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1. 发明申请

US20110039710A1 APPARATUS AND METHODS FOR APPLICATIONS OF GENOMIC MICROARRAYS IN SCREENING, SURVEILLANCE AND DIAGNOSTICS 审中-公开
标题翻译：在筛选，监测和诊断中应用基因组微阵列的装置和方法
公开(公告)号：US20110039710A1
公开(公告)日：2011-02-17
申请号：US12779239
申请日：2010-05-13
申请人： Clark TIBBETTS
发明人： Clark TIBBETTS
IPC分类号： C40B30/00
CPC分类号： C12Q1/6809 , C12Q1/6806 , C12Q1/6837 , C12Q2565/501
摘要： This disclosure describes combinations of apparatus and methods to comprise a system for broad use and effective application of analytical genomic microarrays for screening and surveillance. The methodology abandons reliance on typical volumes of peripheral blood samples obtained by phlebotomy, in preference for protocols enabling collection, stabilization, archive, extraction and purification of small volumes as obtained from a finger prick. Recommended processing protocols from such starting material favor preparation of sufficient quantities of RNA or DNA of sufficient quality for subsequent steps of targeted amplification and fluorescent labeling. A strategy is offered for effective integration of capabilities for genotype and phenotype analysis on the same microarray layout. These gene expression re-sequencing arrays (GXR) are well suited for screening and surveillance applications.
摘要翻译：本公开描述了包括用于筛选和监测的分析基因组微阵列的广泛使用和有效应用的系统的装置和方法的组合。该方法放弃依赖于通过静脉切开术获得的外周血样品的典型体积，优于通过手指刺刺获得的能够收集，稳定，归档，提取和纯化小体积的方案。这种起始物质的推荐加工方案有利于制备足够质量的足够量的RNA或DNA，以便后续步骤进行靶向扩增和荧光标记。提供了一种策略，用于在相同的微阵列布局上有效地整合基因型和表型分析的能力。这些基因表达重排序阵列（GXR）非常适合筛选和监测应用。

2. 发明申请

US20080020379A1 Diagnosis and prognosis of infectious diseases clinical phenotypes and other physiologic states using host gene expression biomarkers in blood 审中-公开
标题翻译：使用宿主基因表达生物标志物在血液中的传染病临床表型和其他生理状态的诊断和预后
公开(公告)号：US20080020379A1
公开(公告)日：2008-01-24
申请号：US11268373
申请日：2005-11-07
申请人： Brian Agan , Eric Hanson , Michael Jenkins , Baochuan Lin , Chris Olsen , Robb Rowley , David Stenger , Dzung Thach , Clark Tibbetts , Elizabeth Walter , Jinny Liu
发明人： Brian Agan , Eric Hanson , Michael Jenkins , Baochuan Lin , Chris Olsen , Robb Rowley , David Stenger , Dzung Thach , Clark Tibbetts , Elizabeth Walter , Jinny Liu
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/158
摘要： The present invention provides a specific set of gene expression markers from peripheral blood leukocytes that are indicative of a host response to exposure, response, and recovery infectious pathogen infections. The present invention further provides methods for identifying the specific set of gene expression markers, methods of monitoring disease progression and treatment of infectious pathogen infections, methods of prognosing the onset of an infectious pathogen infection, and methods of diagnosing an infectious pathogen infection and identifying the pathogen involved.
摘要翻译：本发明提供来自外周血白细胞的特异性基因表达标志物，其指示宿主对暴露，应答和恢复感染性病原体感染的反应。本发明还提供了用于鉴定特定基因表达标志物组的方法，监测疾病进展和感染性病原体感染治疗的方法，预测感染性病原体感染发病的方法，诊断感染性病原体感染的方法以及鉴定涉及病原体。

3. 发明授权

US5502773A Method and apparatus for automated processing of DNA sequence data 失效
标题翻译：用于自动处理DNA序列数据的方法和装置
公开(公告)号：US5502773A
公开(公告)日：1996-03-26
申请号：US88208
申请日：1993-07-06
申请人： Clark Tibbetts , James B. Golden, III , Deborah L. Torgersen
发明人： Clark Tibbetts , James B. Golden, III , Deborah L. Torgersen
IPC分类号： G01N27/447 , G06F17/00 , G06F19/00 , G06K9/00 , G06F15/18
CPC分类号： G01N27/447
摘要： A method and apparatus for the processing of DNA sequence image data in real time is implemented using a series of linked neural network processors. As raw image data is received from a sequencing machine, it is buffered and then separately transformed in real time in the processors to enhance the signals indicative of the unknown DNA sequence. A fourth processor receives the transformed data and determines and reports the sequence indicating events.
摘要翻译：使用一系列链接的神经网络处理器来实现用于处理DNA序列图像数据的实时方法和装置。当从测序机接收到原始图像数据时，将其缓冲，然后在处理器中实时地单独变换，以增强指示未知DNA序列的信号。第四处理器接收变换的数据并确定并报告指示事件的序列。

