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1. 发明申请

WO2013006794A1 SYSTEM AND METHOD FOR NARROW BEAM SCANNING MICROSEISMIC MONITORING 审中-公开
标题翻译：用于窄光束扫描微观监测的系统和方法
公开(公告)号：WO2013006794A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045765
申请日：2012-07-06
申请人： DILLER, David
发明人： DILLER, David
IPC分类号： G01V1/30
CPC分类号： G01V1/288 , G01V2210/123 , G01V2210/65
摘要： Disclosed herein are various embodiments of methods and systems for optimizing signals generated by microseismic sources, comprising recording microseismic data using patches of geophones, filtering the data to impart a directionality to the data, and performing a source scan to determine the times and locations of microseismic events. The subsurface is divided into a voxel grid that is further subdivided into subgrids. Using a filter designed for each patch-subgrid pair, only data arriving within a predetermined angle of incidence are input to the source scan, thus reducing noise, and enhancing the quality and accuracy of the identified microseismic events. The method is also applicable to data previously recorded with sensor grids or other arrays such as star arrays.
摘要翻译：本文公开了用于优化由微震源产生的信号的方法和系统的各种实施例，包括使用地震检波器的区块记录微震数据，过滤数据以赋予数据的方向性，以及执行源扫描以确定微震的时间和位置事件。地下分为一个体素网格，进一步细分为子网格。使用为每个贴片 - 子网对设计的滤波器，仅将到达预定入射角的数据输入到源扫描，从而降低噪声，并且增强所识别的微震事件的质量和准确性。该方法也适用于以前使用传感器网格或其他阵列（如星形阵列）记录的数据。

2. 发明申请

WO2010022358A8 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES AND 6-SUBSTITUTED 2-(IMIDAZOLO[4,5- C]PYRIDINYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译： 6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物和6-取代的2-（咪唑并[4,5- C]吡啶基）嘌呤和嘌呤衍生物用于免疫抑制
公开(公告)号：WO2010022358A8
公开(公告)日：2011-03-24
申请号：PCT/US2009054663
申请日：2009-08-21
申请人： LIGAND PHARM INC , NEAGU IRINA , DILLER DAVID , KINGSBURY CELIA , BOHNSTEDT ADOLPH C , OHLMEYER MICHAEL J , PARADKAR VIDYADHAR , ANSARI NASRIN
发明人： NEAGU IRINA , DILLER DAVID , KINGSBURY CELIA , BOHNSTEDT ADOLPH C , OHLMEYER MICHAEL J , PARADKAR VIDYADHAR , ANSARI NASRIN
IPC分类号： C07D473/16 , A61K31/52 , A61K31/522 , A61P11/06 , A61P17/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07D473/18 , C07D473/32 , C07D473/40 , C07D519/00
CPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the genera formulae I and II wherein R1, R2, R3, R4, R9, Q, A and y are as defined in the specification.
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。该化合物具有式I和II类，其中R 1，R 2，R 3，R 4，R 9，Q，A和y如说明书中所定义。

3. 发明申请

WO2007104053A3 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译： 8-HETEROARYLPURINE MNK2用于治疗代谢性疾病的抑制剂
公开(公告)号：WO2007104053A3
公开(公告)日：2007-11-01
申请号：PCT/US2007063699
申请日：2007-03-09
申请人： PHARMACOPEIA INC , COLE ANDREW G , BRESCIA MARC-RALEIGH , ZHANG JOAN J , HUSSAIN ZAHID , DILLER DAVID J , METZGER AXEL , AHMED GULZAR , HENDERSON IAN
发明人： COLE ANDREW G , BRESCIA MARC-RALEIGH , ZHANG JOAN J , HUSSAIN ZAHID , DILLER DAVID J , METZGER AXEL , AHMED GULZAR , HENDERSON IAN
IPC分类号： C07D473/32 , A61K31/52 , A61P3/00
CPC分类号： C07D473/32
摘要： This invention relates to 8-Heteroarylpurine Mnk2 Inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要翻译：本发明涉及可用于治疗和预防代谢性疾病如肥胖症和糖尿病的8-杂芳基嘌呤Mnk2抑制剂。

4. 发明申请

WO2010022358A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES AND 6-SUBSTITUTED 2-(IMIDAZOIO[4,5- C]PYRIDINYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译： 6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物和6-取代的2-（咪唑并[4,5- C]吡啶基）嘌呤和嘌呤衍生物用于免疫抑制
公开(公告)号：WO2010022358A1
公开(公告)日：2010-02-25
申请号：PCT/US2009/054663
申请日：2009-08-21
申请人： LIGAND PHARMACEUTICALS INC. , NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph, C. , OHLMEYER, Michael, J. , PARADKAR, Vidyadhar , ANSARI, Nasrin
发明人： NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph, C. , OHLMEYER, Michael, J. , PARADKAR, Vidyadhar , ANSARI, Nasrin
IPC分类号： C07D473/16 , A61P29/00 , C07D473/18 , A61K31/52 , A61P35/00 , C07D473/32 , A61K31/522 , A61P35/02 , C07D473/40 , A61P11/06 , A61P37/00 , C07D519/00 , A61P17/06 , A61P37/06
CPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the genera formulae I and II wherein R 1 , R 2 , R 3 , R 4 , R 9 , Q, A and y are as defined in the specification.
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。该化合物具有式I和II类，其中R 1，R 2，R 3，R 4，R 9，Q，A和y如说明书中所定义。

