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1. 发明申请

US20090275581A1 RENIN INHIBITORS 审中-公开
标题翻译：雷宁抑制剂
公开(公告)号：US20090275581A1
公开(公告)日：2009-11-05
申请号：US12225987
申请日：2007-04-05
申请人： John J. Baldwin , David A. Claremon , Colin M. Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Wei Zhao , Robert D. Simpson , Suresh B. Singh , Patrick T. Flaherty , Lara S. Kallander , Colin A. Leach , Brian Lawhorn , Qing Lu , Lamont R. Terrell , Bahman Ghavini-Alagha , Jing Zhang , Damiano Ghirlanda , Xiaoping Hou , Simon Semus
发明人： John J. Baldwin , David A. Claremon , Colin M. Tice , Salvacion Cacatian , Lawrence W. Dillard , Alexey V. Ishchenko , Jing Yuan , Zhenrong Xu , Gerard McGeehan , Wei Zhao , Robert D. Simpson , Suresh B. Singh , Patrick T. Flaherty , Lara S. Kallander , Colin A. Leach , Brian Lawhorn , Qing Lu , Lamont R. Terrell , Bahman Ghavini-Alagha , Jing Zhang , Damiano Ghirlanda , Xiaoping Hou , Simon Semus
IPC分类号： A61K31/5377 , C07D207/14 , A61K31/40 , C07D211/32 , A61K31/445 , A61K31/4545 , C07D401/10 , C07D413/06 , A61P9/12
CPC分类号： C07D211/22 , C07D265/30 , C07D401/06
摘要： Disclosed are compounds according to Formula I: wherein the variables are defined herein. Such compounds are can bind aspartic proteases to inhibit their activity. They are useful in the treatment or amelioration of diseases associated with aspartic protease activity.Also described herein are methods of antagonizing aspartic protease inhibitors in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound according to Formula I.
摘要翻译：公开了根据式I的化合物：其中变量在本文中定义。这些化合物可以结合天冬氨酸蛋白酶以抑制其活性。它们可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。本文还描述了在有需要的受试者中拮抗天冬氨酸蛋白酶抑制剂的方法，包括向受试者施用治疗有效量的根据式I的化合物。

2. 发明授权

US07534893B2 Imidazol-2-one compounds useful in the treatment of various disorders 失效
标题翻译：可用于治疗各种疾病的咪唑-2-酮化合物
公开(公告)号：US07534893B2
公开(公告)日：2009-05-19
申请号：US11570059
申请日：2005-06-07
申请人： Giuseppe Alvaro , Damiano Ghirlanda
发明人： Giuseppe Alvaro , Damiano Ghirlanda
IPC分类号： C07D405/00 , C07D233/00
CPC分类号： C07D401/04
摘要： A compound of formula (I) wherein: R is a group selected from: A-B is a bivalent radical of formula (v), (vi) or (vii) —CH═C(R11)— (v) —C(R10)═CH— or (vi) —C(R12)(R10)—C(R11)(R13)— (viii) and all other variables are as defined herein or a pharmaceutically acceptable salt or solvate thereof, process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
摘要翻译：式（I）的化合物其中：R是选自：AB是式（v），（vi）或（vii）的二价基团<？在线式描述=“在线式”末端 =“lead”？> - CH-C（R11） - （v）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in-line-formula description =“In -line“=”lead“→C（R10）-CH-或（vi）<？in-line-formula description =”In-line formula“end =”tail“？> <？in-line -formulae description =“In-line Formulas”end =“lead”？> -C（R12）（R10）-C（R11）（R13） - （viii）<？in-line-formula description =“In-line 并且所有其它变量如本文所定义或其药学上可接受的盐或溶剂化物，其制备方法及其用于治疗由速激肽介导的病症和/或通过选择性抑制5-羟色胺再摄取转运蛋白。

3. 发明申请

US20070249679A1 Imidazol-2-One Compounds Useful in the Treatment of Various Disorders 失效
标题翻译：用于治疗各种疾病的咪唑-2-酮化合物
公开(公告)号：US20070249679A1
公开(公告)日：2007-10-25
申请号：US11570059
申请日：2005-06-07
申请人： Giuseppe Alvaro , Damiano Ghirlanda
发明人： Giuseppe Alvaro , Damiano Ghirlanda
IPC分类号： A61K31/445 , A61P25/18 , A61P25/24 , A61P29/00 , C07D401/02
CPC分类号： C07D401/04
摘要： A compound of formula (I) wherein: R is a group selected from: A-B is a bivalent radical of formula (v), (vi) or (vii) —CH═C(R11)— (v) —C(R10)═CH— or (vi) —C(R12)(R10)—C(R11)(R13)— (viii) and all other variables are as defined herein or a pharmaceutically acceptable salt or solvate thereof, process for their preparation and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.
摘要翻译：式（I）的化合物其中：R是选自：AB是式（v），（vi）或（vii）的二价基团<？在线式描述=“在线式”末端 =“lead”→CH-C（R 11） - （v）<？in-line-formula description =“In-line Formulas”end =“tail”？> <？in -line-formula description =“In-line Formulas”end =“lead”？> -C（R 10） - CH-或（vi）<？in-line-formula description =“In -line公式“end =”tail“？> <？in-line-formula description =”In-line Formulas“end =”lead“？> - C（R＆lt; 12＆lt; （R 11） - （viii）<？在线公式描述=“在线公式” 并且所有其它变量如本文所定义或其药学上可接受的盐或溶剂化物，其制备方法及其用于治疗由速激肽介导的病症和/或通过选择性抑制5-羟色胺再摄取转运蛋白。

