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1. 发明申请

WO2011060321A1 TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：转谷氨酰胺酶TG2抑制剂，药物组合物及其使用方法
公开(公告)号：WO2011060321A1
公开(公告)日：2011-05-19
申请号：PCT/US2010/056614
申请日：2010-11-12
申请人： CHDI, INC. , DOMINGUEZ, Celia , WITYAK, John , PRIME, Michael , COURTNEY, Stephen , YARNOLD, Christoper , BROOKFIELD, Frederick , MARSTON, Richard , MACDONALD, Douglas
发明人： DOMINGUEZ, Celia , WITYAK, John , PRIME, Michael , COURTNEY, Stephen , YARNOLD, Christoper , BROOKFIELD, Frederick , MARSTON, Richard , MACDONALD, Douglas
IPC分类号： A01N41/06 , A61K31/18 , A61K31/497
CPC分类号： C07C311/46 , C07C2601/14 , C07D211/34 , C07D211/54 , C07D211/58 , C07D211/96 , C07D213/38 , C07D213/40 , C07D213/56 , C07D215/38 , C07D217/14 , C07D217/22 , C07D239/42 , C07D263/58 , C07D277/42 , C07D295/205 , C07D295/26 , C07D307/52 , C07D401/04 , C07D487/04 , C07D495/04
摘要： Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.
摘要翻译：本文提供了某些化合物和药学上可接受的盐。还提供了包含至少一种化合物或其药学上可接受的盐的药物组合物和一种或多种药学上可接受的载体。描述了治疗患有某种疾病状态的患者对抑制转谷氨酰胺酶TG2活性有反应的方法。这些疾病状态包括神经变性疾病如亨廷顿病。还描述了治疗方法，包括给予至少一种化合物或其药学上可接受的盐作为单一活性剂，或者与一种或多种其它治疗剂组合施用至少一种化合物或其药学上可接受的盐。

2. 发明申请

WO2006044860A2 THIADIAZOLE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：噻唑化合物及其使用方法
公开(公告)号：WO2006044860A2
公开(公告)日：2006-04-27
申请号：PCT/US2005/037374
申请日：2005-10-18
申请人： AMGEN, INC. , ZENG, Qingping , YAO, Guomin , WOHLHIETER, George, Erich , VISWANADHAN, Vellarkad, N. , TASKER, Andrew , RIDER, James, Thomas , MONENSCHEIN, Holger , DOMINGUEZ, Celia , BOURBEAU, Matthew, Paul
发明人： ZENG, Qingping , YAO, Guomin , WOHLHIETER, George, Erich , VISWANADHAN, Vellarkad, N. , TASKER, Andrew , RIDER, James, Thomas , MONENSCHEIN, Holger , DOMINGUEZ, Celia , BOURBEAU, Matthew, Paul
IPC分类号： A61K31/433
CPC分类号： C07D417/14 , C07D417/04 , C07D471/04
摘要： The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及可用于治疗由蛋白激酶B（PKB）介导的疾病的噻二唑化合物。本发明还涉及这种噻二唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病状态中的治疗用途。

3. 发明申请

WO2004014871A1 VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS 审中-公开
标题翻译：香草酸受体配体及其在治疗中的应用
公开(公告)号：WO2004014871A1
公开(公告)日：2004-02-19
申请号：PCT/US2003/025191
申请日：2003-08-08
申请人： AMGEN INC. , CHKRABARTI, Partha, P , CHEN, Ning , DOHERTY, Elisabeth, M. , DOMINGUEZ, Celia , FALSEY, James, Richard , FOTSH, Christopher, H. , HULME, Christopher , KATON, Jodie , NIXEY, Thomas , NORMAN, Mark, H. , OGNYANOV, Vassil, I. , PETTUS, Liping, H. , RZASA, Robert, Michael , STEC, Markian , WANG, Hui-Ling , ZHU, Jiawang
发明人： CHKRABARTI, Partha, P , CHEN, Ning , DOHERTY, Elisabeth, M. , DOMINGUEZ, Celia , FALSEY, James, Richard , FOTSH, Christopher, H. , HULME, Christopher , KATON, Jodie , NIXEY, Thomas , NORMAN, Mark, H. , OGNYANOV, Vassil, I. , PETTUS, Liping, H. , RZASA, Robert, Michael , STEC, Markian , WANG, Hui-Ling , ZHU, Jiawang
IPC分类号： C07D239/34
CPC分类号： C07D231/40 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/56 , C07D233/38 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译：具有通用结构和含有它们的组合物的化合物，用于治疗急性，炎性和神经性疼痛，牙齿疼痛，一般性头痛，偏头痛，丛集性头痛，混合血管和非血管性综合征，张力头痛，一般炎症，关节炎，风湿性疾病，骨关节炎，炎症性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，炎性疼痛和相关的痛觉过敏和异常性疼痛，神经性疼痛和相关痛觉过敏和异常性疼痛，糖尿病性神经病疼痛，灼痛，交感神经维持性疼痛，传入神经缺失综合征，哮喘，上皮组织损伤或功能障碍，单纯疱疹，呼吸系统，泌尿生殖系统，胃肠或血管区域内脏运动障碍，伤口，瘙痒症，白癜风，一般胃肠道 l溃疡，胃溃疡，十二指肠溃疡，腹泻，由坏死物质诱导的胃损伤，毛发生长，血管舒缩或过敏性鼻炎，支气管疾病或膀胱疾病。

