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1. 发明授权

US06645198B1 Systems and methods for reducing post-surgical complications 失效
标题翻译：用于减少手术后并发症的系统和方法
公开(公告)号：US06645198B1
公开(公告)日：2003-11-11
申请号：US09665730
申请日：2000-09-20
申请人： D. Bommi Bommannan , Michael D. Laufer
发明人： D. Bommi Bommannan , Michael D. Laufer
IPC分类号： A61B1818
CPC分类号： A61B18/1487 , A61B2017/00734 , A61B2018/00648 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875
摘要： The present invention provides systems and methods for applying RF energy to injured tissue, particularly the peritoneum, in order to prevent harmful post-surgical adhesions. One aspect of the invention is RF energy delivery systems employing trocars, which are designed for use in laparotomies and laparoscopies. Another aspect of the invention is an RF delivery system comprising a surgical sheet with one or more electrodes for delivering the RF energy to the injured tissue resulting from conventional surgical incisions into the abdominal wall. Additionally, another aspect of the invention provides methods for controlling the treatment dosage of RF heat to the injured tissue using parameters such as treatment time, change in tissue temperature, and change in tissue impedance.
摘要翻译：本发明提供了用于将RF能量应用于损伤的组织，特别是腹膜的系统和方法，以便防止有害的手术后粘连。本发明的一个方面是使用套管针的RF能量输送系统，其被设计用于剖腹手术和腹腔镜手术。本发明的另一方面是RF递送系统，其包括具有一个或多个电极的外科手术片，用于将RF能量传递到由常规外科切口进入腹壁的损伤组织。此外，本发明的另一方面提供了使用诸如治疗时间，组织温度变化和组织阻抗变化的参数来控制对受伤组织的RF热治疗剂量的方法。

2. 发明授权

US06775575B2 System and method for reducing post-surgical complications 失效
标题翻译：减少术后并发症的系统和方法
公开(公告)号：US06775575B2
公开(公告)日：2004-08-10
申请号：US10085237
申请日：2002-02-26
申请人： D. Bommi Bommannan , Michael D. Laufer
发明人： D. Bommi Bommannan , Michael D. Laufer
IPC分类号： A61F200
CPC分类号： A61B18/1445 , A61B18/082 , A61B2018/00702 , A61B2018/00791 , A61B2018/00875
摘要： Systems and methods for reducing or minimizing post-surgical complications are described. By applying energy to tissues under specifically controlled conditions, the formation of adhesions in response to cutting or other damage of those tissue may be eliminated or significantly reduced. According to an embodiment of the method of the invention, energy application is controlled to heat the tissue within a range of 61 to 100 degrees centigrade. In one embodiment, the system of the invention includes an easily manipulated applicator, having a scissor-like configuration and a controller for the energy application.
摘要翻译：描述了用于减少或最小化手术后并发症的系统和方法。通过在特定控制的条件下向组织施加能量，可以消除或显着降低响应于这些组织的切割或其他损伤的粘连形成。根据本发明的方法的一个实施例，控制能量施加以在61至100摄氏度的范围内加热组织。在一个实施例中，本发明的系统包括具有剪刀状构造的容易操作的施加器和用于能量应用的控制器。

3. 发明授权

US06520185B1 Systems and methods for reducing post-surgical complications 失效
公开(公告)号：US06520185B1
公开(公告)日：2003-02-18
申请号：US09388363
申请日：1999-09-01
申请人： D. Bommi Bommannan , Michael D. Laufer
发明人： D. Bommi Bommannan , Michael D. Laufer
IPC分类号： A61B1900
CPC分类号： A61B18/1487
摘要： The present invention provides systems and methods for applying RF energy to injured tissue, particularly the peritoneum, in order to prevent harmful post-surgical adhesions. One aspect of the invention is RF energy delivery systems employing trocars, which are designed for use in laparotomies and laparoscopies. Another aspect of the invention is an RF delivery system comprising a surgical sheet with one or more electrodes for delivering the RF energy to the injured tissue resulting from conventional surgical incisions into the abdominal wall. Additionally, another aspect of the invention provides methods for controlling the treatment dosage of RF heat to the injured tissue using parameters such as treatment time, change in tissue temperature, and change in tissue impedance.

4. 发明申请

US20110190726A1 Method and apparatus for micro-needle array electrode treatment of tissue 审中-公开
标题翻译：微针阵列电极治疗组织的方法和装置
公开(公告)号：US20110190726A1
公开(公告)日：2011-08-04
申请号：US13085971
申请日：2011-04-13
申请人： Basil M. Hantash , Joseph L. Dallarosa , D. Bommi Bommannan
发明人： Basil M. Hantash , Joseph L. Dallarosa , D. Bommi Bommannan
IPC分类号： A61M37/00 , A61N5/00
CPC分类号： A61N1/06 , A61B18/14 , A61B18/1477 , A61B2018/00023 , A61B2018/00083 , A61B2018/0016 , A61B2018/00452 , A61B2018/00476 , A61B2018/143 , A61B2018/1497 , A61M2037/0023 , A61M2037/0061 , A61N1/0502 , A61N1/40
摘要： Systems and methods for revitalizing aging skin using electromagnetic energy that is delivered using a plurality of needles that are capable of penetrating the skin to desired depths. A particular aspect is the capability to spare zones of tissue from thermal exposure. This sparing of tissue allows new tissue to be regenerated while the heat treatment can shrink the collagen and tighten the underlying structures. Additionally, the system is capable of delivering therapeutically beneficial substances either through the penetrating needles or through channels that have been created by the penetration of the needles.
摘要翻译：使用使用能够将皮肤穿透到期望深度的多个针递送的电磁能来振兴老化皮肤的系统和方法。一个特定的方面是从热暴露中排除组织区域的能力。这种组织的保留允许新组织再生，而热处理可以收缩胶原并收紧下面的结构。此外，该系统能够通过穿透针或通过由针的穿透产生的通道递送治疗有益的物质。

