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1. 发明授权

US08965075B2 System and method for predicting future fractures 有权
$System and method for predicting future fractures$
标题翻译：预测未来骨折的系统和方法
公开(公告)号：US08965075B2
公开(公告)日：2015-02-24
申请号：US12779552
申请日：2010-05-13
申请人： Claude Arnaud , Siau-Way Liew , Daniel Steines , Rene Vargas-Voracek
发明人： Claude Arnaud , Siau-Way Liew , Daniel Steines , Rene Vargas-Voracek
IPC分类号： G06K9/00 , G06T7/00
CPC分类号： G06T7/0012 , G06K2209/055 , G06T2200/04 , G06T2207/10081 , G06T2207/10088 , G06T2207/10116 , G06T2207/20104 , G06T2207/30008
摘要： A method of predicting bone or articular disease in a subject includes determining one or more micro-structural parameters, one or more macroanatomical parameters or biomechanical parameters of a joint in the subject and combining at least two of the parameters to predict the risk of bone or articular disease.
摘要翻译：在受试者中预测骨或关节疾病的方法包括确定受试者中关节的一个或多个微观结构参数，一个或多个宏观解剖参数或生物力学参数，并组合至少两个参数以预测骨骼或关节疾病

2. 发明申请

US20080031412A1 Method for Bone Structure Prognosis and Simulated Bone Remodeling 有权
标题翻译：骨结构预后和模拟骨重建方法
公开(公告)号：US20080031412A1
公开(公告)日：2008-02-07
申请号：US11846018
申请日：2007-08-28
申请人： Philipp Lang , Daniel Steines , Claude Arnaud , Siau-Way Liew , Rene Vargas-Voracek
发明人： Philipp Lang , Daniel Steines , Claude Arnaud , Siau-Way Liew , Rene Vargas-Voracek
IPC分类号： G01B15/02 , A61B5/05
CPC分类号： A61B5/00 , G01B15/045 , G01N23/046 , G01N2223/419 , G01N2223/612 , G06T7/0012 , G06T7/41 , G06T7/62 , G06T2207/10081 , G06T2207/10116 , G06T2207/30008
摘要： Described herein are methods for analyzing bone structure and/or bone density, methods for estimating fracture risk in a subject as well as methods for monitoring the efficacy of an agent on bone structure and/or bone density.
摘要翻译：本文描述了用于分析骨骼结构和/或骨密度的方法，用于估计受试者的骨折风险的方法以及用于监测药剂对骨结构和/或骨密度的功效的方法。

3. 发明授权

US06425429B1 Tire having circumferential cables for anchoring the carcass and process of preparing such cables 失效
标题翻译：轮胎具有用于锚定胴体的周向电缆和制备这种电缆的过程
公开(公告)号：US06425429B1
公开(公告)日：2002-07-30
申请号：US09523911
申请日：2000-03-09
申请人： Jean-Claude Arnaud , Pedro Costa Pereira
发明人： Jean-Claude Arnaud , Pedro Costa Pereira
IPC分类号： B60C100
CPC分类号： D07B1/062 , B60C15/0018 , B60C15/04 , B60C15/05 , C21D1/26 , C21D9/525 , D07B2201/2023 , D07B2401/2005 , D07B2501/2053 , Y10S156/91 , Y10T152/10819 , Y10T152/10828 , Y10T152/10846 , Y10T428/12924
摘要： The anchoring of the carcass reinforcing elements 1 is assured by circumferential cables 2, with the interposition of a connecting rubber composition 3. The circumferential cable 2 is arranged in several turns forming one or more helices. These circumferential cables have an operational elongation rate Af=Ae+Ap of more than 4%. This operational elongation rate does not include the specific elongation As of the “cable” effect. The maximum stress Rm of the cable 2 is preferably more than 2000 MPa. The cables have undergone a heat treatment which has, in combination, the features of being a recovery annealing treatment and which is carried out directly on cable comprising wires previously separately covered by an adherent coating.
摘要翻译：通过插入连接橡胶组合物3，圆周电缆2确保了胎体增强元件1的锚固。周向电缆2以几匝布置形成一个或多个螺旋。这些周向电缆具有大于4％的可操作伸长率Af = Ae + Ap。该操作伸长率不包括“缆线”效应的特定伸长率。电缆2的最大应力Rm优选大于2000MPa。电缆已经经过热处理，其组合具有回收退火处理的特征，并且其直接在包含先前由粘附涂层覆盖的电线的电缆上进行。

