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1. 发明申请

WO2011057780A3 PROCESS FOR PREPARING RUTHENIUM(0)-OLEFIN COMPLEXES 审中-公开
标题翻译：制备钌（0） - 烯烃配合物的方法
公开(公告)号：WO2011057780A3
公开(公告)日：2011-08-25
申请号：PCT/EP2010006858
申请日：2010-11-11
申请人： UMICORE AG & CO KG , DOPPIU ANGELINO , RIVAS-NASS ANDREAS , KARCH RALF , WINDE ROLAND , WOERNER EILEEN
发明人： DOPPIU ANGELINO , RIVAS-NASS ANDREAS , KARCH RALF , WINDE ROLAND , WOERNER EILEEN
IPC分类号： C07F15/00 , A61K31/28 , B01J31/00 , C23C16/18
CPC分类号： C07F15/0046
摘要： The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X)p(Y)q (in which X = an anionic group, Y = an uncharged two-electron donor ligand, p = 1 or 2, q = an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl2(acetonitrile)4, RuCl2(pyridine)4 or RuCl2(DMSO)4. The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications.
摘要翻译：本发明涉及通过使式Ru（+ II）（X）p（Y）的钌起始化合物与式（I）的钌起始化合物反应来制备（芳烃）（二烯）Ru （其中X =阴离子基团，Y =不带电荷的双电子供体配体，p = 1或2，q = 1至6的整数）与环己二烯衍生物或包含环己二烯衍生物的二烯混合物在基地的存在。在该过程中，（芳烃）（二烯）Ru（0）络合物中的芳烃通过氧化由该环己二烯衍生物形成。合适的钌（II）起始化合物为例如RuCl 2（乙腈）4，RuCl 2（吡啶）4或RuCl 2（DMSO）4。所用的碱是无机碱或有机碱。通过根据本发明的方法制备的钌（0） - 烯烃络合物具有高纯度并且可以用作均相催化剂的前体，用于制备功能性的含钌或钌氧化物的层以及用于治疗应用。

2. 发明申请

WO2010127829A1 METHOD FOR PREPARATION OF RUTHENIUM-BASED METATHESIS CATALYSTS WITH CHELATING ALKYLIDENE LIGANDS 审中-公开
标题翻译：用碱性氨基酸配体制备基于钌的金属催化剂的方法
公开(公告)号：WO2010127829A1
公开(公告)日：2010-11-11
申请号：PCT/EP2010/002720
申请日：2010-05-04
申请人： UMICORE AG & CO. KG , WINDE, Roland , DOPPIU, Angelino , WOERNER, Eileen , RIVAS-NASS, Andreas , GRAZ UNIVERSITY OF TECHNOLOGY , KARCH, Ralf , SLUGOVC, Christian , LEXER, Christina
发明人： WINDE, Roland , DOPPIU, Angelino , WOERNER, Eileen , RIVAS-NASS, Andreas , KARCH, Ralf , SLUGOVC, Christian , LEXER, Christina
IPC分类号： B01J31/16 , C07F15/00
CPC分类号： C08F4/80 , B01J31/2265 , B01J31/2278 , B01J2231/543 , B01J2531/821 , C07F15/0046
摘要： The invention relates to a method for preparation of ruthenium-based carbene catalysts with a chelating alkylidene ligand ("Hoveyda-type catalysts") by reacting a penta-coordinated ruthenium (IΙ)-alkylidene complex of the type (L)(Py)X 1 X 2 Ru(alkylidene) with a suitable olefin derivative in a cross metathesis reaction. The method delivers high yields and is conducted preferably in aromatic hydrocarbon solvents. The use of phosphine-containing Ru carbene complexes as starting materials can be avoided. Catalyst products with high purity, particularly with low Cu content, can be obtained.
摘要翻译：本发明涉及通过使（L）型（Py）类型的五配位钌（I） - 亚烷基配合物与螯合亚烷基配体（“Hoveyda型催化剂”）制备钌基碳烯催化剂的方法， X1X2Ru（亚烷基）与交叉复分解反应中的合适的烯烃衍生物。该方法提供高产率并优选在芳族烃溶剂中进行。可以避免使用含膦的Ru卡宾络合物作为原料。可以获得具有高纯度，特别是低Cu含量的催化剂产品。

