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1. 发明专利

IL137522A HUMAN MONOCLONAL ANTIBODY AGAINST HEPATITIS C VIRUS E2 GLYCOPROTEIN 未知
公开(公告)号：IL137522A
公开(公告)日：2007-06-17
申请号：IL13752200
申请日：2000-07-26
申请人： DRK BLUTSPENDEDIENDST BADEN WU , DAGAN SHLOMO , EREN RACHEL , CARDOSO MARCIA DA SILVA , SIEMONEIT KARL , KUBANEK BERNHARD
发明人： DAGAN SHLOMO , EREN RACHEL , CARDOSO MARCIA DA SILVA , SIEMONEIT KARL , KUBANEK BERNHARD
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/21 , A61K39/395 , A61K39/42 , A61K45/00 , A61P31/14 , A61P43/00 , C07K14/47 , C07K16/10 , C12N5/10 , C12N5/28 , C12N15/13 , C12P21/08
摘要： Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis C virus (HCV) E2 glycoprotein and capable of neutralizing HCV infection in vivo in an animal model, as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HCV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HCV E2 antibodies are transformed in vitro by Epstein-Barr virus and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HCV E2 glycoprotein.

2. 发明申请

WO1997047654A1 HUMAN MONOCLONAL ANTIBODIES TO THE HEPATITIS B SURFACE ANTIGEN 审中-公开
标题翻译： HEPATITIS B表面抗原的人体单克隆抗体
公开(公告)号：WO1997047654A1
公开(公告)日：1997-12-18
申请号：PCT/IL1997000184
申请日：1997-06-10
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , XTL BIOPHARMACEUTICALS LIMITED , REISNER, Yair , DAGAN, Shlomo
发明人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , XTL BIOPHARMACEUTICALS LIMITED
IPC分类号： C07K16/08
CPC分类号： A01K67/0271 , A61K38/00 , A61K39/00 , C07K16/082
摘要： Disclosed is a process for obtaining hybridoma cell lines which produce human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as the hybridoma cell lines, and antibodies produced by the cell lines. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are engrafted into normal strains of mice which were lethally irradiated and radioprotected with SCID bone marrow. After immunization of such chimeric mice with HBVsAg, human cells are obtained from the mice spleens and fused in vitro with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.
摘要翻译：公开了一种获得能够结合乙型肝炎病毒表面抗原（HBVsAg）的人抗体以及杂交瘤细胞系和由细胞系产生的抗体的杂交瘤细胞系的方法。还公开了所述抗体在预防和治疗HBV感染中的各种用途。从具有高滴度的抗HBVsAg抗体的人供体获得的外周血淋巴细胞被移植到正常的小鼠细胞中，其被致死照射并用SCID骨髓放射防护。用HBVsAg免疫这样的嵌合小鼠后，从小鼠脾获得人细胞，并与异源骨髓瘤细胞体外融合以产生分泌具有高亲和性和对HBVsAg特异性的人抗体的杂交瘤。

3. 发明申请

WO9427556A3 ANIMAL MODEL FOR HEPATITIS VIRUS INFECTION 审中-公开
标题翻译：用于感染乙型肝炎病毒的动物模型
公开(公告)号：WO9427556A3
公开(公告)日：1995-06-08
申请号：PCT/US9405410
申请日：1994-05-13
申请人： YEDA RES & DEV , DAGAN SHLOMO
发明人： REISNER YAIR
IPC分类号： A01K67/027 , A61K35/28 , A61K35/38 , A61K35/407 , A61K39/395 , C07K16/10 , C12N5/06 , G01N33/531 , G01N33/576 , A61K
CPC分类号： A61K35/28 , A01K67/0271 , A61K35/38 , A61K35/407 , C07K16/109
摘要： A non-human chimeric animal useful as a model for human HV infection, comprising a mammal M5 having xenogeneic cells; mammal M5 being derived from a mammal M1 treated to substantially destroy its hematopoietic cells and then transplanted with hematopoietic cells derived from one or more mammals M2 and transplanted with liver tissue from a mammal M3, the one or more mammals M2 and mammal M3 being from the same or from a different species; the transplanted hematopoietic cells from the one or more mammals M2 being either one or both of a hematopoietic cell preparation from a T cell deficient mammal or of a T cell depleted mammalian stem cell or bone marrow preparation; the transplanted liver tissue from mammal M3 being either a human liver tissue preparation or a liver tissue preparation from a non-human mammal capable of being infected by HV; the liver tissue preparation in the M5 mammal being infected by HV.