4. 发明授权

US08639009B2 Methods and devices for evaluating and treating a bone condition based on x-ray image analysis 有权
标题翻译：基于x射线图像分析评估和治疗骨骼状况的方法和装置
公开(公告)号：US08639009B2
公开(公告)日：2014-01-28
申请号：US12749231
申请日：2010-03-29
申请人： Philipp Lang , Daniel Steines , Siau-Way Liew , Rene Vargas-Voracek , Claude Arnaud
发明人： Philipp Lang , Daniel Steines , Siau-Way Liew , Rene Vargas-Voracek , Claude Arnaud
IPC分类号： G06K9/00
CPC分类号： G06T7/20 , A61B6/4423 , A61B6/482 , A61B6/505 , A61B6/583 , G06K9/46 , G06K2009/4666 , G06T7/0012 , G06T2207/10116 , G06T2207/30008
摘要： This disclosure relates to methods and devices for analyzing x-ray images. Furthermore, bone condition of a subject can be evaluated by analyzing x-ray images of the subject's bone from a sliding region of interest (ROI), e.g., an ROI that is moved on a pixel-by-pixel basis on the image, and therapies can then be selected or devised for the subject.
摘要翻译：本公开涉及用于分析X射线图像的方法和装置。此外，可以通过从感兴趣的滑动区域（ROI）分析被摄体的骨骼的X射线图像，例如在图像上逐像素地移动的ROI来评估对象的骨骼状况，以及然后可以为受试者选择或设计治疗。

5. 发明授权

US08000766B2 Methods to diagnose treat and prevent bone loss 有权
标题翻译：诊断和预防骨质流失的方法
公开(公告)号：US08000766B2
公开(公告)日：2011-08-16
申请号：US10157745
申请日：2002-05-28
申请人： Philipp Lang , Claude Arnaud , Daniel Steines
发明人： Philipp Lang , Claude Arnaud , Daniel Steines
IPC分类号： A61B5/05 , G06K9/00
CPC分类号： G01N33/6893 , A61B5/055 , A61B6/037 , A61B6/505 , A61B6/508 , A61B6/583 , A61B8/0875 , G01N2333/78 , G01N2800/108 , G01N2800/52
摘要： Methods of diagnosing and preventing bone loss and/or enhancing bone formation are disclosed. The invention additionally provides methods of diagnosing a predisposition to bone loss. The methods mathematically combine the information provided by imaging tests with the information provided by biomarkers to provide an index value. The index value is used for diagnosis of bone diseases, and to assess the progress of treatment of bone diseases.
摘要翻译：公开了诊断和预防骨丢失和/或增强骨形成的方法。本发明还提供诊断骨质疏松倾向的方法。该方法将成像测试提供的信息与生物标志物提供的信息数学结合，提供指标值。指标值用于诊断骨骼疾病，并评估骨病的治疗进展。

