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1. 发明公开

EP3218397A1 NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE 有权转让
标题翻译：使埃博拉病毒糖蛋白中性化抗体及其应用
公开(公告)号：EP3218397A1
公开(公告)日：2017-09-20
申请号：EP15797815.6
申请日：2015-11-13
申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services , Corti, Davide , The United States Government, as represented by The Secretary of The Army , Humabs Biomed S.A. , Institute for Research in Biomedicine
发明人： CORTI, Davide , LANZAVECCHIA, Antonio , TREFRY, John , SULLIVAN, Nancy , MULANGU, Sabue , GRAHAM, Barncy , MUYEMBE-TAMFUN, Jean-Jacques , LEDGERWOOD, Julie , STANLEY, Daphne
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/08
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
摘要翻译：公开了特异性结合埃博拉病毒糖蛋白的中和抗体和抗原结合片段。还提供了编码这些抗体的核酸，载体和宿主细胞。公开了使用抗体和抗原结合片段检测埃博拉病毒的方法。例如，抗体，抗原结合片段，核酸和载体可用于预防和/或治疗受试者中的埃博拉病毒感染。

2. 发明公开

EP2828293A1 ANTIBODIES THAT NEUTRALIZE RSV, MPV AND PVM AND USES THEREOF 有权转让
标题翻译： ANTKÖRPERZUR NEUTRALISIERUNG VON RSV，MPV UND PVM SOWIE VERWENDUNGEN DAVON
公开(公告)号：EP2828293A1
公开(公告)日：2015-01-28
申请号：EP13724357.2
申请日：2013-03-14
申请人： Humabs Biomed S.A. , Corti, Davide
发明人： CORTI, Davide
IPC分类号： C07K16/10 , A61K39/395 , A61P31/14 , C07K14/135
CPC分类号： C07K16/1027 , A61K39/42 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N2760/18522
摘要： The invention relates to antibodies, and antigen binding fragments thereof, that neutralize infection of both RSV, MPV and PVM. The invention also relates to nucleic acids that encode, immortalized B cells and cultured plasma cells that produce, and to polypeptides that bind to such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and polypeptides recognized by the antibodies of the invention in screening methods as well as in the diagnosis, treatment and prevention of RSV or MPV infection and RSV and MPV co-infection.
摘要翻译：本发明涉及中和RSV，MPV和PVM感染的抗体及其抗原结合片段。本发明还涉及编码永生化B细胞的核酸和产生与这些抗体和抗体片段结合的多肽的培养浆细胞。此外，本发明涉及本发明抗体识别的抗体，抗体片段和多肽在筛选方法以及RSV或MPV感染和RSV和MPV共感染的诊断，治疗和预防中的用途。

3. 发明申请

WO2022067269A2 ANTIBODIES AGAINST SARS-COV-2 审中-公开
公开(公告)号：WO2022067269A2
公开(公告)日：2022-03-31
申请号：PCT/US2021/052481
申请日：2021-09-28
申请人： HUMABS BIOMED SA , CORTI, Davide , DE MARCO, Anna , PIZZUTO, Matteo Samuele , GUARINO, Barbara , LEMPP, Florian , CHEN, Alex , ROSEN, Laura
发明人： CORTI, Davide , DE MARCO, Anna , PIZZUTO, Matteo Samuele , GUARINO, Barbara , LEMPP, Florian , CHEN, Alex , ROSEN, Laura
IPC分类号： C07K16/10 , A61P31/14 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K2317/21 , C07K2317/526 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to a SARS-CoV-2 antigen and, in certain embodiments, are capable of neutralizing a SARS-CoV-2 infection. In certain embodiments, an antibody or antigen-binding fragment is capable of binding to a SARS-CoV-2 spike protein in the N-terminal domain (NTD). Also provided are polynucleotides that encode an antibody or antigen-binding fragment, vectors that comprise a polynucleotide, host cells that express an antibody or antigen-binding fragment, pharmaceutical compositions, and methods for treating or diagnosing a SARS-CoV-2 infection.

4. 发明申请

WO2021226560A1 ANTIBODIES AGAINST SARS-COV-2 审中-公开
公开(公告)号：WO2021226560A1
公开(公告)日：2021-11-11
申请号：PCT/US2021/031442
申请日：2021-05-07
申请人： VIR BIOTECHNOLOGY, INC. , HUMABS BIOMED SA , CORTI, Davide , PIZZUTO, Matteo , PINTO, Dora , BELTRAMELLO, Martina , DE MARCO, Anna , CAMERONI, Elisabetta , SNELL, Gyorgy , CZUDNOCHOWSKI, Nadine , HAVENAR, Colin , LEMPP, Florian , TELENTI, Amalio
发明人： CORTI, Davide , PIZZUTO, Matteo , PINTO, Dora , BELTRAMELLO, Martina , DE MARCO, Anna , CAMERONI, Elisabetta , SNELL, Gyorgy , CZUDNOCHOWSKI, Nadine , HAVENAR, Colin , LEMPP, Florian , TELENTI, Amalio
IPC分类号： C07K16/10 , A61P31/14 , A61K39/395
摘要： The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind to a SARS-CoV-2 antigen and, in certain embodiments, are capable of potently neutralizing a SARS-CoV-2 infection. Also provided are polynucleotides that encode antibodies and antigen-binding fragments, vectors, host cells, and related compositions and uses, including for preventing, treating, and diagnosing an infection by SARS-CoV-2 or another coronavirus.

