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1. 发明申请

WO2011008570A2 SULFONATE SURFACTANTS AND METHODS OF PREPARATION AND USE 审中-公开
标题翻译：磺化表面活性剂及其制备和使用方法
公开(公告)号：WO2011008570A2
公开(公告)日：2011-01-20
申请号：PCT/US2010/040570
申请日：2010-06-30
申请人： DOW GLOBAL TECHNOLOGIES, INC. , YU, Wanglin , RAND, Cynthia, L. , DAUGS, Edward, D. , CHENG, Yang , GRAF, Irina, V. , ARGENTON, Andre, B. , PHILLIPSON, Kari, S.
发明人： YU, Wanglin , RAND, Cynthia, L. , DAUGS, Edward, D. , CHENG, Yang , GRAF, Irina, V. , ARGENTON, Andre, B. , PHILLIPSON, Kari, S.
IPC分类号： C07C309/10
CPC分类号： C07C309/10 , C08F2/26 , C09K8/035 , C09K8/584 , C11D1/143
摘要： Provided are new anionic surfactants and methods of their preparation and use. The surfactants are compounds of the formula I: wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined herein.
摘要翻译：提供了新的阴离子表面活性剂及其制备和使用方法。表面活性剂是式I化合物：其中R，R 1，R 2，R 3，R 4，R 5和R 6如本文所定义。

2. 发明申请

WO2005110986A1 HYDROFORMYLATION PROCESS FOR PHARMACEUTICAL INTERMEDIATE 审中-公开
标题翻译：药物中间体的水解过程
公开(公告)号：WO2005110986A1
公开(公告)日：2005-11-24
申请号：PCT/US2005/014349
申请日：2005-04-26
申请人： DOW GLOBAL TECHNOLOGIES INC. , DAUGS, Edward, D. , PENG, Wei-Jun , RAND, Cynthia, L.
发明人： DAUGS, Edward, D. , PENG, Wei-Jun , RAND, Cynthia, L.
IPC分类号： C07D209/48
CPC分类号： C07D401/06 , C07D209/48 , C07D471/04
摘要： The invention relates to an improved process for the preparation of an advanced synthetic intermediate of ACE inhibitors. In one aspect, the present invention is based on a novel process for the preparation of an aldehyde of formula (I), wherein (N) PrG is a protected amino group, R is an alkyl or aralkyl group and X 1-4 are each independently H or a non-reacting substituent, which comprises hydroformylation of an α-olefin of formula (II), by reaction with syngas (CO/H 2 ) in the presence of, as catalyst, a group VIII transition metal complex of a phosphorus-containing ligand. Aldehyde (I), the product of linear hydroformylation, is formed in preference to aldehyde (III). In another aspect of the invention, α-olefin (II) is a novel composition. The process to convert (II) to (I) enables an efficient manufacturing route to MDL 28,726 and analogues.
摘要翻译：本发明涉及用于制备ACE抑制剂的高级合成中间体的改进方法。一方面，本发明是基于制备式（I）的醛的新方法，其中（N）PrG是被保护的氨基，R是烷基或芳烷基，X <1-4> 各自独立地是H或非反应性取代基，其包括式（II）的α-烯烃的羰基化，通过在作为催化剂的催化剂存在下与合成气（CO / H 2）反应的第VIII族过渡金属络合物含磷配体。醛（I）是线性加氢甲酰化的产物，优选醛（III）。在本发明的另一方面，α-烯烃（II）是一种新的组合物。将（II）转化为（I）的过程能够实现MDL 28,726和类似物的有效制造路线。

