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1. 发明专利

JP5497292B2 Device and method for non-contact manner imaging electrical impedance 有权
公开(公告)号：JP5497292B2
公开(公告)日：2014-05-21
申请号：JP2008524585
申请日：2006-08-03
申请人：デモントフォートユニバーシティDe Montfort University
发明人：ワンウェイ
IPC分类号： A61B5/05 , A61B5/053 , G01R27/02
CPC分类号： A61B5/0536 , A61B2562/0209 , A61B2562/046

2. 发明专利

JP2010529870A A method for analyzing the structure of the conductive object 审中-公开
公开(公告)号：JP2010529870A
公开(公告)日：2010-09-02
申请号：JP2010510880
申请日：2008-06-06
申请人：デモントフォートユニバーシティDe Montfort University
发明人：ウェイワン
IPC分类号： A61B5/05 , A61B10/00 , G01N27/02 , G01N33/48 , G01N33/483 , G01R27/02
CPC分类号： A61B5/0536
摘要： A method for analyzing the structure of an electrically conductive object, the method comprising the steps of: (i) obtaining electrical impedance data for the object over a range of frequencies; (ii) analyzing the obtained electrical impedance data using a transfer function of an assumed electrical model to determine a plurality of electrical impedance properties for the object; (iii) constructively combining selected ones of the determined plurality of electrical impedance properties to provide at least one parametric impedance value for the object; and (iii) imaging one or more of the determined parametric impedance values.

3. 发明专利

JP2009502394A Device and method for non-contact manner imaging electrical impedance 有权
公开(公告)号：JP2009502394A
公开(公告)日：2009-01-29
申请号：JP2008524585
申请日：2006-08-03
申请人：デモントフォートユニバーシティDe Montfort University
发明人：ワンウェイ
IPC分类号： A61B5/05 , A61B5/053 , G01R27/02
CPC分类号： A61B5/0536 , A61B2562/0209 , A61B2562/046
摘要：各々は被画像化物とは接触しないが、被画像化物を少なくとも部分的に浸漬させる、イオンを含有する液体を介して被画像化物と電気的に連結される多数の電極を使用して電気的インピーダンスを画像化する方法が提供される。

4. 发明申请

US20010021717A1 Hydroxylation activated prodrugs 有权
标题翻译：羟化活化前药
公开(公告)号：US20010021717A1
公开(公告)日：2001-09-13
申请号：US09765861
申请日：2001-01-19
申请人： De Montfort University
发明人： Gerald Andrew Potter , Lawrence Hylton Patterson , Michael Danny Burke
IPC分类号： A61K031/44 , C07D211/82 , C07D211/70 , A61K031/277 , A61K031/165
CPC分类号： C07C43/215 , C07C49/84 , C07C205/35 , C07C255/36 , C07C327/48 , C07C2602/10 , C07D213/57
摘要： The present invention concerns enzymatic aromatic hydroxylation-activated prodrugs, particularly anti-tumor prodrugs and those which are specifically activated by the hydroxylation activity of the enzyme CYP1B1.
摘要翻译：本发明涉及酶促芳族羟基化活化的前体药物，特别是抗肿瘤前体药物以及由CYP1B1酶的羟基化活性特异性活化的药物。

5. 发明申请

US20180297873A1 ROTACTING CONTACTOR REACTOR 审中-公开
公开(公告)号：US20180297873A1
公开(公告)日：2018-10-18
申请号：US15759731
申请日：2016-09-14
申请人： De Montfort University
发明人： Katherine Huddersman , George Chitangyie
IPC分类号： C02F1/72 , C02F1/30 , C02F1/32 , C02F1/42
CPC分类号： C02F1/725 , C02F1/302 , C02F1/32 , C02F1/42 , C02F1/722 , C02F2101/20 , C02F2101/305 , C02F2101/306 , C02F2103/06 , C02F2209/02 , C02F2301/024 , C02F2303/04 , C02F2303/16 , C02F2305/023 , C02F2305/026 , C02F2305/10 , Y02W10/37
摘要： The present invention relates to a reactor for the treatment of a liquid stream, the reactor comprising: a liquid stream inlet, a reaction zone for holding the liquid stream, at least one rotating contactor in the reaction zone arranged to rotate through the liquid stream, and a liquid outlet, wherein the at least one rotating contactor includes a fabric mesh.

6. 发明申请

US20170007676A1 MATRIX GEL 审中-公开
标题翻译： MATRIX凝胶
公开(公告)号：US20170007676A1
公开(公告)日：2017-01-12
申请号：US15042629
申请日：2016-02-12
申请人： DE MONTFORT UNIVERSITY
发明人： Margaret Joan Taylor
IPC分类号： A61K38/28 , A61K47/42 , A61K47/36 , A61K9/06
CPC分类号： A61K38/28 , A61K9/06 , A61K47/36 , A61K47/42
摘要： The present invention relates to a gel having a three dimensional matrix structure and a drug in the form of a solid contained within the three dimensional matrix. Gels of the invention are preferably for implantation into a patient. Storing the drug as a solid within the gel means that the drug density is high in those areas of the gel which contain solid drug. The high drug density means that a larger amount of drug can be stored in a gel of a given size relative to the amount of drug that can be stored as individual molecules. The large deposit of solid drug means that the gel can sustain release of the drug for an extended period of time. This is advantageous because it minimises the frequency of replacement or replenishment of the implanted gel, thereby minimising discomfort and inconvenience to the patient.
摘要翻译：本发明涉及具有三维矩阵结构的凝胶和包含在三维矩阵内的固体形式的药物。本发明的凝胶优选用于植入患者体内。将药物作为固体储存在凝胶中意味着在含有固体药物的凝胶的那些区域中的药物密度高。高药物浓度意味着相对于作为单独分子可以储存的药物的量，可以将较大量的药物储存在给定尺寸的凝胶中。固体药物的大量沉积意味着凝胶可以延长药物的释放时间。这是有利的，因为它使植入的凝胶的置换或补充的频率最小化，从而最小化对患者的不适和不便。