4. 发明授权

US4775630A Transcriptional control element adapted for regulation of gene expression in animal cells 失效
标题翻译：用于调节动物细胞中基因表达的转录调控元件
公开(公告)号：US4775630A
公开(公告)日：1988-10-04
申请号：US897042
申请日：1986-08-15
申请人： Clark Tibbetts , Pamela L. Larsen , Stephen N. Jones , Mary M. McGrane
发明人： Clark Tibbetts , Pamela L. Larsen , Stephen N. Jones , Mary M. McGrane
IPC分类号： C12N15/09 , C12N15/00 , C12N15/85 , C12R1/91 , C12P21/00 , C07H15/12 , C12P19/00
CPC分类号： C12N15/85
摘要： A novel alteration of a viral DNA sequence, derived from a human adenovirus type 3 mutant (Ad3) designaed Ad3h15, provides a transcriptional control element which can be used to regulate expression of a selected gene in animal and human cells. The Ad3h15 control element blocks transcription of a controlled gene in the presence of the products of the Ad3 E1A gene, and amplifies transcription in the presence of type 5 (Ad5) adenovirus E1A gene products.
摘要翻译：衍生自设计Ad3h15的人腺病毒3型突变体（Ad3）的病毒DNA序列的新颖改变提供了可用于调节动物和人细胞中所选基因表达的转录控制元件。 Ad3h15对照元件在Ad3 E1A基因产物存在下阻断受控基因的转录，并在5型（Ad5）腺病毒E1A基因产物存在下扩增转录。

5. 发明授权

US4920211A Mutated adenovirus E1A gene for E1A promoter stimulation 失效
标题翻译：用于E1A启动子刺激的突变腺病毒E1A基因
公开(公告)号：US4920211A
公开(公告)日：1990-04-24
申请号：US140625
申请日：1988-01-04
申请人： Clark Tibbetts , Pamela L. Larsen
发明人： Clark Tibbetts , Pamela L. Larsen
IPC分类号： C07K14/075
CPC分类号： C07K14/005 , C12N2710/10322
摘要： A functional mutated E1A gene of human adenovirus subgroup B:1 is provided which has a modified autorepression functional domain that is effective to express E1A products that stimulate without net repression of promoters controlling an E1A mutated gene.
摘要翻译：提供人腺病毒亚组B：1的功能性突变E1A基因，其具有修饰的自抗体功能结构域，其有效表达刺激而没有抑制E1A突变基因的启动子的净抑制的E1A产物。

6. 发明申请

US20070263914A1 MICROARRAY IMAGING SYSTEM AND ASSOCIATED METHODOLOGY 失效
标题翻译：微型成像系统及相关方法
公开(公告)号：US20070263914A1
公开(公告)日：2007-11-15
申请号：US11684484
申请日：2007-03-09
申请人： Clark Tibbetts
发明人： Clark Tibbetts
IPC分类号： G06K9/00
CPC分类号： G01J3/02 , G01J3/0229 , G01J3/10 , G01J3/2846 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2201/0626 , G01N2201/0631
摘要： An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire micro array.
摘要翻译：提供了一种用于创建微阵列图像的装置和方法。该装置包括被配置为将光引向微阵列的至少一个光源。该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。二色镜将光反射到微阵列上，导致微阵列发射电磁能。该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。该装置还包括具有电荷耦合器件（CCD）的成像单元，该CCD具有被针孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像。

7. 发明授权

US07961323B2 Microarray imaging system and associated methodology 失效
标题翻译：微阵列成像系统及相关方法
公开(公告)号：US07961323B2
公开(公告)日：2011-06-14
申请号：US11684484
申请日：2007-03-09
申请人： Clark Tibbetts
发明人： Clark Tibbetts
IPC分类号： G01N21/25
CPC分类号： G01J3/02 , G01J3/0229 , G01J3/10 , G01J3/2846 , G01N21/6428 , G01N21/6452 , G01N21/6456 , G01N2201/0626 , G01N2201/0631
摘要： An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire microarray.
摘要翻译：提供了一种用于创建微阵列图像的装置和方法。该装置包括被配置为将光引向微阵列的至少一个光源。该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。二色镜将光反射到微阵列上，导致微阵列发射电磁能。该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。该装置还包括具有电荷耦合器件（CCD）的成像单元，该CCD具有由针孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像。