3. 发明申请

WO2012078728A1 APPARATUS AND PROCESS FOR USING OLEFIN AS AN AZEOTROPIC ENTRAINER FOR ISOLATING 1,3-DICHLORO-2-PROPANOL FROM A 2,2'-OXYBIS (1-CHLOROPROPANE) WASTE STREAM 审中-公开
标题翻译：使用烯烃作为AZEOTROPIC设备的装置和方法，用于从2,2'-氧化物（1-氯丙烯）废物流中分离1,3-二氯-2-丙醇
公开(公告)号：WO2012078728A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063697
申请日：2011-12-07
申请人： DOW GLOBAL TECHNOLOGIES LLC , SAWANT, Mahesh, Ratnakar , DAUGS, Edward, D. , SMIT, Mark, R.
发明人： SAWANT, Mahesh, Ratnakar , DAUGS, Edward, D. , SMIT, Mark, R.
IPC分类号： C07C29/80 , C07C29/82 , C07C31/36 , B01D3/36
CPC分类号： B01D3/36 , C07C29/74 , C07C29/78 , C07C29/80 , C07C29/82 , C07C29/86 , C07C31/36
摘要： Disclosed are a process and an apparatus for using an olefin as an azeotropic entrainer to isolate a target organic compound from a waste stream. The olefin may be, for example, 1- decene, 1-dodecene, or 1-tetradecene. The target organic compound may be l,3-dichloro-2- propanol in waste stream comprising a 2,2'-oxybis(l-chloropropane).
摘要翻译：公开了一种使用烯烃作为共沸夹带剂从废物流中分离目标有机化合物的方法和装置。烯烃可以是例如1-癸烯，1-十二碳烯或1-十四碳烯。目标有机化合物可以是包含2,2'-氧双（1-氯丙烷）的废物流中的1,3-二氯-2-丙醇。

4. 发明申请

WO2011056620A1 DIFUNCTIONAL, AMINE-BASED SURFACTANTS, AND THEIR PRECURSORS, PREPARATION, COMPOSITIONS AND USE 审中-公开
标题翻译：功能性，基于胺的表面活性剂及其前体，制备，组合物和用途
公开(公告)号：WO2011056620A1
公开(公告)日：2011-05-12
申请号：PCT/US2010054196
申请日：2010-10-27
申请人： DOW GLOBAL TECHNOLOGIES INC , DROVETSKAYA TATIANA , WASSERMAN ERIC P , FRANK DIANE , JORDAN SUSAN L , WAGLIN YU , RAND CYNTHIA , GRAF IRINA V , DAUGS EDWARD D
发明人： DROVETSKAYA TATIANA , WASSERMAN ERIC P , FRANK DIANE , JORDAN SUSAN L , WAGLIN YU , RAND CYNTHIA , GRAF IRINA V , DAUGS EDWARD D
IPC分类号： C07C217/42 , A01N33/12 , A61Q5/02 , A61Q5/12 , C07C229/16 , C07C239/12 , C08L63/00
CPC分类号： A01N25/30 , A01N57/20 , A61K8/41 , A61K8/416 , A61Q5/02 , A61Q5/12 , C07C217/42 , C07C229/16 , C07C239/12 , C11D1/42 , C11D1/62 , C11D1/75 , D06M13/332 , D06M13/467 , A01N33/08 , A01N33/12 , A01N2300/00
摘要： Cationic surfactants of formula I in which R1, R2, R3, R4, R5, R6, X and n are as defined are useful in a variety of applications, including in cleaners, detergents and personal care products, particularly shampoos and conditioners.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 6，X和n如所定义的式I的阳离子表面活性剂可用于各种应用，包括清洁剂，洗涤剂和个人护理产品，特别是洗发剂和调理剂。

5. 发明申请

WO2006036825A1 POLYETHYLENE GLYCOL COMPOUNDS AND PROCESS FOR MAKING 审中-公开
标题翻译：聚乙二醇化合物及其制备方法
公开(公告)号：WO2006036825A1
公开(公告)日：2006-04-06
申请号：PCT/US2005/034251
申请日：2005-09-27
申请人： DOW GLOBAL TECHOLOGIES INC. , DAUGS, Edward, D. , APPELL, Robert, Bruce , HIPPLER, Jeffrey, G. , KEEN, Brian, T.
发明人： DAUGS, Edward, D. , APPELL, Robert, Bruce , HIPPLER, Jeffrey, G. , KEEN, Brian, T.
IPC分类号： C08G65/30
CPC分类号： C08G65/2603 , C08G65/00
摘要： A substituted polyethylene glycol compound and process for making. The compound has the formula RO(C 2 H 4 O) n H wherein R represents a C 1-7 hydrocarbon group and n represents the average number of moles of C 2 H 4 O groups, ranging from 500 to 2000. The compound has a ratio of weight average molecular weight to a number average molecular weight in the range of from 1 to 1.1. The compound contains less than ten weight percent polyethylene glycol. The gist of the process is the use of an aprotic polar solvent. When the aprotic polar solvent is a polyether solvent, then the n value of the compound ranges from 100 to 2000.
摘要翻译：取代的聚乙二醇化合物及其制备方法。化合物具有式RO（C 2 H 4 O）n H H其中R表示C 1-7 - >烃基，n表示C 2 H 4 H 4 O基团的平均摩尔数，范围为500-2000。化合物的重均分子量与数均分子量在1至1.1的范围内。该化合物含有少于10重量％的聚乙二醇。该过程的要点是使用非质子极性溶剂。当非质子极性溶剂是聚醚溶剂时，化合物的n值范围为100-2000。

