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1. 发明授权

US08652506B2 Bio-degradable block co-polymers for controlled release 有权
标题翻译：用于控制释放的生物可降解嵌段共聚物
公开(公告)号：US08652506B2
公开(公告)日：2014-02-18
申请号：US12133728
申请日：2008-06-05
申请人： Courtney Sikes , Mark Boden
发明人： Courtney Sikes , Mark Boden
IPC分类号： A61F2/00 , C08G63/08 , A61K47/34
CPC分类号： C08G63/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/602 , A61L2300/606 , C08L67/04
摘要： A block or graft copolymer includes a first block, and a second block different from the first block, wherein the first block is a poly(lactide-glycolide) copolymer. The polymers may be formulated in compositions with drug components for use in coating medical devices such as stents. Different blocks of the block or graft copolymer degrade in the body at different rates. The drug release profile from the coating is a combination the individual release rates of the different blocks and so can be controlled by controlling the selection and relative amounts of the respective blocks.
摘要翻译：嵌段或接枝共聚物包括第一嵌段和不同于第一嵌段的第二嵌段，其中第一嵌段是聚（丙交酯 - 乙交酯）共聚物。聚合物可以配制成具有药物组分的组合物，用于涂覆医疗装置如支架。嵌段或接枝共聚物的不同嵌段在体内以不同的速率降解。来自涂层的药物释放曲线是不同块的单独释放速率的组合，因此可以通过控制各个块的选择和相对量来控制。

2. 发明申请

US20090304767A1 Bio-Degradable Block Co-Polymers for Controlled Release 有权
标题翻译：用于控制释放的生物降解性共聚物
公开(公告)号：US20090304767A1
公开(公告)日：2009-12-10
申请号：US12133728
申请日：2008-06-05
申请人： Courtney Sikes , Mark Boden
发明人： Courtney Sikes , Mark Boden
IPC分类号： A61F2/00 , C08G63/08 , A61K47/34
CPC分类号： C08G63/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/602 , A61L2300/606 , C08L67/04
摘要： A block or graft copolymer includes a first block, and a second block different from the first block, wherein the first block is a poly(lactide-glycolide) copolymer. The polymers may be formulated in compositions with drug components for use in coating medical devices such as stents. Different blocks of the block or graft copolymer degrade in the body at different rates. The drug release profile from the coating is a combination the individual release rates of the different blocks and so can be controlled by controlling the selection and relative amounts of the respective blocks.
摘要翻译：嵌段或接枝共聚物包括第一嵌段和不同于第一嵌段的第二嵌段，其中第一嵌段是聚（丙交酯 - 乙交酯）共聚物。聚合物可以配制成具有药物组分的组合物，用于涂覆医疗装置如支架。嵌段或接枝共聚物的不同嵌段在体内以不同的速率降解。来自涂层的药物释放曲线是不同块的单独释放速率的组合，因此可以通过控制各个块的选择和相对量来控制。

3. 发明申请

US20070224234A1 Medical devices having biodegradable polymeric regions 审中-公开
标题翻译：医疗器械具有可生物降解的聚合物区域
公开(公告)号：US20070224234A1
公开(公告)日：2007-09-27
申请号：US11386273
申请日：2006-03-22
申请人： Mark Steckel , Courtney Sikes
发明人： Mark Steckel , Courtney Sikes
IPC分类号： A61F2/02
CPC分类号： A61L27/58 , A61F2210/0004 , A61L27/14
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more biodegradable polymeric regions. These biodegradable polymeric regions, in turn, contain one or more polymers, at least one of which is a biodegradable copolymer that includes: (a) one or more amorphous polymer blocks that display a glass transition temperature below 37° C. and (b) one or more amorphous polymer blocks displaying a glass transition temperature above 37° C.
摘要翻译：根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包含一个或多个可生物降解的聚合物区域。这些可生物降解的聚合物区域又包含一种或多种聚合物，其中至少一种是可生物降解的共聚物，其包括：（a）显示玻璃化转变温度低于37℃的一种或多种无定形聚合物嵌段和（b）显示玻璃化转变温度高于37℃的一种或多种无定形聚合物嵌段

4. 发明申请

US20090074838A1 MEDICAL DEVICES HAVING BIOERODABLE LAYERS FOR THE RELEASE OF THERAPEUTIC AGENTS 审中-公开
标题翻译：具有生物可降解层的医疗器械用于治疗药物释放
公开(公告)号：US20090074838A1
公开(公告)日：2009-03-19
申请号：US12056689
申请日：2008-03-27
申请人： Courtney Sikes , Mark Steckel
发明人： Courtney Sikes , Mark Steckel
IPC分类号： A61F2/04
CPC分类号： A61K9/0024 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/604 , C08L67/04
摘要： According to an aspect of the present invention, medical devices are provided which comprise: (a) a substrate, (b) an inner bioerodable polymeric layer over the substrate that comprises (i) 80 wt % or more of an amorphous biodegradable polymeric component and (ii) 20 wt % or less of a therapeutic agent component, and (c) an outer bioerodable polymeric layer over the inner bioerodable polymeric layer that comprises (i) 80 wt % or more of an amorphous biodegradable polymeric component and (ii) 20 wt % or less of a therapeutic agent component. The compositions of the inner and outer layers differ such that the outer layer has a bioerosion rate that is faster than that of the inner layer.
摘要翻译：根据本发明的一个方面，提供了医疗装置，其包括：（a）基底，（b）在基底上的内生物可蚀解聚合物层，其包含（i）80重量％或更多的无定形可生物降解的聚合物组分和（ii）20重量％或更少的治疗剂组分，和（c）内部生物可蚀解聚合物层上的外生物可蚀解聚合物层，其包含（i）80重量％或更多的无定形可生物降解聚合物组分和（ii）20 重量％以下的治疗剂成分。内层和外层的组成不同，使得外层具有比内层更快的生物腐蚀速率。

