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    • 8. 发明授权
    • Method for preparing L-carnitine
    • L-肉毒碱的制备方法
    • US4413142A
    • 1983-11-01
    • US358326
    • 1982-03-15
    • Mario FioriniClaudio Valentini
    • Mario FioriniClaudio Valentini
    • C07C227/26C07C29/10C07C31/42C07C229/22C07D317/20C07C101/30
    • C07C255/00C07C29/103C07C31/42C07D317/20C07B2200/07
    • L-carnitine is prepared by a synthesizing process starting from D-mannitol. The synthesis is started with the formation of a D-mannitol ketonide (more specifically D-mannitol acetonide from D-mannitol and acetone, whereafter the D-mannitol is split by oxidation to give glyceraldehyde acetonide, which is further reduced to glycerol acetonide. Then the free hydroxyl group is exchanged with a halogen atom (chlorine) with the formation of chlorodihydroxy propane, the primary alcoholic group of which is functionalized with the acid chloride of a sulfonic acid (tosylchloride). The reaction of the tosyl derivative with the salt of hydrogen cyanide leads to the formation of the corresponding nitrile which, when reacted with trimethylamine gives carnitinonitrile. The nitrile group is now hydrolyzed to give L-carnitine chloride. The formation of L-carnitine can then be obtained by exchanging the chloride ion with a hydroxyl ion.
    • L-肉碱通过从D-甘露糖醇开始的合成方法制备。 从D-甘露糖醇和丙酮形成D-甘露醇酮酮(更具体地说是D-甘露糖醇缩酮化合物)开始合成,然后通过氧化将D-甘露糖醇分裂,得到甘油醛缩酮,进一步还原成甘油丙酮化物 游离羟基与卤素原子(氯)交换,形成氯二羟基丙烷,其主要的醇基被磺酸(甲苯磺酰氯)的酰氯官能化,甲苯磺酰基衍生物与盐 氰化氢导致相应的腈的形成,当与三甲胺反应产生肉碱腈时,腈基现在被水解以得到L-肉碱氯化物,然后可以通过将氯离子与羟基交换来获得左旋肉碱的形成 离子。