4. 发明申请

WO2004005548A2 A METHOD FOR DISCOVERY OF HUMAN GENES ASSOCIATED WITH VIRAL HEPATITIS INFECTION 审中-公开
标题翻译：一种发现与病毒性肝炎相关的人类基因的方法
公开(公告)号：WO2004005548A2
公开(公告)日：2004-01-15
申请号：PCT/IL2003/000528
申请日：2003-06-23
申请人： XTL BIOPHARMACEUTICALS LTD , YEDA RESEARCH AND DEVELOPMENT CO. LTD. , BANIN, Sharon , ZAUBERMAN, Arie , DAGAN, Shlomo
发明人： BANIN, Sharon , ZAUBERMAN, Arie , DAGAN, Shlomo
IPC分类号： C12Q1/68
CPC分类号： C12Q1/706 , A01K67/0271 , A01K2227/105 , A01K2267/0337 , C12Q1/6809 , C12Q1/6837
摘要： Disclosed is a method for discovering human genes associated with viral hepatitis infection using a model based on small animals transplanted with human liver fragments. Normal human liver fragments are infected with hepatitis virus and then transplanted into immune compromised mice obtained by irradiation and transplantation with SCID bone marrow. Similar liver fragments are transplanted into the mice without being infected with the virus. Gene expression profiles are then generated from both these types of liver fragments. Comparison using gene arrays allows the detection of hepatitis-infection associated genes. Such genes can be further exploited as targets to generate and screen for anti viral agents.
摘要翻译：公开了使用基于移植了人肝碎片的小动物的模型来发现与病毒性肝炎感染相关的人基因的方法。将正常的人肝碎片感染肝炎病毒，然后移植入用SCID骨髓照射和移植获得的免疫受损小鼠。将相似的肝脏片段移植入小鼠而不感染病毒。然后从这两种肝脏片段产生基因表达谱。使用基因阵列进行比较可以检测肝炎感染相关基因。这些基因可被进一步用作靶标以产生和筛选抗病毒剂。

5. 发明申请

WO2003028722A1 TREATMENT OF HEPATITIS B VIRUS INFECTION WITH HUMAN MONOCLONAL ANTIBODIES 审中-公开
标题翻译：用人类单克隆抗体治疗乙型肝炎病毒感染
公开(公告)号：WO2003028722A1
公开(公告)日：2003-04-10
申请号：PCT/IL2001/000927
申请日：2001-10-04
申请人： XTL BIOPHARMACEUTICALS LTD , DAGAN, Shlomo , EREN, Rachel
发明人： DAGAN, Shlomo , EREN, Rachel
IPC分类号： A61K31/42
CPC分类号： C07K16/082 , A61K39/42 , C07K2317/21 , A61K2300/00
摘要： Disclosed is a pharmaceutical composition for the treatment or prevention of hepatitis B virus infection, comprising a 1:3 mixture of two fully human anti HBsAg monoclonal antibodies 19.79 and 17.1.41. Alto disclosed are preferred modes of administration. The pharmaceutical composition can be given as a monotherapy or in combination with other anti viral agents.
摘要翻译：公开了用于治疗或预防乙型肝炎病毒感染的药物组合物，其包含两种完全人抗HBsAg单克隆抗体19.79和17.1.41的1:3混合物。所公开的Alto是优选的给药方式。药物组合物可以作为单一疗法或与其它抗病毒剂组合给予。