5. 发明授权

US08900619B2 Medical devices for the release of therapeutic agents 有权
标题翻译：医疗器械用于释放治疗剂
公开(公告)号：US08900619B2
公开(公告)日：2014-12-02
申请号：US11827462
申请日：2007-07-11
申请人： Shrirang V. Ranade , Courtney Sikes , Mark Steckel
发明人： Shrirang V. Ranade , Courtney Sikes , Mark Steckel
IPC分类号： A61F2/00 , A61L27/54 , A61L31/16 , A61L29/14 , A61L27/58 , A61L29/08 , A61L31/14 , A61L27/34 , A61L31/10 , A61L29/16
CPC分类号： A61L27/58 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604
摘要： According to one aspect of the invention, medical devices are provided which contain the following: (a) an interior region that contains at least one degradation promoting agent and (b) an exterior region disposed over the interior region that contains at least one biodegradable polymer and at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含以下物质的医疗装置：（a）含有至少一种降解促进剂的内部区域和（b）设置在内部区域上的外部区域，其包含至少一种可生物降解的聚合物和至少一种治疗剂。

6. 发明申请

US20080050418A1 Medical devices for the release of therapeutic agents 有权
标题翻译：医疗器械用于释放治疗剂
公开(公告)号：US20080050418A1
公开(公告)日：2008-02-28
申请号：US11827462
申请日：2007-07-11
申请人： Shrirang V. Ranade , Courtney Sikes , Mark Steckel
发明人： Shrirang V. Ranade , Courtney Sikes , Mark Steckel
IPC分类号： A61F2/04
CPC分类号： A61L27/58 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/148 , A61L29/16 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/604
摘要： According to one aspect of the invention, medical devices are provided which contain the following: (a) an interior region that contains at least one degradation promoting agent and (b) an exterior region disposed over the interior region that contains at least one biodegradable polymer and at least one therapeutic agent.
摘要翻译：根据本发明的一个方面，提供了包含以下物质的医疗装置：（a）含有至少一种降解促进剂的内部区域和（b）设置在内部区域上的外部区域，其包含至少一种可生物降解的聚合物和至少一种治疗剂。

7. 发明申请

US20050249799A1 Polymeric drug delivery system for hydrophobic drugs 审中-公开
标题翻译：用于疏水药物的聚合物药物递送系统
公开(公告)号：US20050249799A1
公开(公告)日：2005-11-10
申请号：US11072098
申请日：2005-03-03
申请人： Jules Jacob , Michael Bassett , Marcus Schestopol , Edith Mathlowitz , Avinash Nangia , Bennett Carter , Peyman Moslemy , Ze'ev Shaked , David Enscore , Courtney Sikes
发明人： Jules Jacob , Michael Bassett , Marcus Schestopol , Edith Mathlowitz , Avinash Nangia , Bennett Carter , Peyman Moslemy , Ze'ev Shaked , David Enscore , Courtney Sikes
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/24 , A61K9/28 , A61K9/48
CPC分类号： A61K9/209 , A61K9/0065 , A61K9/1635 , A61K9/1641 , A61K9/1647 , A61K9/1652 , A61K9/1676 , A61K9/2054 , A61K9/2077 , A61K9/2086 , A61K9/2853
摘要： An oral delivery system for Class II drugs that have low oral bioavailability due to their insolubility in water and slow dissolution kinetics and method for making such a drug delivery system are disclosed herein. The formulation may be a controlled release or immediate release formulation. The immediate release formulation contains a Class II drug, together with a hydrophobic polymer, preferably a bioadhesive polymer. In one embodiment, the drug and polymer are co-dissolved in a common solvent. The solution is formed into small solid particles by any convenient method, particularly by spray drying. The resulting particles contain drug dispersed as small particles in a polymeric matrix. The particles are stable against aggregation, and can be put into capsules or tableted for administration. The controlled release formulations contain a BCS Class II drug and a bioadhesive polymer. The controlled release formulations may be in the form of a tablet, capsules, mini-tab, microparticulate, or osmotic pump. Enhancement of oral uptake of the drug from use of bioadhesive polymers occurs through (1) increased dissolution kinetics due to stable micronization of the drug, (2) rapid release of the drug from the polymer in the GI tract; and (3) prolonged GI transit due to bioadhesive properties of the polymers. The combination of these effects allows the preparation of a compact, stable dosage form suitable for oral administration of many class II drugs.
摘要翻译：本文公开了由于其在水中的不溶性和缓慢的溶解动力学以及制备这种药物递送系统的方法而具有低口服生物利用度的II类药物的口服递送系统。制剂可以是控释或即时释放制剂。立即释放制剂含有II类药物，以及疏水性聚合物，优选生物粘附性聚合物。在一个实施方案中，将药物和聚合物共溶于常用溶剂。通过任何方便的方法，特别是通过喷雾干燥，将溶液形成小的固体颗粒。所得到的颗粒含有作为小颗粒分散在聚合物基质中的药物。颗粒对聚集是稳定的，并且可以放入胶囊或压片以供给药。控释制剂含有BCS II类药物和生物粘附性聚合物。控制释放制剂可以是片剂，胶囊，迷你片，微粒或渗透泵的形式。通过（1）由于药物的稳定的微粉化引起的溶出动力学增加，（2）药物从胃肠道中的聚合物快速释放，增加了使用生物粘附性聚合物对药物的口服摄取。和（3）由于聚合物的生物粘合性质而延长GI运输。这些作用的组合允许制备适于口服多种II类药物的紧凑，稳定的剂型。

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