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1. 发明申请

WO2015106296A8 ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： ENOLI 1（ENO1）组合物及其用途
公开(公告)号：WO2015106296A8
公开(公告)日：2015-08-20
申请号：PCT/US2015011276
申请日：2015-01-13
申请人： BERG LLC , UNIV MIAMI , NARAIN NIVEN RAJIN , SARANGARAJAN RANGAPRASAD , VISHNUDAS VIVEK K , GESTA STEPHANE , JING ENXUAN , DAUNERT SYLVIA , DEO SAPNA K , JIMENEZ JOAQUIN JUAN , DIKICI EMRE , DAFTARIAN PIROUZ MOHAMMAD
发明人： NARAIN NIVEN RAJIN , SARANGARAJAN RANGAPRASAD , VISHNUDAS VIVEK K , GESTA STEPHANE , JING ENXUAN , DAUNERT SYLVIA , DEO SAPNA K , JIMENEZ JOAQUIN JUAN , DIKICI EMRE , DAFTARIAN PIROUZ MOHAMMAD
IPC分类号： A61K38/17 , A61K38/46 , A61P3/10
CPC分类号： A61K38/51 , A61K9/0019 , A61K9/0053 , A61K38/00 , A61K47/48246 , A61K47/59 , A61K47/64 , A61K49/0008 , C12N9/88 , C12Q1/54 , C12Y402/01011 , G01N2333/988 , G01N2800/042
摘要： The invention provides compositions comprising Enol for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Enol), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Enol), thereby treating the condition in the subject. In certain methods of the invention, the Enol is delivered to muscle.
摘要翻译：本发明提供包含用于递送至肌肉的Enol的组合物。此外，本发明提供了一种用于使患有血糖升高的受试者的血糖正常化的方法，包括给予受试者烯醇化酶1（Enol），从而使受试者的血糖正常化。本发明还提供了治疗一种或多种病症的方法，包括受试者的葡萄糖耐量降低，胰岛素抵抗，前期糖尿病和糖尿病，特别是2型糖尿病，包括给予受试者烯醇化酶1（Enol），从而治疗主题。在本发明的某些方法中，将烯醇递送至肌肉。

2. 发明申请

WO2013012434A1 BIOLUMINESCENT STEM-LOOP PROBES, COMPOSITIONS CONTAINING THE SAME AND METHODS UTILIZING THE SAME 审中-公开
标题翻译：生物降解性循环探针，含有它们的组合物和使用其的方法
公开(公告)号：WO2013012434A1
公开(公告)日：2013-01-24
申请号：PCT/US2011/063444
申请日：2011-12-06
申请人： UNIVERSITY OF MIAMI , DEO, Sapna, K. , HUNT, Eric, A.
发明人： DEO, Sapna, K. , HUNT, Eric, A.
IPC分类号： C12Q1/68 , C12N15/115 , G01N33/68 , G01N33/52 , G01N33/53 , C12N15/11
CPC分类号： G01N33/533
摘要： A bioluminescent stem-loop probe, compositions containing bioluminescent stem-loop probes and methods of using the same are disclosed. The bioluminescent stem-loop probe can include a hairpin-loop sequence comprising a sequence complementary to a biological target sequence; a bioluminescent marker coupled to the hairpin-loop sequence; and a quencher coupled to the hairpin-loop sequence. The hairpin-loop sequence can be between the bioluminescent marker and the quencher. The bioluminescent stem-loop probe can be capable of switching between a closed configuration and an open configuration, and the quencher can reduce a bioluminescent output of the bioluminescent marker when the probe is in the closed configuration. Also disclosed are bioluminescent stem-loop probes where more than one hairpin-loop sequence-quencher complex is coupled to each bioluminescent marker.
摘要翻译：公开了一种生物发光茎环探针，含有生物发光茎环探针的组合物及其使用方法。生物发光茎环探针可以包括包含与生物靶序列互补的序列的发夹环序列; 偶联到发夹环序列的生物发光标记; 和与发夹环序列偶联的猝灭剂。发夹环序列可以在生物发光标记和猝灭剂之间。生物发光茎环探针能够在闭合构型和开放构型之间切换，并且当探针处于封闭构型时，猝灭剂可以减少生物发光标记的生物发光输出。还公开了生物发光茎环探针，其中多于一个发夹环序列猝灭剂复合物与每个生物发光标记偶联。

