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1. 发明专利

IL196287D0 CRYSTALLINE VENLAFAXINE BASE AND NOVEL POLYMORPHS OF VENLAFAXINE HYDROCHLORIDE AND PROCESSES FOR PREPARING THEREOF 未知
公开(公告)号：IL196287D0
公开(公告)日：2011-08-01
申请号：IL19628708
申请日：2008-12-31
申请人： TEVA PHARMA , JUDITH ARONHIME , DOLITZKY BEN ZION , WIZEL SHLOMIT , GENNADY NISNEVICH
IPC分类号： A61P25/24 , A61K31/137 , C07C20060101 , C07C209/84 , C07C213/08 , C07C213/10 , C07C215/42 , C07C217/60 , C07C217/74
摘要： The present invention relates to novel essentially pure venlafaxine and the process of preparation thereof. The present invention also relates to novel solvate forms of venlafaxine hydrochloride and the process of preparation thereof. Furthermore, the present invention provides a novel process for preparing venlafaxine hydrochloride from venlafaxine; the process comprises the steps of: I) preparing a mixture of venlafaxine with acetone; and ii) exposing the mixture in gaseous hydrochloric acid.

2. 发明专利

IL174001D0 A RECYCLING PROCESS FOR PREPARING SERTRALINE 未知
公开(公告)号：IL174001D0
公开(公告)日：2006-08-01
申请号：IL17400106
申请日：2006-02-28
申请人： TEVA PHARMA , GENNADY NISNEVISH , DOLITZKY BEN ZION , MENDELOVICI MARIOARA , ETINGER MARINA YU
IPC分类号： C07C20100101 , C07C45/80 , C07C45/81 , C07C51/41 , C07C51/43 , C07C51/48 , C07C209/68 , C07C209/88 , C07C211/42
摘要： Provided is a recycling process for preparing sertraline, which may be carried out on an industrial scale.

3. 发明专利

IL197006D0 CRYSTAL FORMS OF 9-HYDROXY-RISPERIDONE (PALIPERIDONE) 未知
公开(公告)号：IL197006D0
公开(公告)日：2009-11-18
申请号：IL19700609
申请日：2009-02-11
申请人： TEVA PHARMA , CHEN KOBI , INI SANTIAGO , DOLITZKY BEN ZION , SHMUELY YARON , CHASID NAAMA , LANCRY ELI
IPC分类号： C07D20100101
摘要： The present invention provides amorphous and crystalline forms of Paliperidone, and processes for preparing thereof.

4. 发明专利

IL183610D0 PROCESS FOR PRODUCING POLYPEPTIDE MIXTURES USING HYDROGENOLYSIS 未知
公开(公告)号：IL183610D0
公开(公告)日：2008-04-13
申请号：IL18361007
申请日：2007-05-31
申请人： TEVA PHARMA , DOLITZKY BEN ZION
IPC分类号： A61K20100101
摘要： The subject invention provides for a process for making a mixture of acetate salts of polypeptides, each of which consisting of glutamic acid, alanine, tyrosine and lysine, wherein the mixture has a desired peak molecular weight, comprising: a) polymerizing N-carboxyanhydrides of tyrosine, alanine, gamma-benzyl glutamate and trifluoroacetyllysine with an initiator in an amount of 0.01% to 20% by weight for a suitable period of time and at a suitable temperature to form a mixture of protected polypeptides, which mixture of polypeptides in unprotected form having a first peak molecular weight; b) removing the benzyl protecting group from the mixture of protected polypeptides by contacting the polypeptides with a hydrogenolysis catalyst and hydrogen to produce a mixture of trifluoroacetyl protected polypeptides, which mixture of polypeptides in unprotected form having the first peak molecular weight; c) removing the trifluoroacetyl protecting group from the trifluoroacetyl protected polypeptides by contacting the polypeptides with an organic base solution to form a mixture of polypeptides, which mixtures of polypeptides in unprotected form having the first peak molecular weight; d) removing the free trifluoroacetyl groups and low molecular weight impurities by ultrafiltration to obtain the mixture of polypeptides each of which consisting of glutamic acid, alanine, tyrosine and lysine; and e) contacting the mixture of polypeptides each of which consisting of glutamic acid, alanine, tyrosine and lysine with an aqueous solution of acetic acid to form the mixture of acetate salts of polypeptides each of which consisting of glutamic acid, alanine, tyrosine and lysine and having the desired peak molecular weight.

