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1. 发明申请

US20070160561A1 AMPHIPHILIC STAR BLOCK COPOLYMERS 审中-公开
标题翻译：大众星型嵌段共聚物
公开(公告)号：US20070160561A1
公开(公告)日：2007-07-12
申请号：US11690074
申请日：2007-03-22
申请人： Lahoussine Ouali , Andreas Herrmann , Celine Ternat , Christopher Plummer , Harm-Anton Klok , Georg Kreutzer , Jan-Anders Manson , Horst Sommer , Maria Ines Velazco
发明人： Lahoussine Ouali , Andreas Herrmann , Celine Ternat , Christopher Plummer , Harm-Anton Klok , Georg Kreutzer , Jan-Anders Manson , Horst Sommer , Maria Ines Velazco
IPC分类号： A61K8/81 , C08L61/00 , A01N25/00
CPC分类号： C08F293/00 , C08F293/005 , C08L53/00 , C08L2666/02
摘要： The present invention relates to a basically spherical hyperbranched block copolymer having an internal hydrophobic block and an external hydrophilic block. Within the spherical copolymer, the hydrophobic block constitutes a hydrophobic layer, suitable to associate or encapsulate hydrophobic bioactive agents, while the hydrophilic block provides an outer layer, which is suitable to render the copolymer soluble or dispersible in aqueous solutions. Also claimed is a method for preparing the copolymer, which is suitable to encapsulate fragrances, flavours, drugs, agrochemicals, for example.
摘要翻译：本发明涉及具有内部疏水嵌段和外部亲水嵌段的基本上球形的超支化嵌段共聚物。在球形共聚物内，疏水性嵌段构成适于缔合或包封疏水性生物活性剂的疏水层，而亲水嵌段提供外层，其适于使共聚物溶解或分散在水溶液中。还要求的是制备共聚物的方法，其适用于包封香料，香料，药物，农用化学品。

2. 发明申请

US20050038167A1 Composites and methods for their production 有权
标题翻译：复合材料及其生产方法
公开(公告)号：US20050038167A1
公开(公告)日：2005-02-17
申请号：US10486958
申请日：2002-08-13
申请人： Christopher Plummer , Laszlo Garamszegi , Yves Leterrier , Marlene Rodlert , Jan-Anders Manson
发明人： Christopher Plummer , Laszlo Garamszegi , Yves Leterrier , Marlene Rodlert , Jan-Anders Manson
IPC分类号： C01B33/44 , C08J5/00 , C08K9/08 , C08K3/34
CPC分类号： C08J5/005 , B82Y30/00 , C01B33/44 , C08K9/08
摘要： Intercalates and exfoliates formed from layered materials and dendritic polymers are disclosed, together with the uses of these materials, e.g. in producing composite materials. The dispersion of layered materials in a dendritic polymer matrix (hyperbranched polymers, star shaped polymers or star branched polymers) or has not been disclosed in the prior art. The high number of end-groups per molecule of dendritic polymer combined with their unique globular architectures leads to large intergallery spacings when intercalated in layered silicates and particularly facile exfoliation in spite of the high molar mass of the dendritic polymer. The excellent processability and potential high reactivity of dendritic polymers makes them extremely promising for thermoset applications, and coatings.
摘要翻译：公开了由层状材料和树枝状聚合物形成的插层物和去角质，以及这些材料的用途，例如。在生产复合材料。层状材料在树枝状聚合物基质（超支化聚合物，星形聚合物或星形支化聚合物）中的分散体或在现有技术中未公开。每分子树枝状聚合物的大量端基与其独特的球状结构相结合导致了插入层状硅酸盐中的大的间隙间距，并且尽管树枝状聚合物的摩尔质量高，特别容易剥离。树枝状聚合物的优异加工性和潜在的高反应性使得它们对热固性应用和涂料非常有希望。

3. 发明申请

US20170223993A1 VEGETABLE-BASED SLICES FOR IMPROVED NUTRITION AND METHODS OF MAKING 审中-公开
公开(公告)号：US20170223993A1
公开(公告)日：2017-08-10
申请号：US15503137
申请日：2015-08-05
申请人： Christopher Plummer
发明人： Christopher Plummer
IPC分类号： A23L19/00 , B33Y80/00 , A23P30/00
CPC分类号： A23L19/09 , A23P30/00 , B33Y80/00
摘要： The present invention offers an intentional use of a slice as a system for the deliberate delivery of vegetable or fruit servings. The slice comprises the use of whole vegetable powders, whole fruit powders or a combination thereof as a highly concentrated source of vegetable or fruit material. In addition, the formulation provides for desirable organoleptic properties which over-come the negative texture and flavor qualities generally associated with vegetable powders and or fruit powders.

