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1. 发明申请

US20080260711A1 Detoxifizyme with Activity of Transforming Aflatoxin and the Gene Encodes Thereof 有权
标题翻译：具有黄曲霉毒素转化活性的脱毒酶及其基因编码
公开(公告)号：US20080260711A1
公开(公告)日：2008-10-23
申请号：US11629450
申请日：2005-01-13
申请人： Dongsheng Yao , Daling Liu , Min Guan , Chunfang Xie
发明人： Dongsheng Yao , Daling Liu , Min Guan , Chunfang Xie
IPC分类号： C12N9/00 , C12N15/52 , C12N15/74 , C12N1/21 , C12P21/00 , A61K38/43 , A61P35/00 , A23L3/00
CPC分类号： C12N9/00
摘要： The present invention relates to a detoxifizyme with the activity of transforming aflatoxin and the gene encodes thereof. Inventors firstly isolate and purify a novel protein, named aflatoxin-detoxifizyme (ADTZ), which has the activity of transforming aflatoxin. The primes specify to the ADTZ gene are obtained through purification and sequencing. The gene encoding of ADTZ is cloned from the total RNA of Armillariella tabescens. The recombinant protein is expressed and purified through various expression systems using genetic engineering methods. The said detoxifizyme has bioactivity of transforming AFB1, reducing mutagenic effects of AFB1. It has great potential for the manufacturing of feed or food and development of anti-tumor medicament.
摘要翻译：本发明涉及具有转化黄曲霉毒素的活性的脱毒酶及其基因编码。发明人首先分离和纯化具有转化黄曲霉毒素活性的新型蛋白质，称为黄曲霉毒素 - 解毒（ADTZ）。通过纯化和测序获得ADTZ基因的原子序列。从Armillariella tabescens的总RNA中克隆编码ADTZ的基因。通过使用基因工程方法的各种表达系统表达和纯化重组蛋白。所述脱毒酶具有转化AFB 1 的生物活性，降低AFB 1 的诱变作用。饲料或食品的制造和抗肿瘤药物的开发具有很大的潜力。

2. 发明授权

US08843870B2 Method of reducing current leakage in a device and a device thereby formed 有权
标题翻译：减少装置和由此形成的装置中的电流泄漏的方法
公开(公告)号：US08843870B2
公开(公告)日：2014-09-23
申请号：US13535835
申请日：2012-06-28
申请人： Bruce Scatchard , Chunfang Xie , Scott Barrick , Kenneth D. Wagner
发明人： Bruce Scatchard , Chunfang Xie , Scott Barrick , Kenneth D. Wagner
IPC分类号： G06F17/50
CPC分类号： H01L21/823807 , H01L21/26513 , H01L21/823412 , H01L21/823418
摘要： A method of reducing current leakage in unused circuits performed during semiconductor fabrication and a semiconductor device or integrated circuit thereby formed. The method involves modifying a characteristic of at least one idle circuit that is unused in a product variant, to inhibit the circuit and reduce current leakage therefrom upon powering as well as during operation. The method can substantially increase the Vt (threshold voltage) of all transistors of a given type, such as all N-type transistors or all P-type transistors. The method is also suitable for controlling other transistor parameters, such as transistor channel length, as well as other active elements, such as N-type resistors or P-type resistors, in unused circuits which affect leakage current as well as for other unused circuits, such as a high Vt circuit, a standard Vt circuit, a low Vt circuit, and an SRAM cell Vt circuit.
摘要翻译：减少在半导体制造期间执行的未使用电路中的电流泄漏的方法以及由此形成的半导体器件或集成电路。该方法包括修改在产品变型中未使用的至少一个空闲电路的特性，以在供电以及在操作期间抑制电路并减少其电流泄漏。该方法可以显着增加给定类型的所有晶体管的Vt（阈值电压），例如所有N型晶体管或所有P型晶体管。该方法还适用于控制其他晶体管参数，例如晶体管沟道长度，以及其他有源元件，例如N型电阻器或P型电阻器，在影响漏电流的未使用电路中以及其他未使用的电路，例如高Vt电路，标准Vt电路，低Vt电路和SRAM单元Vt电路。