4. 发明申请

WO2003099808A8 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
公开(公告)号：WO2003099808A8
公开(公告)日：2003-12-04
申请号：PCT/US2003/015473
申请日：2003-05-13
申请人： AMGEN INC. , DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
发明人： DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
IPC分类号： C07D401/04
摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R l is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R 1 is additionally substituted; and R 2 is a substituted C 1 -6 balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

5. 发明申请

WO2003099808A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：取代的杂环化合物及其使用方法
公开(公告)号：WO2003099808A1
公开(公告)日：2003-12-04
申请号：PCT/US2003/015473
申请日：2003-05-15
申请人： AMGEN INC. , DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
发明人： DOMINGUEZ, Celia , ZHANG, Dawei , CAO, Guo-Qiang , GOLDBERG, Martin, H. , HONG, Fang-Tsao , SHAM, Kelvin, K., C. , TADESSE, Seifu , TAMAYO, Nuria, A. , WEILER, Kurt, E. , LIAO, Hongyu
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to compounds having the general formula (I) or a pharmaceutically acceptable salt thereof, wherein R l is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, wherein the ring may be fused with a benzo group, and is substituted by 0, 1 or 2 oxo groups, and wherein R 1 is additionally substituted; and R 2 is a substituted C 1 -6 balkyl. Also included is a method of prophylaxis or treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.
摘要翻译：本发明涉及具有通式（I）的化合物或其药学上可接受的盐，其中R 1是含有0,1,2或3个原子的饱和或不饱和的5-，6-或7-元环选自N，O和S，其中所述环可以与苯并稠合，并且被0,1或2个氧代基取代，并且其中R 1另外被取代; R 2是取代的C 1-6烷基。还包括预防或治疗炎症，类风湿性关节炎，斑节病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征（ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉退化，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病，中风，心肌梗死，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV1，HIV-2，HIV-3，巨细胞病毒），流感，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的化合物如上所述。

6. 发明申请

WO2003044021A2 SUBSTITUTED INDOLIZINE-LIKE COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：取代的吲哚类化合物和使用方法
公开(公告)号：WO2003044021A2
公开(公告)日：2003-05-30
申请号：PCT/US2002/036699
申请日：2002-11-16
申请人： AMGEN INC. , CAI, Guolin , CHAU, Jennifer, N. , DOMINGUEZ, Celia , RISHTON, Gilbert, M. , LU, Yuelie
发明人： CAI, Guolin , CHAU, Jennifer, N. , DOMINGUEZ, Celia , RISHTON, Gilbert, M. , LU, Yuelie
IPC分类号： C07D487/04
CPC分类号： C07D401/04 , C07D471/04 , C07D487/04
摘要： Selected novel substituted indolizine-like compounds are effective for treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选择的新型取代的中氮茚样化合物对于治疗疾病如TNF-α，IL-1β，IL-6和/或IL-8介导的疾病以及其他疾病，例如癌症，疼痛和糖尿病。本发明包括新化合物，类似物，前药和药学上可接受的盐，用于治疗涉及炎症，癌症，疼痛，糖尿病等的疾病和其它疾病或病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及用于这些方法的中间体。

7. 发明申请

WO2014047288A2 TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：转谷氨酰胺酶TG2抑制剂，药物组合物及其使用方法
公开(公告)号：WO2014047288A2
公开(公告)日：2014-03-27
申请号：PCT/US2013/060620
申请日：2013-09-19
申请人： DOMINGUEZ, Celia , PRIME, Michael , MARSTON, Richard , BROOKFIELD, Frederick, A. , COURTNEY, Stephen, M. , MACDONALD, Douglas , WITYAK, John , YARNOLD, Christopher, John , VAIDYA, Darshan
发明人： DOMINGUEZ, Celia , PRIME, Michael , MARSTON, Richard , BROOKFIELD, Frederick, A. , COURTNEY, Stephen, M. , MACDONALD, Douglas , WITYAK, John , YARNOLD, Christopher, John , VAIDYA, Darshan
IPC分类号： C07D413/04 , C07D401/04
CPC分类号： C07D207/16 , C07D211/16 , C07D213/72 , C07D213/74 , C07D277/42 , C07D295/18 , C07D309/08 , C07D401/12
摘要： Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.
摘要翻译：本文提供了某些化合物和药学上可接受的盐。还提供了包含至少一种化合物或其药学上可接受的盐的药物组合物和一种或多种药学上可接受的载体。描述了治疗患有某种疾病状态的患者对抑制转谷氨酰胺酶TG2活性有反应的方法。这些疾病状态包括神经变性疾病如亨廷顿病。还描述了治疗方法，包括给予至少一种化合物或其药学上可接受的盐作为单一活性剂，或者与一种或多种其它治疗剂组合施用至少一种化合物或其药学上可接受的盐。

