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1. 发明申请

WO2011153010A1 METHODS OF TREATMENT OF PANCREATIC CANCER 审中-公开
标题翻译：治疗胰腺癌的方法
公开(公告)号：WO2011153010A1
公开(公告)日：2011-12-08
申请号：PCT/US2011/037462
申请日：2011-05-20
申请人： ABRAXIS BIOSCIENCES, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K47/42 , A61K9/14 , A61P35/00
CPC分类号： A61K9/5169 , A61K31/16 , A61K31/337 , A61K31/436 , A61K31/4709 , A61K31/4745 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/5377 , A61K31/69 , A61K31/7068 , A61K39/3955 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer (e.g., gemcitabine-based therapy) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating pancreatic cancer (for example, in an individual who has been previously treated for pancreatic cancer) comprising administering to an individual an effective amount of a composition comprising nanoparticles that comprise a taxane and an albumin and another agent.
摘要翻译：本发明提供了通过给予包含包含紫杉烷和白蛋白的纳米颗粒的组合物预先治疗胰腺癌（例如吉西他滨的疗法）的个体中治疗胰腺癌的方法和组合物。本发明还提供了治疗胰腺癌的联合治疗方法（例如，在先前已经用于胰腺癌的个体中），包括向个体施用有效量的包含紫杉烷和白蛋白的纳米颗粒的组合物和另一种药剂。

2. 发明申请

WO2011123393A1 METHODS OF ENHANCING DRUG DELIVERY AND EFFECTIVENESS OF THERAPEUTIC AGENTS 审中-公开
标题翻译：增加治疗药物的药物递送和有效性的方法
公开(公告)号：WO2011123393A1
公开(公告)日：2011-10-06
申请号：PCT/US2011/030206
申请日：2011-03-28
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K9/14 , A61P35/00
CPC分类号： A61K47/42 , A61K31/337 , A61K31/573 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as "the drug uptake capability"). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.
摘要翻译：本发明在一个方面提供了增强靶组织中治疗剂摄取的方法，以及通过共同施用组合物来治疗疾病（例如癌症）或通过治疗剂治疗的有效性的方法包括包含白蛋白和难溶性水溶性药物如紫杉烷与治疗剂的纳米颗粒。本发明的另一方面提供了一种治疗方法或选择用于治疗疾病（例如癌症）的患者的方法，其中治疗剂和包含纳米颗粒的组合物包含白蛋白和水难溶性药物，例如基于目标组织的一个或多个特征的紫杉烷，其与靶组织中紫杉烷纳米颗粒组合物共同给药的结果相关或指示获得增强的治疗剂摄取的能力（称为“药物摄取能力” ）。还提供了可用于本文所述方法的药物组合物，制品和试剂盒。

3. 发明申请

WO2011025838A1 COMBINATION THERAPY WITH NANOPARTICLE COMPOSITIONS OF TAXANE AND HEDGEHOG INHIBITORS 审中-公开
标题翻译：与TAXANE和HEDGEHOG抑制剂纳米复合物的组合治疗
公开(公告)号：WO2011025838A1
公开(公告)日：2011-03-03
申请号：PCT/US2010/046684
申请日：2010-08-25
申请人： ABRAXIS BIOSCIENCE, LLC , TAO, Chunlin , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： TAO, Chunlin , DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/337 , A61K9/20
CPC分类号： A61K47/42 , A61K9/5169 , A61K31/337 , A61K31/4355 , A61K31/7056
摘要： The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a hedgehog inhibitor that inhibits a hedgehog signaling pathway.
摘要翻译：本发明提供了治疗增殖性疾病（例如癌症）的组合治疗方法，其包括向个体施用有效量的纳米颗粒组合物中的紫杉烷，以及抑制刺猬蛋白信号传导途径的刺猬蛋白抑制剂。

4. 发明申请

WO2010144550A1 TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS 审中-公开
标题翻译： TRIAZINE衍生物及其治疗应用
公开(公告)号：WO2010144550A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/037935
申请日：2010-06-09
申请人： ABRAXIS BIOSCIENCE, LLC , TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , POLAT, Tulay , HO, David , DESAI, Neil, P.
发明人： TAO, Chunlin , WANG, Qinwei , NALLAN, Laxman , POLAT, Tulay , HO, David , DESAI, Neil, P.
IPC分类号： A01N43/66 , A61K31/53
CPC分类号： A61K31/53 , A61K31/496 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The invention provides Triazine derivatives and further provides methods of using these compounds to modulate protein kinases and for treating diseases and conditions mediated by protein kinases.
摘要翻译：本发明提供三嗪衍生物，并进一步提供使用这些化合物调节蛋白激酶和治疗由蛋白激酶介导的疾病和病症的方法。