7. 发明申请

US20160158145A1 Container 审中-公开
标题翻译：容器
公开(公告)号：US20160158145A1
公开(公告)日：2016-06-09
申请号：US14959502
申请日：2015-12-04
申请人： De Montfort University
发明人： Margaret Joan Taylor
IPC分类号： A61K9/00 , A61K47/36 , A61K38/28 , A61K47/42
CPC分类号： A61K9/0004 , A61K9/0024 , A61K38/28 , A61K47/36 , A61K47/42 , G01N33/66 , G01N2333/4724 , G01N2333/62 , G01N2400/22
摘要： The present invention relates to a container for an analyte-sensitive gel. When analyte contacts such a gel it causes a gel-sol transition resulting in decreased viscosity of the gel. Such gels can be used for controlling the rate of release of an agent from a reservoir in response to the concentration of an analyte. The container is configured to allow analyte to pass into the container and contact the gel and to allow agent to diffuse out of the container. Such a container may be implantable in the body of a subject and therefore it is preferred if the container is constructed from materials that can be tolerated by the body for a period of time. Advantageously, the container limits the swelling and dilution of gel contained within the container caused by the influx of water into the gel by osmosis. The container therefore maintains the gel in a desired conformation and ensures a predictable release profile of the agent.
摘要翻译：本发明涉及用于分析物敏感性凝胶的容器。当分析物接触这样的凝胶时，其引起凝胶 - 溶胶转变，导致凝胶的粘度降低。这样的凝胶可以用于响应于分析物的浓度来控制药剂从贮存器释放的速率。容器被配置为允许分析物进入容器并接触凝胶并允许试剂扩散出容器。这样的容器可以植入到受试者的身体中，因此优选的是，容器由能够被身体容忍一段时间的材料构成。有利地，容器限制由于通过渗透将水流入凝胶中而容纳在容器内的凝胶的膨胀和稀释。因此，容器将凝胶保持在期望的构象，并确保试剂的可预测释放曲线。

8. 发明授权

US10689275B2 Rotating contactor reactor 有权
公开(公告)号：US10689275B2
公开(公告)日：2020-06-23
申请号：US15759731
申请日：2016-09-14
申请人： De Montfort University
发明人： Katherine Huddersman , George Chitangyie
IPC分类号： C02F1/72 , C02F1/30 , C02F1/32 , C02F1/42 , C02F101/20 , C02F101/30 , C02F103/06
摘要： The present invention relates to a reactor for the treatment of a liquid stream, the reactor comprising: a liquid stream inlet, a reaction zone for holding the liquid stream, at least one rotating contactor in the reaction zone arranged to rotate through the liquid stream, and a liquid outlet, wherein the at least one rotating contactor includes a fabric mesh.

9. 发明授权

US10675334B2 Matrix gel 有权
公开(公告)号：US10675334B2
公开(公告)日：2020-06-09
申请号：US15042629
申请日：2016-02-12
申请人： DE MONTFORT UNIVERSITY
发明人： Margaret Joan Taylor
IPC分类号： A61K38/28 , A61K47/36 , A61K9/06 , A61K47/42
摘要： The present invention relates to a gel having a three dimensional matrix structure and a drug in the form of a solid contained within the three dimensional matrix. Gels of the invention are preferably for implantation into a patient. Storing the drug as a solid within the gel means that the drug density is high in those areas of the gel which contain solid drug. The high drug density means that a larger amount of drug can be stored in a gel of a given size relative to the amount of drug that can be stored as individual molecules. The large deposit of solid drug means that the gel can sustain release of the drug for an extended period of time. This is advantageous because it minimises the frequency of replacement or replenishment of the implanted gel, thereby minimising discomfort and inconvenience to the patient.

10. 发明申请

US20160298090A1 MODIFIED P450 REDUCTASE WITH N-TERMINAL DELETIONS AND ENDOPLASMIC RETICULUM RETENTION TAG 审中-公开
标题翻译：具有N-末端残基和内含子保留标签的改性P450还原酶
公开(公告)号：US20160298090A1
公开(公告)日：2016-10-13
申请号：US15180288
申请日：2016-06-13
申请人： DE MONTFORT UNIVERSITY
发明人： Bhabatosh Chaudhuri
IPC分类号： C12N9/02
CPC分类号： C12N9/0042 , C07K2319/04 , C12Y106/02004
摘要： The present invention provides an isolated or recombinant polypeptide comprising or consisting of a modified P450 reductase which lacks N-terminal amino acids relative to the corresponding wild type P450 reductase and comprises an epitope tag comprising the sequence HDEL or KDEL. The modified P450 reductase, when co-expressed with a cytochrome P450, increases the activity and/or expression of the cytochrome P450 compared to the activity and/or expression of the cytochrome P450 when co-expressed with the wild type P450 reductase.
摘要翻译：本发明提供了一种分离或重组的多肽，其包含相对于相应的野生型P450还原酶缺少N-末端氨基酸的修饰的P450还原酶或由其组成，并且包含包含序列HDEL或KDEL的表位标签。当与野生型P450还原酶共表达时，经修饰的P450还原酶与细胞色素P450共表达时，与细胞色素P450的活性和/或表达相比，增加细胞色素P450的活性和/或表达。

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