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1. 发明申请

WO2004096220A1 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS 审中-公开
标题翻译： 8-（3-二氨基）苯基喹啉磷酸酯酶抑制剂
公开(公告)号：WO2004096220A1
公开(公告)日：2004-11-11
申请号：PCT/CA2004/000622
申请日：2004-04-27
申请人： MERCK FROSST CANADA & CO. , DUBE, Daniel , DUBE, Laurence , GALLANT, Michel , LACOMBE, Patrick , DESCHENES, Denis , MACDONALD, Dwight
发明人： DUBE, Daniel , DUBE, Laurence , GALLANT, Michel , LACOMBE, Patrick , DESCHENES, Denis , MACDONALD, Dwight
IPC分类号： A61K31/4709
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D401/14 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Novel substituted 8-phenylquinolines represented by Formula (I), wherein the phenyl group at the 8-position contains an aryl or heteroaryl substituent in the meta position, are PDE4 inhibitors.
摘要翻译：由式（I）表示的新型取代的8-苯基喹啉，其中8位上的苯基在间位含有芳基或杂芳基取代基是PDE4抑制剂。

2. 发明专利

AU2003243870A1 8-(BIARYL) QUINOLINE PDE4 INHIBITORS 未知
公开(公告)号：AU2003243870A1
公开(公告)日：2004-01-06
申请号：AU2003243870
申请日：2003-06-23
申请人： DESCHENES DENIS , DUBE DANIEL , DUBE LAURENCE , GALLANT MICHEL , GIRARD YVES , LACOMBE PATRICK , MACDONALD DWIGHT , MERCK FROSST CANADA INC
发明人： DESCHENES DENIS , DUBE DANIEL , DUBE LAURENCE , GALLANT MICHEL , GIRARD YVES , LACOMBE PATRICK , MACDONALD DWIGHT
IPC分类号： A61P29/00 , C07D215/04 , C07D215/12 , C07D401/04 , C07D401/10 , C07D403/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D471/02 , C07D471/04 , C07F7/08 , C07F9/60 , A61K31/497 , A61K31/4709 , A61K31/47
摘要： 8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues. In another aspect, the present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.

3. 发明专利

CA1179565A SOLAR AIR COLLECTOR 未知
公开(公告)号：CA1179565A
公开(公告)日：1984-12-18
申请号：CA385756
申请日：1981-09-11
申请人： MISRAHI EDDY , DESCHENES DENIS
发明人： MISRAHI EDDY , DESCHENES DENIS
IPC分类号： F24J3/02
摘要： A solar heating system including a radiant heat collector apparatus made up of an enclosure having glazed panels. The collector provided within the enclosure is upstanding with the enclosure and the collector has heat absorbent flat walls spaced inwardly from the glazed panels. A heat storage core is provided centrally within the collector and spaced from the walls of the collector. The heat storage core includes an insulated housing and a heat retaining member within the insulated housing. Air passageways are formed between the collector walls and the insulated housing for passing input air, and duct members are provided for communicating with a household.

4. 发明申请

WO1995015798A1 DICE GAME FOR LEARNING MULTIPLICATION TABLES 审中-公开
标题翻译：数学游戏学习多用表
公开(公告)号：WO1995015798A1
公开(公告)日：1995-06-15
申请号：PCT/CA1994000679
申请日：1994-12-08
申请人： DESCHENES, Denis
IPC分类号： A63F03/04
CPC分类号： A63F3/0415 , A63F9/0413 , A63F2003/0418
摘要： A game device for aiding in the learning of certain mathematical operations, such as multiplication tables, comprises a pad of score sheets for at least two players. Each score sheet includes a series of numbers ranging from 2 to 12 and, for each of the players, one or more blank spaces associated with each of these numbers. Four six-faced dice are provided and deployed to obtain four numeric readings ranging from 1 to 6 which are grouped in two pairs and added by one player within these two pairs for producing two sums which are multiplied by the same player to obtain a product that the player inserts in a blank space of the score sheet located opposite one of the two numbers corresponding to the aforementioned sums. The four dice are grouped in as many sets of pairs as possible so as to obtain, for a same deployment of the four dice, as many different products as possible for insertion in the score sheet. The players take turns in rolling the dice, determining the possible product(s) obtainable therefrom, and then placing these results on the score sheet always in the appropriate player's blank spaces associated with one of the multiplier and multiplicand until each of the blank spaces of one player is occupied by a product. Alternatively, the blank spaces can be of different background colors with the object of the game being filling out with numbers all of each player's same colored boxes before the other players. Various scoring systems are proposed for the colored boxes appropriated by each player.
摘要翻译：用于帮助学习某些数学运算（例如乘法表）的游戏装置包括用于至少两个玩家的记分纸垫。每个记分表包括范围从2到12的一系列数字，并且对于每个玩家，与这些数字中的每一个相关联的一个或多个空白空间。提供和部署四个六面骰子以获得1到6的四个数字读数，这两个数字读数分成两对，并由这两对中的一个玩家添加，以产生由相同玩家乘以的两个总和，以获得产品玩家插入到与上述和值相对应的两个数字相对的得分表的空白空间。四个骰子被分组成尽可能多的成对集合，以便对于四个骰子的相同部署，获得尽可能多的不同的产品以插入到分数表中。玩家轮流掷骰子，确定可能的产品，然后将这些结果放在得分记录表上，总是在与乘法器和被乘数之一相关联的适当玩家的空白处，直到每个空格一个玩家被一个产品占据。或者，空白空间可以具有不同的背景颜色，游戏对象在其他玩家之前用每个玩家相同颜色的盒子填充数字。针对每个玩家所使用的彩色盒子提出了各种评分系统。

