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1. 发明申请

WO2005037775A1 NOVEL MOLECULE FOR INDUCING DIFFERENTIATION OF DENDRITIC CELLS 审中-公开
标题翻译：用于诱导分化细胞分化的新分子
公开(公告)号：WO2005037775A1
公开(公告)日：2005-04-28
申请号：PCT/IN2003/000432
申请日：2003-12-31
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , CHATTERJI, Anil , NATARAJAN, Krishnamurthy , MANIVEL, Venkatasamy , RAO, Kanury, Venkata, Subba , SUBRAYAN, Parameswaran, Perunninakulath , SINGH, Vinod, Kumar , ANAND, Ramasamy, Vijaya , DESA, Ehrlich
发明人： CHATTERJI, Anil , NATARAJAN, Krishnamurthy , MANIVEL, Venkatasamy , RAO, Kanury, Venkata, Subba , SUBRAYAN, Parameswaran, Perunninakulath , SINGH, Vinod, Kumar , ANAND, Ramasamy, Vijaya , DESA, Ehrlich
IPC分类号： C07C309/18
CPC分类号： A61K31/255 , A61K31/16 , A61K31/185 , A61K31/19 , A61K31/194 , A61K31/195 , C07C305/06 , C07C307/02 , C07C309/17 , C07C309/18
摘要： The present invention is related to compound having general formula Z-OC (C Rn1Rn2) -CO-Z wherein Z = OH or NH2 and n1 = n2 =1 to useful for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid / sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC-CR3R4-CR2(NHR1)-COOH, ZOC-CR5R6-CR3R4-CR1(NHR2)-COOH, ZOC-CR7R8-CR5R6-CR3R4-CR1(NHR2)-COOH wherein Z=OH or NH2; R1 to R8 denotes H, SO3H, or OSO3H. In addition, the dicarboxylic acids and their amides ZOC-(CH2)n-CR1R2-COOH, where Z=OH or NH2; and n=1,2,3. The groups R1 / R2 =H / SO3H or OSO3H or CH2-SO3H or CH2-OSO3H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid / dicarboxylic acid derivatives or their pharmaceutically acceptable alkali / alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.
摘要翻译：本发明涉及具有通式Z-OC（C Rn1Rn2）-CO-Z的化合物，其中Z = OH或NH2，n1 = n2 = 1，用于通过诱导树突状细胞的分化来调节免疫应答，通式ZOC-CR3R4-CR2（NHR1）-COOH，ZOC-CR5R6-CR3R4-CR1（NHR2）-COOH，ZOC-CR7R8的氨基酸衍生物（天然氨基酸的磺酸/硫酸盐衍生物及其酰胺） -CR5R6-CR3R4-CR1（NHR2）-COOH其中Z = OH或NH2; R1至R8表示H，SO3H或OSO3H。此外，二羧酸及其酰胺ZOC-（CH2）n-CR1R2-COOH，其中Z = OH或NH2; 和n = 1,2,3。基团R1 / R2 = H / SO3H或OSO3H或CH2-SO3H或CH2-OSO3H，反之亦然。这些因素还含有不同的二价金属阳离子如Mg，Ca和Zn。组合物由不同量的上述氨基酸/二羧酸衍生物或其药学上可接受的碱金属/碱土金属盐或其盐组成，用于制备用于树突状细胞分化和成熟的前述化合物的方法。

