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1. 发明授权

US08687204B2 Method and apparatus for measuring refractive index based on a ratio between a number of second fringes divided by a difference of the number of second fringes minus a number of first fringes 失效
$Method and apparatus for measuring refractive index based on a ratio between a number of second fringes divided by a difference of the number of second fringes minus a number of first fringes$
标题翻译：用于根据第二条纹的数量除以第二条纹数减去第一条纹数量之差的比率来测量折射率的方法和装置
公开(公告)号：US08687204B2
公开(公告)日：2014-04-01
申请号：US13071383
申请日：2011-03-24
申请人： Chung-Chieh Yu
发明人： Chung-Chieh Yu
IPC分类号： G01N21/41
CPC分类号： G01N21/45
摘要： A method and apparatus for measuring refractive index of an object are disclosed. The method includes, acquiring a number of first fringes of a first interference pattern formed by interference of a first beam of light transmitted through the object with a second beam of light not transmitted through the object; acquiring a number of second fringes of a second interference pattern formed by interference of a third beam of light reflected from a first surface of the object with a fourth beam of light transmitted through the object and reflected from a second surface of the object; and calculating the refractive index of the object based on the number of first fringes and the number of second fringes. The method may further include calculating the Abbe number of the object based on the refractive indices of the object measured at different wavelengths.
摘要翻译：公开了一种用于测量物体折射率的方法和装置。该方法包括：获取由透射通过物体的第一光束的干涉而形成的第一干涉图案的第一条纹和不透过物体的第二光束; 获取由从物体的第一表面反射的第三光束的干涉与透射通过物体并从物体的第二表面反射的第四光束的干涉形成的第二干涉图案的多个第二条纹; 并且基于第一条纹的数量和第二条纹的数量来计算物体的折射率。该方法还可以包括基于在不同波长处测量的物体的折射率来计算物体的阿贝数。

2. 发明申请

US20120259228A1 TRI MODAL SPECTROSCOPIC IMAGING 审中-公开
标题翻译： TRI模式光谱成像
公开(公告)号：US20120259228A1
公开(公告)日：2012-10-11
申请号：US13464578
申请日：2012-05-04
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
IPC分类号： A61B6/00 , A61B18/20
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

3. 发明授权

US07433377B2 Laser drive method and apparatus 有权
标题翻译：激光驱动方法和装置
公开(公告)号：US07433377B2
公开(公告)日：2008-10-07
申请号：US10444460
申请日：2003-05-22
申请人： Patrick A. Quinn , Chung-Chieh Yu
发明人： Patrick A. Quinn , Chung-Chieh Yu
IPC分类号： H01S3/00
CPC分类号： H01S5/042 , H01S5/0427
摘要： A laser diode is employed to output light. A laser driver is employed to drive the laser diode. A laser driver control unit is employed to control the driving, such that carrier concentration of the laser is substantially forced to a desired concentration as photon level of the laser initially arrives at a desired level. In one embodiment, the laser driver outputs a drive pulse to drive the laser diode, with the drive pulse having a complex waveform. In one embodiment, the complex waveform includes different transition time periods, and transient rates to raise the drive pulse from an initial level to a peak level. In another embodiment, the complex waveform includes different transition time periods and transient rates to raise the drive pulse from an initial level to a transition peak level and then drop the drive pulse back to an intermediate low level and then finally transition to a final peak level.
摘要翻译：采用激光二极管输出光。采用激光驱动器驱动激光二极管。使用激光驱动器控制单元来控制驱动，使得激光的载流子浓度基本上被迫到期望的浓度，因为激光的光子水平最初到达期望的水平。在一个实施例中，激光驱动器输出驱动脉冲以驱动激光二极管，其中驱动脉冲具有复杂波形。在一个实施例中，复波形包括不同的转变时间段，以及将驱动脉冲从初始电平升高到峰值电平的瞬态速率。在另一个实施例中，复波形包括不同的转变时间段和瞬态速率，以将驱动脉冲从初始电平升高到转变峰值电平，然后将驱动脉冲降低回中间低电平，然后最终转变到最终峰值电平。