8. 发明申请

US20070212718A1 APPARATUS AND METHODS FOR APPLICATIONS OF GENOMIC MICROARRAYS IN SCREENING, SURVEILLANCE AND DIAGNOSTICS 审中-公开
标题翻译：在筛选，监测和诊断中应用基因组微阵列的装置和方法
公开(公告)号：US20070212718A1
公开(公告)日：2007-09-13
申请号：US11684371
申请日：2007-03-09
申请人： Clark TIBBETTS
发明人： Clark TIBBETTS
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6809 , C12Q1/6806 , C12Q1/6837 , C12Q2565/501
摘要： This disclosure describes combinations of apparatus and methods to comprise a system for broad use and effective application of analytical genomic microarrays for screening and surveillance. The methodology abandons reliance on typical volumes of peripheral blood samples obtained by phlebotomy, in preference for protocols enabling collection, stabilization, archives extraction and purification of small volumes as obtained from a finger prick. Recommended processing protocols from such starting material favor preparation of sufficient quantities of RNA or DNA of sufficient quality for subsequent steps of targeted amplification and fluorescent labeling. A strategy is offered for effective integration of capabilities for genotype and phenotype analysis on the same microarray layout. These gene expression re-sequencing arrays (GXR) are well suited for screening and surveillance applications.
摘要翻译：本公开描述了包括用于筛选和监测的分析基因组微阵列的广泛使用和有效应用的系统的装置和方法的组合。该方法放弃依赖于通过静脉切开术获得的外周血样品的典型体积，优选通过手指刺取获得的能够收集，稳定，归档提取和纯化小体积的方案。这种起始物质的推荐加工方案有利于制备足够质量的足够量的RNA或DNA，以便后续步骤进行靶向扩增和荧光标记。提供了一种策略，用于在相同的微阵列布局上有效地整合基因型和表型分析的能力。这些基因表达重排序阵列（GXR）非常适合筛选和监测应用。

9. 发明申请

US20060210967A1 Re-sequencing pathogen microarray 审中-公开
标题翻译：重新测序病原体微阵列
公开(公告)号：US20060210967A1
公开(公告)日：2006-09-21
申请号：US11177646
申请日：2005-07-02
申请人： Brian Agan , Eric Hanson , Russell Kruzelock , Baochuan Lin , Robb Rowley , Donald Seto , David Stenger , Jennifer Johnson , Clark Tibbetts , Dzung Thach , Gary Vora , Elizabeth Walter , Zheng Wang
发明人： Brian Agan , Eric Hanson , Russell Kruzelock , Baochuan Lin , Robb Rowley , Donald Seto , David Stenger , Jennifer Johnson , Clark Tibbetts , Dzung Thach , Gary Vora , Elizabeth Walter , Zheng Wang
IPC分类号： C12Q1/70 , C12Q1/68 , C12M1/34
CPC分类号： G16B30/00 , C12Q1/6874 , C12Q1/6888 , C12Q1/689 , C12Q1/6893 , C12Q1/701
摘要： The present invention relates to pathogen detection and identification by use of DNA resequencing microarrays. The present invention also provides resequencing microarray chips for differential diagnosis and serotyping of pathogens present in a biological sample. The present invention further provides methods of detecting the presence and identity of pathogens present in a biological sample.
摘要翻译：本发明涉及使用DNA重排序微阵列进行病原体检测和鉴定。本发明还提供用于鉴别诊断和生物样品中存在的病原体血清分型的重新测序微阵列芯片。本发明还提供了检测存在于生物样品中的病原体的存在和身份的方法。

10. 发明授权

US5365455A Method and apparatus for automatic nucleic acid sequence determination 失效
标题翻译：自动核酸序列测定的方法和装置
公开(公告)号：US5365455A
公开(公告)日：1994-11-15
申请号：US763457
申请日：1991-09-20
申请人： Clark Tibbetts , John M. Bowling
发明人： Clark Tibbetts , John M. Bowling
IPC分类号： G01N27/447 , G06F17/00 , G06F19/00 , G06G7/58
CPC分类号： G01N27/447 , Y10S706/924
摘要： A method and system for automated nucleic acid sequence determination of a polynucleotide, wherein a nucleic acid sequencing ladder comprises signals corresponding to oligonucleotides formed from the polynucleotide, comprising the step of correlating, particularly in a trained neural network or a scatter plot, an intensity variable for each signal in the nucleic acid sequencing ladder with an informative variable for that signal, wherein the informative variable comprises information from at least two adjacent signals in the nucleic acid sequencing ladder, such that each signal in the nucleic acid sequencing ladder identified so as to determine the nucleic acid sequence corresponding to the polynucleotide. In particular, the relative separation between consecutive signals, the relative intensities between consecutive signals, and a pattern recognition factor, which incorporates a comparison of relative separations and intensities of at least two adjacent signals with pattern recognition templates, can be used as informative variables. Furthermore, this invention relates to a method and system for the on-the-fly resolution and extraction of information of signals contained in a digitized data stream involving calculation of the smoothed second derivative of a data point from the smoothed first derivative of the data point.
摘要翻译：一种用于多核苷酸的自动化核酸序列测定的方法和系统，其中核酸测序梯度包括对应于由所述多核苷酸形成的寡核苷酸的信号，包括特别是在经过训练的神经网络或散点图中的强度变量对于核酸测序梯度中的每个信号具有用于该信号的信息变量，其中所述信息变量包含来自所述核酸测序梯级中的至少两个相邻信号的信息，使得所述核酸测序梯中的每个信号被识别为确定对应于多核苷酸的核酸序列。特别地，可以使用连续信号之间的相对间隔（连续信号之间的相对强度）和模式识别因子（其包含具有模式识别模板的至少两个相邻信号的相对间隔和强度的比较）作为信息变量。此外，本发明涉及一种用于即时分辨和提取包含在数字化数据流中的信号的信息的方法和系统，包括从数据点的平滑一阶导数计算数据点的平滑二阶导数。

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