6. 发明授权

US5702548A Tire having circumferential cables for anchoring the carcass 失效
标题翻译：轮胎具有用于锚定胴体的周向电缆
公开(公告)号：US5702548A
公开(公告)日：1997-12-30
申请号：US673072
申请日：1996-06-28
申请人： Jean-Claude Arnaud , Pedro Costa Pereira
发明人： Jean-Claude Arnaud , Pedro Costa Pereira
IPC分类号： B60C9/02 , B60C15/00 , B60C15/04 , B60C15/05 , C08L21/00 , C21D1/26 , C21D9/52 , D07B1/06 , B60C1/00
CPC分类号： D07B1/062 , B60C15/0018 , B60C15/04 , B60C15/05 , C21D1/26 , C21D9/525 , D07B2201/2023 , D07B2401/2005 , D07B2501/2053 , Y10S156/91 , Y10T152/10819 , Y10T152/10828 , Y10T152/10846 , Y10T428/12924
摘要： The anchoring of the carcass reinforcing elements 1 is assured by circumferential cables 2, with the interposition of a connecting rubber composition 3. The circumferential cable 2 is arranged in several turns forming one or more helices. These circumferential cables have an operational elongation rate A.sub.f =A.sub.e +A.sub.p of more than 4%. This operational elongation rate does not include the specific elongation A.sub.s of the "cable" effect. The maximum stress R.sub.m of the cable 2 is preferably more than 2000 MPa. The cables have undergone a heat treatment which has, in combination, the features of being a recovery annealing treatment and which is carried out directly on cable comprising wires previously separately covered by an adherent coating.
摘要翻译：通过插入连接橡胶组合物3，圆周电缆2确保了胎体增强元件1的锚固。周向电缆2以几匝布置形成一个或多个螺旋。这些周向电缆具有大于4％的可操作伸长率Af = Ae + Ap。该操作伸长率不包括“缆线”效应的特定伸长率。电缆2的最大应力Rm优选大于2000MPa。电缆已经经过热处理，其组合具有回收退火处理的特征，并且其直接在包含先前由粘附涂层覆盖的电线的电缆上进行。

7. 发明授权

US5503688A Metal wire comprising a substrate of steel of work-hardened tempered martensite type structure and a coating 失效
标题翻译：金属线包括加工硬化的回火马氏体型结构的钢基体和涂层
公开(公告)号：US5503688A
公开(公告)日：1996-04-02
申请号：US98378
申请日：1993-08-10
申请人： Jean-Claude Arnaud , Bernard Prudence , Raoul Serre
发明人： Jean-Claude Arnaud , Bernard Prudence , Raoul Serre
IPC分类号： C21D1/18 , C21D8/06 , C21D9/52 , C22C38/00 , C23C10/00 , C23C30/00 , B60C9/00 , C21D1/09
CPC分类号： C21D9/525 , C21D1/18 , C21D8/06 , D07B1/066 , C21D2211/008
摘要： A metal wire having a substrate and a coating. The substrate is a steel the carbon content of which is equal to at least 0.05% and at most 0.6%, this steel having a structure comprising more than 90% work-hardened tempered martensite. The substrate is coated with a metal alloy other than steel. Method of obtaining this wire. A steel machine wire comprising 28% to 96% proeutectoid ferrite and 72% to 4% pearlite is work hardened. A hardening treatment is carried out in order to obtain a structure comprising more than 90% martensite. A depositing of metals is then effected, the wire is heated to cause the formation of an alloy and the formation of a structure comprising more than 90% tempered martensite. The wire is cooled and work hardened. This wire is used, for instance, to reinforce tires.
摘要翻译： PCT No.PCT / FR92 / 00134 Sec。 371日期：1993年8月10日 102（e）日期1993年8月10日PCT提交1992年2月12日PCT公布。出版物WO92 / 14811 日期：1992年9月3日。具有基材和涂层的金属线。该基材是碳含量等于至少0.05％且至多0.6％的钢，该钢具有包含超过90％加工硬化的回火马氏体的结构。基材用除了钢之外的金属合金涂覆。获得该电线的方法包括28％至96％的先共析铁素体和72％至4％的珠光体的钢丝网加工硬化。进行硬化处理以获得包含大于90％的马氏体的结构。然后进行金属的沉积，加热电线以形成合金并形成包含超过90％的回火马氏体的结构。电线被冷却并加工硬化。这种电线用于例如加强轮胎。

