专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009049257A2 PREDICTIVE MODELS AND METHODS FOR DIAGNOSING AND ASSESSING CORONARY ARTERY DISEASE 审中-公开
标题翻译：预测模型和方法诊断和评估冠状动脉疾病
公开(公告)号：WO2009049257A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/079646
申请日：2008-10-10
申请人： CARDIO DX, INC. , ROSENBERG, Steve , DANIELS, Susan , ELASHOFF, Michael, R. , WINGROVE, James, A. , TINGLEY, Whittemore, G. , SEHNEERT, Amy, J. , PAONI, Nicholas, F.
发明人： ROSENBERG, Steve , DANIELS, Susan , ELASHOFF, Michael, R. , WINGROVE, James, A. , TINGLEY, Whittemore, G. , SEHNEERT, Amy, J. , PAONI, Nicholas, F.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： Biomarkers useful for diagnosing and assessing the extent of coronary artery disease (CAD) are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers are organized into clustered groups. The expression level of the biomarkers within a group are highly correlated to each other in normal and disease states. Expression values of genes chosen from each of two, three, four or five of the clustered gene groups, A, B, C, D, E may be used. Alternatively, expression values of genes chosen from the groups are combined into a metagene. Preferred biomarkers include S100A12, S100A8, S100A9, BCL2A1, and F5 (group A); XK, P62, and FECH (group B); TUBB2 (group C); IFNG, PDGFB, VSIG4, and TNF (group D); CSF3R, TLR5, CD46, and NCFl (group E); S100A12, S100A9, BCL2A1, TXN and CSTA (group I); OLIGl, 0LIG2, AD0RA3, CLC, and SLC29A1 (group II); and CBS and ARGl (group IV).
摘要翻译：提供用于诊断和评估冠状动脉疾病（CAD）程度的生物标志物，以及用于测量其表达的试剂盒。本发明还提供了基于生物标志物的预测模型以及计算机系统和用于对样品进行评分和任选分类的模型的软件实施例。在一个优选的实施方案中，生物标志物被组织成群集。组内生物标志物的表达水平在正常和疾病状态下彼此高度相关。可以使用从2,3,4或5个群集基因组A，B，C，D，E中的每一个中选择的基因的表达值。或者，将选自这些基因的基因的表达值组合成一种变应原。优选的生物标志物包括S100A12，S100A8，S100A9，BCL2A1和F5（A组）; XK，P62和FECH（B组）; TUBB2（C组）; IFNG，PDGFB，VSIG4和TNF（D组）; CSF3R，TLR5，CD46和NCF1（E组）; S100A12，S100A9，BCL2A1，TXN和CSTA（组I）; OLIG1，0LIG2，AD0RA3，CLC和SLC29A1（组II）; 和CBS和ARG1（第IV组）。

