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    • 9. 发明申请
    • NOVEL RADIOTHERAPEUTIC FORMULATIONS CONTAINING <224>RA AND A METHOD FOR THEIR PRODUCTION
    • NEW,<224> RA CONTAINING RADIO活性治疗制剂及其制备方法
    • WO0215943A3
    • 2002-06-20
    • PCT/EP0109121
    • 2001-08-07
    • ALTMANN THERAPIE GMBH & CO KGSCHWARZ UWEDANIELS ROLF
    • SCHWARZ UWEDANIELS ROLF
    • A61K51/02A61K51/12A61P29/00
    • A61K51/02A61K51/121
    • The invention relates to novel radiotherapeutic formulations containing Ra and methods for their production. The invention discloses, in particular, radiotherapeutic formulations comprising at least one salt of the isotope Ra, which are characterised in that the content of other radionuclides, in particular, the respective content of certain longeval radionuclides does not exceed a specific numerical value in mBq/g. The invention also relates to a method for producing radiotherapeutic formulations of this type, which is characterised by the following steps: after at least one centrifugation of an aqueous suspension of the compound Th(OH)4 and optionally after the resuspension of the raw sediment obtained in said centrifugation, the precipitated Th(OH)4 sediment is separated. The supernatant solution of a Ra salt that has been obtained is subsequently subjected to sterile filtration and is then made up to the required dose. Finally, said solution is sterilised and bottled in ampoules in a manner known per se.
    • 本发明涉及新的,含有<224>镭,无线电治疗有效的制剂和它们的制备方法。 特别地,所公开的无线电治疗有效制剂,其包含同位素<224>中的至少一种盐Ra和它的特征在于,其它放射性核素的含量,尤其是某些长寿命放射性核素的含量比在MBQ /克去一定数值各不多。 此外,描述了用于制造这种,无线电治疗有效的制剂的方法,其特征在于,所述化合物<228>的水性悬浮液中的至少一次离心后的Th(OH)4,任选地将所得的原始沉积物沉淀该重悬<228后 分离>钍(OH)4沉淀物,然后进行无菌过滤,将得到的上层清液的所需剂量的后续装瓶被一个<224>镭盐,其溶液最终灭菌以传统方式并包装。