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1. 发明申请

WO2012094620A2 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
标题翻译：疏水性分子引发的支化聚合物聚集体及其应用
公开(公告)号：WO2012094620A2
公开(公告)日：2012-07-12
申请号：PCT/US2012020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES INC , DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
发明人： DUJIE QIN , YIN RAY , PAN JING , ZHANG YUBEI
IPC分类号： A61K47/30 , A61K47/48 , A61K49/04 , A61K49/06
CPC分类号： A61K9/14 , A61K9/19 , A61K9/513 , A61K9/5146 , A61K31/337 , A61K31/4375 , A61K33/24 , A61K45/06 , A61K47/34 , A61K47/48384 , A61K47/6803 , A61K49/0004 , A61K49/12 , A61K51/06
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.
摘要翻译：对称和不对称支化均聚物在表面水平被官能团改性，所述官能团能够与水不溶性或水溶性差的药物活性剂（PAA）形成聚集体。形成的聚集体由PAA和均聚物的相互作用特异性诱导，并且不同于不存在PAA时单独由聚合物形成的聚集体或不存在聚合物时由单独PAA形成的聚集体。这种聚集体可用于改善药物的溶解性，稳定性，递送和功效。

2. 发明申请

WO2012094620A9 HYDROPHOBIC MOLECULE-INDUCED BRANCHED POLYMER AGGREGATES AND THEIR USE 审中-公开
公开(公告)号：WO2012094620A9
公开(公告)日：2012-07-12
申请号：PCT/US2012/020524
申请日：2012-01-06
申请人： ANP TECHNOLOGIES, INC. , DUJIE, Qin , YIN, Ray , PAN, Jing , ZHANG, Yubei
发明人： DUJIE, Qin , YIN, Ray , PAN, Jing , ZHANG, Yubei
IPC分类号： A61K47/30 , A61K49/06 , A61K49/04 , A61K47/48
摘要： Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.

3. 发明申请

US20160024252A1 Oxazoline Polymer Compositions and Use Thereof 审中-公开
标题翻译：恶唑啉聚合物组合物及其用途
公开(公告)号：US20160024252A1
公开(公告)日：2016-01-28
申请号：US14236758
申请日：2012-08-03
申请人： Ray Yin , Jing Pan , Dujie Qin , Yubei Zhang
发明人： Ray Yin , Jing Pan , Dujie Qin , Yubei Zhang
IPC分类号： C08G69/48 , C08G81/00 , A61K31/4745 , A61K47/48 , A61K31/7068
摘要： Compositions comprising an oxazoline polymer and optional linkers to carry a variety of molecules.
摘要翻译：包含恶唑啉聚合物和任选的接头以携带各种分子的组合物。

4. 发明申请

US20080200562A1 Polymer Conjugate Enhanced Bioassays 有权
标题翻译：聚合物共轭增强生物测定
公开(公告)号：US20080200562A1
公开(公告)日：2008-08-21
申请号：US11913265
申请日：2006-05-02
申请人： Ray Yin , Dujie Qin , Jing Pan
发明人： Ray Yin , Dujie Qin , Jing Pan
IPC分类号： A61K47/30 , C08F20/52 , C08G65/00 , G01N33/53 , C08G69/10
CPC分类号： G01N33/545 , B82Y5/00 , B82Y10/00 , G01N33/532 , G01N33/54353 , G01N33/6854
摘要： Modified branched polymers are combined with bioactive agents which are one member of a binding pair for use in an assay.
摘要翻译：改性支化聚合物与作为测定中使用的结合对的一个成员的生物活性剂组合。

5. 发明授权

US08591904B2 Asymmetrically branched polymer conjugates and microarray assays 有权
标题翻译：不对称支化的聚合物共轭物和微阵列测定
公开(公告)号：US08591904B2
公开(公告)日：2013-11-26
申请号：US12833991
申请日：2010-07-11
申请人： Ray Yin , Dujie Qin , Jing Pan
发明人： Ray Yin , Dujie Qin , Jing Pan
IPC分类号： A61K47/00
CPC分类号： G01N33/5308 , A61K47/6949 , A61K49/0002 , B82Y5/00 , B82Y10/00 , B82Y30/00 , Y10S435/975 , Y10T436/11
摘要： A conjugate of a modified randomly branched asymmetric polymer without a core and a member of a binding pair is described. The modified randomly branched asymmetric polymer can contain chain branches, terminal branches or both. The modified randomly branched asymmetric polymer can contain random asymmetric branches or random asymmetric junctions. The binding pair can be an antibody, antigen or a ligand. The conjugate includes a drug.
摘要翻译：描述了不具有核心和结合对成员的改性的随机支化的不对称聚合物的缀合物。改性的无规支化不对称聚合物可以含有支链，末端分枝或两者。改性的无规支化不对称聚合物可以包含随机不对称分支或随机不对称连接。结合对可以是抗体，抗原或配体。缀合物包括药物。

6. 发明申请

US20060041058A1 Asymmetrically branched polymer conjugates and microarray assays 有权
标题翻译：不对称支化的聚合物共轭物和微阵列测定
公开(公告)号：US20060041058A1
公开(公告)日：2006-02-23
申请号：US10993474
申请日：2004-11-22
申请人： Ray Yin , Dujie Qin , Jing Pan
发明人： Ray Yin , Dujie Qin , Jing Pan
IPC分类号： C08F290/14
CPC分类号： G01N33/5308 , A61K47/6949 , A61K49/0002 , B82Y5/00 , B82Y10/00 , B82Y30/00 , Y10S435/975 , Y10T436/11
摘要： Asymmetrically branched polymers are combined with bioactive agents for a variety of purposes including drug delivery and conjugation to one member of a binding pair for use in an assay.
摘要翻译：不对称支化的聚合物与生物活性剂结合用于各种目的，包括药物递送和与用于测定中的结合对的一个成员结合。