4. 发明申请

US20200045900A1 SINGLE-PIECE FLOATING TRAY FOR HYDROPONIC CULTIVATION 审中-公开
公开(公告)号：US20200045900A1
公开(公告)日：2020-02-13
申请号：US16605788
申请日：2018-04-24
申请人： Damiano GHIRLANDA , Martino GHIRLANDA
发明人： Damiano GHIRLANDA , Martino GHIRLANDA
IPC分类号： A01G31/06 , A01G9/02
摘要： A single-piece tray for hydroponic cultivation, composed of a plastic material shaped to define identical cultivation cells inside the tray. Each cultivation cell has: a housing defining a raised plane and configured to house a bulb or seedling to be cultivated, with a hole dimensioned to support the bulb or seedling without letting it fall through, while allowing its roots to protrude below the tray; a buoyant portion, defining a lowered plane intended to sink below a waterline, and delimited by side walls, each buoyant portion defining: a bottomside with a first height, a waterline zone with a second height, a topside with a third height; the sum of the first, second and third heights corresponding to the height of the side walls which connect the raised plane to the lowered plane. The side walls forming a channel.

5. 发明申请

US20100317697A1 Renin Inhibitors 审中-公开
标题翻译：肾素抑制剂
公开(公告)号：US20100317697A1
公开(公告)日：2010-12-16
申请号：US12665217
申请日：2008-06-20
申请人： John J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Qing Lu , Gerard McGeehan , Beth A. Knapp-Reid , Simon Semus , Robert D. Simpson , Suresh B. Singh , Lamont R. Terrell , Colin Tice , Tritin Tran , Zherong Xu , Jing Yuan , Wei Zhao , Yongdong Y. Zhao
发明人： John J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Qing Lu , Gerard McGeehan , Beth A. Knapp-Reid , Simon Semus , Robert D. Simpson , Suresh B. Singh , Lamont R. Terrell , Colin Tice , Tritin Tran , Zherong Xu , Jing Yuan , Wei Zhao , Yongdong Y. Zhao
IPC分类号： A61K31/445 , C07D211/06
CPC分类号： C07D211/22 , C07D265/30
摘要： Disclosed are compounds having the formula (I): wherein the R1, R2, R3, X, Y, A, L, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
摘要翻译：公开了具有式（I）的化合物：其中R1，R2，R3，X，Y，A，L和G如本文所定义。这些化合物与天冬氨酸蛋白酶结合以抑制其活性，并且可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还公开了使用式I化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。

6. 发明申请

US20100179109A1 RENIN INHIBITORS 审中-公开
标题翻译：雷宁抑制剂
公开(公告)号：US20100179109A1
公开(公告)日：2010-07-15
申请号：US12450631
申请日：2008-04-04
申请人： Jonh J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Colin A. Leach , Qing Lu , Gerard McGeehan , Jaclyn R. Patterson , Robert D. Simpson , Suresh B. Singh , Patrick Stoy , Lamont R. Terrell , Colin Tice , Zhenrong Xu , Jing Yuan , Catherine C. K. Yuan , Jing Zhang , Wei Zhao
发明人： Jonh J. Baldwin , Salvacion Cacatian , David Claremon , Lawrence W. Dillard , Patrick T. Flaherty , Bahman Ghavimi-Alagha , Damiano Ghirlanda , Alexey V. Ishchenko , Lara S. Kallander , Brian Lawhorn , Colin A. Leach , Qing Lu , Gerard McGeehan , Jaclyn R. Patterson , Robert D. Simpson , Suresh B. Singh , Patrick Stoy , Lamont R. Terrell , Colin Tice , Zhenrong Xu , Jing Yuan , Catherine C. K. Yuan , Jing Zhang , Wei Zhao
IPC分类号： A61K31/675 , C07D211/34 , A61K31/445 , C07D265/30 , A61K31/5375 , C07D413/06 , A61K31/5377 , A61K31/535 , A61K31/517 , A61K31/554 , A61K31/4965 , A61K31/5415 , A61K31/55 , A61K31/551 , A61K31/47 , A61K31/566 , A61P25/28 , A61P33/06 , A61P31/18 , A61P9/12 , A61P9/10 , A61P25/22 , A61P27/06
CPC分类号： C07D211/96 , C07D211/22 , C07D401/10 , C07D401/12
摘要： Disclosed are compounds of Formula (I) wherein the R, R1, R2, R3, X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.
摘要翻译：公开了式（I）的化合物，其中R，R 1，R 2，R 3，X，Y，A，Q，E和G如本文所定义。这些化合物与天冬氨酸蛋白酶结合以抑制其活性，并且可用于治疗或改善与天冬氨酸蛋白酶活性相关的疾病。还公开了使用式I化合物在有需要的受试者中改善或治疗天冬氨酸蛋白酶相关病症的方法。

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