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1. 发明授权

US4902286A Container for fertilization of human ovocytes in the absence of CO.sub.2 -enriched air 失效
标题翻译：在没有二氧化碳浓缩空气的情况下，人体卵母细胞受精的容器
公开(公告)号：US4902286A
公开(公告)日：1990-02-20
申请号：US80537
申请日：1987-07-06
申请人： Claude Ranoux
发明人： Claude Ranoux
IPC分类号： A61B17/42 , A61B17/425 , A61B17/435 , A61B19/02 , A61H1/00 , C12M1/00
CPC分类号： A61B17/435 , A61B50/00
摘要： The invention relates to a container for fertilization of human ovocytes in the absence of CO.sub.2 which may be done in an incubuator at 37.degree. C. or in the vaginal cavity. The container of cylindrical shape has smooth and rounded walls 1 whose thickness is 2 mm in the body 2 of the cylinder but only 1 mm at the neck 3. On the outer wall of the neck is seen a screwthread 4 permitting external screwing on of the plug 12 whose sides are smooth and rounded. The blind end 5 of the container is rounded, the other 6 is flat and has a round orifice 7, which orifice is closed by a fine membrane 9 permitting hermeticity of the tube in order to avoid disorders of the culture medium 8 present in the container as of manufacture. Above the liquid remains about 200 .mu.l of gas 10. The inner walls 11 are smooth and rounded. After depositing the ovocytes and spermatozoa necessary for fertilization, and therefore after rupture of the membrane, hermeticity will be effected by two seals, after screwing on the plug, a circular one 13 at the neck of the tube, the other 14 on the endwall of the plug which will be flattened against the orifice of the tube 7 by a relief portion, located on the endwall of the plug 15, whose diameter is substantially that of the orifice. The container will be held in the posterior fornix of the vaginal cavity by a flexible ring comprised of a metal strip 17 sheathed in rubber 18 to which is fixed a rubber pouch 19 in which the container is placed.This device thus permits inter-vaginal, fertilization of human ovocytes in the absence of CO.sub.2 -enriched air, the vaginal cavity replacing the incubator conventionally used.
摘要翻译： PCT No.PCT / FR86 / 00378 Sec。 371日期1987年7月6日 102（e）1987年7月6日PCT PCT 1986年11月7日PCT公布。出版物WO87 / 02879 日期：1987年5月21日。本发明涉及在不存在CO 2的情况下对人卵母细胞受精的容器，其可以在37℃或阴道腔的培养器中进行。圆柱形容器具有平滑且圆形的壁1，其在圆筒体2中的厚度为2mm，而在颈部3处仅为1mm。在颈部的外壁上看到螺纹4，允许外部拧紧插头12的侧面光滑圆滑。容器的盲端5是圆形的，另一个6是平的并且具有圆形孔口7，该孔口被允许管的气密性的细膜9封闭，以避免存在于容器中的培养基8的紊乱作为制造。液体上方保留有约200微升的气体10.内壁11是平滑和圆形的。沉积卵母细胞和受精精子后，因此在膜破裂后，气密性将通过两个密封件进行，在螺栓上拧上塞子后，在管子的颈部有一个圆形的13，另一个在端壁上的14个该插头将通过位于插头15的端壁上的释放部分而平直于管7的孔口，该直径基本上是孔口的端壁。容器将通过柔性环保持在阴道腔的后穹窿中，所述柔性环由固定在其中放置容器的橡胶囊19的橡胶18中的金属带17组成。因此，该装置允许在没有富含CO 2的空气的情况下进行人卵母细胞的阴道内受精，阴道腔代替常规使用的培养箱。