5. 发明申请

US20100286600A1 TRANSDERMAL PATCH DEVICE 审中-公开
标题翻译：透明贴片装置
公开(公告)号：US20100286600A1
公开(公告)日：2010-11-11
申请号：US12777037
申请日：2010-05-10
申请人： D. Bommi Bommannan
发明人： D. Bommi Bommannan
IPC分类号： A61M5/168 , A61K31/4402
CPC分类号： A61M5/14248 , A61K9/0004 , A61K9/0021 , A61K9/7084 , A61K31/4402 , A61M5/14276 , A61M37/00 , A61M2205/3303
摘要： A patch device worn by a user is disclosed that is configured to sense the presence of a harmful substance in the environment and to deliver an antidote to that substance into the user without the intervention of the user. The patch device incorporates a sensing mechanism configured to sense a presence of the harmful substance in the environment surrounding the patch device. On sensing the presence of the harmful substance, the sensor triggers a delivery mechanism, which causes the therapeutic agent to be injected into the user. The therapeutic agent acts to antidote the effects of the harmful substance within the user. The patch device could be used for protection against exposure to substances such as nerve gas and pesticides. The patch could be used to deliver the therapeutic agent either subcutaneously or transdermally.
摘要翻译：公开了一种用户佩戴的补丁装置，其被配置为感测环境中有害物质的存在并且在没有用户干预的情况下将该物质的解毒剂输送到用户中。补片装置包括感测机构，其被配置为感测在贴片装置周围的环境中有害物质的存在。在感测有害物质的存在时，传感器触发传递机制，其导致将治疗剂注射到使用者中。治疗剂用于解决用户内有害物质的影响。补片装置可用于防止暴露于神经气体和农药等物质。该贴剂可用于皮下或经皮递送治疗剂。

6. 发明申请

US20100256175A1 TREATMENT FOR DRUG ADDICTION 审中-公开
标题翻译：治疗药物滥用
公开(公告)号：US20100256175A1
公开(公告)日：2010-10-07
申请号：US12754559
申请日：2010-04-05
申请人： D. Bommi Bommannan
发明人： D. Bommi Bommannan
IPC分类号： A61K31/4355 , A61K31/135 , A61P25/30 , G01N33/68
CPC分类号： A61K31/135 , A61K31/137 , A61K31/4355 , G01N33/94
摘要： The invention discloses a method of treatment for drug addiction, comprising administering a therapeutic agent to a patient. The therapeutic agent is delivered in an inactive state and is converted into its active form in the presence of a narcotic. The conversion produces at least one unpleasant side effect for the patient. The therapeutic agent is implanted in the form of a depot, and maybe a prodrug or microspheres. The agent may be injectable or may be packaged in the form of bioerodible sticks. The agent may also be delivered via a surgical method. The disclosed method can also be used to detect the consumption of a banned substance.
摘要翻译：本发明公开了一种治疗药物成瘾的方法，包括向患者施用治疗剂。治疗剂以无活性状态递送，并在麻醉剂存在下转化为其活性形式。该转化对患者产生至少一种不愉快的副作用。治疗剂以贮库的形式植入，并且可以是前药或微球。试剂可以是可注射的或可以以生物浸渍棒的形式包装。该药剂也可以通过外科手术方式递送。所公开的方法也可用于检测禁用物质的消耗。

7. 发明授权

US06338731B1 Method and systems for reducing surgical complications 失效
标题翻译：减少手术并发症的方法和系统
公开(公告)号：US06338731B1
公开(公告)日：2002-01-15
申请号：US09271268
申请日：1999-03-17
申请人： Michael D. Laufer , D. Bommi Bommannan
发明人： Michael D. Laufer , D. Bommi Bommannan
IPC分类号： A61B1804
CPC分类号： A61B18/1487
摘要： Surgical complications can be minimized by reducing, or eliminating, the release of substances such as TGF-&bgr; from a surgical site by immediately sealing the edges of a surgically-made puncture or incision site. In one system, a treatment device includes an electrically conductive surface that is connected to a source of electrical energy and which can be placed in contact with the edge of a surgical incision or perforation site such that, when the conductive surface is electrically activated, it operates to heat the cellular material at the edge of the surgical incision or perforation site to inhibit (i.e., reduce) the formation of complicating connective tissue bridges. The source of electrical energy is, preferably, a radio-frequency generator.
摘要翻译：通过立即密封外科手术穿刺或切口部位的边缘，可通过减少或消除外科手术部位等物质如TGF-β的释放来最小化手术并发症。在一个系统中，治疗装置包括导电表面，其连接到电能源并且可以放置成与手术切口或穿孔部位的边缘接触，使得当导电表面被电激活时用于加热手术切口或穿孔部位边缘处的细胞材料以抑制（即，减少）复杂的结缔组织桥的形成。电能源优选地是射频发生器。

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