3. 发明申请

WO2010127964A1 PROCESS FOR THE PREPARATION OF RUTHENIUM METATHESIS COMPLEX CATALYSTS 审中-公开
标题翻译：制备金属复合催化剂的方法
公开(公告)号：WO2010127964A1
公开(公告)日：2010-11-11
申请号：PCT/EP2010/055649
申请日：2010-04-27
申请人： F. HOFFMANN-LA ROCHE AG , DOPPIU, Angelino , KARCH, Ralf , PUENTENER, Kurt , RIVAS-NASS, Andreas , SCALONE, Michelangelo , WINDE, Roland , WOERNER, Eileen
发明人： DOPPIU, Angelino , KARCH, Ralf , PUENTENER, Kurt , RIVAS-NASS, Andreas , SCALONE, Michelangelo , WINDE, Roland , WOERNER, Eileen
IPC分类号： C07F15/00
CPC分类号： C07F15/0046
摘要： The invention relates to a novel process for the preparation of Ruthenium metathesis catalysts of the formula (I). Ruthenium metathesis catalysts have been widely applied in the synthesis of macrocyclic drug compounds.
摘要翻译：本发明涉及制备式（I）的钌复分解催化剂的新方法。钌复分解催化剂已经广泛应用于大环化合物的合成中。

4. 发明申请

WO2009121513A1 RUTHENIUM COMPLEXES HAVING (P-P)-COORDINATED DISPHOSPHORUS DONOR LIGANDS AND PROCESSES FOR PREPARING THEM 审中-公开
标题翻译：具有（P-P）相互作用的二磷酸盐配位体的钌络合物及其制备方法
公开(公告)号：WO2009121513A1
公开(公告)日：2009-10-08
申请号：PCT/EP2009/002204
申请日：2009-03-26
申请人： UMICORE AG & CO. KG , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland , DOPPIU, Angelino , SCHNEIDER, Tina
发明人： RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland , DOPPIU, Angelino , SCHNEIDER, Tina
IPC分类号： C07F15/00
CPC分类号： C07F17/02 , B01J31/185 , B01J31/1865 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/821 , C07B53/00 , C07C51/36 , C07C53/126
摘要： The invention relates to ruthenium complexes which have a chiral diphosphorus donor ligand and in which the ruthenium has the oxidation state (+11) and the chiral diphosphorus donor ligand has bidentate P-P coordination to the ruthenium. The ruthenium complexes are present in two forms (cationic type A and uncharged type B), are cyclic and have a four- to six-membered ring incorporating the diphosphorus donor ligand. The chiral diphosphorus donor ligands are selected from the group consisting of diphosphines, diphospholanes, diphosphites, diphosphonites and diazaphospholanes. Furthermore, processes for preparing the ruthenium complexes of types A and B, which are based on ligand exchange reactions, are described. The Ru complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.
摘要翻译：本发明涉及具有手性二磷供体配体并且其中钌具有氧化态（+11）并且手性二磷供体配体的钌络合物与钌具有双齿P-P配位体。钌络合物以两种形式（阳离子型A和不带电荷的B）存在，是环状的并且具有掺入二磷供体配体的四至六元环。手性二磷供体配体选自二膦，二磷脂，二亚磷酸酯，二膦酸酯和二氮杂磷杂环戊烷。此外，描述了基于配体交换反应制备A型和B型钌络合物的方法。 Ru配合物用作制备有机化合物的均相不对称催化剂。