5. 发明申请

WO2010121000A1 PRION-FREE NANOPARTICLE COMPOSITIONS AND METHODS 审中-公开
标题翻译：无免疫纳米颗粒组合物和方法
公开(公告)号：WO2010121000A1
公开(公告)日：2010-10-21
申请号：PCT/US2010/031197
申请日：2010-04-15
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , PEYKOV, Viktor , SOON-SHIONG, Patrick
发明人： DESAI, Neil, P. , PEYKOV, Viktor , SOON-SHIONG, Patrick
IPC分类号： G01N33/53
CPC分类号： A61K9/5169 , A61K9/1658 , A61K31/337 , A61K47/42 , B82Y5/00 , G01N33/6896 , G01N2800/2828 , Y10S210/905
摘要： Prion-free compositions comprising nanoparticles comprising albumin and substantially water insoluble drugs are disclosed. Also provided are methods of making prion-free compositions and methods of removing prion proteins from the nanoparticle compositions. Methods of using the compositions, as well as kits useful for carrying out the methods are also provided.
摘要翻译：公开了包含白蛋白和基本上不溶于水的药物的纳米颗粒的无朊病毒组合物。还提供了制备无朊病毒组合物和从纳米颗粒组合物中除去朊病毒蛋白的方法。还提供了使用组合物的方法以及用于实施方法的试剂盒。

6. 发明申请

WO2009126401A1 COMPOSITIONS OF HYDROPHOBIC TAXANE DERIVATIVES AND USES THEREOF 审中-公开
标题翻译：疏水性紫杉烷衍生物的组合物及其用途
公开(公告)号：WO2009126401A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/036942
申请日：2009-03-12
申请人： ABRAXIS BIOSCIENCE, LLC , DESAI, Neil, P. , TAO, Chunlin , DE, Tapas , CI, Sherry, Xiaopei , TRIEU, Vuong
发明人： DESAI, Neil, P. , TAO, Chunlin , DE, Tapas , CI, Sherry, Xiaopei , TRIEU, Vuong
IPC分类号： A61K9/19 , A61K9/51 , A61K31/337
CPC分类号： A61K9/14 , A61K9/107 , A61K9/19 , A61K9/5169 , A61K31/337 , A61K47/42
摘要： The present invention provides compositions comprising nanoparticles comprising: 1) a hydrophobic taxane derivative; and 2) a carrier protein. Also provided are methods of treating diseases (such as cancer) using the compositions, as well as kits and unit dosages.
摘要翻译：本发明提供了包含纳米颗粒的组合物，其包含：1）疏水紫杉烷衍生物; 和2）载体蛋白。还提供了使用所述组合物治疗疾病（例如癌症）的方法，以及试剂盒和单位剂量。

7. 发明申请

WO2008128169A8 SPARC AND METHODS OF USE THEREOF 审中-公开
标题翻译： SPARC及其使用方法
公开(公告)号：WO2008128169A8
公开(公告)日：2009-07-16
申请号：PCT/US2008060213
申请日：2008-04-14
申请人： ABRAXIS BIOSCIENCE INC , TRIEU VUONG , DESAI NEIL P
发明人： TRIEU VUONG , DESAI NEIL P
IPC分类号： A61K38/17 , A61K31/337 , A61K45/06 , A61P35/00
CPC分类号： A61K38/17 , A61K31/337 , A61K38/39 , A61K45/06 , A61K2300/00
摘要： The invention provides methods of treating a mammalian tumors comprising combination therapy with SPARC polypeptides, an angiogenesis inhibitor and paclitaxel. The invention provides also methods of treating a mammalian tumors comprising combination therapy with SPARC polypeptides and paclitaxel. Further, the invention produces kits and methods to predict therapy responses.
摘要翻译：本发明提供了治疗哺乳动物肿瘤的方法，其包括与SPARC多肽，血管发生抑制剂和紫杉醇的联合治疗。本发明还提供了治疗包含SPARC多肽和紫杉醇的组合疗法的哺乳动物肿瘤的方法。此外，本发明产生预测治疗反应的试剂盒和方法。