4. 发明授权

US09176054B2 System for tomographic imaging using coherent light that has a random phase distribution 有权
标题翻译：使用具有随机相位分布的相干光的断层成像系统
公开(公告)号：US09176054B2
公开(公告)日：2015-11-03
申请号：US13491322
申请日：2012-06-07
申请人： Isao Matsubara , Chung-Chieh Yu , William Dallas
发明人： Isao Matsubara , Chung-Chieh Yu , William Dallas
IPC分类号： G01B9/02 , G01N21/45 , G01N21/47
CPC分类号： G01N21/45 , G01B9/02024 , G01B2290/40 , G01N21/4795
摘要： The present invention provides an apparatus for tomographic imaging of an object. The apparatus includes a light unit configured to generate illumination, which comprises coherent light and has random phase distribution in a plane perpendicular to an optical axis, for illuminating an object, a coupler which combines a reference beam and an object beam for an interference, a shifter configured to shift relative phase difference between the object light and the reference coherent light, a detector configured to detect an interference caused by the reference coherent light and object light for the each phase, and a processor configured to calculate an optical propagation based on the detected interference for the each phase.
摘要翻译：本发明提供一种用于物体的层析成像的装置。该装置包括配置成产生照明的光单元，其包括相干光并且在垂直于光轴的平面中具有随机相位分布，用于照射物体，组合参考光束和物体光束以用于干涉的耦合器，移位器，被配置为移动所述对象光和所述参考相干光之间的相对相位差;检测器，被配置为检测由所述参考相干光和对象光引起的针对每个相位的干扰;以及处理器，被配置为基于检测到每个相位的干扰。

5. 发明申请

US20100249607A1 QUANTITATIVE SPECTROSCOPIC IMAGING 审中-公开
标题翻译：量化光谱成像
公开(公告)号：US20100249607A1
公开(公告)日：2010-09-30
申请号：US12568459
申请日：2009-09-28
申请人： Chung-Chieh Yu , Condon Lau , Ramachandra Dasari , Michael Feld
发明人： Chung-Chieh Yu , Condon Lau , Ramachandra Dasari , Michael Feld
IPC分类号： A61B6/00 , A61B1/06
CPC分类号： A61B5/4255 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0088
摘要： The present invention relates to a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a powerful surveillance tool for objective early cancer detection. The design, construction, calibration, and diagnostics applications of this system is described with the use of physical tissue models. Measurements were conducted on a resected colon adenoma, and the system can be used for vivo imaging in the oral cavity.
摘要翻译：本发明涉及用于早期癌症（发育不良）的广域检测的全定量光谱成像仪。该仪器提供组织生物化学和形态学的定量图，使其成为客观早期癌症检测的强大的监测工具。使用物理组织模型描述了该系统的设计，构造，校准和诊断应用。对切除的结肠腺瘤进行测量，该系统可用于口腔中的体内成像。

6. 发明申请

US20070167835A1 Tri modal spectroscopic imaging 审中-公开
标题翻译：三态光谱成像
公开(公告)号：US20070167835A1
公开(公告)日：2007-07-19
申请号：US11492298
申请日：2006-07-25
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-Yen , Ramachandra Dasari , Michael Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-Yen , Ramachandra Dasari , Michael Feld
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

7. 发明授权

US09433351B2 Tri modal spectroscopic imaging 有权
标题翻译：三态光谱成像
公开(公告)号：US09433351B2
公开(公告)日：2016-09-06
申请号：US13464578
申请日：2012-05-04
申请人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人： Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld
IPC分类号： A61B6/00 , A61B5/00 , G01J3/02 , G01J3/10 , G01J3/32 , G01N21/47 , G01N21/49
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。

