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1. 发明申请

WO2004056982A3 KINASE SEQUENCES 审中-公开
标题翻译：激酶序列
公开(公告)号：WO2004056982A3
公开(公告)日：2004-09-16
申请号：PCT/EP0314674
申请日：2003-12-19
申请人： DEVGEN NV , DE WILDE GERT JULES HECTOR
发明人： DE WILDE GERT JULES HECTOR
IPC分类号： C12N9/12 , C07K16/40 , C12N5/10 , G01N33/53
CPC分类号： C12N9/1205
摘要： The present invention relates to nucleotide sequences that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds with activity as pharmaceuticals, in particular of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences - such as proteins and polypeptides - that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly the amino acid sequences of J1K, PSK, TAO1 and Q9P2I6. The invention also relates to various uses and modulators of, and methods incorporating, the nucleotide and amino acid sequences of the invention.
摘要翻译：本发明涉及编码并可用于表达可用于鉴定和开发具有作为药物的化合物的氨基酸序列的核苷酸序列，特别是用于预防和治疗代谢性疾病如糖尿病和肥胖的化合物。本发明还涉及由本发明的核苷酸序列，特别是J1K，PSK，TAO1的氨基酸序列以及通过适当表达本发明的核苷酸序列编码并可获得的氨基酸序列 - 例如蛋白质和多肽 - Q9P2I6。本发明还涉及本发明的核苷酸和氨基酸序列的各种用途和调节剂以及结合本发明的核苷酸和氨基酸序列的方法。

2. 发明申请

WO2004113519A3 ALCOHOL DEHYDROGENASE SEQUENCES USEFUL FOR DEVELOPING COMPOUNDS FOR THE PREVENTION AND/OR TREATMENT OF METABOLIC DISEASES 审中-公开
公开(公告)号：WO2004113519A3
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002628
申请日：2004-06-17
申请人： DEVGEN NV , DE WILDE, Gert, Jules, Hector , SAUNDERS, Michael, John, Scott , LOGGHE, Marc, Georges
发明人： DE WILDE, Gert, Jules, Hector , SAUNDERS, Michael, John, Scott , LOGGHE, Marc, Georges
IPC分类号： C12N9/04
摘要： The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences - such as proteins and/or polypeptides - that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly those set out in SEQ ID NO's 1 , 6 and 8. The invention further relates to genetic constructs, host cells and organisms that have been transformed with the nucleotide sequences of the invention and that can express the amino acid sequences of the invention and methods and compositions which utilize the nucleotide and amino acid sequences of the invention.

3. 发明申请

WO2005030985A3 USE OF AMINO ACID SEQUENCES INVOLVED IN THE ELONGATION OF FATTY ACIDS IN IDENTIFYING AND/OR DEVELOPING COMPOUNDS FOR PREVENTING AND/OR TREATING METABOLIC DISEASES 审中-公开
标题翻译：在鉴定和/或开发用于预防和/或治疗代谢性疾病的化合物中，涉及脂肪酸延长的氨基酸序列的使用
公开(公告)号：WO2005030985A3
公开(公告)日：2005-11-17
申请号：PCT/GB2004004103
申请日：2004-09-24
申请人： DEVGEN NV , DE WILDE GERT JULES HECTOR , SAUNDERS MICHAEL JOHN SCOTT
发明人： DE WILDE GERT JULES HECTOR , SAUNDERS MICHAEL JOHN SCOTT
IPC分类号： C12N9/10 , G01N5/00 , G01N33/50 , G01N33/92
CPC分类号： C12N9/1029 , G01N33/92 , G01N2500/00
摘要： The present invention relates to methods for the identification and/or the development of compounds that can be used to prevent and/or to treat metabolic diseases, and to the use of amino acid sequences that are involved in the elongation of fatty acids in such methods. The invention also relates to compounds that have been identified and/or developed using said methods, to pharmaceutical compositions that contain such compounds, and to the use of said compounds in the preparation of pharmaceutical compositions, in particular of pharmaceutical compositions for the prevention and/or treatment of metabolic diseases. The invention further relates to compounds that can interact with amino acid sequences that are involved in the elongation of fatty acids, to pharmaceutical compositions that contain such compounds, and to the use of said compounds in the preparation of pharmaceutical compositions, in particular of pharmaceutical compositions for the prevention and/or treatment of metabolic diseases.
摘要翻译：本发明涉及用于鉴定和/或开发可用于预防和/或治疗代谢性疾病的化合物的方法，以及在这些方法中使用涉及脂肪酸延伸的氨基酸序列。本发明还涉及已经使用所述方法鉴定和/或开发的化合物，含有这些化合物的药物组合物，以及所述化合物在制备药物组合物，特别是药物组合物中用于预防和/ 或治疗代谢性疾病。本发明还涉及可以与参与脂肪酸延伸的氨基酸序列相互作用的化合物，含有这些化合物的药物组合物以及所述化合物在制备药物组合物，特别是药物组合物中的用途用于预防和/或治疗代谢性疾病。