2. 发明申请

WO2005105201A3 ELECTRICAL NERVE STIMULATION DEVICE 审中-公开
标题翻译：电刺激装置
公开(公告)号：WO2005105201A3
公开(公告)日：2006-01-19
申请号：PCT/GB2005001647
申请日：2005-04-29
申请人： ALGOTEC LTD , DANIELS SUSAN ROMAO-DUARTE
发明人： DANIELS SUSAN ROMAO-DUARTE
IPC分类号： A61N1/05 , A61N1/34 , A61N1/36 , A61N1/372
CPC分类号： A61N1/0551 , A61N1/025 , A61N1/36071 , A61N1/37211
摘要： An electrical nerve stimulation device (500) has an electrode lead (502) and pulse generator (504) connected to one another and sealed in a fluid impermeable housing (526) to form a single sealed unit. The housing (526) is generally flat and both the electrode lead (502) and the pulse generator (504) are substantially flexible. Electrodes (516) are positioned along the length of the lead (502). Each electrode (516) comprises a group of electrical contacts spaced apart from one another along the length of the lead (502) so that the electrodes (516) can also be generally flexible. The distance along the lead (502) between the pulse generator (504) and the electrode (516) closest to the pulse generator (504) is less than around 5 cm. The electrodes (516) each extend along the length of the lead (502) for around 2 cm or more. The electrode lead (502) has an electronically readable memory for storing information about the lead (502), which can be read by the pulse generator (504). The pulse generator (504) can deliver pulses of electrical potential between the electrodes (516). The device (500) can be implanted in a human or animal body and used for treatments such as subcutaneous electrical nerve stimulation (SENS).
摘要翻译：电神经刺激装置（500）具有彼此连接并密封在流体不可渗透壳体（526）中以形成单个密封单元的电极引线（502）和脉冲发生器（504）。外壳（526）通常是平坦的，电极引线（502）和脉冲发生器（504）都基本上是柔性的。电极（516）沿引线（502）的长度定位。每个电极（516）包括沿引线（502）的长度彼此间隔开的一组电触头，使得电极（516）也可以是大致柔性的。脉冲发生器（504）和最接近脉冲发生器（504）的电极（516）之间的引线（502）的距离小于约5cm。电极（516）各自沿着引线（502）的长度延伸约2cm或更大。电极引线（502）具有用于存储关于引线（502）的信息的电子可读存储器，其可由脉冲发生器（504）读取。脉冲发生器（504）可以在电极（516）之间传递电位脉冲。装置（500）可植入人体或动物体内，用于皮下电神经刺激（SENS）等治疗。

3. 发明申请

WO2011116311A1 DETERMINING SUSCEPTIBILITY TO A SUDDEN CARDIAC EVENT 审中-公开
标题翻译：确定对减轻心脏事件的不确定性
公开(公告)号：WO2011116311A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/029041
申请日：2011-03-18
申请人： CARDIODX, INC. , ROSENBERG, Steven , ELASHOFF, Michael R. , BLANCHARD, John Lincoln , DANIELS, Susan Elizabeth , WINGROVE, James Alan , SEHNERT, Amy Jo-Nell
发明人： ROSENBERG, Steven , ELASHOFF, Michael R. , BLANCHARD, John Lincoln , DANIELS, Susan Elizabeth , WINGROVE, James Alan , SEHNERT, Amy Jo-Nell
IPC分类号： G01N33/48 , G06F19/22
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： Disclosed herein is a method of do terming the likelihood of a sudden cardiac event, such as an arrythmia, in a subject. Also disclosed is a method of determining whether a subject is at risk of a sudden cardiac event arid whether the subject would benefit from a treatment such as implantation of an ICD.
摘要翻译：本文公开了一种在受试者中确定突发性心脏事件（例如心律失常）的可能性的方法。还公开了一种确定受试者是否处于突发性心脏事件风险的方法，以及受试者是否将受益于诸如植入ICD的治疗。

4. 发明申请

WO2007083108A3 IMPLANTABLE ELONGATE MEMBER 审中-公开
公开(公告)号：WO2007083108A3
公开(公告)日：2007-07-26
申请号：PCT/GB2007/000134
申请日：2007-01-18
申请人： ALGOTEC LIMITED , DANIELS, Susan, Romao-Duarte , MANNING, Mitchell, Luke
发明人： DANIELS, Susan, Romao-Duarte , MANNING, Mitchell, Luke
IPC分类号： A61N1/05 , A61M25/04 , A61M25/00
摘要： The present invention relates to a lead (100) or catheter (202) having at least one member (116; 210) with interstices for facilitating the in-growth of tissue to anchor the lead (100) or catheter (202). The present invention also relates to a method of manufacturing a lead (100) or catheter (202). Furthermore, the present invention relates to a method of anchoring a lead (100) or catheter (202) in a body.