5. 发明专利

CA2111070A1 DICE GAME FOR LEARNING MULTIPLICATION TABLES 未知
公开(公告)号：CA2111070A1
公开(公告)日：1995-06-10
申请号：CA2111070
申请日：1993-12-09
申请人： DESCHENES DENIS
发明人： DESCHENES DENIS
IPC分类号： A63F3/04 , A63F9/04 , G09B19/22 , A63F1/00 , G09B19/02
摘要： A game device for aiding in the learning of certain mathematical operations, such as multiplication tables, comprises a pad of score sheets for at least two players. Each score sheet includes a series of numbers ranging from 2 to 12 and, for each of the players, one or more blank spaces associated with each of these numbers. Four six-faced dice are provided and deployed to obtain four numeric readings ranging from 1 to 6 which are grouped in two pairs and added by one player within these two pairs for producing two sums which are multiplied by the same player to obtain a product that the player inserts in a blank space of the score sheet located opposite one of the two numbers corresponding to the aforementioned sums. The four dice are grouped in as many sets of pairs as possible so as to obtain, for a same deployment of the four dice, as many different products as possible for insertion in the score sheet. The players take turns in rolling the dice, determining the possible product(s) obtainable therefrom, and then placing these results on the score sheet always in the appropriate player's blank spaces associated with one of the multiplier and multiplicand until each of the blank spaces of one player is occupied by a product. Alternatively, the blank spaces can be of different background colors with the object of the game being filling out with numbers all of each player's same colored boxes before the other players. Various scoring systems are proposed for the colored boxes appropriated by each player.

6. 发明专利

CA2111070C DICE GAME FOR LEARNING MULTIPLICATION TABLES 未知
公开(公告)号：CA2111070C
公开(公告)日：2007-03-27
申请号：CA2111070
申请日：1993-12-09
申请人： DESCHENES DENIS
发明人： DESCHENES DENIS
IPC分类号： G09B19/02 , A63F3/04 , A63F9/04
摘要： A game device for aiding in the learning of certain mathematical operations, such as multiplication tables, comprises a pad of score sheets for at least two players. Each score sheet includes a series of numbers ranging from 2 to 12 and, for each of the players, one or more blank spaces associated with each of these numbers. Four six-faced dice are provided and deployed to obtain four numeric readings ranging from 1 to 6 which are grouped in two pairs and added by one player within these two pairs for producing two sums which are multiplied by the same player to obtain a product that the player inserts in a blank space of the score sheet located opposite one of the two numbers corresponding to the aforementioned sums. The four dice are grouped in as many sets of pairs as possible so as to obtain, for a same deployment of the four dice, as many different products as possible for insertion in the score sheet. The players take turns in rolling the dice, determining the possible product(s) obtainable therefrom, and then placing these results on the score sheet always in the appropriate player's blank spaces associated with one of the multiplier and multiplicand until each of the blank spaces of one player is occupied by aproduct. Alternatively, the blank spaces can be of different background colors with the object of the game being filling out with numbers all of each player's same colored boxes before the other players. Various scoring systems are proposed for the colored boxes appropriated by each player.

