专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005010009A1 THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS 审中-公开
标题翻译：三烯吡啶和呋喃亚胺激酶抑制剂
公开(公告)号：WO2005010009A1
公开(公告)日：2005-02-03
申请号：PCT/US2004/024003
申请日：2004-07-26
申请人： ABBOTT LABORATORIES , BETSCHMANN, Patrick , BURCHAT, Andrew, F. , CALDERWOOD, David, J. , CURTIN, Michael, L. , DAVIDSEN, Steven, K. , DAVIS, Heather, M. , FREY, Robin, R. , HEYMAN, Howard, R. , HIRST, Gavin, C. , HRNCIAR, Peter , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , WADA, Carol, K.
发明人： BETSCHMANN, Patrick , BURCHAT, Andrew, F. , CALDERWOOD, David, J. , CURTIN, Michael, L. , DAVIDSEN, Steven, K. , DAVIS, Heather, M. , FREY, Robin, R. , HEYMAN, Howard, R. , HIRST, Gavin, C. , HRNCIAR, Peter , MICHAELIDES, Michael, R. , MUCKEY, Melanie, A. , RAFFERTY, Paul , WADA, Carol, K.
IPC分类号： C07D495/04
CPC分类号： C07D491/04 , C07D495/04
摘要： Compounds having the formula: (I), are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

2. 发明申请

WO1993001813A1 PLATELET ACTIVATING FACTOR ANTAGONISTS 审中-公开
标题翻译： PLATELET激活因子拮抗剂
公开(公告)号：WO1993001813A1
公开(公告)日：1993-02-04
申请号：PCT/US1992005890
申请日：1992-07-14
申请人： ABBOTT LABORATORIES , SUMMERS, James, B. , DAVIDSEN, Steven, K. , HOLMS, James, H. , PIREH, Daisy , HEYMAN, H., Robin , MARTIN, Michael, B. , STEINMAN, Douglas, H. , SHEPPARD, George, S. , CARRERA, George, M., Jr.
发明人： ABBOTT LABORATORIES
IPC分类号： A61K31/44
CPC分类号： C07D487/04 , A61K49/06 , C07D213/69 , C07D513/04
摘要： Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazoline, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
摘要翻译：通过7-羰基（吡啶-3-基）吡咯并[1,2-c]噻唑，7-羰基（吡啶-3-基）吡咯并[1,2-c]恶唑啉在3-位上取代的吲哚化合物，或7-羰基（吡啶-3-基）吡咯并[1,2-c]吡咯基是PAF的有效拮抗剂，可用于治疗PAF相关疾病，包括哮喘，休克，呼吸窘迫综合征，急性炎症，移植器官排斥，胃肠溃疡，过敏性皮肤病，延迟的细胞免疫，分娩，胎儿肺成熟和细胞分化。

3. 发明申请

WO2004108672A1 ISOINDOLIN-1-ONE COMPOUNDS AS KINASE INHIBITORS 审中-公开
标题翻译： ISOINDOLIN-1-ONE化合物作为激酶抑制剂
公开(公告)号：WO2004108672A1
公开(公告)日：2004-12-16
申请号：PCT/US2004/017105
申请日：2004-06-02
申请人： ABBOTT LABORATORIES , CURTIN, Michael, L. , DAVIDSEN, Steven, K , FREY, Robin, R. , HEYMAN, Howard, R. , HOLMS, James, H. , MICHAELIDES, Michael , STEINMAN, Douglas, H.
发明人： CURTIN, Michael, L. , DAVIDSEN, Steven, K , FREY, Robin, R. , HEYMAN, Howard, R. , HOLMS, James, H. , MICHAELIDES, Michael , STEINMAN, Douglas, H.
IPC分类号： C07D209/46
CPC分类号： C07D209/46 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , C07D413/12 , C07D417/12
摘要： Compounds having the formula, (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds and compositions containing the compounds.
摘要翻译：具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备含有该化合物的化合物和组合物的方法。

4. 发明申请

WO1990014362A1 ATRIAL PEPTIDE DERIVATIVES 审中-公开
标题翻译： ATRIAL肽衍生物
公开(公告)号：WO1990014362A1
公开(公告)日：1990-11-29
申请号：PCT/US1990002917
申请日：1990-05-23
申请人： ABBOTT LABORATORIES , LUCAS, Scott, D. , ROCKWAY, Todd, W. , DAVIDSEN, Steven, K. , THOMAS, A., Mitchell , VON GELDERN, Thomas, W.
发明人： ABBOTT LABORATORIES
IPC分类号： C07K07/08
CPC分类号： C07K14/58 , A61K38/00
摘要： The present invention provides novel peptides which exhibit useful hypotensive, natriuretic, diuretic, renovasodilating, reno-protective, smooth muscle relaxant, and vasorelaxant activities. The novel atrial peptides of the instant invention are encompassed by formula (I) or a pharmaceutically acceptable salt, ester or amide thereof, wherein R is selected from hydrogen, AcetylArg, Aha, Arg, Cit, His, Lys, Orn and Ser-Ser; R is a sulfur-containing group; R is a hydrophobic amino acid or dipeptide; R is a dipeptide spacer or a tripeptide of the formula X-Y, where X is a dipeptide spacer and Y is a basic amino acid; R is a hydrophobic amino acid; R is a peptide of up to three amino acids; R is selected from Cha, Phe, Cha-Arg, Phe-Arg, (D)Phe-Arg, Phe-(D)Arg, Phe Arg, Leu-Arg, Ala-Arg, Arg and Gly-Ala; and R is a sulfur-containing group.
摘要翻译：本发明提供了具有有用的低血压，利尿钠，利尿剂，改善释放，肾保护，平滑肌松弛剂和血管舒张活性的新型肽。本发明的新型心房肽包括式（I）或其药学上可接受的盐，酯或酰胺，其中R 1选自氢，乙酰基氨基，氨基，Arg，Cit，His，Lys，Orn和丝氨酸 - 丝氨酸; R 2是含硫基团; R 3是疏水性氨基酸或二肽; R 4是二肽间隔物或式X-Y的三肽，其中X是二肽间隔物，Y是碱性氨基酸; R 5是疏水性氨基酸; R 6是多至三个氨基酸的肽; R 7选自Cha，Phe，Cha-Arg，Phe-Arg，（D）Phe-Arg，Phe-（D）Arg，Phe> Arg，Leu-Arg，Ala-Arg，Arg和Gly -翼; R 8为含硫基团。