5. 发明申请

WO2007032832A2 METHOD AND APPARATUS TO SHAPE A COMPOSITE STRUCTURE WITHOUT CONTACT 审中-公开
标题翻译：形成无接触的复合结构的方法和装置
公开(公告)号：WO2007032832A2
公开(公告)日：2007-03-22
申请号：PCT/US2006/030602
申请日：2006-08-04
申请人： KIMBERLY-CLARK WORLDWIDE, INC. , HUNTER, David, P. , SCHMIDT, Michael, A. , DANIELS, Susan, J. , SCHEWE, Sara, J. , FOSS, Randall, W.
发明人： HUNTER, David, P. , SCHMIDT, Michael, A. , DANIELS, Susan, J. , SCHEWE, Sara, J. , FOSS, Randall, W.
CPC分类号： D04H1/56 , D04H1/407 , D04H1/425 , D04H1/732 , D04H3/05 , D04H5/08
摘要： A method and apparatus including means for delivery of at least one high speed composite stream of polymer fibers and secondary material. The method and apparatus also includes a movable collection device which intersects in the composite stream of polymer fibers and secondary material and at least one non-contact deflector to redirect at least a portion of the composite stream.
摘要翻译：一种方法和装置，包括用于输送聚合物纤维和次级材料的至少一种高速复合物流的装置。该方法和装置还包括可移动收集装置，其在聚合物纤维和次级材料的复合流中相交，以及至少一个非接触偏转器，以重定向至少一部分复合流。

6. 发明申请

WO0075298A8 MOLECULES FOR DISEASE DETECTION AND TREATMENT 审中-公开
标题翻译：疾病检测和治疗分子
公开(公告)号：WO0075298A8
公开(公告)日：2001-11-15
申请号：PCT/US0015344
申请日：2000-06-01
申请人： INCYTE GENOMICS INC , HODGSON DAVID M , LINCOLN STEPHEN E , RUSSO FRANK D , SPIRO PETER A , BANVILLE STEVEN C , BRATCHER SHAWN R , DUFOUR GERARD E , COHEN HOWARD J , ROSEN BRUCE H , CHALUP MICHAEL S , HILLMAN JENNIFER L , JONES ANISSA LEE , YU JIMMY Y , GREENAWALT LILA B , PANZER SCOTT R , ROSEBERRY ANN M , WRIGHT RACHEL J , DANIELS SUSAN E
发明人： HODGSON DAVID M , LINCOLN STEPHEN E , RUSSO FRANK D , SPIRO PETER A , BANVILLE STEVEN C , BRATCHER SHAWN R , DUFOUR GERARD E , COHEN HOWARD J , ROSEN BRUCE H , CHALUP MICHAEL S , HILLMAN JENNIFER L , JONES ANISSA LEE , YU JIMMY Y , GREENAWALT LILA B , PANZER SCOTT R , ROSEBERRY ANN M , WRIGHT RACHEL J , DANIELS SUSAN E
IPC分类号： C07K14/47 , C12N15/00 , C07K16/00 , C12N15/63 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47
摘要： The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.
摘要翻译：本发明提供了纯化的疾病检测和治疗分子多核苷酸（mddt）。还包括由mddt编码的多肽（MDDT）。本发明还提供在诊断测定中使用mddt或其互补序列，寡核苷酸或其片段。本发明进一步提供含有mddt用于表达MDDT的载体和宿主细胞。本发明另外提供分离和纯化的MDDT在诊断测定中诱导抗体和筛选化合物文库以及使用抗MDDT抗体的用途。还提供了含有mddt和使用方法的微阵列。