7. 发明申请

WO2013192098A1 SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS 审中-公开
标题翻译：取代的吡啶类吡虫啉激酶（Syk）抑制剂
公开(公告)号：WO2013192098A1
公开(公告)日：2013-12-27
申请号：PCT/US2013/046151
申请日：2013-06-17
申请人： MERCK SHARP & DOHME CORP. , MERCK CANADA INC. , HAIDLE, Andrew, M. , KNOWLES, Sandra Lee , KATTAR, Solomon, D. , DESCHENES, Denis , BURCH, Jason , ROBICHAUD, Joel , CHRISTOPHER, Matthew , ALTMAN, Michael, D. , JEWELL, James, P. , NORTHRUP, Alan, B. , BLOUIN, Marc , ELLIS, John, Michael , ZHOU, Hua , FISCHER, Christian , SCHELL, Adam, J. , REUTERSHAN, Michael, H. , TAOKA, Brandon, M. , DONOFRIO, Anthony
发明人： HAIDLE, Andrew, M. , KNOWLES, Sandra Lee , KATTAR, Solomon, D. , DESCHENES, Denis , BURCH, Jason , ROBICHAUD, Joel , CHRISTOPHER, Matthew , ALTMAN, Michael, D. , JEWELL, James, P. , NORTHRUP, Alan, B. , BLOUIN, Marc , ELLIS, John, Michael , ZHOU, Hua , FISCHER, Christian , SCHELL, Adam, J. , REUTERSHAN, Michael, H. , TAOKA, Brandon, M. , DONOFRIO, Anthony
IPC分类号： A61K31/505 , A61P35/00
CPC分类号： C07D401/12 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D491/08 , C07D491/107 , C07D491/113 , C07D498/04 , A61K2300/00
摘要： The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2, R 3 , R 4 , R cy ,C y , and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.
摘要翻译：本发明提供了式（I）的某些取代的吡啶或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，Rcy，Cy和t如本文所定义。本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。

8. 发明申请

WO2007076611A1 SAND FILTER CLEANING APPARATUS AND METHOD THEREOF 审中-公开
标题翻译： SAND过滤器清洗装置及其方法
公开(公告)号：WO2007076611A1
公开(公告)日：2007-07-12
申请号：PCT/CA2007/000017
申请日：2007-01-05
申请人： SONITEC INC. , DESCHENES, Denis
发明人： DESCHENES, Denis
IPC分类号： B01D24/46
CPC分类号： B01D24/105 , B01D24/4631 , B01D2201/085
摘要： An apparatus for cleaning and/or sterilizing sand filter is provided. The apparatus comprises at least one sand filter but preferably a plurality. The apparatus generally comprises a clean water pipe circuit and a backwash water pipe circuit. Preferably connected to the backwash water pipe circuit is a cleaning and/or sterilizing means provider. On a regular basis and/or when it is detected that the efficiency of the filter has decreased below a certain threshold, cleaning and/or sterilizing means are added to the backwash water in order to remove unwanted particles, bacteria, oils and/or greases, metal deposits and the like that previous simple backwashes failed to remove. A method for using the apparatus thereof is also provided.
摘要翻译：提供了一种用于清洗和/或消毒砂滤器的设备。该装置包括至少一个砂滤器，但优选多个。该设备通常包括清洁水管回路和反冲洗水管回路。优选地连接到反洗水管回路是清洁和/或消毒装置提供者。和/或当检测到过滤器的效率已经降低到某一阈值以下时，清洗和/或消毒装置被添加到回洗水中，以便去除不想要的颗粒，细菌，油和/或油脂，金属沉积物等，以前的简单反冲洗不能去除。还提供了一种使用该装置的方法。

9. 发明申请

WO2007071023A1 HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE 审中-公开
标题翻译：作为硬脂酸苄酯A DELTA-9去饱和酶抑制剂的异构化合物
公开(公告)号：WO2007071023A1
公开(公告)日：2007-06-28
申请号：PCT/CA2006/002053
申请日：2006-12-18
申请人： MERCK FROSST CANADA LTD. , DESCHENES, Denis , FORTIN, Rejean , LI, Chun, Sing , OBALLA, Renata, M. , RAMTOHUL, Yeeman, K.
发明人： DESCHENES, Denis , FORTIN, Rejean , LI, Chun, Sing , OBALLA, Renata, M. , RAMTOHUL, Yeeman, K.
IPC分类号： C07D401/04 , A61K31/501 , A61P3/00 , A61P35/00 , A61P9/10 , C07D403/04
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/14 , C07D471/04
摘要： Heteroaromatic compounds of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; lipid disorders; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; fatty liver disease and cancer.
摘要翻译：结构式（I）的杂芳族化合物是相对于其他已知的硬脂酰辅酶A去饱和酶的硬脂酰辅酶Aδ-9去饱和酶（SCD1）的选择性抑制剂。本发明的化合物可用于预防和治疗与脂质合成和代谢异常有关的病症，包括心血管疾病，如动脉粥样硬化; 脂质紊乱肥胖; 糖尿病; 神经系统疾病; 代谢综合征; 胰岛素抵抗; 脂肪肝病和癌症。