5. 发明申请

WO2004113304A1 INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS 审中-公开
标题翻译：吲哚，苄唑唑和苯并噻唑激酶抑制剂
公开(公告)号：WO2004113304A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/016166
申请日：2004-05-21
申请人： ABBOTT LABORATORIES , DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
发明人： DAI, Yujia , DAVIDSEN, Steven, K. , ERICSSON, Anna, M. , HARTANDI, Kresna , JI, Zhiqin , MICHAELIDES, Michael, R.
IPC分类号： C07D231/56
CPC分类号： C07D231/56 , C07D261/20 , C07D275/04 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/04 , Y02P20/582
摘要： Compounds having the formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译：具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

6. 发明申请

WO1992014732A1 INDOLES USEFUL AS PLATELET ACTIVATING FACTOR ANTAGONISTS 审中-公开
标题翻译：不适用于平板电脑激活因子拮抗剂
公开(公告)号：WO1992014732A1
公开(公告)日：1992-09-03
申请号：PCT/US1992001195
申请日：1992-02-14
申请人： ABBOTT LABORATORIES , SUMMERS, James, B. , SHEPPARD, George, S. , PHILLIPS, James, G. , PIREH, Daisy , STEINMAN, Douglas, H. , MAY, Paul, D. , GUINN, Denise, E. , HEYMAN, H., Robin , CARRERA, George, M., Jr. , DAVIDSEN, Steven, K.
发明人： ABBOTT LABORATORIES
IPC分类号： C07D417/14
CPC分类号： C07D409/14 , C07D417/14
摘要： Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.

7. 发明申请

WO1989010935A1 ATRIAL PEPTIDE DERIVATIVES 审中-公开
标题翻译： ATRIAL肽衍生物
公开(公告)号：WO1989010935A1
公开(公告)日：1989-11-16
申请号：PCT/US1989001928
申请日：1989-05-05
申请人： ABBOTT LABORATORIES , ROCKWAY, Todd, W. , KISO, Yoshiaki , DAVIDSEN, Steven, K. , LUCAS, Scott, D. , THOMAS, A., Mitchell , VON GELDERN, Thomas, W.
发明人： ABBOTT LABORATORIES
IPC分类号： C07K07/08
CPC分类号： C07K14/582 , A61K38/00
摘要： Atrial peptides comprising the amino acid sequence (I), wherein R1 is hydrogen, Ser, Cit, SerSer, Arg, Carbamoyl Ser, Guanido-Ser-Ser, Amcca, Guanido-Amcca, Lys, ArgArg, Ser-Arg, Ser-Lys, Acetyl-Ser-Ser, D-Ser-Ser, Ser-D-Ser, Guanido-Aocta, Aunda, Aocta, Ahexa, HSer, Apenta, Papaa, Abuta, Mamba, Orn, D-Orn or Acetyl-apenta, Acetyl-Ahexa, Guanido; R2 is Cys, D-Cys or Pen; R3 is L-Phe, D-Ala, L-Ala, D-Val, D-Cha, Sar, D-Phg, Aib, beta-Ala or Gly; R4 is Phe, Trp, D-Tic, L-Tic, N-MePhe, D-Ala, Tyr, 2-Thi, DimeDOPA or DOPA; R5 is Gly-Gly, Ala-Gly, D-Ala-Gly, Gly-Ala, Amcca, Mapaa or Papaa; R6 is Arg, D-Arg or Cit; R7 is Ile, Leu, D-Leu or Met; R8 is Asp, Asn, beta-methylAsp, cycloAsp, Gly or Ser; R9 is Arg, D-Arg or Ala; R10 is Ile, Leu or Phe; R11 is Cys, D-Cys, HCys, Cys-4-thiomethylproline, or trans-4-thiomethylproline; R12 is absent, Phe, D-Ala-Phe, D-Phe, Cha, Pro, D-Pro, 2-Thi, Aic, D-Tic, trans-4-FPro, L-Tic, Leu, Ile or beta-NA1; R13 is OH, Arg, Arg-NH2, D-Arg, Gln, Lys, HomoArg, or Gly; or pharmaceutically acceptable salts, esters or amides thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式