7. 发明申请

WO0075298A3 MOLECULES FOR DISEASE DETECTION AND TREATMENT 审中-公开
公开(公告)号：WO0075298A3
公开(公告)日：2001-09-20
申请号：PCT/US0015344
申请日：2000-06-01
申请人： INCYTE GENOMICS INC , HODGSON DAVID M , LINCOLN STEPHEN E , RUSSO FRANK D , SPIRO PETER A , BANVILLE STEVEN C , BRATCHER SHAWN R , DUFOUR GERARD E , COHEN HOWARD J , ROSEN BRUCE H , CHALUP MICHAEL S , HILLMAN JENNIFER L , JONES ANISSA LEE , YU JIMMY Y , GREENAWALT LILA B , PANZER SCOTT R , ROSEBERRY ANN M , WRIGHT RACHEL J , DANIELS SUSAN E
发明人： HODGSON DAVID M , LINCOLN STEPHEN E , RUSSO FRANK D , SPIRO PETER A , BANVILLE STEVEN C , BRATCHER SHAWN R , DUFOUR GERARD E , COHEN HOWARD J , ROSEN BRUCE H , CHALUP MICHAEL S , HILLMAN JENNIFER L , JONES ANISSA LEE , YU JIMMY Y , GREENAWALT LILA B , PANZER SCOTT R , ROSEBERRY ANN M , WRIGHT RACHEL J , DANIELS SUSAN E
IPC分类号： C07K14/47 , C12N15/00 , C07K16/00 , C12N15/63 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/47
摘要： The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce antibodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.

8. 发明申请

WO2010148017A1 DETERMINATION OF CORONARY ARTERY DISEASE RISK. 审中-公开
标题翻译：确定冠状动脉疾病风险。
公开(公告)号：WO2010148017A1
公开(公告)日：2010-12-23
申请号：PCT/US2010/038712
申请日：2010-06-15
申请人： CARDIODX, INC. , ROSENBERG, Steven , ELASHOFF, Michael, R. , BEINEKE, Philip , WINGROVE, James, A. , TINGLEY, Whittemore, G. , DANIELS, Susan, E.
发明人： ROSENBERG, Steven , ELASHOFF, Michael, R. , BEINEKE, Philip , WINGROVE, James, A. , TINGLEY, Whittemore, G. , DANIELS, Susan, E.
IPC分类号： G01N33/00
CPC分类号： G06F19/34 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16 , G06F19/20 , G06F19/24 , G16H50/30
摘要： Markers and methods useful for assessing coronary artery disease in a subject are provided, along with kits for measuring their expression. Also provided arc predictive models, based on the markers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
摘要翻译：提供了用于评估受试者冠状动脉疾病的标记物和方法，以及用于测量其表达的试剂盒。还提供了基于标记的电弧预测模型，以及用于评分和可选地分类样本的模型的计算机系统和软件实施例。

9. 发明申请

WO2009049257A9 PREDICTIVE MODELS AND METHODS FOR DIAGNOSING AND ASSESSING CORONARY ARTERY DISEASE 审中-公开
标题翻译：预测模型和方法诊断和评估冠状动脉疾病
公开(公告)号：WO2009049257A9
公开(公告)日：2009-10-29
申请号：PCT/US2008079646
申请日：2008-10-10
申请人： CARDIO DX INC , ROSENBERG STEVE , DANIELS SUSAN , ELASHOFF MICHAEL R , WINGROVE JAMES A , TINGLEY WHITTEMORE G , SEHNEERT AMY J , PAONI NICHOLAS F
发明人： ROSENBERG STEVE , DANIELS SUSAN , ELASHOFF MICHAEL R , WINGROVE JAMES A , TINGLEY WHITTEMORE G , SEHNEERT AMY J , PAONI NICHOLAS F
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： Biomarkers useful for diagnosing and assessing the extent of coronary artery disease (CAD) are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers are organized into clustered groups. The expression level of the biomarkers within a group are highly correlated to each other in normal and disease states. Expression values of genes chosen from each of two, three, four or five of the clustered gene groups, A, B, C, D, E may be used. Alternatively, expression values of genes chosen from the groups are combined into a metagene. Preferred biomarkers include S100A12, S100A8, S100A9, BCL2A1, and F5 (group A); XK, P62, and FECH (group B); TUBB2 (group C); IFNG, PDGFB, VSIG4, and TNF (group D); CSF3R, TLR5, CD46, and NCFl (group E); S100A12, S100A9, BCL2A1, TXN and CSTA (group I); OLIGl, 0LIG2, AD0RA3, CLC, and SLC29A1 (group II); and CBS and ARGl (group IV).
摘要翻译：提供用于诊断和评估冠状动脉疾病（CAD）程度的生物标志物，以及用于测量其表达的试剂盒。本发明还提供了基于生物标志物的预测模型以及计算机系统和用于对样品进行评分和任选分类的模型的软件实施例。在一个优选的实施方案中，生物标志物被组织成群集。组内生物标志物的表达水平在正常和疾病状态下彼此高度相关。可以使用从2,3,4或5个群集基因组A，B，C，D，E中的每一个中选择的基因的表达值。或者，将选自这些基因的基因的表达值组合成一种变应原。优选的生物标志物包括S100A12，S100A8，S100A9，BCL2A1和F5（A组）; XK，P62和FECH（B组）; TUBB2（C组）; IFNG，PDGFB，VSIG4和TNF（D组）; CSF3R，TLR5，CD46和NCF1（E组）; S100A12，S100A9，BCL2A1，TXN和CSTA（组I）; OLIG1，0LIG2，AD0RA3，CLC和SLC29A1（组II）; 和CBS和ARG1（第IV组）。