2. 发明申请

WO2004046647A1 A TIDE STAFF SYSTEM 审中-公开
标题翻译： TIDE工作人员系统
公开(公告)号：WO2004046647A1
公开(公告)日：2004-06-03
申请号：PCT/IB2002/004889
申请日：2002-11-21
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , JOSEPH, Antony , PRABHUDESAI, Shivanand , TENGALI, Suryakant , DESA, Ehrlich , MEHRA, Prakash , SUKERKAR, Amol , KUMAR, Vijay , MONTEIRO, Robert
发明人： JOSEPH, Antony , PRABHUDESAI, Shivanand , TENGALI, Suryakant , DESA, Ehrlich , MEHRA, Prakash , SUKERKAR, Amol , KUMAR, Vijay , MONTEIRO, Robert
IPC分类号： G01C13/00
CPC分类号： G01C13/008
摘要： The present invention relates to a segmented cylindrical tide staff system [11] for erection at remote areas for dynamic calibration of electronic tide meters and computer models of tides, said tide staff system consisting of plurality of cylindrical tubes [12], said cylindrical tube being coupled to a flange [13] at its end through a circular orthogonal hole [20] drilled on a flat surface of the flange, said flange being provided with plurality of equally spaced slots [15] drilled on the flat surface of the flange, an outwardly protruding tide indicating arm [14] being mounted on the flange wherein said tide indicating arm consists of two mutually orthogonal planes [22] and [23], wherein plane [22] is perpendicular to the axis of the tide staff and plane [23] is parallel to the axis of the tide staff, said perpendicular plane [22] being provided with a mounting terminal [21] and a circular hole [27] and said parallel plane being partitioned into two compartments [24] and [25] by a separating line [26] thereby permitting indication of tide reading in more than one language, including a vernacular language and two or more cylindrical tubes being coupled to each other through slots [15] using coupling means.
摘要翻译：本发明涉及一种用于在偏远地区架设用于动态校准电子潮汐计和潮汐计算机的分段圆柱形潮汐工作人员系统[11]，所述潮汐工作人员系统由多个圆柱形管[12]组成，所述圆柱形管为在其端部通过在凸缘的平坦表面上钻出的圆形正交孔[20]连接到凸缘[13]，所述凸缘设置有在凸缘的平坦表面上钻出的多个等间距的槽[15] 向外突出的潮汐指示臂[14]安装在凸缘上，其中所述潮汐指示臂由两个相互正交的平面[22]和[23]组成，其中平面[22]垂直于潮汐人员和平面的轴线[23 所述垂直平面[22]设置有安装端子[21]和圆形孔[27]，并且所述平行平面被分隔成两个隔室[24]和[25]，由一个从而允许以多于一种语言的潮汐读数的指示，包括本地语言以及通过使用耦合装置的插槽[15]彼此耦合的两个或多个圆柱形管。

3. 发明申请

WO2003081198A1 AN IMPROVED SYSTEM FOR CALIBRATION OF PRESSURE TRANSDUCERS 审中-公开
标题翻译：改进的压力传感器校准系统
公开(公告)号：WO2003081198A1
公开(公告)日：2003-10-02
申请号：PCT/IB2002/001124
申请日：2002-03-25
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , JOSEPH, Antony , KUMAR, Vijay , PRABHUDESAI, Shivanand , MEHRA, Prakash , DESA, Ehrlich , NAGVEKAR, Surekha, Mahesh
发明人： JOSEPH, Antony , KUMAR, Vijay , PRABHUDESAI, Shivanand , MEHRA, Prakash , DESA, Ehrlich , NAGVEKAR, Surekha, Mahesh
IPC分类号： G01L27/00
CPC分类号： G01L27/005
摘要： The present invention relates to a system for calibrating plurality of pressure transducers, said systemcomprising plurality of pressure transducers (13.1 to 13.n) mounted on a mounting means (12) which receives pressure input from a pressure source (11) via a hollow cylinder (14) and distributes the pressure evenly to all the pressure transducers, said plurality of pressure transducers are mounted on the mounting means and placed inside a vessel (15) so as to vary the temperature of the pressure transducers, said pressure source is also connected to a standard pressure transducer (17) whose temperature is maintained at the same level as that of pressure transducers(13.1 to 13.n).
摘要翻译：本发明涉及一种用于校准多个压力传感器的系统，所述系统包括安装在安装装置（12）上的多个压力传感器（13.1至13.n），所述安装装置（12）接收经由空心圆筒（11）从压力源（11）输入的压力（14）并将压力均匀地分布到所有压力传感器，所述多个压力传感器安装在安装装置上并放置在容器（15）内，以便改变压力传感器的温度，所述压力源也连接到标准的压力传感器（17），其温度保持在与压力传感器（13.1至13.n）相同的水平。

4. 发明申请

WO2005037774A1 NOVEL MOLECULES TO DEVELOP DRUG FOR THE TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译：开发用于治疗OSTEOPOSOSIS的药物的新分子
公开(公告)号：WO2005037774A1
公开(公告)日：2005-04-28
申请号：PCT/IN2003/000431
申请日：2003-12-31
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , RAO, Kanury, Venkata, Subba , WANI, Mohan, Ramachandra , MANIVEL, Venkatasamy , SUBRAYAN, Parameswaran, Perunninakulath , SINGH, Vinod, Kumar , ANAND, Ramasamy, Vijaya , DESA, Ehrlich , MISHRA, Gyan, Chandra , CHATTERJI, Anil
发明人： RAO, Kanury, Venkata, Subba , WANI, Mohan, Ramachandra , MANIVEL, Venkatasamy , SUBRAYAN, Parameswaran, Perunninakulath , SINGH, Vinod, Kumar , ANAND, Ramasamy, Vijaya , DESA, Ehrlich , MISHRA, Gyan, Chandra , CHATTERJI, Anil
IPC分类号： C07C309/18
CPC分类号： A61K31/255 , A61K31/16 , A61K31/185 , A61K31/19 , A61K31/194 , A61K31/195 , C07C305/06 , C07C307/02 , C07C309/17 , C07C309/18
摘要： This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of using the novel class of acidic amino acid/dicarboxylic acid derivatives of the general formula Z-OC-CRn1Rn2-COOZ, wherein n1=n2= 1 to 8 and Z=OH or NH2 and its derivatives for inhibition of osteoclastogenesis.
摘要翻译：本发明涉及可用作破骨细胞发生抑制剂的新型酸性氨基酸/二羧酸衍生物（天然氨基酸的磺酸/硫酸衍生物及其酰胺）。本发明还提供了使用通式为Z-OC-CRn1Rn2-COOZ的新一类酸性氨基酸/二羧酸衍生物的方法，其中n1 = n2 = 1〜8，Z = OH或NH2及其衍生物用于抑制破骨细胞。