7. 发明授权

US06716450B1 Enhancing protein activity through nanoencapsulation 有权
标题翻译：通过纳米胶囊增强蛋白质活性
公开(公告)号：US06716450B1
公开(公告)日：2004-04-06
申请号：US09859260
申请日：2001-05-17
申请人： Ray Yin , Tu-Chen Cheng , H. Dupont Durst , Dujie Qin
发明人： Ray Yin , Tu-Chen Cheng , H. Dupont Durst , Dujie Qin
IPC分类号： A61K948
CPC分类号： A61K9/5146 , A61K31/74 , A61K31/765
摘要： Nanocapsules useful for encapsulating bioactive molecules such as proteins are disclosed. These nanocapsules are comprised of branched or hyperbranched polymers and copolymers and have a core-shell structure forming a pocket volume appropriate for complexing and retaining enzymes and other bioactive molecules. The nanoencapsulated bioactive molecule is stable in extreme temperatures and pH, soluble in aqueous or organic solvents, and can be lyophilized to a dry powder for long-term storage without loss of enzyme activity.
摘要翻译：公开了可用于包封生物活性分子如蛋白质的纳米胶囊。这些纳米胶囊由支链或超支化聚合物和共聚物组成，并且具有形成适于络合和保留酶和其它生物活性分子的口袋体积的核 - 壳结构。纳米封装的生物活性分子在极端温度和pH下是稳定的，可溶于水溶液或有机溶剂，并且可以冻干至干燥粉末以进行长期保存而不损失酶活性。

8. 发明授权

US06632889B1 Convergent self-branching polymerization 失效
标题翻译：会聚自分支聚合
公开(公告)号：US06632889B1
公开(公告)日：2003-10-14
申请号：US09365609
申请日：1999-08-02
申请人： Rui Yin , Donald A. Tomalia , Dujie Qin , Jamie Dunham
发明人： Rui Yin , Donald A. Tomalia , Dujie Qin , Jamie Dunham
IPC分类号： C08J27102
CPC分类号： C08G83/005 , C08F8/30 , C08F293/00 , C08F293/005 , C08F297/00 , C08G81/00
摘要： A method of forming a branched polymer includes forming a plurality of growing linear polymer chains by polymerizing a monomer which is protected against branching and which forms a reactive end group which is in a first condition which is one of electrophilic or nucleophilic, exposing the growing linear polymer chains to a chain transfer agent to cause the reactive end group of at least a first growing linear polymer chain to reverse its electrophilic or nucleophilic character, whereby a non-reversed reactive end group on a second growing linear polymer chain reacts with the reversed reactive end group on the first growing linear polymer chain to create a branched polymer and reverses the electrophilic or nucleophilic character of the reversed reactive end group back to its first condition, whereby it may continue adding monomer in a linear fashion; and quenching the polymerization by adding a compound having multiple reactive sites capable of reacting with the reactive end groups of the polymer chains when they are in the first condition. The method allows the preparation of ultra-high molecular weight dendritic polymers in which the branching junctures are assembled in situ (i.e., are self-branching) in a convergent manner during polymerization of the monomers.
摘要翻译：形成支化聚合物的方法包括通过聚合保护不支化的单体形成多个生长的线性聚合物链，并形成作为亲电子或亲核之一的第一条件的反应性端基，暴露生长线聚合物链与链转移剂反应以使至少第一生长的线性聚合物链的反应性端基反向其亲电或亲核性质，由此第二生长线性聚合物链上的非反相端基与反应的反应性在第一次生长的线性聚合物链上产生支链聚合物并将反向反应端基的亲电或亲核特性反转回其第一条件，由此其可以以线性方式继续添加单体; 并且当它们处于第一状态时，通过添加具有能够与聚合物链的反应性端基反应的多个反应性位点的化合物来淬灭聚合。该方法允许制备超高分子量树枝状聚合物，其中在聚合单体期间，分支接合点原位组装（即自支化）以收敛的方式组装。

9. 发明授权

US08501399B2 Asymmetrically branched polymer conjugates and microarray assays 有权
标题翻译：不对称支化的聚合物共轭物和微阵列测定
公开(公告)号：US08501399B2
公开(公告)日：2013-08-06
申请号：US12834029
申请日：2010-07-12
申请人： Ray Yin , Dujie Qin , Jing Pan
发明人： Ray Yin , Dujie Qin , Jing Pan
IPC分类号： C12Q1/00
CPC分类号： G01N33/5308 , A61K47/6949 , A61K49/0002 , B82Y5/00 , B82Y10/00 , B82Y30/00 , Y10S435/975 , Y10T436/11
摘要： A method of detection comprising a conjugate of a randomly and asymmetrically branched dendritic polymer.
摘要翻译：一种检测方法，包括随机和不对称分支的树枝状聚合物的共轭物。

10. 外观设计

USD672053S1 Multi-lateral flow assay strip carrier assembly 有权
标题翻译：多侧流测定条带载体组件
公开(公告)号：USD672053S1
公开(公告)日：2012-12-04
申请号：US29361248
申请日：2010-05-07
申请人： De Chen , Ray Yin , Remo Vallejo, Jr. , Jing Pan , Thomas Small , Dujie Qin
设计人： De Chen , Ray Yin , Remo Vallejo, Jr. , Jing Pan , Thomas Small , Dujie Qin

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