8. 发明申请

US20130286403A1 INTERFEROMETRIC METHOD AND DIGITAL HOLOGRAPHIC MICROSCOPE 有权
标题翻译：干涉法和数字全息显微镜
公开(公告)号：US20130286403A1
公开(公告)日：2013-10-31
申请号：US13455931
申请日：2012-04-25
申请人： Isao Matsubara , Chung-Chieh Yu , Yasuyuki Unno , William Dallas
发明人： Isao Matsubara , Chung-Chieh Yu , Yasuyuki Unno , William Dallas
IPC分类号： G01B9/02 , G01B9/023 , G01B11/24
CPC分类号： G01N21/453 , G02B21/0052 , G03H1/0443 , G03H2001/005 , G03H2001/0456 , G03H2001/046 , G03H2222/36 , G03H2222/44
摘要： An interferometric method for detecting information about a sample includes emitting a laser beam; splitting the laser beam into a reference beam and an object beam; transmitting the object beam through the sample in an incident angle; combining the reference beam with the object beam passed through the sample to form an interference pattern; detecting the interference pattern, and non-linearly scanning the object beam in order to detect a plurality of interference patterns.
摘要翻译：用于检测关于样本的信息的干涉测量方法包括发射激光束; 将激光束分成参考光束和物体光束; 以入射角透射物体通过样品; 将参考光束与通过样本的物体光束组合以形成干涉图案; 检测干涉图案，以及非线性扫描物体光束，以便检测多个干涉图案。

9. 发明授权

US09360423B2 Optical system for a holographic microscope including a spatial filter 有权
标题翻译：用于包括空间滤光片的全息显微镜的光学系统
公开(公告)号：US09360423B2
公开(公告)日：2016-06-07
申请号：US13538185
申请日：2012-06-29
申请人： Chung-Chieh Yu , Isao Matsubara , Yasuyuki Unno
发明人： Chung-Chieh Yu , Isao Matsubara , Yasuyuki Unno
IPC分类号： G01N21/45 , G02B21/00 , G03H1/00 , G03H1/04
CPC分类号： G01N21/453 , G02B21/0056 , G03H1/0005 , G03H1/0443 , G03H2001/005 , G03H2001/0445 , G03H2001/0452 , G03H2222/24 , G03H2223/12 , G03H2223/22 , G03H2223/23 , G03H2223/52 , G03H2223/55
摘要： An optical system for a holographic microscope includes: a light source configured to emit a light beam; a grating configured to split the light beam into a reference beam and an object beam; a lens unit configured to irradiate a sample by the reference and object beams split by the grating; a spatial filter including a first region for the reference beam and a second region for the object beam; and a detector configured to detect an interference pattern caused by the reference and object beams.
摘要翻译：用于全息显微镜的光学系统包括：被配置为发射光束的光源; 被配置为将光束分割成参考光束和物体光束的光栅; 透镜单元，被配置为通过由光栅分割的参考光束和物体光束照射样本; 空间滤波器，包括用于参考光束的第一区域和用于物体光束的第二区域; 以及检测器，其被配置为检测由所述参考和物体光束引起的干涉图案。

10. 发明授权

US08896840B2 Interferometric method and digital holographic microscope 有权
标题翻译：干涉法和数字全息显微镜
公开(公告)号：US08896840B2
公开(公告)日：2014-11-25
申请号：US13455931
申请日：2012-04-25
申请人： Isao Matsubara , Chung-Chieh Yu , Yasuyuki Unno , William Dallas
发明人： Isao Matsubara , Chung-Chieh Yu , Yasuyuki Unno , William Dallas
IPC分类号： G01B9/021
CPC分类号： G01N21/453 , G02B21/0052 , G03H1/0443 , G03H2001/005 , G03H2001/0456 , G03H2001/046 , G03H2222/36 , G03H2222/44
摘要： An interferometric method for detecting information about a sample includes emitting a laser beam; splitting the laser beam into a reference beam and an object beam; transmitting the object beam through the sample in an incident angle; combining the reference beam with the object beam passed through the sample to form an interference pattern; detecting the interference pattern, and non-linearly scanning the object beam in order to detect a plurality of interference patterns.
摘要翻译：用于检测关于样本的信息的干涉测量方法包括发射激光束; 将激光束分成参考光束和物体光束; 以入射角透射物体通过样品; 将参考光束与通过样本的物体光束组合以形成干涉图案; 检测干涉图案，以及非线性扫描物体光束，以便检测多个干涉图案。

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