6. 发明申请

WO2009137282A1 PROCESS FOR OLEFIN ETHERIFICATION 审中-公开
标题翻译：烯烃加工方法
公开(公告)号：WO2009137282A1
公开(公告)日：2009-11-12
申请号：PCT/US2009/041747
申请日：2009-04-27
申请人： DOW GLOBAL TECHNOLOGIES INC. , DAUGS, Edward, D. , FLICK, Derrick, W. , RAND, Cynthia, L. , TULCHINSKY, Michael, L. , YU, Wanglin
发明人： DAUGS, Edward, D. , FLICK, Derrick, W. , RAND, Cynthia, L. , TULCHINSKY, Michael, L. , YU, Wanglin
IPC分类号： C07C41/06 , C07C43/12
CPC分类号： C07C41/06 , C07C41/42 , Y02P20/127 , C07C43/12
摘要： The invention relates to processes for the etherification of olefins with alcohols. According to one aspect, a heterogeneous etherification catalyst is used under conditions that permit limiting the contact time between the desired product and the catalyst, thereby mitigation reverse reactions. According to a second aspect, a recycling process is used that significantly increases the yield of desired product.
摘要翻译：本发明涉及烯烃与醇醚化的方法。根据一个方面，在允许限制所需产物和催化剂之间的接触时间的条件下使用异相醚化催化剂，从而减轻逆向反应。根据第二方面，使用显着增加所需产物的产率的再循环方法。

7. 发明申请

WO2006113917A9 CRYSTALLINE SOLID AND AMORPHOUS FORMS OF (-)- HALOFENATE 审中-公开
标题翻译：（ - ） - HALOFENATE的结晶固体和非晶形式
公开(公告)号：WO2006113917A9
公开(公告)日：2008-02-14
申请号：PCT/US2006015163
申请日：2006-04-20
申请人： METABOLEX INC , DAUGS EDWARD D , HAGEN ERIC J , HANKO JASON A , LOUKS DAVID H
发明人： DAUGS EDWARD D , HAGEN ERIC J , HANKO JASON A , LOUKS DAVID H
IPC分类号： C07C69/76
CPC分类号： C07C233/18 , A61K9/0053 , A61K31/216 , C07B2200/07 , C07B2200/13 , C07C235/78
摘要： The present invention provides crystalline solid and amorphous forms of (-)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (-)-halofenate.
摘要翻译：本发明提供（ - ） - 卤代苯甲酸酯的结晶固体和无定形形式。结晶固体形式可以用于各种药物组合物中，并且对于预防和/或治疗与哺乳动物血脂沉积相关的病症特别有效，特别是与2型糖尿病和高脂血症有关的疾病。本发明还涉及一种用于预防或治疗哺乳动物的2型糖尿病和高脂血症的方法，其包括施用治疗有效量的（ - ） - 氟酸盐的结晶固体和无定形形式的步骤。

8. 发明申请

WO2006113917A1 CRYSTALLINE SOLID AND AMORPHOUS FORMS OF (-)- HALOFENATE 审中-公开
标题翻译：（ - ） - HALOFENATE的结晶固体和非晶形式
公开(公告)号：WO2006113917A1
公开(公告)日：2006-10-26
申请号：PCT/US2006/015163
申请日：2006-04-20
申请人： METABOLEX, INC. , DAUGS, Edward, D. , HAGEN, Eric, J. , HANKO, Jason, A. , LOUKS, David, H.
发明人： DAUGS, Edward, D. , HAGEN, Eric, J. , HANKO, Jason, A. , LOUKS, David, H.
IPC分类号： C07C69/76
CPC分类号： C07C233/18 , A61K9/0053 , A61K31/216 , C07B2200/07 , C07B2200/13 , C07C235/78
摘要： The present invention provides crystalline solid and amorphous forms of (-)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (-)-halofenate.
摘要翻译：本发明提供（ - ） - 卤代苯甲酸酯的结晶固体和无定形形式。结晶固体形式可以用于各种药物组合物中，并且对于预防和/或治疗与哺乳动物血脂沉积相关的病症，特别是涉及2型糖尿病和高脂血症的疾病特别有效。本发明还涉及一种用于预防或治疗哺乳动物的2型糖尿病和高脂血症的方法，其包括施用治疗有效量的（ - ） - 氟酸盐的结晶固体和无定形形式的步骤。

