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1. 发明申请

WO2004063705A2 LIQUID-LIQUID INTERFACIAL NANOPARTICLE ASSEMBLIES 审中-公开
标题翻译：液体液体纳米材料组件
公开(公告)号：WO2004063705A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000291
申请日：2004-01-08
申请人： UNIVERSITY OF MASSACHUSETTS , EMRICK, Todd , RUSSEL, Tom , DINSMORE, Anthony , SKAFF, Habib , LIN, Yao , BÖKER, Alexander
发明人： EMRICK, Todd , RUSSEL, Tom , DINSMORE, Anthony , SKAFF, Habib , LIN, Yao , BÖKER, Alexander
IPC分类号： G01N
CPC分类号： A61K9/5089 , A61K9/501 , B01J13/14 , Y10S977/787
摘要： Self-assembly of nanoparticles at the interface between two fluids, and methods to control such self-assembly process, e.g., the surface density of particles assembling at the interface; to utilize the assembled nanoparticles and their ligands in fabrication of capsules, where the elastic properties of the capsules can be varied from soft to tough; to develop capsules with well defined porosities for ultimate use as delivery systems; and to develop chemistries whereby multiple ligands or ligands with multiple functionalities can be attached to the nanoparticles to promote the interfacial segregation and assembly of the nanoparticles. Certain embodiments use cadmium selenide (CdSe) nanoparticles, since the photoluminescence of the particles provides a convenient means by which the spatial location and organization of the particles can be probed. However, the systems and methodologies presented here are general and can, with suitable modification of the chemistries, be adapted to any type of nanoparticle.
摘要翻译：纳米颗粒在两种流体之间的界面处的自组装，以及控制这种自组装过程的方法，例如在界面处组装的颗粒的表面密度; 在胶囊的制造中利用组装的纳米颗粒及其配体，其中胶囊的弹性性质可以从柔软变为韧性; 开发具有明确定义的孔隙度的胶囊，以最终用作输送系统; 并且开发化学物质，由此具有多个官能团的多个配体或配体可以连接到纳米颗粒以促进纳米颗粒的界面分离和组装。某些实施方案使用硒化镉（CdSe）纳米颗粒，因为颗粒的光致发光提供了可以探测颗粒的空间位置和组织的便利手段。然而，这里呈现的系统和方法是通用的，并且可以通过适当的化学修饰来适应任何类型的纳米颗粒。

2. 发明申请

WO2004063705A3 LIQUID-LIQUID INTERFACIAL NANOPARTICLE ASSEMBLIES 审中-公开
标题翻译：液体液体纳米材料组件
公开(公告)号：WO2004063705A3
公开(公告)日：2005-02-17
申请号：PCT/US2004000291
申请日：2004-01-08
申请人： UNIV MASSACHUSETTS , EMRICK TODD , RUSSEL TOM , DINSMORE ANTHONY , SKAFF HABIB , LIN YAO , BOEKER ALEXANDER
发明人： EMRICK TODD , RUSSEL TOM , DINSMORE ANTHONY , SKAFF HABIB , LIN YAO , BOEKER ALEXANDER
IPC分类号： A61K9/50 , A61K9/51 , B01J13/14 , A61K9/14
CPC分类号： A61K9/5089 , A61K9/501 , B01J13/14 , Y10S977/787
摘要： Self-assembly of nanoparticles at the interface between two fluids, and methods to control such self-assembly process, e.g., the surface density of particles assembling at the interface; to utilize the assembled nanoparticles and their ligands in fabrication of capsules, where the elastic properties of the capsules can be varied from soft to tough; to develop capsules with well defined porosities for ultimate use as delivery systems; and to develop chemistries whereby multiple ligands or ligands with multiple functionalities can be attached to the nanoparticles to promote the interfacial segregation and assembly of the nanoparticles. Certain embodiments use cadmium selenide (CdSe) nanoparticles, since the photoluminescence of the particles provides a convenient means by which the spatial location and organization of the particles can be probed. However, the systems and methodologies presented here are general and can, with suitable modification of the chemistries, be adapted to any type of nanoparticle.
摘要翻译：纳米颗粒在两种流体之间的界面处的自组装，以及控制这种自组装过程的方法，例如在界面处组装的颗粒的表面密度; 在胶囊的制造中利用组装的纳米颗粒及其配体，其中胶囊的弹性性质可以从柔软变为韧性; 开发具有明确定义的孔隙度的胶囊，以最终用作输送系统; 并且开发化学物质，由此具有多个官能团的多个配体或配体可以连接到纳米颗粒以促进纳米颗粒的界面分离和组装。某些实施方案使用硒化镉（CdSe）纳米颗粒，因为颗粒的光致发光提供了可以探测颗粒的空间位置和组织的便利手段。然而，这里呈现的系统和方法是通用的，并且可以通过适当的化学修饰来适应任何类型的纳米颗粒。