6. 发明申请

WO0208292A3 HUMAN MONOCLONAL ANTIBODY AGAINST HEPATITIS C VIRUS E2 GLYCOPROTEIN 审中-公开
标题翻译：人类单克隆抗体对抗HEPATITIS C病毒E2 GLYCOPROTEIN
公开(公告)号：WO0208292A3
公开(公告)日：2002-12-12
申请号：PCT/IL0100684
申请日：2001-07-25
申请人： DRK BLUTSPENDEDIENST BADEN WUR , KUBANEK BERNHARD , DA SILVA CARDOSO MARCIA , SIEMONEIT KARL , DAGAN SHLOMO , EREN RACHEL
发明人： KUBANEK BERNHARD , DA SILVA CARDOSO MARCIA , SIEMONEIT KARL , DAGAN SHLOMO , EREN RACHEL
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/21 , A61K39/395 , A61K39/42 , A61K45/00 , A61P31/14 , A61P43/00 , C07K14/47 , C07K16/10 , C12N5/10 , C12N5/28 , C12N15/13 , C12P21/08 , A61K31/00 , C07K14/18
CPC分类号： C07K16/109 , A61K39/42 , A61K2039/505 , C07K2317/24 , A61K2300/00
摘要： Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis C virus (HCV) E2 glycoprotein and capable of neutralizing HCV infection in vivo in an animal model, as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HCV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HCV E2 antibodies are transformed in vitro by Epstein-Barr virus and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HCV E2 glycoprotein.
摘要翻译：公开了产生能够结合丙型肝炎病毒（HCV）E2糖蛋白并且能够在动物模型中中和HCV感染的人抗体以及由细胞系产生的抗体的杂交瘤细胞系。还公开了所述抗体在预防和治疗HCV感染中的各种用途。从具有高滴度的抗HCV E2抗体的人供体获得的外周血淋巴细胞在体外通过爱泼斯坦 - 巴尔病毒转化，然后与异源骨髓瘤细胞融合，以产生分泌对HCV E2糖蛋白具有高亲和力和特异性的人抗体的杂交瘤。

7. 发明申请

WO2006112838A1 STABILIZED ANTI-HEPATITIS B (HBV) ANTIBODY FORMULATIONS 审中-公开
标题翻译：稳定的抗乙型肝炎病毒（HBV）抗体制剂
公开(公告)号：WO2006112838A1
公开(公告)日：2006-10-26
申请号：PCT/US2005/013151
申请日：2005-04-18
申请人： XTL BIOPHARMACEUTICALS LTD. , DAGAN, Shlomo , EREN, Rachel , MISRA, Hemant, Kumar , GOWAN, Walter, G., Jr. , O'CONNOR, Sandra
发明人： DAGAN, Shlomo , EREN, Rachel , MISRA, Hemant, Kumar , GOWAN, Walter, G., Jr. , O'CONNOR, Sandra
IPC分类号： C07K16/00 , A61K39/395 , A61K47/26 , A61K47/18
CPC分类号： C07K16/082 , A61K9/0019 , A61K39/39591 , A61K47/12 , A61K47/183 , A61K47/26
摘要： The present invention provides liquid formulations of antibodies or fragments thereof that specifically bind to a hepatitis B virus (HBV) antigen, which formulations exhibit stability, low to undetectable levels of aggregations, and very little to no loss of the biological activities of the antibodies or antibody fragments, even during long periods of storage. Furthermore, the invention provides methods of preventing, treating or ameliorating one or more symptoms associated with HBV infection utilizing the liquid formulations of the present invention.
摘要翻译：本发明提供了特异性结合乙型肝炎病毒（HBV）抗原的抗体或其片段的液体制剂，该制剂表现出稳定性，低至不可检测的聚集水平，以及抗体的生物活性很少甚至没有损失，抗体片段，即使在长时间的储存期间。此外，本发明提供使用本发明的液体制剂预防，治疗或改善与HBV感染相关的一种或多种症状的方法。

8. 发明申请

WO1997047653A1 HUMAN MONOCLONAL ANTIBODY AGAINST HEPATITIS B VIRUS SURFACE ANTIGEN (HBVSAG) 审中-公开
标题翻译：人类单克隆抗体对乙型肝炎病毒表面抗原（HBVSAG）
公开(公告)号：WO1997047653A1
公开(公告)日：1997-12-18
申请号：PCT/IL1997000183
申请日：1997-06-10
申请人： XTL BIOPHARMACEUTICALS LIMITED , DAGAN, Shlomo
发明人： XTL BIOPHARMACEUTICALS LIMITED
IPC分类号： C07K16/08
CPC分类号： C07K16/082 , A61K38/00
摘要： Disclosed is a hybridoma cell line which produces human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as antibodies produced by the cell line. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are activated in vitro with pokeweed mitogen and then fused with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.
摘要翻译：公开了产生能够结合乙型肝炎病毒表面抗原（HBVsAg）的人抗体以及由细胞系产生的抗体的杂交瘤细胞系。还公开了所述抗体在预防和治疗HBV感染中的各种用途。从具有高滴度的抗HBVsAg抗体的人供体获得的外周血淋巴细胞在体外用pokeweed有丝分裂原激活，然后与异源骨髓瘤细胞融合，以产生分泌具有高亲和力和对HBVsAg特异性的人抗体的杂交瘤。