5. 发明申请

WO2008043031A1 6-SUBSTITUTED 2-(BENZIMIDAZOLYL)PURINE AND PURINONE DERIVATIVES FOR IMMUNOSUPPRESSION 审中-公开
标题翻译： 6-取代的2-（苯并咪唑）嘌呤和嘌呤衍生物用于免疫抑制
公开(公告)号：WO2008043031A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/080464
申请日：2007-10-04
申请人： PHARMACOPEIA, INC. , NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph , OHLMEYER, Michael , PARADKAR, Vidyadhar , ANSARI, Nasrin
发明人： NEAGU, Irina , DILLER, David , KINGSBURY, Celia , BOHNSTEDT, Adolph , OHLMEYER, Michael , PARADKAR, Vidyadhar , ANSARI, Nasrin
IPC分类号： C07D473/16 , C07D473/18 , C07D473/32 , C07D473/40 , A61K31/52 , A61P9/00 , A61P11/06 , A61P17/06 , A61P27/02 , A61P35/00 , A61P37/00
CPC分类号： C07D473/32 , C07D473/16 , C07D473/18 , C07D473/40
摘要： The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II.
摘要翻译：本发明提供了可用于预防和治疗自身免疫性疾病，炎性疾病，肥大细胞介导的疾病和移植排斥的新型嘌呤酮和嘌呤。该化合物具有通式I和II。

6. 发明申请

WO2006055918A3 ONE-DIMENSIONAL QSAR MODELS 审中-公开
标题翻译：一维QSAR模型
公开(公告)号：WO2006055918A3
公开(公告)日：2007-02-01
申请号：PCT/US2005042189
申请日：2005-11-21
申请人： PHARMACOPEIA DRUG DISCOVERY , DILLER DAVID JOHN , WANG NORMAN , DELISLE ROBERT KIRK , ANGHELESCU ANDREI VICTOR
发明人： DILLER DAVID JOHN , WANG NORMAN , DELISLE ROBERT KIRK , ANGHELESCU ANDREI VICTOR
IPC分类号： G06G7/48
CPC分类号： C07K1/00 , C07K2299/00 , G06F19/704
摘要： A set of molecules, the members of which have the same type of biological activity, are represented as one-dimensional strings of atoms. The one-dimensional strings of all members of the set are aligned, in order to obtain a multiple alignment profile of a consensus active compound. The one-dimensional multiple alignment profile is used in deriving a one-dimensional QSAR model to identify other compounds likely to have the same biological activity, and also may be used to derive a three-dimensional multiple alignment profile of the molecules in the set.
摘要翻译：一组分子，其成员具有相同类型的生物活性，被表示为一维原子串。将该组的所有成员的一维串排列，以获得共有活性化合物的多重比对分布。一维多重比对分布用于推导一维QSAR模型以鉴定可能具有相同生物活性的其他化合物，并且还可用于导出该组中分子的三维多重比对分布。

7. 发明申请

WO2012068546A1 HETEROCYCLE AMINES AND USES THEREOF 审中-公开
标题翻译：杂环胺及其用途
公开(公告)号：WO2012068546A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/061532
申请日：2011-11-18
申请人： LIGAND PHARMACEUTICALS INCORPORATED , HO, Koc-kan , DILLER, David , LETOURNEAU, Jeffrey, J. , MCGUINNESS, Brian, F. , COLE, Andrew, G. , ROSEN, David , VAN OEVEREN, Cornelis, A. , PICKENS, Jason, C. , ZHI, Lin , SHEN, Yixing , PEDRAM, Bijan
发明人： HO, Koc-kan , DILLER, David , LETOURNEAU, Jeffrey, J. , MCGUINNESS, Brian, F. , COLE, Andrew, G. , ROSEN, David , VAN OEVEREN, Cornelis, A. , PICKENS, Jason, C. , ZHI, Lin , SHEN, Yixing , PEDRAM, Bijan
IPC分类号： C07D235/02 , C07D269/02 , C07D277/42 , C07D277/60 , A61K31/407 , A61K31/4168 , A61K31/4353
CPC分类号： C07D513/04 , A61K31/407 , A61K31/4168 , A61K31/4353 , A61P29/00 , A61P37/00 , C07D235/02 , C07D269/02 , C07D277/42 , C07D277/60 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Compounds and methods in the fields of chemistry and medicine are disclosed. Some of the disclosed embodiments include compounds, compositions and methods of using heterocycle amines. Some of the disclosed embodiments include heterocycle amines useful to treat inflammatory disorders.
摘要翻译：公开了化学和医学领域中的化合物和方法。一些所公开的实施方案包括使用杂环胺的化合物，组合物和方法。一些所公开的实施方案包括可用于治疗炎症性疾病的杂环胺。