3. 发明申请

WO0247665A3 METHODS AND COMPOSITIONS FOR ENCAPSULATING ACTIVE AGENTS 审中-公开
标题翻译：包封活性剂的方法和组合物
公开(公告)号：WO0247665A3
公开(公告)日：2003-07-24
申请号：PCT/US0146181
申请日：2001-12-07
申请人： HARVARD COLLEGE , BAUSCH ANDREAS , DINSMORE ANTHONY , HSU MING , NIKOLAIDES MICHAEL , WEITZ DAVID
发明人： BAUSCH ANDREAS , DINSMORE ANTHONY , HSU MING , NIKOLAIDES MICHAEL , WEITZ DAVID
IPC分类号： A61K9/50
CPC分类号： A61K9/5026 , A61K9/5089
摘要： Methods for making self-assembled, selectively permeable elastic microscopie structures, referred to herein as colloidosomes, that have controlled pore-size, porosity and advantageous mechanical properties are described. In one form of the invention, a method of forming colloidosomes includes providing particles formed from a biocompatible material in a first solvent and forming an emulsion by adding a first fluid to the first solvent wherein the emulsion is defined by droplets of the first fluid surrounded by the first solvent. The method includes coating the surface of droplet with the particles and the stabilizing the particles on the surface of droplet. The colloidosomes produced typically have a yield strength of at least about 20 Pascals. In certain forms of the invention, the particles are spherical and are formed of a biocompatible polymer. Colloidosomes formed according to the methods described herein are also provided. In one form, a colloidosome includes a shell formed of biocompatible, substantially spherical particles wherein each of the particles are linked to neighboring particles. The shell defines an inner chamber sized for housing a desired active agent and has a plurality of pores extending therethrough. The colloidosomes are structurally stable, typically having a yield strength of at least about 20 Pascals. Colloidal suspension and methods of encapsulating a desired active agent are also described.
摘要翻译：描述了具有受控的孔径，孔隙率和有利的机械性质的自组装，选择性渗透的弹性微观结构（本文称为胶体体）的方法。在本发明的一种形式中，形成胶体体的方法包括在第一溶剂中提供由生物相容性材料形成的颗粒，并通过向第一溶剂中加入第一流体形成乳液，其中乳液由第一流体的液滴限定，第一溶剂。该方法包括用颗粒涂覆液滴的表面，并将颗粒稳定在液滴的表面上。生产的胶体体通常具有至少约20帕斯卡的屈服强度。在本发明的某些形式中，颗粒是球形的并且由生物相容性聚合物形成。还提供根据本文所述方法形成的胶体细胞。在一种形式中，胶体体包括由生物相容的，基本上为球形的颗粒形成的壳，其中每个颗粒连接到相邻的颗粒。壳体限定了内室，其尺寸适于容纳期望的活性剂并具有延伸穿过其中的多个孔。胶体体系结构稳定，通常具有至少约20帕斯卡的屈服强度。还描述了胶体悬浮液和包封所需活性剂的方法。

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