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2. 发明专利

IL298190A Modified filamentous fungi for production of exogenous proteins 未知
公开(公告)号：IL298190A
公开(公告)日：2023-01-01
申请号：IL29819022
申请日：2022-11-13
申请人： DYADIC INT USA INC , MARIKA VITIKAINEN , ANNE HUUSKONEN , ANDRIY KOVALCHUK , CHRISTOPHER LANDOWSKI , MARK AARON EMALFARB , MARKKU SALOHEIMO , RONEN TCHELET
发明人： MARIKA VITIKAINEN , ANNE HUUSKONEN , ANDRIY KOVALCHUK , CHRISTOPHER LANDOWSKI , MARK AARON EMALFARB , MARKKU SALOHEIMO , RONEN TCHELET
IPC分类号： A61K39/12 , C07K14/005 , C12N15/80 , C12P21/02
摘要： The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica, having reduced activity or expression of KEX2 and/or ALP7, said filamentous fungi is capable of producing elevated amounts and stability of an exogenous protein.

3. 发明专利

BRPI1009488B1 cepa de fungo hospedeiro e métodos para produção homóloga e/ou heteróloga de uma proteína pura com uma pureza superior a 75%, para produção de misturas artificiais de proteínas e para triagem simplificada de cepas que expressam 5 funcionalmente uma enzima desejada 未知
公开(公告)号：BRPI1009488B1
公开(公告)日：2020-09-15
申请号：BRPI1009488
申请日：2010-03-16
申请人： DANISCO US INC , DYADIC INT USA INC , DYADIC NEDERLAND B V
发明人： CHRISTINE M PYNNONEN , JACOB VISSER , JAN WERY , JOHANNES HEINRICH VISSER , MARK A EMALFARB , PETER J PUNT , PHILLIP T OLSON , RICHARD PAUL BURLINGAME
IPC分类号： C12N15/00 , C12N15/09 , C12P21/02 , C12R1/645
摘要： novo sistema de produção de fungos. a presente invenção fornece um novo sistema de produção de fungos que compreende uma cepa de fungos hospedeiros de chrysosporium iucknowense onde a secreção endógena de celulase é inferior a 20% da secreção endógena de celulase deb chrysosporium lucknowense cepa 18-25 uv. preferencialmente, ainda a secreção de protease endógena, b-glucanase endógena e celobiohidrolase endógena é inferior a 20% da secreção de chrysosporium lucknowense cepa 18-25 uv. além disso, cepas fúngicas hospedeiras são fornecidas onde vários genes foram interrompidos. de acordo com outro aspecto da invenção um método para produção homóloga e/ou heteróloga de uma proteína pura com uma pureza superior a 75%, que compreende expressar um gene que codifica dita proteína em uma cepa de acordo com a invenção foi descrito. além disso, um método para a produção de misturas de proteínas artificiais compreendendo a expressão de genes que codificam cada uma de ditas proteínas em uma cepa de acordo com a invenção foi revelado. finalmente, um método para triagem simplificada de cepas que funcionalmente expressam uma enzima desejada pela aplicação de ditas cepas foi fornecido.

4. 发明专利

CA2657684C CONSTRUCTION OF HIGHLY EFFICIENT CELLULASE COMPOSITIONS FOR ENZYMATIC HYDROLYSIS OF CELLULOSE 未知
公开(公告)号：CA2657684C
公开(公告)日：2016-06-28
申请号：CA2657684
申请日：2006-10-06
申请人： DYADIC INT (USA) INC
发明人： GUSAKOV ALEXANDER V , SALANOVICH TATYANA N , ANTONOV ALEXEY I , USTINOV BORIS B , OKUNEV OLEG N , BURLINGAME RICHARD P , EMALFARB MARK A , BAEZ MARCO A , SINITSYN ARKADY P
IPC分类号： C12N15/56 , C12N1/14 , C12N1/15 , C12N9/24 , C12N9/42 , C12P1/00 , C12P7/10 , C12P19/00 , C12P19/02 , C12P19/04
摘要： This invention provides novel enzyme compositions using newly identified and isolated C. lucknowense enzymes, including CBH Ib, CBH IIb, EG II, EG VI, .beta.-glucosidase, and xylanase II in conjunction with previously identified enzymes CBH Ia, CBH IIa (previously described as Endo 43), and EG V. These enzyme compositions demonstrate an extremely high ability to convert lignocellulosic biomass (e.g., Avicel, cotton, Douglas fir wood pretreated by organosolv) to glucose. CBH Ia and IIb, which both have a cellulose-binding module (CBM) displayed a pronounced synergism with three major endoglucanases (EG II, EG V, EG VI) from the same fungus in hydrolysis of cotton as well as a strong synergy with each other. The enzyme compositions are effective in hydrolysis of the lignocellulosic biomass.

