： C07D221/02 , C07C211/00
CPC分类号： C07D211/78 , C07D211/34 , C07D211/70 , C07D401/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08
摘要： The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
摘要翻译：本发明涉及式（I）的新型仲胺衍生物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。

9. 发明申请

US20090176823A1 Secondary Amines as Renin Inhibitors 失效
标题翻译：二胺作为肾素抑制剂
公开(公告)号：US20090176823A1
公开(公告)日：2009-07-09
申请号：US12223597
申请日：2007-01-31
申请人： Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
发明人： Olivier Bezencon , Daniel Bur , Olivier Corminboeuf , Daniel Dube , Corinna Grisostomi , Dwight MacDonald , Dan McKay , David Powell , Lubos Remen , Sylvia Richard-Bildstein , John Scheigetz , Michel Therien , Thomas Weller
IPC分类号： A61K31/437 , C07D471/04 , C07D413/14 , A61K31/444 , A61P9/12
CPC分类号： C07D211/78 , C07D211/34 , C07D211/70 , C07D401/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/08
摘要： The invention relates to novel secondary amine derivatives of formula (I) and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors of renin.
摘要翻译：本发明涉及式（I）的新型仲胺衍生物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为肾素抑制剂的用途的相关方面。

10. 发明申请

US20090215888A1 TOPICAL NAIL FORMULATION 审中-公开
标题翻译：主题指甲制剂
公开(公告)号：US20090215888A1
公开(公告)日：2009-08-27
申请号：US12281258
申请日：2007-03-01
申请人： Singh Jagat , Dan McKay
发明人： Singh Jagat , Dan McKay
IPC分类号： A61K31/27
CPC分类号： A61Q3/00 , A61K8/36 , A61K8/361 , A61K8/447 , A61K8/4906 , A61Q17/00 , A61Q17/005
摘要： The present invention relates to a topical nail formulation comprising at least one active agent (e.g., tolnaftate) and at least one nail penetration enhancer selected from the group consisting of a fatty acid, an azone derivative, and mixtures thereof. The invention also relates to the use of said topical nail formulation for the treatment of nail disorders such as onychomycosis. The invention further provides a method of enhancing the nail flux of an active agent by using a topical nail formulation containing the said penetration enhancer.
摘要翻译：本发明涉及包含至少一种活性剂（例如，tolnaftate）和至少一种选自脂肪酸，氮酮衍生物及其混合物的指甲渗透促进剂的局部指甲制剂。本发明还涉及所述外用指甲制剂用于治疗指甲疾病如甲真菌病的用途。本发明还提供一种通过使用含有所述渗透增强剂的局部指甲制剂来增强活性剂的指甲通量的方法。

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