5. 发明申请

WO2008138540A1 RUTHENIUM COMPLEXES WITH (P-P)-COORDINATED FERROCENYLDIPHOSPHINE LIGANDS, PROCESS FOR PREPARING THEM AND THEIR USE IN HOMOGENEOUS CATALYSIS 审中-公开
标题翻译：具有（P-P）-COORINATED FERROCENYLDIPHOSPHINE LIGANDS的RUTHENIUM复合物，其制备方法及其在均相催化中的用途
公开(公告)号：WO2008138540A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/003695
申请日：2008-05-08
申请人： UMICORE AG & CO. KG , SALZER, Albrecht , DOPPIU, Angelino , LANGENSCHEIDT, Nadine , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland , MAYRHOFER, Stefanie
发明人： SALZER, Albrecht , DOPPIU, Angelino , LANGENSCHEIDT, Nadine , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland , MAYRHOFER, Stefanie
IPC分类号： C07F17/02 , B01J31/24
CPC分类号： B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/821 , C07F17/02
摘要： The invention relates to ruthenium complexes with a chiral ferrocenyldiphosphine ligand, wherein the ruthenium has the oxidation state (+II) and the chiral ferrocenyldiphosphine ligand has bidentate P-P coordination to the ruthenium. The ruthenium complexes are cyclic and with the ferrocenyldiphosphine ligand have an at least eight-membered ring. The ferrocenyldiphosphine ligands are selected from the group consisting of Taniaphos, Taniaphos-OH and Walphos ligands. A process for preparing the Ru complexes is described. The Ru complexes are used as catalysts for homogeneous asymmetric catalysis for preparing organic compounds.
摘要翻译：本发明涉及具有手性二茂铁基二膦配体的钌络合物，其中钌具有氧化态（+ II），并且手性二茂铁基二膦配体与钌具有双齿P-P配位。钌络合物是环状的，并且二茂铁基二膦配体具有至少八元环。二茂铁基二膦配体选自Taniaphos，Taniaphos-OH和Walphos配体。描述了Ru配合物的制备方法。 Ru配合物用作制备有机化合物的均相不对称催化剂。

6. 发明申请

WO2011057780A2 PROCESS FOR PREPARING RUTHENIUM(0)-OLEFIN COMPLEXES 审中-公开
标题翻译：制备（0） - 烯烃复合物的方法
公开(公告)号：WO2011057780A2
公开(公告)日：2011-05-19
申请号：PCT/EP2010/006858
申请日：2010-11-11
申请人： UMICORE AG & CO. KG , DOPPIU, Angelino , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland , WOERNER, Eileen
发明人： DOPPIU, Angelino , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland , WOERNER, Eileen
IPC分类号： C07F15/00 , C23C16/18 , B01J31/00 , A61K31/28
CPC分类号： C23C16/18 , A61K31/28 , B01J31/00
摘要： The present invention relates to a process for preparing ruthenium(0)-olefin complexes of the (arene)(diene)Ru(0) type by reacting a ruthenium starting compound of the formula Ru(+II)(X) p (Y) q (in which X = an anionic group, Y = an uncharged two-electron donor ligand, p = 1 or 2, q = an integer from 1 to 6), with a cyclohexadiene derivative or a diene mixture comprising a cyclohexadiene derivative, in the presence of a base. In this process, the arene bound in the (arene)(diene)Ru(0) complex is formed from this cyclohexadiene derivative by oxidation. Suitable ruthenium(II) starting compounds are, for example, RuCl 2 (acetonitrile) 4 , RuCl 2 (pyridine) 4 or RuCl 2 (DMSO) 4 . The bases used are inorganic or organic bases. The ruthenium(0)-olefin complexes prepared by the process according to the invention have a high purity and can be used as precursors for homogeneous catalysts, for preparation of functional ruthenium- or ruthenium oxide-containing layers and for therapeutic applications.
摘要翻译：本发明涉及一种制备（芳烃）（二烯）Ru（O）型钌（O） - 烯烃络合物的方法，通过使式钌（+ II）（X）p（Y） q（其中X =阴离子基团，Y =不带电荷的双电子供体配体，p = 1或2，q = 1至6的整数）与环己二烯衍生物或包含环己二烯衍生物的二烯混合物一个基地的存在。在该方法中，通过氧化由该环己二烯衍生物形成（芳烃）（二烯）Ru（O）络合物中的芳烃。合适的钌（II）起始化合物是例如RuCl 2（乙腈）4，RuCl 2（吡啶）4或RuCl 2（DMSO）4。使用的碱是无机或有机碱。通过本发明方法制备的钌（O） - 烯烃络合物具有高纯度，可用作均相催化剂的前体，用于制备功能性含钌或氧化钌层并用于治疗应用。