10. 发明申请

WO2009049257A3 PREDICTIVE MODELS AND METHODS FOR DIAGNOSING AND ASSESSING CORONARY ARTERY DISEASE 审中-公开
标题翻译：用于诊断和评估冠状动脉疾病的预测模型和方法
公开(公告)号：WO2009049257A3
公开(公告)日：2009-07-02
申请号：PCT/US2008079646
申请日：2008-10-10
申请人： CARDIO DX INC , ROSENBERG STEVE , DANIELS SUSAN , ELASHOFF MICHAEL R , WINGROVE JAMES A , TINGLEY WHITTEMORE G , SEHNEERT AMY J , PAONI NICHOLAS F
发明人： ROSENBERG STEVE , DANIELS SUSAN , ELASHOFF MICHAEL R , WINGROVE JAMES A , TINGLEY WHITTEMORE G , SEHNEERT AMY J , PAONI NICHOLAS F
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： Biomarkers useful for diagnosing and assessing the extent of coronary artery disease (CAD) are provided, along with kits for measuring their expression. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples. In a preferred embodiment, the biomarkers are organized into clustered groups. The expression level of the biomarkers within a group are highly correlated to each other in normal and disease states. Expression values of genes chosen from each of two, three, four or five of the clustered gene groups, A, B, C, D, E may be used. Alternatively, expression values of genes chosen from the groups are combined into a metagene. Preferred biomarkers include S100A12, S100A8, S100A9, BCL2A1, and F5 (group A); XK, P62, and FECH (group B); TUBB2 (group C); IFNG, PDGFB, VSIG4, and TNF (group D); CSF3R, TLR5, CD46, and NCFl (group E); S100A12, S100A9, BCL2A1, TXN and CSTA (group I); OLIGl, 0LIG2, AD0RA3, CLC, and SLC29A1 (group II); and CBS and ARGl (group IV).
摘要翻译：提供了有助于诊断和评估冠状动脉疾病（CAD）程度的生物标志物，以及用于测量其表达的试剂盒。本发明还提供了基于生物标志物的预测模型，以及用于评分和可选地分类样品的模型的计算机系统和软件实施方案。在优选的实施方案中，生物标志物被组织成聚集的组。一组中生物标志物的表达水平在正常和疾病状态下彼此高度相关。可以使用从两个，三个，四个或五个聚簇基因组A，B，C，D，E中的每一个中选择的基因的表达值。或者，选自组中的基因的表达值被组合成元源。优选的生物标志物包括S100A12，S100A8，S100A9，BCL2A1和F5（组A）; XK，P62和FECH（B组）; TUBB2（C组）; IFNG，PDGFB，VSIG4和TNF（D组）; CSF3R，TLR5，CD46和NCF1（组E）; S100A12，S100A9，BCL2A1，TXN和CSTA（组I）; OLIG1，0LIG2，AD0RA3，CLC和SLC29A1（组II）; 和CBS和ARG1（组IV）。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式