2. 发明授权

US06050935A Container assembly for intravaginal fertilization and culture and embryo transfer and method of intravaginal fertilization and culture employing such a container 失效
标题翻译：用于阴道内受精和培养和胚胎移植的容器组装和使用这种容器的阴道内受精和培养的方法
公开(公告)号：US06050935A
公开(公告)日：2000-04-18
申请号：US854272
申请日：1997-05-09
申请人： Claude Ranoux , Francis G. Gleason, Jr.
发明人： Claude Ranoux , Francis G. Gleason, Jr.
IPC分类号： C12M3/00 , A61B20060101 , A61B17/42 , A61B17/435 , A61B19/02 , A61D19/02 , A61D19/04 , C07C229/64 , C07C233/54 , C07C311/21 , C12N5/06 , A61D7/00
CPC分类号： C07C229/64 , A61B17/435 , A61B50/00 , A61D19/04 , C07C233/54 , C07C311/21 , A61B17/425 , A61D19/022 , Y10S604/906
摘要： An intravaginal fertilization and culture container includes a main chamber and a microchamber. A culture medium, one or more oocytes and sperm are introduced through an access opening having an associated resealable closure device. The container is enveloped in a capsule of soft elastic material prior to lodgment in the posterior fornix. A loop on one capsule part adapts the length to anatomic variations. The microchamber has a channel which receives the catheter tip to facilitate embryo retrieval while eliminating risk of injury thereto. The microchamber permits embryos to be microscopically inspected in situ before transfer to the uterine cavity.
摘要翻译：阴道内受精和培养容器包括主室和微室。培养基，一个或多个卵母细胞和精子通过具有相关联的可密封闭合装置的进入开口引入。在后穹窿放置之前，容器被包裹在软弹性材料的胶囊中。一个胶囊部分上的环将长度适应于解剖变异。微室具有接收导管尖端以便于胚胎恢复的通道，同时消除其损伤的风险。微生物允许胚胎在转移到子宫腔之前在原位进行微观检查。

3. 发明授权

US5532155A Spontaneous cycle fertilization method 失效
标题翻译：自发周期受精方法
公开(公告)号：US5532155A
公开(公告)日：1996-07-02
申请号：US977409
申请日：1993-04-30
申请人： Claude Ranoux
发明人： Claude Ranoux
IPC分类号： A61B17/425 , A61B17/42 , A61B17/435 , A61B17/43
CPC分类号： A61B17/435 , Y10S436/906
摘要： A fertilization method wherein an oocyte puncture is performed and one or more oocytes are inserted into a container containing a culture medium having no added air or CO.sub.2 and intended for the fertilization and culture of the oocyte(s), as well as spermatozoa, whereafter the container is sealed and inserted into the vagina or uterus to allow fertilization of the oocyte(s) and culture of the embryo(s). The method is characterized in that it is performed without stimulating the cycle, with LH supervision by means of blood assays, and by programming the oocyte puncture according to the LH value. The container may be kept at a temperature of approximately 37.degree. C. for 2 to 6 hours for maturation before being inserted into the vagina.
摘要翻译： PCT No.PCT / FR92 / 00615 Sec。 371日期：1993年04月30日 102（e）日期1993年4月30日PCT提交1992年7月1日PCT公布。公开号WO93 / 00863 日期1993年1月21日。一种受精方法，其中进行卵母细胞穿刺，并将一个或多个卵母细胞插入含有不含添加空气或CO 2并用于受精和培养卵母细胞的培养基的容器中，以及精子，然后将容器密封并插入阴道或子宫以允许卵母细胞受精和胚胎培养。该方法的特征在于其不刺激循环而进行，通过血液检测进行LH监督，并根据LH值编程卵母细胞穿刺。在插入阴道之前，将容器保持在约37℃的温度下2至6小时以便成熟。