9. 发明申请

WO2004005548A3 A METHOD FOR DISCOVERY OF HUMAN GENES ASSOCIATED WITH VIRAL HEPATITIS INFECTION 审中-公开
标题翻译：发现与病毒性肝炎相关感染的人类基因的方法
公开(公告)号：WO2004005548A3
公开(公告)日：2004-02-26
申请号：PCT/IL0300528
申请日：2003-06-23
申请人： XTL BIOPHARMACEUTICALS LTD , YEDA RES & DEV , BANIN SHARON , ZAUBERMAN ARIE , DAGAN SHLOMO
发明人： BANIN SHARON , ZAUBERMAN ARIE , DAGAN SHLOMO
IPC分类号： A01K67/027 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/706 , A01K67/0271 , A01K2227/105 , A01K2267/0337 , C12Q1/6809 , C12Q1/6837
摘要： Disclosed is a method for discovering human genes associated with viral hepatitis infection using a model based on small animals transplanted with human liver fragments. Normal human liver fragments are infected with hepatitis virus and then transplanted into immune compromised mice obtained by irradiation and transplantation with SCID bone marrow. Similar liver fragments are transplanted into the mice without being infected with the virus. Gene expression profiles are then generated from both these types of liver fragments. Comparison using gene arrays allows the detection of hepatitis-infection associated genes. Such genes can be further exploited as targets to generate and screen for anti viral agents.
摘要翻译：公开了使用基于移植有人肝脏片段的小动物的模型来发现与病毒性肝炎感染相关的人类基因的方法。正常人肝脏片段被肝炎病毒感染，然后移植到用SCID骨髓照射和移植获得的免疫受损小鼠中。将类似的肝片段移植到小鼠中而不感染病毒。然后从这两种类型的肝脏片段产生基因表达谱。使用基因阵列的比较允许检测肝炎感染相关基因。可以进一步利用这些基因作为产生和筛选抗病毒剂的目标。

10. 发明申请

WO1994027556A2 ANIMAL MODEL FOR HEPATITIS VIRUS INFECTION 审中-公开
标题翻译：用于感染乙型肝炎病毒的动物模型
公开(公告)号：WO1994027556A2
公开(公告)日：1994-12-08
申请号：PCT/US1994005410
申请日：1994-05-13
申请人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , DAGAN, Shlomo
发明人： YEDA RESEARCH AND DEVELOPMENT CO. LTD. , DAGAN, Shlomo , REISNER, Yair
IPC分类号： A61K00/00
CPC分类号： A61K35/28 , A01K67/0271 , A61K35/38 , A61K35/407 , C07K16/109
摘要： A non-human chimeric animal useful as a model for human HV infection, comprising a mammal M5 having xenogeneic cells; mammal M5 being derived from a mammal M1 treated to substantially destroy its hematopoietic cells and then transplanted with hematopoietic cells derived from one or more mammals M2 and transplanted with liver tissue from a mammal M3, the one or more mammals M2 and mammal M3 being from the same or from a different species; the transplanted hematopoietic cells from the one or more mammals M2 being either one or both of a hematopoietic cell preparation from a T cell deficient mammal or of a T cell depleted mammalian stem cell or bone marrow preparation; the transplanted liver tissue from mammal M3 being either a human liver tissue preparation or a liver tissue preparation from a non-human mammal capable of being infected by HV; the liver tissue preparation in the M5 mammal being infected by HV.
摘要翻译：可用作人HV感染模型的非人嵌合动物，其包含具有异种细胞的哺乳动物M5; 哺乳动物M5衍生自被治疗以基本上破坏其造血细胞并随后从源自一种或多种哺乳动物M2并从哺乳动物M3移植到肝组织的造血细胞移植的哺乳动物M1，一种或多种哺乳动物M2和哺乳动物M3来自相同或不同的物种; 来自一种或多种哺乳动物M2的移植的造血细胞是来自T细胞缺陷型哺乳动物或T细胞缺失的哺乳动物干细胞或骨髓制剂的造血细胞制剂中的一种或两种; 来自哺乳动物M3的移植的肝组织是人肝组织制剂或能够被HV感染的非人哺乳动物的肝组织制剂; M5哺乳动物的肝组织制剂被HV感染。

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