3. 发明申请

US20140001601A1 METHOD OF REDUCING CURRENT LEAKAGE IN A DEVICE AND A DEVICE THEREBY FORMED 有权
标题翻译：降低器件中的电流泄漏的方法及其形成的器件
公开(公告)号：US20140001601A1
公开(公告)日：2014-01-02
申请号：US13535835
申请日：2012-06-28
申请人： Bruce SCATCHARD , Chunfang XIE , Scott BARRICK , Kenneth D. WAGNER
发明人： Bruce SCATCHARD , Chunfang XIE , Scott BARRICK , Kenneth D. WAGNER
IPC分类号： H01L21/265 , H01L29/02 , H01L21/66
CPC分类号： H01L21/823807 , H01L21/26513 , H01L21/823412 , H01L21/823418
摘要： A method of reducing current leakage in unused circuits performed during semiconductor fabrication and a semiconductor device or integrated circuit thereby formed. The method involves modifying a characteristic of at least one idle circuit that is unused in a product variant, to inhibit the circuit and reduce current leakage therefrom upon powering as well as during operation. The method can substantially increase the Vt (threshold voltage) of all transistors of a given type, such as all N-type transistors or all P-type transistors. The method is also suitable for controlling other transistor parameters, such as transistor channel length, as well as other active elements, such as N-type resistors or P-type resistors, in unused circuits which affect leakage current as well as for other unused circuits, such as a high Vt circuit, a standard Vt circuit, a low Vt circuit, and an SRAM cell Vt circuit.
摘要翻译：减少在半导体制造期间执行的未使用电路中的电流泄漏的方法以及由此形成的半导体器件或集成电路。该方法包括修改在产品变型中未使用的至少一个空闲电路的特性，以在供电以及在操作期间抑制电路并减少其电流泄漏。该方法可以显着增加给定类型的所有晶体管的Vt（阈值电压），例如所有N型晶体管或所有P型晶体管。该方法还适用于控制其他晶体管参数，例如晶体管沟道长度，以及其他有源元件，例如N型电阻器或P型电阻器，在影响漏电流的未使用电路中以及其他未使用的电路，例如高Vt电路，标准Vt电路，低Vt电路和SRAM单元Vt电路。

4. 发明授权

US07695751B2 Detoxifizyme with activity of transforming aflatoxin and the gene encodes thereof 有权
标题翻译：具有转化黄曲霉毒素活性的脱毒酶及其基因编码
公开(公告)号：US07695751B2
公开(公告)日：2010-04-13
申请号：US11629450
申请日：2005-01-13
申请人： Dongsheng Yao , Daling Liu , Min Guan , Chunfang Xie
发明人： Dongsheng Yao , Daling Liu , Min Guan , Chunfang Xie
IPC分类号： A23J1/00 , C12N9/00 , C12N1/20 , C12N15/00 , C12P21/06 , C12P19/34 , C07H21/04
CPC分类号： C12N9/00
摘要： The present invention relates to a detoxifizyme with the activity of transforming aflatoxin and the gene encodes thereof. Firstly a novel protein is isolated and purified, named aflatoxin-detoxifizyme (ADTZ), which has the activity of transforming aflatoxin. The ADTZ gene is obtained through specific primers, and the gene is purified and sequenced. The gene encoding of ADTZ is cloned from the total RNA of Armillariella tabescens. The recombinant protein is expressed and purified through various expression systems using genetic engineering methods. The said detoxifizyme has bioactivity of transforming AFB1, reducing mutagenic effects of AFB1. It has great potential for the manufacturing of feed or food and development of anti-tumor medicament.
摘要翻译：本发明涉及具有转化黄曲霉毒素的活性的脱毒酶及其基因编码。首先将新型蛋白质分离纯化，称为黄曲霉毒素 - 脱毒（ADTZ），其具有转化黄曲霉毒素的活性。通过特异性引物获得ADTZ基因，纯化和测序基因。从Armillariella tabescens的总RNA中克隆编码ADTZ的基因。通过使用基因工程方法的各种表达系统表达和纯化重组蛋白。所述脱毒酶具有转化AFB1的生物活性，降低AFB1的诱变作用。饲料或食品的制造和抗肿瘤药物的开发具有很大的潜力。

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