7. 发明申请

WO2010037550A1 METHOD FOR PREPARATION OF RUTHENIUM-INDENYLIDENE CARBENE CATALYSTS 审中-公开
标题翻译：制备亚苄基碳二亚胺催化剂的方法
公开(公告)号：WO2010037550A1
公开(公告)日：2010-04-08
申请号：PCT/EP2009/007072
申请日：2009-10-02
申请人： UMICORE AG & CO. KG , WINDE, Roland , KARCH, Ralf , RIVAS-NASS, Andreas , DOPPIU, Angelino , PETER, Gerhard , WOERNER, Eileen
发明人： WINDE, Roland , KARCH, Ralf , RIVAS-NASS, Andreas , DOPPIU, Angelino , PETER, Gerhard , WOERNER, Eileen
IPC分类号： C07F15/00
CPC分类号： C07F15/0046
摘要： The present invention is directed to a method for the preparation of ruthenium indenylidene carbene catalysts of the type (L)(L' )X 2 Ru(II)(aryl-indenylidene). The method comprises the steps of reacting the precursor compound Ru(PPh 3 ) n X 2 (n = 3 - 4) with a propargyl alcohol derivative in an cyclic diether solvent such as 1,4-dioxane at temperatures in the range of 80 to 130°C and reaction times of 1 to 60 minutes. Optionally, additional neutral electron donor ligands such as PCy 3 , phobane ligands or NHC ligands are added to the reaction mixture for ligand exchange. The method includes a precipitation step for purification, after which the product is isolated. The ruthenium-indenylidene carbene catalysts are obtained in high purity and are used as catalysts for metathesis reactions (RCM, ROMP and CM) and as precursors for the synthesis of modified ruthenium carbene catalysts.
摘要翻译：本发明涉及一种（L）（L'）X2Ru（II）（芳基 - 亚茚基）类型的钌亚茚基碳烯催化剂的制备方法。该方法包括以下步骤：使前体化合物Ru（PPh 3）n X 2（n = 3- 4）与炔丙醇衍生物在环状二醚溶剂如1,4-二恶烷中在80-130℃的温度下反应反应时间为1〜60分钟。任选地，向反应混合物中加入另外的中性电子给体配体如PCy3，phobane配体或NHC配体用于配体交换。该方法包括用于纯化的沉淀步骤，之后分离产物。获得高纯度的钌 - 亚茚基碳烯催化剂，并用作复分解反应（RCM，ROMP和CM）的催化剂，并用作合成改性钌卡宾催化剂的前体。

8. 发明申请

WO2009146870A1 PROCESS FOR PREPARING DIENYL-RUTHENIUM COMPLEXES 审中-公开
标题翻译：制备二烯 - 钌复合物的方法
公开(公告)号：WO2009146870A1
公开(公告)日：2009-12-10
申请号：PCT/EP2009/003904
申请日：2009-05-30
申请人： UMICOR AG & CO. KG , DOPPIU, Angelino , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland
发明人： DOPPIU, Angelino , RIVAS-NASS, Andreas , KARCH, Ralf , WINDE, Roland
IPC分类号： C07F15/00 , C07F17/00
CPC分类号： C07F15/0046 , C07F17/02
摘要： The present invention relates to a single-stage process for preparing dienyl- ruthenium complexes of the formula Ru(+II)(dienyl) 2 , wherein an Ru(II) starting compound of the formula Ru(X) p (Y) q is reacted with a diene ligand in the presence of an inorganic and/or organic base in a single-stage process. Here, polar organic solvents, preferably mixtures of polar organic solvents with water, are used. The dienyl-ruthenium complexes prepared according to the invention are used as precursors for homogeneous catalysts, for producing functional coatings and for therapeutic applications.
摘要翻译：本发明涉及制备式Ru（+ II）（二烯基）2的二烯基 - 钌络合物的单阶段方法，其中式Ru（X）p（Y）q的Ru（II）起始化合物是在单级方法中在无机和/或有机碱的存在下与二烯配体反应。这里，使用极性有机溶剂，优选极性有机溶剂与水的混合物。根据本发明制备的二烯基 - 钌络合物用作均相催化剂的前体，用于制备功能性涂层和用于治疗应用。

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