5. 发明专利

IL185029D0 PREPARATION OF TADALAFIL INTERMEDIATES 未知
公开(公告)号：IL185029D0
公开(公告)日：2007-12-03
申请号：IL18502907
申请日：2007-08-02
申请人： TEVA PHARMA , DOLITZKY BEN ZION , DILLER DOV
IPC分类号： C07C20100101
摘要： Provided is a process for preparing tadalafil intermediates in various solvents. Also provided is a method for converting said intermediates to tadalafil.

6. 发明专利

IL176141D0 CRYSTALLINE FORMS OF VALACYCLOVIR HYDROCHLORIDE 未知
公开(公告)号：IL176141D0
公开(公告)日：2006-10-05
申请号：IL17614106
申请日：2006-06-06
申请人： TEVA PHARMA , GENNADY NISNEVISH , WIZEL SHLOMIT , ARONHIME JUDITH , ETINGER MARINA YU , DOLITZKY BEN ZION , NIDDAM VALERIE , YUZEFOVICH MICHAEL , PERTSIKOV BORIS , TISHIN BORIS , DINA BLASBERGER
IPC分类号： A61K31/522 , C07D20100101 , C07D473/00 , C07D473/18
摘要： Provided are novel crystalline forms of valacyclovir hydrochloride, in particular a novel hydrated form of valacyclovir hydrochloride having about 6% to about 10% by weight water. Also provided are methods for making the novel crystalline forms.

7. 发明专利

IL175966D0 PROCESS FOR PREPARING ARIPIPRAZOLE 未知
公开(公告)号：IL175966D0
公开(公告)日：2006-10-05
申请号：IL17596606
申请日：2006-05-28
申请人： TEVA PHARMA , DOLITZKY BEN ZION , LERMAN ORI
IPC分类号： C07D20100101 , C07D215/22 , C07D215/227

8. 发明专利

IL175634D0 METHODS OF PREPARING OLANZAPINE 未知
公开(公告)号：IL175634D0
公开(公告)日：2006-09-05
申请号：IL17563406
申请日：2006-05-16
申请人： TEVA PHARMA , DOLITZKY BEN ZION , DILLER DOV
IPC分类号： A61K31/551 , C07D20100101 , C07D495/04 , C07D498/02
摘要： This invention encompasses methods of synthesizing olanzapine without solvents or by using low boiling organic solvents.

9. 发明专利

IL175512A Pure crystalline form ii of aripiprazole 未知
公开(公告)号：IL175512A
公开(公告)日：2014-11-30
申请号：IL17551206
申请日：2006-05-09
申请人： TEVA PHARMA , ARONHIME JUDITH , DOLITZKY BEN-ZION , LUVCHICK ERAN , HILDESHEIM JEAN , EISEN-NEVO HAGIT , ITSAK REUVEN
发明人： ARONHIME JUDITH , DOLITZKY BEN-ZION , LUVCHICK ERAN , HILDESHEIM JEAN , EISEN-NEVO HAGIT , ITSAK REUVEN
IPC分类号： C07D20060101 , A61K31/496 , C07D215/22 , C07D215/227 , C07D487/00

10. 发明专利

IL184039D0 PROCESS OF SYNTHESIZING TADALAFIL 未知
公开(公告)号：IL184039D0
公开(公告)日：2007-10-31
申请号：IL18403907
申请日：2007-06-19
申请人： TEVA PHARMA , DOLITZKY BEN ZION , DILLER DOV
IPC分类号： C07D20100101
摘要： The present invention provides tadalafil of high purity and processes of making such tadalafil by cyclization of TDCl in a solution.

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