4. 发明申请

US20060089356A1 Substituted imidazoles as cannabinoid receptor modulators 失效
公开(公告)号：US20060089356A1
公开(公告)日：2006-04-27
申请号：US11265850
申请日：2005-11-03
申请人： Paul Finke , Sander Mills , Christopher Plummer , Shrenik Shah , Quang Truong
发明人： Paul Finke , Sander Mills , Christopher Plummer , Shrenik Shah , Quang Truong
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4172 , A61K31/4178 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07D233/90
摘要： The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) receptor. As such, compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith. Novel compounds of structural formula (I) are also claimed.

5. 发明申请

US20050166185A1 METHOD AND APPARATUS FOR ELIMINATING C RECURSION FROM A JAVA PROGRAMMING LANGUAGE BYTECODE INTERPRETER 有权
标题翻译：用于从JAVA编程语言中保存C语言的解码器的方法和装置
公开(公告)号：US20050166185A1
公开(公告)日：2005-07-28
申请号：US10907698
申请日：2005-04-12
申请人： Christopher Plummer , Dean Long
发明人： Christopher Plummer , Dean Long
IPC分类号： G06F9/40 , G06F9/45 , G06F9/44
CPC分类号： G06F9/45508 , G06F9/4484
摘要： Methods and apparatus for eliminating C recursion from interpreter loops are disclosed. According to one aspect of the present invention, a computer-implemented method for substantially eliminating C recursion from the execution of static initializer methods in a virtual machine environment includes rewriting native C code associated with a static initializer as a Java programming language method, and using a transition frame in a Java programming language stack to execute the Java programming language method. The method also includes using a native method to manipulate the Java programming language stack, and using a first opcode in the transition frame. In one embodiment, using the first opcode in the transition frame includes using the first opcode to determine that the transition frame is associated with the static initializer. In another embodiment, the method further includes causing the static initializer to run, wherein the static initializer using a second opcode, and resuming execution at the second opcode after the static initializer has run.
摘要翻译：公开了从解释器循环中消除C递归的方法和装置。根据本发明的一个方面，用于基本上消除在虚拟机环境中执行静态初始化方法的C递归的计算机实现的方法包括将与静态初始化器相关联的本地C代码重新编程为Java编程语言方法，并且使用 Java编程语言栈中的一个过渡框架来执行Java编程语言方法。该方法还包括使用本地方法来操纵Java编程语言栈，并且在转换帧中使用第一操作码。在一个实施例中，在转换帧中使用第一操作码包括使用第一操作码来确定转移帧与静态初始化器相关联。在另一个实施例中，该方法还包括使静态初始化器运行，其中静态初始化器使用第二操作码，并且在静态初始化器运行之后恢复在第二操作码处的执行。

6. 发明授权

US09534043B2 Anti-serum albumin binding variants 有权
标题翻译：抗血清白蛋白结合变体
公开(公告)号：US09534043B2
公开(公告)日：2017-01-03
申请号：US13202353
申请日：2010-02-17
申请人： Elena De Angelis , Carolyn Enever , Haiqun Liu , Christopher Plummer , Oliver Schon
发明人： Elena De Angelis , Carolyn Enever , Haiqun Liu , Christopher Plummer , Oliver Schon
IPC分类号： C07K16/18 , C07K14/56 , C07K14/575 , C07K16/28
CPC分类号： C07K16/18 , C07K14/56 , C07K14/57563 , C07K16/2878 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/569 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/31
摘要： The invention relates to improved variants of the anti-serum albumin immunoglobulin single variable domain DOM7h-11, as well as ligands and drug conjugates comprising such variants, compositions, nucleic acids, vectors and hosts.
摘要翻译：本发明涉及抗血清白蛋白免疫球蛋白单可变结构域DOM7h-11的改进变体，以及包含这些变体，组合物，核酸，载体和宿主的配体和药物偶联物。

7. 发明授权

US08168759B2 Compositions monovalent for CD28 binding and methods of use 有权
标题翻译：用于CD28结合的单价组合物和使用方法
公开(公告)号：US08168759B2
公开(公告)日：2012-05-01
申请号：US12505166
申请日：2009-07-17
申请人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
发明人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
IPC分类号： C07K16/00 , A61K39/395
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K2317/31 , C07K2317/569 , C07K2317/73
摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
摘要翻译：公开了单价结合CD28的结构域抗体。对CD28结合而言是单价的域抗体可抑制CD28活性。在一个方面，结构域抗体由一个方面组成或包含单个免疫球蛋白可变区，其特异性结合并拮抗CD28的活性，一方面，没有实质上激动的CD28活性。另一方面，结构域抗体是人结构域抗体。本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及与CD28相互作用的CD80和/或CD86相互作用的疾病或病症的方法，所述方法涉及对个体施用结构域抗体。