8. 发明申请

WO2007059118A1 COMBRETASTATIN DERIVATIVES AND RELATED THERAPEUTIC METHODS 审中-公开
标题翻译：化合物衍生物及相关治疗方法
公开(公告)号：WO2007059118A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/044167
申请日：2006-11-14
申请人： ABRAXIS BIOSCIENCE, INC. , TAO, Chunlin , WANG, Qinwei , DE, Tapas , DESAI, Neil, P. , SOON-SHIONG, Patrick
发明人： TAO, Chunlin , WANG, Qinwei , DE, Tapas , DESAI, Neil, P. , SOON-SHIONG, Patrick
IPC分类号： A61K31/265 , C07C69/76 , A61P35/00
CPC分类号： C07C69/533 , C07C59/64 , C07C69/017 , C07C69/24 , C07C69/587
摘要： Compounds of the formula (I) wherein R 1 , R 5 , R 6 , R 7 and R 10 are H, wherein R 2 , R 3 , R 4 and R 8 are OMe, and wherein R 9 is -X-CO-R", R" is an unsubstituted or a substituted alkyl, alkenyl or aryl group comprising 5-21 carbon atoms and does not include N, and X is O, S or N, compounds related thereto, and methods for their use, particularly for modulating tumor growth or metastasis in an animal.
摘要翻译：式（I）的化合物，其中R 1，R 5，R 6，R 7和R 3，其中R 2是H，其中R 2，R 3，R 4和R 8都是H，是OMe，并且其中R 9是-X-CO-R“，R”是未取代的或取代的烷基，包含5-21个碳原子的烷基，烯基或芳基，并且不包括N和 X是O，S或N，与之有关的化合物，及其用途的方法，特别是调节动物的肿瘤生长或转移。

9. 发明申请

WO2007027819A3 COMPOSITIONS COMPRISING POORLY WATER SOLUBLE PHARMACEUTICAL AGENTS AND ANTIMICROBIAL AGENTS 审中-公开
标题翻译：包含不良水溶性药物和抗微生物剂的组合物
公开(公告)号：WO2007027819A3
公开(公告)日：2007-04-26
申请号：PCT/US2006033931
申请日：2006-08-30
申请人： ABRAXIS BIOSCIENCE INC , DESAI NEIL P , SELVARAJ RAJ , YANG ANDREW , SOON-SHIONG PATRICK M D
发明人： DESAI NEIL P , SELVARAJ RAJ , YANG ANDREW , SOON-SHIONG PATRICK M D
IPC分类号： A61K9/51 , A61K9/00 , A61K9/19 , A61K31/337 , A61K47/26 , A61K47/42
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/19 , A61K9/5169 , A61K38/13 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/42 , Y10S977/702 , Y10S977/705 , Y10S977/773 , Y10S977/788 , Y10T428/2982 , A61K2300/00
摘要： The present invention provides compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, and an antimicrobial agent, wherein significant microbial growth is inhibited in the composition. The amount of the antimicrobial agent in the composition may be below the level that induces a toxicological effect or at a level where a potential side effect can be controlled or tolerated. Also provided are compositions comprising a poorly water soluble pharmaceutical agent, a carrier protein, a sugar, and optionally an antimicrobial agent. Methods of using the compositions are also provided.
摘要翻译：本发明提供了包含水溶性差的药剂，载体蛋白和抗微生物剂的组合物，其中组合物中显着的微生物生长被抑制。组合物中抗微生物剂的量可以低于诱导毒性作用的水平或者可以控制或耐受潜在副作用的水平。还提供了包含难溶于水的药剂，载体蛋白，糖和任选的抗微生物剂的组合物。还提供了使用组合物的方法。

10. 发明申请

WO2006034147A3 COMPOSITIONS AND METHODS FOR THE PREPARATION AND ADMINISTRATION OF POORLY WATER SOLUBLE DRUGS 审中-公开
标题翻译：用于制备和给药水溶性差的药物的组合物和方法
公开(公告)号：WO2006034147A3
公开(公告)日：2006-12-14
申请号：PCT/US2005033396
申请日：2005-09-16
申请人： ABRAXIS BIOSCIENCE INC , DESAI NEIL P , TAO CHUNLIN , YANG ANDREW , BEALS GRIM BRIDGET , DE TAPAS , SOON-SHIONG PATRICK
发明人： DESAI NEIL P , TAO CHUNLIN , YANG ANDREW , BEALS GRIM BRIDGET , DE TAPAS , SOON-SHIONG PATRICK
IPC分类号： A61K9/00
CPC分类号： A61K9/0019 , A61K31/00 , A61K47/26
摘要： Sterile, stable pharmaceutical formulations of poorly water-soluble drugs dissolved in dimethyl isosorbide, a water-miscible solvent, as well as methods for their preparation and administration.
摘要翻译：溶于二甲基异山梨醇（一种与水混溶的溶剂）中的水溶性差的药物的无菌，稳定的药物制剂以及它们的制备和给药方法。

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