4. 发明授权

US5135865A Container for fertilization of human ovocytes in the absence of CO.sub.2 -enriched air 失效
标题翻译：在没有二氧化碳浓缩空气的情况下，人体卵母细胞受精的容器
公开(公告)号：US5135865A
公开(公告)日：1992-08-04
申请号：US329640
申请日：1989-03-28
申请人： Claude Ranoux
发明人： Claude Ranoux
IPC分类号： A61B17/435 , A61B19/02 , C12N5/08
CPC分类号： A61B17/435 , A61B50/00
摘要： The invention relates to a container for fertilization of human ovocytes in the absence of CO.sub.2 which may be done in an incubator at 37.degree. C. or in the vaginal cavity. The container will be held in the posterior fornix of the vaginal cavity by a flexible ring comprised of a metal strip 17 sheathed in rubber 18 to which is fixed a rubber pouch 19 in which the container is placed. This device thus permits inter-vaginal fertilization of human ovocytes in the absence of CI.sub.2 -enriched air, the vaginal cavity replacing the incubator conventionally used.
摘要翻译：本发明涉及一种用于在不存在CO 2的情况下对人卵母细胞受精的容器，其可以在37℃或阴道腔的培养箱中进行。容器将通过柔性环保持在阴道腔的后穹窿中，所述柔性环由固定在其中放置容器的橡胶囊19的橡胶18中的金属带17组成。因此，在不存在富CI2的空气的情况下，该装置允许人卵母细胞的阴道内受精，阴道腔代替常规使用的培养箱。

5. 再颁专利

USRE39533E1 Process for intra-uterine fertilization in mammals and device for implementation thereof 失效
标题翻译：哺乳动物子宫内受精的方法及其实施装置
公开(公告)号：USRE39533E1
公开(公告)日：2007-03-27
申请号：US08128682
申请日：1988-05-02
申请人： Claude Ranoux
发明人： Claude Ranoux
IPC分类号： A61B17/43 , A61D7/00
CPC分类号： A61B17/435 , Y10S604/906
摘要： The A fertilization process comprises includes the following steps: a) a container (15) which can be introduced into, and lodged in, the uterine cavity of the mammal is provided; b) the container (15) is filled with a culture medium, at least one ovocyte of the mammal, and spermatozoa; c) the filled container (15) is inserted into the uterine cavity; d) the container (15) is left for a given length of time to allow fertilization of the ovocyte(s) to take place; e) the contents of the container (15) are released into the uterine cavity. The container may be made from a tube of biodegradable or non-biodegradable material. In the latter case, it is associated with a stiffening device. A biodegradable container (15) filled with gametes and a culture medium is placed in the uterine cavity using an implantation device (20) which is then withdrawn from the mammal's genital tract.
摘要翻译： A受精过程包括以下步骤：a）提供可以引入哺乳动物的子宫腔内并容纳在哺乳动物的子宫腔中的容器（15）; b）容器（15）填充有培养基，哺乳动物的至少一个卵母细胞和精子; c）将填充的容器（15）插入子宫腔中; d）将容器（15）放置一段给定的时间以允许卵母细胞受精; e）容器（15）的内容物释放到子宫腔中。容器可以由可生物降解的或不可生物降解的材料管制成。在后一种情况下，它与加强装置相关联。使用植入装置（20）将填充有配子和培养基的可生物降解的容器（15）放置在子宫腔中，然后将其从哺乳动物的生殖道中取出。