5. 发明申请

WO2005037776A1 NOVEL MOLECULE FOR INDUCING DIFFERENTIATION OF DENDRITIC CELLS 审中-公开
标题翻译：用于诱导分化细胞分化的新分子
公开(公告)号：WO2005037776A1
公开(公告)日：2005-04-28
申请号：PCT/IN2003/000476
申请日：2003-12-31
申请人： COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH , CHATTERJI, Anil , NATARAJAN, Krishnamurthy , MANIVEL, Venkatasamy , RAO, Kanury, Venkata, Subba , SUBRAYAN, Parameswaran, Perunninakulath , SINGH, Vinod, Kumar , ANAND, Ramasamy, Vijaya , DESA, Ehrlich
发明人： CHATTERJI, Anil , NATARAJAN, Krishnamurthy , MANIVEL, Venkatasamy , RAO, Kanury, Venkata, Subba , SUBRAYAN, Parameswaran, Perunninakulath , SINGH, Vinod, Kumar , ANAND, Ramasamy, Vijaya , DESA, Ehrlich
IPC分类号： C07C309/18
CPC分类号： A61K31/255 , A61K31/16 , A61K31/185 , A61K31/19 , A61K31/194 , A61K31/195 , C07C305/06 , C07C307/02 , C07C309/17 , C07C309/18
摘要： The present invention is related to compound having general formula Z-OC (C R n1 R n2 ) -CO-Z wherein Z = OH or NH 2 and n1 = n2 = 1 to 8 for modulation of immune response by inducing differentiation of dendritic cells consisting novel class of amino acid derivatives (sulfonic acid / sulfate derivatives of naturally occurring amino acids, and their amides) of the general formula ZOC-CR 3 R 4 -CR 2 (NHR 1 )-COOH, ZOC-CR 5 R 6 -CR 3 R 4 -CR 1 (NHR 2 )-COOH, ZOC-CR 7 R 8 -CR 5 R 6 -CR 3 R 4 -CR 1 (NHR 2 )-COOH wherein Z=OH or NH 2 ; R 1 to R 8 denotes H, SO 3 H, or OSO 3 H. In addition, the dicarboxylic acids and their amides ZOC-(CH 2 )n-CR 1 R 2 -COOH, where Z=OH or NH 2 ; and n=1,2,3. The groups R 1 / R 2 =H / SO 3 H or OSO 3 H or CH 2 -SO 3 H or CH 2 -OSO 3 H and vice versa. The factors also contain different divalent metal cations such as Mg, Ca and Zn. The composition consists of varying amounts of the above amino acid / dicarboxylic acid derivatives or their pharmaceutically acceptable alkali / alkaline earth metal salts or their salts, the processes for the preparation of the aforesaid compounds useful for the differentiation and maturation of dendritic cells.
摘要翻译：本发明涉及具有通式Z-OC（C Rn1Rn2）-CO-Z的化合物，其中Z = OH或NH2，n1 = n2 = 1〜8，用于通过诱导树突状细胞的分化来调节免疫应答，通式ZOC-CR3R4-CR2（NHR1）-COOH，ZOC-CR5R6-CR3R4-CR1（NHR2）-COOH，ZOC-CR7R8的氨基酸衍生物（天然氨基酸的磺酸/硫酸盐衍生物及其酰胺） -CR5R6-CR3R4-CR1（NHR2）-COOH其中Z = OH或NH2; R1至R8表示H，SO3H或OSO3H。此外，二羧酸及其酰胺ZOC-（CH2）n-CR1R2-COOH，其中Z = OH或NH2; 和n = 1,2,3。基团R1 / R2 = H / SO3H或OSO3H或CH2-SO3H或CH2-OSO3H，反之亦然。这些因素还含有不同的二价金属阳离子如Mg，Ca和Zn。该组合物由不同量的上述氨基酸/二羧酸衍生物或其药学上可接受的碱金属/碱土金属盐或其盐组成，上述化合物的制备方法可用于树突状细胞的分化和成熟。

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