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1. 发明申请

WO2015002729A2 CELL STABILIZATION 审中-公开
标题翻译：细胞稳定
公开(公告)号：WO2015002729A2
公开(公告)日：2015-01-08
申请号：PCT/US2014/042396
申请日：2014-06-13
申请人： BIOMATRICA, INC. , MULLER-COHN, Judy , DIAZ, Paul
发明人： MULLER-COHN, Judy , DIAZ, Paul , MULLER, Rolf , LIBERAL, Vasco , PEREZ-LADAGA, Albert
IPC分类号： A01N1/02
CPC分类号： A01N1/0226 , C12N11/00
摘要： The present invention relates to stabilization of cells at ambient temperatures. More particularly, the present invention relates to formulations, compositions, kits and methods that allow dehydration and rehydration of cells and dramatically increased recovery of functional cells after dry storage at room temperature.
摘要翻译：本发明涉及在环境温度下稳定细胞。更具体地说，本发明涉及允许细胞脱水和再水合并且在室温下干燥储存后功能细胞的恢复显着增加的制剂，组合物，试剂盒和方法。

2. 发明申请

WO2004061409A2 PARALLEL INDUCIBLE CELL-BASED KINASE SCREEN 审中-公开
标题翻译：平行可诱导基于细胞的激酶筛选
公开(公告)号：WO2004061409A2
公开(公告)日：2004-07-22
申请号：PCT/US2002/040757
申请日：2002-12-19
申请人： RIBAPHARM INC. , HONG, Zhi , RICKETTS, William , DIAZ, Paul
发明人： HONG, Zhi , RICKETTS, William , DIAZ, Paul
IPC分类号： G01N
CPC分类号： C12Q1/485 , G01N2500/10
摘要： A parallel inducible cell-based kinase screen (PICKS) includes a plurality of cells that express a kinase gene under the control of an inducer and a reporter gene, wherein the cells are derived from a single cell line, and wherein the reporter gene generates a signal in response to catalytic activity or inhibition of the expressed kinases. Particularly preferred systems include cells expressing kinases from a single kinase signaling pathway, kinases from a kinase family, and/or kinases from various different kinase signaling pathways. Consequently, contemplated systems provide a platform for screening for novel kinase inhibitors, inhibition specificity of particular kinase inhibitors, and for analysis of inter-pathway and/or intra-pathway inhibition of a kinase inhibitor.
摘要翻译：平行可诱导的基于细胞的激酶筛选（PICKS）包括在诱导物和报道基因的控制下表达激酶基因的多个细胞，其中所述细胞衍生自单个细胞系，并且其中所述报告基因产生响应于催化活性或抑制表达的激酶的信号。特别优选的系统包括表达来自单一激酶信号通路的激酶的细胞，来自激酶家族的激酶和/或来自各种不同激酶信号通路的激酶。因此，预期的系统提供筛选新型激酶抑制剂的平台，特异性激酶抑制剂的抑制特异性，以及激酶抑制剂的通路间途径和/或通路内抑制的分析。

3. 发明申请

WO2015002729A3 CELL STABILIZATION 审中-公开
标题翻译：细胞稳定
公开(公告)号：WO2015002729A3
公开(公告)日：2015-05-07
申请号：PCT/US2014042396
申请日：2014-06-13
申请人： BIOMATRICA INC , MULLER-COHN JUDY , DIAZ PAUL
发明人： MULLER-COHN JUDY , DIAZ PAUL , MULLER ROLF , LIBERAL VASCO , PEREZ-LADAGA ALBERT
IPC分类号： A01N1/02 , A61K31/17 , A61K31/4706
CPC分类号： A01N1/0226 , C12N11/00
摘要： The present invention relates to stabilization of cells at ambient temperatures. More particularly, the present invention relates to formulations, compositions, kits and methods that allow dehydration and rehydration of cells and dramatically increased recovery of functional cells after dry storage at room temperature.
摘要翻译：本发明涉及在环境温度下稳定细胞。更具体地说，本发明涉及允许细胞脱水和再水合并且在室温下干燥储存后显着提高功能细胞回收的制剂，组合物，试剂盒和方法。

4. 发明申请

WO2004061409A3 PARALLEL INDUCIBLE CELL-BASED KINASE SCREEN 审中-公开
标题翻译：平行诱导的基于细胞的激酶屏
公开(公告)号：WO2004061409A3
公开(公告)日：2004-10-14
申请号：PCT/US0240757
申请日：2002-12-19
申请人： RIBAPHARM INC , HONG ZHI , RICKETTS WILLIAM , DIAZ PAUL
发明人： HONG ZHI , RICKETTS WILLIAM , DIAZ PAUL
IPC分类号： C12Q1/02 , C12Q1/48 , G01N20060101
CPC分类号： C12Q1/485 , G01N2500/10
摘要： A parallel inducible cell-based kinase screen (PICKS) includes a plurality of cells that express a kinase gene under the control of an inducer and a reporter gene, wherein the cells are derived from a single cell line, and wherein the reporter gene generates a signal in response to catalytic activity or inhibition of the expressed kinases. Particularly preferred systems include cells expressing kinases from a single kinase signaling pathway, kinases from a kinase family, and/or kinases from various different kinase signaling pathways. Consequently, contemplated systems provide a platform for screening for novel kinase inhibitors, inhibition specificity of particular kinase inhibitors, and for analysis of inter-pathway and/or intra-pathway inhibition of a kinase inhibitor.
摘要翻译：平行诱导型基于细胞的激酶筛选（PICKS）包括多个在诱导剂和报道基因控制下表达激酶基因的细胞，其中所述细胞来源于单细胞系，并且其中所述报道基因产生响应催化活性或抑制表达的激酶而发出信号。特别优选的系统包括表达来自单一激酶信号传导途径的激酶，来自激酶家族的激酶和/或来自各种不同激酶信号传导途径的激酶的细胞。因此，所设想的系统提供了用于筛选新型激酶抑制剂，抑制特定激酶抑制剂的特异性以及用于分析激酶抑制剂的途径间和/或途径内抑制的平台。

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