5. 发明专利

CA3129577A1 PRODUCTION OF CANNABINOIDS IN FILAMENTOUS FUNGI 未知
公开(公告)号：CA3129577A1
公开(公告)日：2020-08-13
申请号：CA3129577
申请日：2020-02-10
申请人： DYADIC INT USA INC
发明人： EMALFARB MARK AARON , TCHELET RONEN , KERESZTES GABOR , ILMEN MARJA HANNELE , KOIVISTOINEN OUTI MIRJAMI , KOIVURANTA KARI TAPIO , JOUHTEN PAULA , CASTILLO SANDRA
IPC分类号： C12P17/02 , A01H15/00
摘要： The present invention relates to genetically modified ascomycetous filamentous fungi, particularly of the species Thermothelomyces heterothallica capable of producing cannabinoids and precursors thereof, particularly of producing cannabigerolic acid (CBGA) and/or cannabigerovarinic acid (CBGVA) and products thereof, including tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabidivarinic acid (CBDVA), and use thereof for producing said precursors and cannabinoids.

6. 发明专利

IL215116A Chrysosporium lucknowense protein production system 未知
公开(公告)号：IL215116A
公开(公告)日：2017-01-31
申请号：IL21511611
申请日：2011-09-13
申请人： DANISCO US INC , DYADIC INT (USA) INC , DYADIC NEDERLAND B V
摘要： The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20 % of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous ²-glucanase and endogenous cellobiohydrolase is less than 20 % of the secretion of Chrysosporium lucknowense strain UV 18-25. Furthermore, fungal host strains are provided wherein several genes have been disrupted. According to another aspect of the invention a method for homologous and/or heterologous production of a pure protein with a purity of higher than 75 %, comprising expressing a gene encoding said protein in the strains according to the invention have been described. Furthermore, a method for production of artificial protein mixes comprising expressing a gene encoding each of said proteins in a strain according to the invention have been disclosed. Finally a method for simplified screening of strains functionally expressing a desired enzyme by application of said strains have been provided.

7. 发明专利

IL247068D0 Chrysosporium lucknowense protein production system 未知
公开(公告)号：IL247068D0
公开(公告)日：2016-09-29
申请号：IL24706816
申请日：2016-08-02
申请人： DANISCO US INC , DYADIC INT USA INC
IPC分类号： C12N20060101
摘要： The present invention provides a new fungal production system comprising a fungal host strain of Chrysosporium lucknowense wherein the endogenous cellulase secretion is less than 20 % of the endogenous cellulase secretion of Chrysosporium lucknowense strain UV 18-25. Preferably, also the secretion of endogenous protease, endogenous ²-glucanase and endogenous cellobiohydrolase is less than 20 % of the secretion of Chrysosporium lucknowense strain UV 18-25. Furthermore, fungal host strains are provided wherein several genes have been disrupted. According to another aspect of the invention a method for homologous and/or heterologous production of a pure protein with a purity of higher than 75 %, comprising expressing a gene encoding said protein in the strains according to the invention have been described. Furthermore, a method for production of artificial protein mixes comprising expressing a gene encoding each of said proteins in a strain according to the invention have been disclosed. Finally a method for simplified screening of strains functionally expressing a desired enzyme by application of said strains have been provided.

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