6. 发明申请

US20060228794A1 Incubation and/or stroage container system and method 审中-公开
标题翻译：孵化和/或分配容器系统和方法
公开(公告)号：US20060228794A1
公开(公告)日：2006-10-12
申请号：US10544990
申请日：2004-02-10
申请人： Claude Ranoux , John Walsh , Robert Etheredge III , Robert Maloney , Francis Gleason Jr.
发明人： Claude Ranoux , John Walsh , Robert Etheredge III , Robert Maloney , Francis Gleason Jr.
IPC分类号： C12M1/00 , C12M3/00
CPC分类号： A61D19/022 , A61D19/04 , Y10S604/906
摘要： A container assembly (10) comprises a vessel (21) for containing a biological medium, gametes and/or one or more embryo(s). The vessel (21) has a CO2 permeable seal (28) and a closure device (30) for selective access. A buffer chamber (60) for a CO2 enriched atmosphere at least partially surrounds the vessel and is defined by a shell (61). The buffer chamber is in communication with the CO2 permeable wall. Such a container assembly is particularly adapted for IVC in which case the permeable seal (28) prevents ingress of vaginal secretions. The buffer chamber (60) mediates the aqueous pH in the vessel after the container assembly is removed from a CO2 enriched environment.
摘要翻译：容器组件（10）包括用于容纳生物介质，配子和/或一个或多个胚胎的容器（21）。容器（21）具有CO 2/2渗透密封件（28）和用于选择性进入的封闭装置（30）。用于CO 2富集气氛的缓冲室（60）至少部分地围绕容器并由壳体（61）限定。缓冲室与CO 2可渗透壁连通。这种容器组件特别适用于IVC，在这种情况下，可渗透密封件（28）防止阴道分泌物进入。在从CO 2富含环境移除容器组件之后，缓冲室（60）介导容器中的水性pH。

7. 发明申请

US20100103512A1 INSPECTION BLOCK FOR USE IN MICROSCOPIC INSPECTION OF EMBRYOS OR OTHER BIOLOGICAL MATTER INSIDE A CONTAINER UNIT AND METHOD OF MICROSCOPICALLY INSPECTING EMBRYOS OR OTHER BIOLOGICAL MATTER 审中-公开
标题翻译：检查块用于微观检查胚胎或其他生物物质在容器单元内的微观检查方法和微观检查胚胎或其他生物学特性的方法
公开(公告)号：US20100103512A1
公开(公告)日：2010-04-29
申请号：US12258874
申请日：2008-10-27
申请人： CLAUDE RANOUX , JOHN E. WALSH , JAMES A. LUDOVICZ
发明人： CLAUDE RANOUX , JOHN E. WALSH , JAMES A. LUDOVICZ
IPC分类号： G02B21/34 , G02B21/30
CPC分类号： G01N21/03 , A61D19/022
摘要： An inspection block is disclosed for use in inspection of biological matter in a container unit which has a chamber with transparent walls, the inspection block having a transverse docking passage for receiving and positioning a container unit, an observation chamber extending transversely relative to the docking passage and in communication therewith such that the biological matter located inside the container unit may be microscopically inspected through the chamber walls, transparent liquid for immersing at least part of the container unit so as to define a chamber wall/liquid optical interface for microscopic inspection therethrough. The inspection block may be made of steel, aluminum or plastic. In the latter case, the plastic inspection block may have closed cavities for containing insulating blocks and/or one or more downwardly opening air pockets retaining heat given off by a warmed work bench and/or warmed microscope stage on which the inspection block is supported during inspection.
摘要翻译：公开了用于检查具有透明壁的室的容器单元中的生物物质的检查块，检查块具有用于接收和定位容器单元的横向对接通道，观察室相对于对接通道横向延伸并且与其连通，使得位于容器单元内的生物物质可以通过室壁进行微观检查，用于浸入容器单元的至少一部分的透明液体以便限定用于通过其进行显微镜检查的室壁/液体光学界面。检查块可以由钢，铝或塑料制成。在后一种情况下，塑料检查块可以具有闭合的空腔，用于容纳绝缘块和/或一个或多个向下开口的气穴，其保持由加热的工作台和/或加热的显微镜载台所发出的热量，其上检查块被支撑在其上检查。