8. 发明申请

WO2009011871A2 THIADIAZOLE MODULATORS OF PKB 审中-公开
标题翻译： PKB的三唑调节剂
公开(公告)号：WO2009011871A2
公开(公告)日：2009-01-22
申请号：PCT/US2008008690
申请日：2008-07-15
申请人： AMGEN INC , ALLEN JOHN G , BOURBEAU MATTHEW P , DOMINGUEZ CELIA , FOTSCH CHRISTOPHER H , HAN NIANHE , HONG FANG-TSAO , HUANG XIN , LEE MATTHEW R , LIU QINGYIAN , REICHELT ANDREAS , TADESSE SEIFU , WANG XIANGHONG , YAO GUOMIN , YUAN CHESTER CHENGUANG , ZENG QINGPING
发明人： ALLEN JOHN G , BOURBEAU MATTHEW P , DOMINGUEZ CELIA , FOTSCH CHRISTOPHER H , HAN NIANHE , HONG FANG-TSAO , HUANG XIN , LEE MATTHEW R , LIU QINGYIAN , REICHELT ANDREAS , TADESSE SEIFU , WANG XIANGHONG , YAO GUOMIN , YUAN CHESTER CHENGUANG , ZENG QINGPING
IPC分类号： C07D471/02 , A61K31/433 , A61P29/00 , A61P35/00 , C07D285/125 , C07D285/135
CPC分类号： C07D285/135 , C07D417/04 , C07D417/14 , C07D495/04
摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.
摘要翻译：本发明涉及式I和式II的噻唑化合物及其用于治疗由蛋白激酶B（PKB）介导的疾病的组合物，其中变量具有本文提供的定义。本发明还涉及这种噻唑化合物及其组合物治疗与异常细胞生长，癌症，炎症和代谢紊乱相关的疾病的治疗用途。

9. 发明申请

WO2007005668A2 BIS-ARYL KINASE INHIBITORS AND METHOD 审中-公开
标题翻译： BIS-ARYL激酶抑制剂和方法
公开(公告)号：WO2007005668A2
公开(公告)日：2007-01-11
申请号：PCT/US2006025699
申请日：2006-06-29
申请人： AMGEN INC , KIM TAE-SEONG , HARMANGE JEAN-CHRISTOPHE , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID M , LIU LONGBIN , TASKER ANDREW , BELLON STEVEN , HARVEY TIMOTHY S , LEE MATTHEW , GERMAIN JULIE , PATEL VINOD F , KIM JOSEPH L
发明人： KIM TAE-SEONG , HARMANGE JEAN-CHRISTOPHE , BOOKER SHON , D ANGELO NOEL , DOMINGUEZ CELIA , FELLOWS INGRID M , LIU LONGBIN , TASKER ANDREW , BELLON STEVEN , HARVEY TIMOTHY S , LEE MATTHEW , GERMAIN JULIE , PATEL VINOD F , KIM JOSEPH L
IPC分类号： C07D409/12 , C07D333/38 , C07D401/10 , C07D401/12
CPC分类号： C07D333/38 , C07D217/02 , C07D217/24 , C07D401/10 , C07D401/12 , C07D409/12 , C07D417/10 , C07D417/12
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

10. 发明申请

WO2013033085A1 KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
标题翻译：吉非烯-3-MONOOXYGENASE抑制剂，药物组合物及其使用方法
公开(公告)号：WO2013033085A1
公开(公告)日：2013-03-07
申请号：PCT/US2012/052648
申请日：2012-08-28
申请人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
发明人： COURTNEY, Stephen Martin , PRIME, Michael , MITCHELL, William , BROWN, Christopher John , DE AGUIAR PENA, Paula C. , JOHNSON, Peter , DOMINGUEZ, Celia , TOLEDO-SHERMAN, Leticia M. , MUNOZ, Ignacio
IPC分类号： A61K31/44 , C07D401/00
CPC分类号： C07D239/28 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/048 , C07D491/052 , C07H13/10
摘要： Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
摘要翻译：本文提供了某些化学实体。还提供了包含至少一种化学实体和一种或多种药学上可接受的载体的药物组合物。描述了治疗患有对KMO活性的抑制作用的某些疾病和病症的患者的方法，其包括给予这些患者一定量的至少一种有效减少疾病或病症的体征或症状的化学实体。这些疾病包括神经变性疾病如亨廷顿氏病。还描述了治疗方法，包括给予至少一种作为单一活性剂的化学实体或与一种或多种其它治疗剂组合施用至少一种化学实体。还提供了用于筛选能够抑制KMO活性的化合物的方法。

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