5. 发明申请

WO2016077789A8 NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE 审中-公开
公开(公告)号：WO2016077789A8
公开(公告)日：2016-05-19
申请号：PCT/US2015/060733
申请日：2015-11-13
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , CORTI, Davide , LANZAVECCHIA, Antonio , TREFRY, John
发明人： CORTI, Davide , LANZAVECCHIA, Antonio , TREFRY, John , SULLIVAN, Nancy , MULANGU, Sabue , GRAHAM, Barncy , MUYEMBE-TAMFUN, Jean-jacques , LEDGERWOOD, Julie , STANLEY, Daphne
IPC分类号： C07K16/10
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.

6. 发明申请

WO2009135817A1 MEDIUM VOLTAGE SWITCH UNIT. 审中-公开
标题翻译：中压开关单元。
公开(公告)号：WO2009135817A1
公开(公告)日：2009-11-12
申请号：PCT/EP2009/055356
申请日：2009-05-04
申请人： ABB Technology AG , BONFANTI, Alessandro , CORTI, Davide
发明人： BONFANTI, Alessandro , CORTI, Davide
IPC分类号： H01H33/14 , H01H31/00 , H01H31/28
CPC分类号： H01H33/143 , H01H31/003 , H01H31/28 , H02B1/32 , H02B11/18 , H02B13/02
摘要： A medium voltage switch unit comprising an interruption unit and a disconnection unit, wherein the interruption unit comprises a first and a second interruption contact and a first drive unit which moves one of said interruption contacts between a first position in which they are in electrical connection and a second position in which they are spaced apart. The disconnection unit comprises a first and a second fixed disconnection contacts couplable and uncouplable with respective first and second movable disconnection contacts mounted on the interruption unit and electrically connected to the first interruption contact. The interruption unit is mechanically supported by a first fixed conductor and the second interruption contact is electrically connected to said first fixed conductor. The disconnection unit comprises a second drive unit which moves the interruption unit, relative to said first conductor, between: a first disconnector position in which the first movable disconnection contact and the first fixed disconnection contact are coupled while the second movable disconnection contact is isolated from said second fixed disconnection contact; a second disconnector position in which the first and second movable disconnection contacts are isolated from the first and second fixed disconnection contacts; and a third disconnector position in which the second movable disconnection contact and the second fixed disconnection contact are coupled while the first movable disconnection contact is isolated from said first fixed disconnection contact.
摘要翻译：一种中压开关单元，包括中断单元和断开单元，其中所述中断单元包括第一和第二中断触点和第一驱动单元，所述第一和第二中断触点在所述中断触点之间移动所述中断触点之间的第一位置，第二位置，它们被间隔开。断开单元包括第一和第二固定断开触头，可与安装在中断单元上的电连接到第一中断触点的相应的第一和第二可移动断开触点联接和不可分开。中断单元由第一固定导体机械地支撑，并且第二中断触点电连接到所述第一固定导体。所述断开单元包括第二驱动单元，所述第二驱动单元相对于所述第一导体移动所述中断单元，所述第二驱动单元在第一断路器位置处，所述第一断路器位置中所述第一可移动断开触点和所述第一固定断开触点联接，而所述第二可移动断开触点被隔离第二固定断开接点; 第二断路器位置，其中第一和第二可移动断开触点与第一和第二固定断开触点隔离; 以及第三断路器位置，其中所述第二可移动断路触点和所述第二固定断开触点在所述第一可移动断开触点与所述第一固定断开触点隔离的状态下耦合。

7. 发明申请

WO2021247925A1 STRUCTURE-GUIDED IMMUNOTHERAPY AGAINST SARS-COV-2 审中-公开
公开(公告)号：WO2021247925A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035782
申请日：2021-06-03
申请人： VIR BIOTECHNOLOGY, INC. , UNIVERSITY OF WASHINGTON , HUMABS BIOMED SA , CORTI, Davide , SNELL, Gyorgy , CZUDNOCHOWSKI, Nadine , VEESLER, David , WALLS, Alexandra C. , PARK, Young-Jun , TORTORICI, M. Alejandra
发明人： CORTI, Davide , SNELL, Gyorgy , CZUDNOCHOWSKI, Nadine , VEESLER, David , WALLS, Alexandra C. , PARK, Young-Jun , TORTORICI, M. Alejandra
IPC分类号： A61P31/14 , C07K16/10 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The instant disclosure provides antibodies and antigen-binding fragments thereof that can bind in certain regions of a SARS-CoV-2 S glycoprotein and can neutralize a SARS-CoV-2 infection. Also provided are immunogenic compositions that comprise a SARS-CoV-2 S glycoprotein or a portion thereof that is capable of being bound by an antibody or antigen-binding fragment.