4. 发明申请

WO2005082367A1 KINASE INHIBITORS 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：WO2005082367A1
公开(公告)日：2005-09-09
申请号：PCT/IB2005/000600
申请日：2005-02-18
申请人： DEVGEN NV , LEYSEN, Dirk Casimir Maria , DEFERT, Olivier Raynald , DE KERPEL, Jan Octaaf Antoon , FOURMAINTRAUX, Eric Pierre Paul Rene , ARZEL, Philippe , DE WILDE, Gert Jules Hector
发明人： LEYSEN, Dirk Casimir Maria , DEFERT, Olivier Raynald , DE KERPEL, Jan Octaaf Antoon , FOURMAINTRAUX, Eric Pierre Paul Rene , ARZEL, Philippe , DE WILDE, Gert Jules Hector
IPC分类号： A61K31/4406
CPC分类号： A61K31/437 , A61K31/4406 , A61K31/505 , C07D213/38 , C07D213/40 , C07D213/75 , C07D239/42 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要： The invention provides the use of a compound or a composition comprising said compound for inhibiting the activity of at least one kinase, other than ROCK kinase, in vitro or in vivo, pharmaceutical and/or veterinary compositions comprising such compounds, medical and veterinary uses of such compounds and the compounds themselves.
摘要翻译：本发明提供了包含所述化合物的化合物或组合物在体外或体内抑制至少一种激酶（ROCK激酶以外的活性）的活性，包含这些化合物的药物和/或兽医组合物，医学和兽医用途这些化合物和化合物本身。

5. 发明申请

WO2004113519A2 AMINO ACID SEQUENCES USEFUL FOR DEVELOPING COMPOUNDS FOR THE PREVENTION AND/OR TREATMENT OF METABOLIC DISEASES AND NUCLEOTIDE SEQUENCES ENCODING SUCH AMINO ACID SEQUENCES 审中-公开
标题翻译：开发用于预防和/或治疗代谢性疾病的化合物的酒精脱氢酶序列
公开(公告)号：WO2004113519A2
公开(公告)日：2004-12-29
申请号：PCT/GB2004/002628
申请日：2004-06-17
申请人： DEVGEN NV , DE WILDE, Gert, Jules, Hector , SAUNDERS, Michael, John, Scott , LOGGHE, Marc, Georges
发明人： DE WILDE, Gert, Jules, Hector , SAUNDERS, Michael, John, Scott , LOGGHE, Marc, Georges
IPC分类号： C12N9/04
CPC分类号： C12N9/0006
摘要： The present invention relates to nucleotide sequences, particularly those of SEQ ID NO's 2, 7 and 9 that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences - such as proteins and/or polypeptides - that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly those set out in SEQ ID NO's 1 , 6 and 8. The invention further relates to genetic constructs, host cells and organisms that have been transformed with the nucleotide sequences of the invention and that can express the amino acid sequences of the invention and methods and compositions which utilize the nucleotide and amino acid sequences of the invention.
摘要翻译：本发明涉及编码并可用于表达可用于鉴定和开发用于预防和治疗代谢性疾病的化合物的氨基酸序列的核苷酸序列，特别是SEQ ID NO：2,7和9的核苷酸序列，糖尿病和肥胖。本发明还涉及由本发明的核苷酸序列，特别是SEQ ID NO：1中列出的那些的核苷酸序列编码并且可以通过适当表达获得的氨基酸序列 - 例如蛋白质和/或多肽 - 本发明还涉及已经用本发明的核苷酸序列转化并可以表达本发明的氨基酸序列的遗传构建体，宿主细胞和生物体，以及利用核苷酸和氨基酸序列的方法和组合物的本发明。