8. 发明授权

US07282363B1 Intravaginal culture (IVC) method and container therefor 失效
标题翻译：阴道内培养（IVC）方法及其容器
公开(公告)号：US07282363B1
公开(公告)日：2007-10-16
申请号：US10240935
申请日：2000-04-18
申请人： Claude Ranoux , Francis G. Gleason, Jr.
发明人： Claude Ranoux , Francis G. Gleason, Jr.
IPC分类号： C12M1/24 , C12M3/00
CPC分类号： C07C229/64 , A61B17/425 , A61B17/435 , A61B50/00 , A61D19/022 , A61D19/04 , C07C233/54 , C07C311/21 , Y10S604/906
摘要： A fertilization and culture container, e.g. for intravaginal use, comprises a container body having an orifice for introducing a culture medium, one or more oocytes and sperm, resealable closure means for selectively opening and closing the container body orifice, the container body having a main chamber for receiving the culture medium, oocytes and sperm and a microchamber for collecting for retrieval of one or more embryos. The container body has elements for restricting access of retrieval catheter or pipette relative to the microchamber. At least a portion of a sidewall of the container body defining said microchamber is transparent and of optical quality for microscopic inspection of embryos prior to and/or during retrieval with a catheter or a pipette.
摘要翻译：受精和培养容器，例如用于阴道内使用的容器本体包括具有用于引入培养基的孔的容器主体，一个或多个卵母细胞和精子，用于选择性地打开和关闭容器主体孔的可再密封闭合装置，所述容器主体具有用于接收培养基的主室，卵母细胞和精子以及用于收集一个或多个胚胎的微小室。容器主体具有用于限制取出导管或移液管相对于微型仓的通道的元件。限定所述微室的容器主体的侧壁的至少一部分是透明的，并且具有光学质量，用于在用导管或移液管取回之前和/或之前用于显微检查胚胎。

9. 发明授权

US5084004A Process for intra-uterine fertilization in mammals and device for implementation thereof 失效
标题翻译：哺乳动物子宫内膜肥胖的方法及其实施方法
公开(公告)号：US5084004A
公开(公告)日：1992-01-28
申请号：US449942
申请日：1989-12-29
申请人： Claude Ranoux
发明人： Claude Ranoux
IPC分类号： A61B17/00 , A61B17/42 , A61B17/425 , A61B17/435 , A61D19/00 , A61D19/02 , A61D19/04
CPC分类号： A61B17/435 , Y10S604/906
摘要： The fertilization process comprises the following steps: a) a container (15) which can be introduced into, and lodged in, the uterine cavity of the mammal is provided; b) the container (15) is filled with a culture medium, at least one ovocyte of the mammal, and spermatozoa; c) the filled container (15) is inserted in the uterine cavity; d) the container (15) is left for a given length of time to allow fertilization of the ovocyte(s) to take place; e) the contents of the container (15) are released into the uterine cavity. The container may be made from a tube of biodegradable or non-biodegradable material. In the latter case, it is associated with a stiffening device. A biodegradable container (15) filled with gametes and a culture medium is placed in the uterine cavity using an implantation device (20) which is then withdrawn from the mammal's genital tract.
摘要翻译： PCT No.PCT / FR88 / 00212 Sec。 371日期1989年12月29日第 102（e）日期1989年12月29日PCT提交1988年5月2日PCT公布。出版物WO88 / 08280 日期为1988年11月3日。受精过程包括以下步骤：a）可将哺乳动物的子宫腔内的容器（15）引入并置于其中; b）容器（15）填充有培养基，哺乳动物的至少一个卵母细胞和精子; c）将填充的容器（15）插入子宫腔中; d）将容器（15）放置一段给定的时间以允许卵母细胞受精; e）容器（15）的内容物释放到子宫腔中。容器可以由可生物降解的或不可生物降解的材料管制成。在后一种情况下，它与加强装置相关联。使用植入装置（20）将填充有配子和培养基的可生物降解的容器（15）放置在子宫腔中，然后将其从哺乳动物的生殖道中取出。

10. 发明专利

AU2278692A SPONTANEOUS-CYCLE FERTILIZATION METHOD 未知
公开(公告)号：AU2278692A
公开(公告)日：1993-02-11
申请号：AU2278692
申请日：1992-07-01
申请人： CLAUDE RANOUX
发明人： CLAUDE RANOUX
IPC分类号： A61B17/425 , A61B17/42 , A61B17/435

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