9. 发明申请

WO2004074294A1 PREPARATION OF A TRANS-CALANOLIDE KETONE INTERMEDIATE AND CHIRAL SEPATATION OF CALANOLIDE ALCOHOLS TO GIVE RACEMIC CALANOLIDE A 审中-公开
标题翻译：转化乙酸钾中间体的制备和丙醇酸醇的马来酸盐分离以产生聚氨酯
公开(公告)号：WO2004074294A1
公开(公告)日：2004-09-02
申请号：PCT/US2004/002068
申请日：2004-01-27
申请人： DOW GLOBAL TECHNOLOGIES INC. , DAUGS, Edward, D.
发明人： DAUGS, Edward, D.
IPC分类号： C07D493/04
CPC分类号： C07D493/14
摘要： The method of the invention comprises a process for synthesizing a trans-calanolide A ketone intermediate used in the synthesis of racemic trans-calanolide A. The invention further comprises a method for removing a racemic calanolide B diastereomer from a mixture of calanol.ide A and calanolide B diastereomers formed in the last step of the synthesis of calanolide A by crystallization.
摘要翻译：本发明的方法包括合成用于合成外消旋反式正切内酯A的反式 - 正己内酯A酮中间体的方法。本发明还包括一种从丙醇胺A和在通过结晶合成甘洛酸A的最后步骤中形成的甘露糖苷B非对映异构体。

10. 发明申请

WO2012078521A1 PROCESS FOR REDUCING INORGANICS FROM ANIONIC SURFACTANT SOLUTIONS 审中-公开
标题翻译：从阴离子表面活性剂溶液中还原无机物的工艺
公开(公告)号：WO2012078521A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063316
申请日：2011-12-05
申请人： DOW GLOBAL TECHNOLOGIES LLC , SMIT, Mark, R. , DAUGS, Edward, D. , COLLINS, Raymond, M.
发明人： SMIT, Mark, R. , DAUGS, Edward, D. , COLLINS, Raymond, M.
IPC分类号： B01D61/02 , C07C303/44 , C07C309/09 , C11D1/12
CPC分类号： C02F9/00 , B01D61/027 , C07C303/44 , C07C309/10
摘要： A process comprising contacting deionized water with one or more Strecker sulfonation reaction products of one or more halogenated alkyl ethers in the presence of sulfite, wherein the one or more Strecker sulfonation reaction products each comprise one or more inorganic salts on a dry basis and one or more surfactant components, form a filtration mixture; loading the filtration mixture into a high pressure filtration system containing a membrane having a membrane molecular weight cutoff allowing preferential passage of the inorganic salts, for example, of greater than or equal to 200 Daltons; wherein the high pressure filtration system is operated at a pressure greater than ambient pressure and is configured to cause crossflow of the filtration mixture along a surface of the membrane resulting in a permeate solution which substantially passes through the membrane and a retentate solution which substantially does not pass through the membrane; wherein the permeate comprises less than or equal to 15 weight percent surfactant component, based on the weight of the filtration mixture is provided.
摘要翻译：一种方法，包括在亚硫酸盐存在下使去离子水与一种或多种卤代烷基醚的一种或多种降解性磺化反应产物接触，其中所述一种或多种Strecker磺化反应产物各自包含一个或多个基于干基的无机盐，更多的表面活性剂组分，形成过滤混合物; 将过滤混合物装入含有具有膜分子量截留的膜的高压过滤系统，允许无机盐优先通过，例如大于或等于200道尔顿; 其中所述高压过滤系统在大于环境压力的压力下操作并且被配置成使所述过滤混合物沿所述膜的表面交叉流动，导致基本上通过所述膜的渗透液和基本上不通过所述膜的渗余物溶液通过膜; 其中所述渗透物包含基于所述过滤混合物的重量的小于或等于15重量％的表面活性剂组分。

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