8. 发明申请

WO2008051826A2 PURINES AS PKC-THETA INHIBITORS 审中-公开
标题翻译：作为PKC-THETA抑制剂
公开(公告)号：WO2008051826A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/081899
申请日：2007-10-19
申请人： N.V. ORGANON , PHARMACOPEIA INC. , NEAGU, Irina , ROUGHTON, Andrew , HO, Koc-kan , DILLER, David , CHAN, Jui, Hsiang , KINGSBURY, Celia , OHLMEYER, Michael , WIJKMANS, Jacobus Cornelis, Henricus Maria , TEERHUIS, Neeltje, Miranda , LOMMERSE, Johannes Petrus, Maria
发明人： NEAGU, Irina , ROUGHTON, Andrew , HO, Koc-kan , DILLER, David , CHAN, Jui, Hsiang , KINGSBURY, Celia , OHLMEYER, Michael , WIJKMANS, Jacobus Cornelis, Henricus Maria , TEERHUIS, Neeltje, Miranda , LOMMERSE, Johannes Petrus, Maria
IPC分类号： C07D473/32 , A61K31/52 , A61P35/00
CPC分类号： C07D473/32
摘要： A chemical genus of purines, which are useful as PKC θ inhibitors, is disclosed. The genus is represented by the formula (I); A representative example is: (II)
摘要翻译：嘌呤的化学属，可用作PKC？抑制剂。该属由式（I）表示; 一个代表性的例子是：（二）

9. 发明申请

WO2007104053A2 8-HETEROARYLPURINE MNK2 INHIBITORS FOR TREATING METABOLIC DISORDERS 审中-公开
标题翻译： 8-HETEROARYLPURINE MNK2抑制剂治疗代谢性疾病
公开(公告)号：WO2007104053A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/063699
申请日：2007-03-09
申请人： PHARMACOPEIA, INC. , COLE, Andrew G. , BRESCIA, Marc-raleigh , ZHANG, Joan J. , HUSSAIN, Zahid , DILLER, David J. , METZGER, Axel , AHMED, Gulzar , HENDERSON, Ian
发明人： COLE, Andrew G. , BRESCIA, Marc-raleigh , ZHANG, Joan J. , HUSSAIN, Zahid , DILLER, David J. , METZGER, Axel , AHMED, Gulzar , HENDERSON, Ian
IPC分类号： C07D473/32 , A61K31/52 , A61P3/00
CPC分类号： C07D473/32
摘要： This invention relates to 8-Heteroarylpurine Mnk2 Inhibitors which are useful for the treatment and prevention of metabolic disorders such as obesity and diabetes.
摘要翻译：本发明涉及8-杂芳基嘌呤Mnk2抑制剂，其可用于治疗和预防代谢性疾病如肥胖和糖尿病。

10. 发明申请

WO2009124965A1 PYRROLO[2,3-d]PYRIMIDIN-2-YL-AMINE DERIVATIVES AS PKC-THETA INHIBITORS 审中-公开
标题翻译：吡咯并[<我
公开(公告)号：WO2009124965A1
公开(公告)日：2009-10-15
申请号：PCT/EP2009/054209
申请日：2009-04-08
申请人： N.V. ORGANON , PHARMACOPEIA, LLC , ROUGHTON, Andrew Laird , HO, Koc-Kan , OHLMEYER, Michael , DILLER, David , NEAGU, Irina , KINGSBURY, Celia , CHAN, Jui-Hsiang , LOMMERSE, Johannes, Petrus, Maria , TEERHUIS, Neeltje, Miranda , WIJKMANS, Jacobus Cornelis Henricus Maria , PLATE, Ralf
发明人： ROUGHTON, Andrew Laird , HO, Koc-Kan , OHLMEYER, Michael , DILLER, David , NEAGU, Irina , KINGSBURY, Celia , CHAN, Jui-Hsiang , LOMMERSE, Johannes, Petrus, Maria , TEERHUIS, Neeltje, Miranda , WIJKMANS, Jacobus Cornelis Henricus Maria , PLATE, Ralf
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： The present invention relates to a pyrrolo[2,3-d]pyrimidin-2-yl-amine derivative according to formula (I) wherein the variables are defined as in the specification, or to a pharmaceutically acceptable salt or solvate thereof. The present invention also relates to a pharmaceutical composition comprising one or more of said pyrrolo[2,3-d]pyrimidine-2-ylamine derivatives and to their use in therapy, for instance in the treatment of PKCθ mediated disorders.
摘要翻译：本发明涉及式（I）的吡咯并[2,3-d]嘧啶-2-基 - 胺衍生物，其中变量如说明书中所定义，或其药学上可接受的盐或溶剂合物。本发明还涉及包含一种或多种所述吡咯并[2,3-d]嘧啶-2-基胺衍生物的药物组合物及其在治疗中的用途，例如用于治疗PKC？介导的疾病。

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