8. 发明申请

WO2016075546A3 ANTIBODIES THAT NEUTRALIZE EBOLA VIRUS AND USES THEREOF 审中-公开
标题翻译：中毒EBOLA病毒的抗体及其用途
公开(公告)号：WO2016075546A3
公开(公告)日：2016-06-30
申请号：PCT/IB2015002342
申请日：2015-11-13
申请人： LANZAVECCHIA ANTONIO , CORTI DAVIDE
发明人： LANZAVECCHIA ANTONIO , CORTI DAVIDE
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , C07K2317/21 , C07K2317/565
摘要： The invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to the Ebola virus GP protein or neutralize infection of Ebola virus. The invention also relates to antigenic sites to which the antibodies and antigen binding fragments bind, as well as to nucleic acids that encode, and immortalized B cells and cultured plasma cells that produce, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and polypeptides recognized by the antibodies of the invention in screening methods as well as in the diagnosis, treatment and prevention of Ebola virus infection.
摘要翻译：本发明涉及特异性结合埃博拉病毒GP蛋白或中和埃博拉病毒感染的抗体及其抗原结合片段。本发明还涉及抗体和抗原结合片段结合的抗原位点，以及编码和永生化的B细胞的核酸和产生此类抗体和抗体片段的培养的浆细胞。此外，本发明涉及本发明抗体识别的抗体，抗体片段和多肽在筛选方法以及埃博拉病毒感染的诊断，治疗和预防中的用途。

9. 发明申请

WO2016077789A1 NEUTRALIZING ANTIBODIES TO EBOLA VIRUS GLYCOPROTEIN AND THEIR USE 审中-公开
标题翻译：将抗体中和给EBOLA VIRUS GLYCOPROTEIN及其使用
公开(公告)号：WO2016077789A1
公开(公告)日：2016-05-19
申请号：PCT/US2015060733
申请日：2015-11-13
申请人： USA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES , CORTI DAVIDE , LANZAVECCHIA ANTONIO , TREFRY JOHN
发明人： CORTI DAVIDE , LANZAVECCHIA ANTONIO , TREFRY JOHN , SULLIVAN NANCY , MULANGU SABUE , GRAHAM BARNCY , MUYEMBE-TAMFUN JEAN-JACQUES , LEDGERWOOD JULIE , STANLEY DAPHNE
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , A61K2039/505 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/732 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N2333/08
摘要： Neutralizing antibodies and antigen binding fragments that specifically bind to Ebola virus glycoprotein are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting Ebola virus using the antibodies and antigen binding fragments are disclosed. The antibodies, antigen binding fragments, nucleic acids, and vectors, can be used, for example, to prevent and/or treat Ebola virus infection in a subject.
摘要翻译：公开了特异性结合埃博拉病毒糖蛋白的中和抗体和抗原结合片段。还提供了编码这些抗体的核酸，载体和宿主细胞。公开了使用抗体和抗原结合片段检测埃博拉病毒的方法。抗体，抗原结合片段，核酸和载体可用于例如预防和/或治疗受试者中的埃博拉病毒感染。

10. 发明申请

WO2016075546A2 ANTIBODIES THAT NEUTRALIZE EBOLA VIRUS AND USES THEREOF 审中-公开
标题翻译：中和EBOLA病毒及其用途的抗体
公开(公告)号：WO2016075546A2
公开(公告)日：2016-05-19
申请号：PCT/IB2015/002342
申请日：2015-11-13
申请人： LANZAVECCHIA, Antonio , CORTI, Davide
发明人： LANZAVECCHIA, Antonio , CORTI, Davide
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , C07K2317/21 , C07K2317/565
摘要： The invention relates to antibodies, and antigen binding fragments thereof, that specifically bind to the Ebola virus GP protein or neutralize infection of Ebola virus. The invention also relates to antigenic sites to which the antibodies and antigen binding fragments bind, as well as to nucleic acids that encode, and immortalized B cells and cultured plasma cells that produce, such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies, antibody fragments, and polypeptides recognized by the antibodies of the invention in screening methods as well as in the diagnosis, treatment and prevention of Ebola virus infection.
摘要翻译：本发明涉及特异性结合埃博拉病毒GP蛋白或中和埃博拉病毒感染的抗体及其抗原结合片段。本发明还涉及抗体和抗原结合片段结合的抗原位点，以及编码产生这种抗体和抗体片段的永生化B细胞和培养浆细胞的核酸。另外，本发明涉及由本发明的抗体识别的抗体，抗体片段和多肽在筛选方法以及埃博拉病毒感染的诊断，治疗和预防中的用途。

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