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1. 发明申请

WO1994024284A1 HUMAN N-METHYL-D-ASPARTATE RECEPTOR SUBUNITS, NUCLEIC ACIDS ENCODING SAME AND USES THEREFOR 审中-公开
标题翻译：人类N-甲基-D-孕激素受体亚型，编码其的核酸及其用途
公开(公告)号：WO1994024284A1
公开(公告)日：1994-10-27
申请号：PCT/US1994004387
申请日：1994-04-20
申请人： THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC. , DAGGETT, Lorrie, P. , ELLIS, Steven, B. , LIAW, Chen, Wang , LU, Chin-Chun
发明人： THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC.
IPC分类号： C12N15/12
CPC分类号： G01N33/5008 , A01K2217/05 , A61K38/00 , C07K14/70571 , G01N33/502 , G01N33/5041 , G01N33/5058 , G01N33/5091 , G01N33/6872 , G01N2333/70571
摘要： In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor proteins subunit, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. Functional glutamate receptors can be assembled, in accordance with the present invention, from a plurality of one type of NMDA receptor subunit protein (homomeric) or from a mixture of two or more types of subunit proteins (heteromeric). In addition to disclosing novel NMDA receptor protein subunits, the present invention also comprises methods for using such receptor subunits to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function. The invention also comprises methods for determining whether unknown protein(s) are functional as NMDA receptor subunits.
摘要翻译：根据本发明，提供了编码人NMDA受体蛋白质亚基的核酸和由此编码的蛋白质。本发明的NMDA受体亚基包含具有阳离子选择性通道并结合谷氨酸和NMDA的NMDA受体的组分。在本发明的一个方面，核酸编码人NMDA受体的NMDAR1和NMDAR2亚基。在优选的实施方案中，本发明核酸编码人NMDA受体的NMDAR1，NMDAR2A，NMDAR2B，NMDAR2C和NMDAR2D亚基。除了可用于制备NMDA受体蛋白亚基之外，这些核酸也可用作探针，因此使得本领域技术人员无需过多的实验来鉴定和分离相关的人受体亚单位。功能性谷氨酸受体可以根据本发明从多种一种NMDA受体亚基蛋白（同型）或两种或更多种亚基蛋白（异聚体）的混合物组装。除了公开新的NMDA受体蛋白质亚基之外，本发明还包括使用这些受体亚基来鉴定和表征影响这些受体功能的化合物的方法，例如激动剂，拮抗剂和谷氨酸受体功能的调节剂。本发明还包括用于确定未知蛋白质是否作为NMDA受体亚基起作用的方法。

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