6. 发明申请

WO2005030985A2 USE OF AMINO ACID SEQUENCES INVOLVED IN THE ELONGATION OF FATTY ACIDS IN IDENTIFYING AND/OR DEVELOPING COMPOUNDS FOR PREVENTING AND/OR TREATING METABOLIC DISEASES 审中-公开
标题翻译：涉及延长脂肪酸的氨基酸序列在鉴定和/或开发用于预防和/或治疗代谢疾病的化合物中的用途
公开(公告)号：WO2005030985A2
公开(公告)日：2005-04-07
申请号：PCT/GB2004/004103
申请日：2004-09-24
申请人： DEVGEN N.V. , DE WILDE, Gert Jules Hector , SAUNDERS, Michael John Scott
发明人： DE WILDE, Gert Jules Hector , SAUNDERS, Michael John Scott
IPC分类号： C12Q1/00
CPC分类号： C12N9/1029 , G01N33/92 , G01N2500/00
摘要： The present invention relates to methods for the identification and/or the development of compounds that can be used to prevent and/or to treat metabolic diseases, and to the use of amino acid sequences that are involved in the elongation of fatty acids in such methods. The invention also relates to compounds that have been identified and/or developed using said methods, to pharmaceutical compositions that contain such compounds, and to the use of said compounds in the preparation of pharmaceutical compositions, in particular of pharmaceutical compositions for the prevention and/or treatment of metabolic diseases. The invention further relates to compounds that can interact with amino acid sequences that are involved in the elongation of fatty acids, to pharmaceutical compositions that contain such compounds, and to the use of said compounds in the preparation of pharmaceutical compositions, in particular of pharmaceutical compositions for the prevention and/or treatment of metabolic diseases.
摘要翻译：本发明涉及用于鉴定和/或开发可用于预防和/或治疗代谢疾病的化合物的方法，以及涉及涉及的氨基酸序列的用途在这些方法中脂肪酸的伸长。本发明还涉及已经使用所述方法鉴定和/或开发的化合物，含有这些化合物的药物组合物，以及所述化合物在制备药物组合物中的用途，特别是用于预防和/ 或代谢疾病的治疗。本发明进一步涉及可与参与脂肪酸延长的氨基酸序列相互作用的化合物，含有此类化合物的药物组合物，以及所述化合物在制备药物组合物，特别是药物组合物中的用途用于预防和/或治疗代谢性疾病。

7. 发明申请

WO2004056982A2 KINASE SEQUENCES USEFUL FOR DEVELOPING COMPOUNDS FOR THE PREVENTION AND/OR TREATMENT OF METABOLIC DISEASES AND NUCLEOTIDE SEQUENCES ENCODING SUCH KINASE SEQUENCES 审中-公开
标题翻译：用于开发化合物用于预防和/或治疗代谢性疾病和核苷酸序列编码这种激酶序列的激酶序列
公开(公告)号：WO2004056982A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014674
申请日：2003-12-19
申请人： DEVGEN NV , DE WILDE, Gert, Jules, Hector
发明人： DE WILDE, Gert, Jules, Hector
IPC分类号： C12N9/00
CPC分类号： C12N9/1205
摘要： The present invention relates to nucleotide sequences that encode and may be used to express amino acid sequences that are useful in the identification and development of compounds with activity as pharmaceuticals, in particular of compounds for the prevention and treatment of metabolic diseases such as diabetes and obesity. The invention also relates to the amino acid sequences - such as proteins and polypeptides - that are encoded by, and that may be obtained by suitable expression of, the nucleotide sequences of the invention, particularly the amino acid sequences of J1K, PSK, TAO1 and Q9P2I6. The invention also relates to various uses and modulators of, and methods incorporating, the nucleotide and amino acid sequences of the invention.
摘要翻译：本发明涉及编码并可用于表达可用于鉴定和开发具有作为药物的化合物的氨基酸序列的核苷酸序列，特别是用于预防和治疗代谢性疾病如糖尿病和肥胖的化合物。本发明还涉及由本发明的核苷酸序列，特别是J1K，PSK，TAO1的氨基酸序列以及通过适当表达本发明的核苷酸序列编码并可获得的氨基酸序列 - 例如蛋白质和多肽 - Q9P2I6。本发明还涉及本发明的核苷酸和氨基酸序列的各种用途和调节剂以及结合本发明的核苷酸和氨基酸序列的方法。

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