8. 发明授权

US4642294A Process for evaluating the state of the surface of keratinous fibres and a composition for making use of this process 失效
标题翻译：用于评估角质纤维表面状态的方法和使用该方法的组合物
公开(公告)号：US4642294A
公开(公告)日：1987-02-10
申请号：US817604
申请日：1986-01-10
申请人： Jean-Claude Arnaud , Pierre Bore
发明人： Jean-Claude Arnaud , Pierre Bore
IPC分类号： A61K8/34 , A61Q5/00 , G01N31/00 , G01N33/48 , G01N33/52
CPC分类号： G01N33/52 , Y10T436/18
摘要： According to this process, (a) a compound capable of entering the surface interstices of the keratinous fibres is chosen; which is capable of producing, in an aqueous medium, a solution which is colored naturally or capable of being colored by a development, and capable, under the conditions of the process, of being stable and maintained at a pH such that no ionic charge appears; (b) an aqueous immersion solution containing the compounds chosen is prepared; (c) a specimen of the fibres to be studied is immersed therein to produce an "uptake" of the compound on the fibres, which is a function of their surface state; (d) the specimen is withdrawn from the solution and the excess of solution saturating the fibres is removed; (e) the compound present on the fibres is extracted by immersing the latter in at least one aqueous bath at the same pH as that of the aqueous immersion solution to obtain an extraction solution which is colored or whose color is developed in a step (f); and (g) the state of the surface of the fibres is deduced from the quantity of the compounds present in the extraction solution.
摘要翻译：根据该方法，选择（a）能够进入角质纤维的表面间隙的化合物; 其能够在水性介质中产生自然着色或能够通过显影着色的溶液，并且能够在该方法的条件下稳定并保持在不使离子电荷出现的pH ; （b）制备含有所选化合物的含水浸渍溶液; （c）将要研究的纤维的样品浸入其中以产生纤维上的化合物的“吸收”，这是它们的表面状态的函数; （d）将样品从溶液中取出，并除去饱和纤维的过量溶液; （e）存在于纤维上的化合物通过将其浸入到与浸渍水溶液相同的pH的至少一个水浴中而提取，得到着色的或其颜色在步骤（f ）; 和（g）从提取溶液中存在的化合物的量推导出纤维表面的状态。

9. 发明授权

US3971391A Process for improving the quality of living, human hair by lanthionization 失效
标题翻译：改善生活质量的过程，人类头发的衰老
公开(公告)号：US3971391A
公开(公告)日：1976-07-27
申请号：US449437
申请日：1974-03-08
申请人： Pierre Bore , Jean-Claude Arnaud , Gregoire Kalopissis
发明人： Pierre Bore , Jean-Claude Arnaud , Gregoire Kalopissis
IPC分类号： A61K8/00 , A45D7/00 , A45D7/04 , A45D7/06 , A45D19/16 , A61K20060101 , A61Q5/00 , A61Q5/04
CPC分类号： A61Q5/04 , A61K8/19
摘要： Process for improving and modifying the cosmetic properties of living human hair comprising transforming about 25 to 70% of the cystine in hair that is not subjected to any extension stress into lanthionine. The process is carried out with an aqueous medium having a pH between about 10.5 and 13 containing at least one alkali or alkaline earth metal hydroxide.
摘要翻译：用于改善和改善活人的头发的化妆品性质的方法包括将未经任何拉伸应力的毛发中的约25％至70％的胱氨酸转化成甲硫氨酸。该方法用含有至少一种碱金属或碱土金属氢氧化物的pH在约10.5和13之间的水性介质进行。

10. 发明申请

US20060062442A1 System and method of predicting future fractures 有权
$System and method of predicting future fractures$
公开(公告)号：US20060062442A1
公开(公告)日：2006-03-23
申请号：US11228126
申请日：2005-09-16
申请人： Claude Arnaud , Philipp Lang , Siau-Way Liew , Daniel Steines , Rene Vargas-Voracek
发明人： Claude Arnaud , Philipp Lang , Siau-Way Liew , Daniel Steines , Rene Vargas-Voracek
IPC分类号： G06K9/00
CPC分类号： A61B5/7275 , A61B5/4509 , A61B6/505 , A61B6/52 , A61B6/583 , A61B8/52 , A61B2576/02 , G01R33/54 , G06T7/0012 , G06T7/41 , G06T7/62 , G06T7/66 , G06T2207/10116 , G06T2207/20104 , G06T2207/30008
摘要： Methods of predicting fracture risk of a patient include: obtaining an image of a bone of the patient; determining one or more bone structure parameters; predicting a fracture line with the bone structure parameter; predicting a fracture load at which a fracture will happen; estimating body habitus of the patient; calculating a peak impact force on the bone when the patient falls; and predicting a fracture risk by calculating the ratio between the peak impact force and the fracture load. Inventive methods also includes determining the effect of a candidate agent on any subject's risk of fracture.

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