8. 发明授权

US07399804B2 Composites and methods for their production 有权
标题翻译：复合材料及其生产方法
公开(公告)号：US07399804B2
公开(公告)日：2008-07-15
申请号：US10486958
申请日：2002-08-13
申请人： Christopher Plummer , Laszlo Garamszegi , Yves Leterrier , Marlene Rodlert , Jan-Anders E. Manson
发明人： Christopher Plummer , Laszlo Garamszegi , Yves Leterrier , Marlene Rodlert , Jan-Anders E. Manson
IPC分类号： C08K3/34 , C08K9/04
CPC分类号： C08J5/005 , B82Y30/00 , C01B33/44 , C08K9/08
摘要： Intercalates and exfoliates formed from layered materials and dendritic polymers are disclosed, together with the uses of these materials, e.g. in producing composite materials. The dispersion of layered materials in a dendritic polymer matrix (hyperbranched polymers, star shaped polymers or star branched polymers) or has not been disclosed in the prior art. The high number of end-groups per molecule of dendritic polymer combined with their unique globular architectures leads to large intergallery spacings when intercalated in layered silicates and particularly facile exfoliation in spite of the high molar mass of the dendritic polymer. The excellent processability and potential high reactivity of dendritic polymers makes them extremely promising for thermoset applications, and coatings.
摘要翻译：公开了由层状材料和树枝状聚合物形成的插层物和去角质，以及这些材料的用途，例如。在生产复合材料。层状材料在树枝状聚合物基质（超支化聚合物，星形聚合物或星形支化聚合物）中的分散体或在现有技术中未公开。每分子树枝状聚合物的大量端基与其独特的球状结构相结合导致了插入层状硅酸盐中的大的间隙间距，并且尽管树枝状聚合物的摩尔质量高，特别容易剥离。树枝状聚合物的优异加工性和潜在的高反应性使得它们对热固性应用和涂料非常有希望。

9. 发明申请

US20050070609A1 Cyclopentyl modulators of chemokine receptor activity 失效
标题翻译：趋化因子受体活性的环戊基调节剂
公开(公告)号：US20050070609A1
公开(公告)日：2005-03-31
申请号：US10901414
申请日：2004-07-28
申请人： Paul Finke , Jennifer Loebach , Kerry Parker , Christopher Plummer , Sander Mills
发明人： Paul Finke , Jennifer Loebach , Kerry Parker , Christopher Plummer , Sander Mills
IPC分类号： A61K31/19 , C07D471/10 , C07D471/20 , C07D491/10 , C07D491/20 , C07D498/10
CPC分类号： C07D471/10 , C07D471/20 , C07D491/10 , C07D491/20 , C07D498/10
摘要： Cyclopentyl compounds of Formula (I) are modulators of chemokine receptor activity: wherein D, G, R2, R3 and R8 in Formula (I) are defined herein. The compounds, and pharmaceutically acceptable salts and individual diastereomers thereof, are useful in the treatment and prevention of HIV infection, in delaying the onset of AIDS, and in the treatment of AIDS. The compounds are also useful for treating other diseases and conditions mediated by chemokine receptors.
摘要翻译：式（I）的环戊基化合物是趋化因子受体活性的调节剂：其中式（I）中的D，G，R 2，R 3和R 8在本文中定义。化合物及其药学上可接受的盐和单独的非对映异构体可用于治疗和预防艾滋病毒感染，延缓艾滋病的发病和艾滋病的治疗。该化合物也可用于治疗趋化因子受体介导的其它疾病和病症。

10. 发明申请

US20120201814A1 COMPOSITIONS MONOVALENT FOR CD28 BINDING AND METHODS OF USE 有权
标题翻译： CD28结合的组合物单一使用方法和使用方法
公开(公告)号：US20120201814A1
公开(公告)日：2012-08-09
申请号：US13416033
申请日：2012-03-09
申请人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
发明人： Murray McKinnon , Steven G. Nadler , Suzanne J. Suchard , Brendan Classon , Steve Holmes , Olga Ignatovich , Christopher Plummer , Steve Grant
IPC分类号： A61K39/395 , A61P29/00 , A61P37/02 , A61P37/00 , A61P37/06
CPC分类号： C07K16/2818 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K2317/31 , C07K2317/569 , C07K2317/73
摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.
摘要翻译：公开了单价结合CD28的结构域抗体。对CD28结合而言是单价的域抗体可抑制CD28活性。在一个方面，结构域抗体由一个方面组成或包含单个免疫球蛋白可变区，其特异性结合并拮抗CD28的活性，一方面，没有实质上激动的CD28活性。另一方面，结构域抗体是人结构域抗体。本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及与CD28相互作用的CD80和/或CD86相互作用的疾病或病症的方法，所述方法涉及对个体施用结构域抗体。

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