3. 发明申请

WO2009036081A1 SYSTEMS AND METHODS FOR DIAGNOSIS AND MONITORING OF BACTERIA-RELATED CONDITIONS 审中-公开
标题翻译：用于诊断和监测细菌相关条件的系统和方法
公开(公告)号：WO2009036081A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075882
申请日：2008-09-10
申请人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION , DAUNERT, Sylvia , DEO, Sapna K. , PASINI, Patrizia , KUMARI, Anjali , SHASHIDHAR, Harohalli , AUER FLOMENHOF, Deborah R. , RAUT, Nilesh
发明人： DAUNERT, Sylvia , DEO, Sapna K. , PASINI, Patrizia , KUMARI, Anjali , SHASHIDHAR, Harohalli , AUER FLOMENHOF, Deborah R. , RAUT, Nilesh
IPC分类号： A61K39/40
CPC分类号： G01N33/6893 , G01N2800/065 , G01N2800/24 , G01N2800/26 , G01N2800/52
摘要： The presently-disclosed subject matter provides systems, methods, and kits for diagnosing and/or monitoring a bacteria-related condition of interest in a subject by providing a cell sensing system, each system containing a reporter molecule capable of detecting binding of a quorum sensing molecule and capable of generating a detectable signal.
摘要翻译：目前公开的主题提供了用于通过提供细胞感测系统来诊断和/或监测受试者感兴趣的细菌相关状况的系统，方法和试剂盒，每个系统包含能够检测定量感测结合的报告分子分子并且能够产生可检测信号。

4. 发明申请

WO2015106296A1 ENOLSE 1 (ENO1) COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： ENOLS 1（ENO1）的组合物及其用途
公开(公告)号：WO2015106296A1
公开(公告)日：2015-07-16
申请号：PCT/US2015/011276
申请日：2015-01-13
申请人： BERG LLC , UNIVERSITY OF MIAMI , NARAIN, Niven, Rajin , SARANGARAJAN, Rangaprasad , VISHNUDAS, Vivek, K. , GESTA, Stephane , JING, Enxuan , DAUNERT, Sylvia , DEO, Sapna, K. , JIMENEZ, Joaquin, Juan , DIKICI, Emre , DAFTARIAN, Pirouz, Mohammad
发明人： NARAIN, Niven, Rajin , SARANGARAJAN, Rangaprasad , VISHNUDAS, Vivek, K. , GESTA, Stephane , JING, Enxuan , DAUNERT, Sylvia , DEO, Sapna, K. , JIMENEZ, Joaquin, Juan , DIKICI, Emre , DAFTARIAN, Pirouz, Mohammad
IPC分类号： A61K38/17 , A61K38/46 , A61P3/10
CPC分类号： A61K38/51 , A61K9/0019 , A61K9/0053 , A61K38/00 , A61K47/59 , A61K47/64 , A61K49/0008 , C12N9/88 , C12Q1/54 , C12Y402/01011 , G01N2333/988 , G01N2800/042
摘要： The invention provides compositions comprising Enol for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Enol), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Enol), thereby treating the condition in the subject. In certain methods of the invention, the Enol is delivered to muscle.
摘要翻译：本发明提供包含用于递送至肌肉的Enol的组合物。此外，本发明提供了一种用于使患有血糖升高的受试者的血糖正常化的方法，包括给予受试者烯醇化酶1（Enol），从而使受试者的血糖正常化。本发明还提供了治疗一种或多种病症的方法，包括受试者的葡萄糖耐量降低，胰岛素抵抗，前期糖尿病和糖尿病，特别是2型糖尿病，包括给予受试者烯醇化酶1（Enol），从而治疗主题。在本发明的某些方法中，将烯醇递送至肌肉。

5. 发明申请

WO2009036070A1 SPORES FOR THE STABILIZATION AND ON-SITE APPLICATION OF BACTERIAL WHOLE-CELL BIOSENSING SYSTEMS 审中-公开
标题翻译：细菌生物固定系统的稳定和现场应用体育
公开(公告)号：WO2009036070A1
公开(公告)日：2009-03-19
申请号：PCT/US2008/075865
申请日：2008-09-10
申请人： UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION , DAUNERT, Sylvia , DEO, Sapna K. , PASINI, Patrizia , DATE, Amol
发明人： DAUNERT, Sylvia , DEO, Sapna K. , PASINI, Patrizia , DATE, Amol
IPC分类号： C12N1/21 , C12Q1/02 , C12N3/00 , C12M1/34
CPC分类号： C12N3/00 , C12Q1/02
摘要： The presently-disclosed subject matter is directed to biosensors comprising spore-forming bacterial cells and/or spores generated therefrom, a recognition unit within each spore-forming cell for binding an analyte of interest, and a reporter molecule within each spore-forming cell for detecting binding of the analyte of interest, wherein the reporter molecule generates a detectable signal upon binding of the analyte by the recognition element. The presently-disclosed subject matter further provides methods of using the biosensors and systems and kits including the biosensors.
摘要翻译：目前公开的主题涉及包含由其产生的形成孢子的细菌细胞和/或孢子的生物传感器，用于结合感兴趣分析物的每个孢子形成细胞内的识别单元和每个孢子形成细胞内的报道分子检测感兴趣的分析物的结合，其中报告分子在通过识别元件结合分析物时产生可检测的信号。目前公开的主题还提供使用生物传感器和包括生物传感器的系统和试剂盒的方法。

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