10. 发明申请

WO2004000814A1 8-(BIARYL) QUINOLINE PDE4 INHIBITORS 审中-公开
标题翻译： 8-（BIARYL）喹啉PDE4抑制剂
公开(公告)号：WO2004000814A1
公开(公告)日：2003-12-31
申请号：PCT/CA2003/000957
申请日：2003-06-23
申请人： MERCK FROSST CANADA & CO. , DESCHENES, Denis , DUBE, Daniel , DUBE, Laurence , GALLANT, Michel , GIRARD, Yves , LACOMBE, Patrick , MACDONALD, Dwight
发明人： DESCHENES, Denis , DUBE, Daniel , DUBE, Laurence , GALLANT, Michel , GIRARD, Yves , LACOMBE, Patrick , MACDONALD, Dwight
IPC分类号： C07D215/04
CPC分类号： C07D215/04 , C07D215/06 , C07D215/12 , C07D215/14 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12 , C07D471/04 , C07F7/0812 , C07F9/60
摘要： 8-(biaryl) quinolines wherein the bi-aryl group at the 8-position is in a meta relationship to the quinoline group, are PDE4 inhibitors useful in the treatment of asthma, chronic bronchitis, chronic obstructive pulmonary disease, eosinophilic granuloma, psoriasis and other benign or malignant proliferative skin diseases, endotoxic shock, laminitis in horses, colic in horses, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and brain, inflammatory arthritis, chronic glomerulonephritis, atopic dermatitis, urticaria, adult respiratory distress syndrome, chronic obstructive pulmonary disease in animals, diabetes insipidus, allergic rhinitis, allergic conjunctivitis, vernal conjunctivitis, arterial restenosis, ortherosclerosis, atherosclerosis, neurogenic inflammation, pain, cough, rheumatoid arthritis, ankylosing spondylitis, transplant rejection, graft versus host disease, hypersecretion of gastric acid, bacterial, fungal induced sepsis, viral induced sepsis, fungal induced septic shock, viral induced septic shock, inflammation-mediated chronic tissue degeneration, cytokine-mediated chronic tissue degeneration, osteoarthritis, cancer, cachexia, muscle wasting, depression, memory impairment, tumour growth, or cancerous invasion of normal tissues.In another aspect, the present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and cognition enhancing amount of a phosphodiesterase-4 inhibitor.
摘要翻译： 8-（联芳）喹啉，其中8-位上的双芳基与喹啉基团呈元间关系，是可用于治疗哮喘，慢性支气管炎，慢性阻塞性肺疾病，嗜酸性肉芽肿，银屑病的PDE4抑制剂其他良性或恶性增殖性皮肤疾病，内毒素性休克，马匹中的扁桃体炎，马蹄痛，败血性休克，溃疡性结肠炎，克罗恩病，心肌和脑的再灌注损伤，炎症性关节炎，慢性肾小球肾炎，特应性皮炎，荨麻疹，成人呼吸窘迫综合征，动物慢性阻塞性肺病，尿崩症，过敏性鼻炎，过敏性结膜炎，春季结膜炎，动脉再狭窄或动脉粥样硬化，动脉粥样硬化，神经源性炎症，疼痛，咳嗽，类风湿关节炎，强直性脊柱炎，移植排斥反应，移植物抗宿主病，分泌过多的胃酸，细菌，真菌诱导的败血症，病毒诱导 d败血症，真菌诱发的败血症休克，病毒诱导的败血性休克，炎症介导的慢性组织变性，细胞因子介导的慢性组织变性，骨关节炎，癌症，恶病质，肌肉消瘦，抑郁，记忆障碍，肿瘤生长或正常组织的癌性侵袭另一方面，本发明涉及增强健康受试者的认知的方法，包括施用安全认知增加量的磷酸二酯酶-4抑制剂。特别地，本发明涉及增加健康受试者的记忆，学习，保留，召回，意识和判断的方法，包括施用安全和认知增加量的磷酸二酯酶-4抑制剂。

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