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    • 4. 发明申请
    • 8-AZABICYCLO[3.2.1]OCTANE DERIVATIVES USEFUL AS MONOAMINE REUPTAKE INHIBITORS
    • 8-AZABICYCLO [3.2.1] OCTANE衍生物作为单胺类复制抑制剂有用
    • WO2007063071A1
    • 2007-06-07
    • PCT/EP2006/069047
    • 2006-11-29
    • N.V. ORGANONNAPIER, Susan ElizabethBINGHAM, Matilda, JaneDUNBAR, Neil, Andrew
    • NAPIER, Susan ElizabethBINGHAM, Matilda, JaneDUNBAR, Neil, Andrew
    • C07D471/08A61K31/439A61P25/00
    • C07D471/08C07D451/06
    • The present invention relates to a 8-azabicyclo[3.2.1]octane derivative of Formula I, wherein R 1 is H or C 1-5 alkyl; Y is O, S or O(CH 2 ) m ; m is 1 or 2; n is 0 or 1; Ar 1 is phenylene or pyridylene, said phenylene and pyridylene being 1,3-linked with respect to O and when n is 1 with Y and when n is 0 with Ar 2 , said phenylene or pyridylene being optionally substituted with one or two substituents independently selected from halogen, C 1-5 alkyl, C 1-5 alkoxy, C 3-6 cycloalkyl, C 2-5 alkenyl, C 2-5 alkynyl, phenyl, CN and hydroxy, wherein said C 1-5 alkyl and C 1-5 alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar 2 to form a 5-membered ring; Ar 2 is phenyl or a 5-6 membered heteroaryl, said phenyl or 5-6 membered heteroaryl being optionally substituted with one to three substituents independently selected from halogen, C 1-5 alkyl, C 1-5 alkoxy, CN, CONR 2 R 3 , CO 2 R 4 , NHCOR 5 and hydroxy, wherein said C 1-5 alkyl and C 1-5 alkoxy are optionally substituted with one to three halogens and wherein the oxygen of said hydroxy is optionally bonded to Ar 1 to form a 5-membered ring; R 2 -R 4 are independently H or C1-5alkyl and R 5 is C 1-5 alkyl, or a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising a 8- azabicyclo[3.2.1]octane derivative according to the present invention in admixture with one or more pharmaceutically acceptable auxiliaries and to the use of a 8- azabicyclo[3.2.1]octane derivative according to the present invention in therapy.
    • 本发明涉及式I的8-氮杂双环[3.2.1]辛烷衍生物,其中R 1是H或C 1-5烷基; Y是O,S或O(CH 2 CH 2)m。 m为1或2; n为0或1; Ar 1是亚苯基或亚吡啶基,所述亚苯基和亚吡啶相对于O是1,3-连接的,并且当n与Y成为1时,当n是0时,Ar < 所述亚苯基或亚吡啶基任选地被一个或两个取代基取代,所述取代基独立地选自卤素,C 1-5烷基,C 1-5烷氧基,C 3- 6个环烷基,C 2-5链烯基,C 2-5炔基,苯基,CN和羟基,其中所述C 1-5 - 烷基和C 1-5烷氧基任选被一至三个卤素取代,并且其中所述羟基的氧任选地与Ar 2连接形成5元环 环; Ar 2是苯基或5-6元杂芳基,所述苯基或5-6元杂芳基任选地被一至三个独立地选自卤素,C 1-5 - 烷基,C 1-5烷氧基,CN,CONR 2 R 3,SO 2 R 2, 4,NHCOR 5和羟基,其中所述C 1-5烷基和C 1-5烷氧基任选被一个 至三个卤素,并且其中所述羟基的氧任选地键合到Ar 1以形成5元环; R 2〜R 4独立地为H或C 1-5烷基,R 5为C 1-5烷基, 或其药学上可接受的盐或溶剂合物。 本发明还涉及包含根据本发明的8-氮杂双环[3.2.1]辛烷衍生物与一种或多种药学上可接受的助剂混合的药物组合物,以及使用8-氮杂双环[3.2.1]辛烷 衍生物在治疗中。
    • 7. 发明申请
    • FLUID WASTE PROCESSING SYSTEMS
    • 流体废物处理系统
    • WO2009108996A1
    • 2009-09-11
    • PCT/AU2009/000243
    • 2009-03-02
    • SAMARAN INTERNATIONAL PTY LTDDUNBAR, Neil, James
    • DUNBAR, Neil, James
    • E03F11/00C02F1/00E03F1/00
    • E03F11/00C02F3/006C02F3/28C02F2209/008C02F2209/03C02F2209/42
    • A method of managing a plurality of fluid waste processing systems (100), each fluid waste processing system comprising a septic tank (1) for containing a water and sludge or scum mixture, at least one sensor (28) near the bottom of the tank, and an onsite electronic monitor (30), said method comprising: creating an identification code in the form of a location reference such as an address for identifying each septic tank (1), selecting pressure as a parameter for indicating when a septic tank (1) needs to be emptied, sensing the level of pressure in each septic tank (1), monitoring the sensed level in the system with the electronic monitor (30), generating an electronic signal by radio link in the form of an SMS message to characterise the level of pressure when the tank is full or requires emptying, monitoring the electronic signal in each system in a management facility, generating an action prompt in the form of an SMS message or email notification to a waste removalist when a pressure reading varies by at least 2% from a pressure reading if the tank (1) only contained water, initiating an action response on receipt of the action prompt, the action response comprising sending a remediation vehicle to remove waste fluid (20) from the tank (1).
    • 一种管理多个流体废物处理系统(100)的方法,每个流体废物处理系统包括用于容纳水和污泥或浮渣混合物的化粪池(1),在罐的底部附近的至少一个传感器(28) 和现场电子监视器(30),所述方法包括:以诸如用于识别每个化粪池(1)的地址的位置参考的形式创建识别码,选择压力作为参数,用于指示何时化粪池 1)需要清空,检测每个化粪池(1)中的压力水平,用电子监视器(30)监测系统感测到的电平,通过无线电链路以SMS消息的形式产生电子信号, 描述当坦克充满或需要排空时的压力水平,监控管理设施中每个系统中的电子信号,当以预先的方式产生一个SMS消息或电子邮件通知形式的动作提示给废物清理员 如果罐(1)仅含有水,在接收到动作提示时发起动作响应,确定读数与压力读数变化至少为2%,所述动作响应包括发送修复工具以从废液(20)中除去废液(20) 罐(1)。