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1. 发明申请

US20110106749A1 Personalized Prognosis Modeling in Medical Treatment Planning 有权
标题翻译：医疗策划中的个性化预后建模
公开(公告)号：US20110106749A1
公开(公告)日：2011-05-05
申请号：US12944288
申请日：2010-11-11
申请人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
发明人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
IPC分类号： G06N5/02
CPC分类号： A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/3481 , G16H50/30 , G16H50/50
摘要： Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.
摘要翻译：提供自动化治疗计划，具体考虑。一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。通过确定多个剂量的存活率，从特定患者确定作为剂量的函数的存活率所表示的生物学模型。类似地，确定并发症或副作用的机会。生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。

2. 发明授权

US07130372B2 Linear accelerator with X-ray imaging elements mounted on curved support 有权
标题翻译：线性加速器，X射线成像元件安装在弯曲支撑上
公开(公告)号：US07130372B2
公开(公告)日：2006-10-31
申请号：US10864190
申请日：2004-06-08
申请人： Jochen Klaus Kusch , Christopher Jude Amies
发明人： Jochen Klaus Kusch , Christopher Jude Amies
IPC分类号： A61N5/10 , H05G1/02
CPC分类号： A61N5/1049 , A61B6/4441 , A61B6/466 , A61N5/1081 , A61N2005/1061
摘要： A system according to some embodiments may include a treatment head to emit treatment radiation, a gantry coupled to the treatment head, an x-ray tube to emit imaging radiation, an imaging device to acquire an image based on the imaging radiation, and a C-arm coupled to the x-ray tube, the imaging device, and the gantry.
摘要翻译：根据一些实施例的系统可以包括用于发射治疗辐射的治疗头，耦合到治疗头的台架，用于发射成像辐射的X射线管，用于基于成像辐射获取图像的成像装置，以及C - 联接到x射线管，成像装置和龙门架。

3. 发明授权

US08949079B2 Patient data mining 有权
公开(公告)号：US08949079B2
公开(公告)日：2015-02-03
申请号：US12488083
申请日：2009-06-19
申请人： R. Bharat Rao , Sathyakama Sandilya , Christopher Jude Amies , Radu Stefan Niculescu , Arun Kumar Goel , Thomas R. Warrick
发明人： R. Bharat Rao , Sathyakama Sandilya , Christopher Jude Amies , Radu Stefan Niculescu , Arun Kumar Goel , Thomas R. Warrick
IPC分类号： G06F7/60 , G06F17/10 , G06F19/00 , G06F17/30 , G06Q10/10 , G06Q50/22 , G06Q50/24
CPC分类号： G06F19/3443 , G06F17/3061 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/325 , G06F19/328 , G06F19/3418 , G06F19/3481 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/60 , G16H15/00 , G16H40/20 , G16H40/63 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70 , Y10S128/92
摘要： The present invention provides a data mining framework for mining high-quality structured clinical information. The data mining framework includes a data miner that mines medical information from a computerized patient record (CPR) based on domain-specific knowledge contained in a knowledge base. The data miner includes components for extracting information from the CPR, combining all available evidence in a principled fashion over time, and drawing inferences from this combination process. The mined medical information is stored in a structured CPR which can be a data warehouse.

4. 发明申请

US20110213239A1 Combined Radiation Therapy and Magnetic Resonance Unit 有权
标题翻译：联合放射治疗和磁共振单位
公开(公告)号：US20110213239A1
公开(公告)日：2011-09-01
申请号：US13036202
申请日：2011-02-28
申请人： Christopher Jude Amies , Paul Beasley , Juan Carlos Celi , Oliver Heid , Francisco Miguel Hernandez-Guerra , Marcel Jan Marie Kruip , Markus Vester
发明人： Christopher Jude Amies , Paul Beasley , Juan Carlos Celi , Oliver Heid , Francisco Miguel Hernandez-Guerra , Marcel Jan Marie Kruip , Markus Vester
IPC分类号： A61B6/00 , A61B5/055
CPC分类号： A61N5/1049 , A61N2005/1055 , G01R33/3806 , G01R33/385 , G01R33/4215 , G01R33/4812
摘要： The invention relates to a combined radiation therapy and magnetic resonance unit. For this purpose, in accordance with the invention a combined radiation therapy and magnetic resonance unit is provided comprising a magnetic resonance diagnosis part with an interior, which is limited in radial direction by a main magnet, and a radiation therapy part for the irradiation of an irradiation area within the interior, wherein at least parts of the radiation therapy part, which comprise a beam deflection arrangement, are arranged within the interior.
摘要翻译：本发明涉及组合放射治疗和磁共振单元。为此，根据本发明，提供了一种组合的放射治疗和磁共振单元，其包括具有内部的磁共振诊断部分，所述磁共振诊断部分通过主磁体在径向上受到限制，并且辐射治疗部件用于照射内部的照射区域，其中包括光束偏转装置的辐射治疗部分的至少一部分布置在内部。

5. 发明授权

US07844560B2 Personalized prognosis modeling in medical treatment planning 有权
标题翻译：医疗策划中的个性化预后建模
公开(公告)号：US07844560B2
公开(公告)日：2010-11-30
申请号：US11735720
申请日：2007-04-16
申请人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
发明人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
IPC分类号： G06N5/02 , G06N5/04 , G06F17/30
CPC分类号： A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/3481 , G16H50/30 , G16H50/50
摘要： Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.
摘要翻译：提供自动化治疗计划，具体考虑。一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。通过确定多个剂量的存活率，从特定患者确定作为剂量的函数的存活率所表示的生物学模型。类似地，确定并发症或副作用的机会。生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。

6. 发明申请

US20090259487A1 Patient Data Mining 有权
标题翻译：患者数据挖掘
公开(公告)号：US20090259487A1
公开(公告)日：2009-10-15
申请号：US12488083
申请日：2009-06-19
申请人： R. Bharat Rao , Sathyakama Sandilya , Christopher Jude Amies , Radu Stefan Niculescu , Arun Kumar Goel , Thomas R. Warrick
发明人： R. Bharat Rao , Sathyakama Sandilya , Christopher Jude Amies , Radu Stefan Niculescu , Arun Kumar Goel , Thomas R. Warrick
IPC分类号： G06Q50/00
CPC分类号： G06F19/3443 , G06F17/3061 , G06F19/00 , G06F19/321 , G06F19/324 , G06F19/325 , G06F19/328 , G06F19/3418 , G06F19/3481 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H10/20 , G16H10/60 , G16H15/00 , G16H40/20 , G16H40/63 , G16H50/20 , G16H50/30 , G16H50/50 , G16H50/70 , Y10S128/92
摘要： The present invention provides a data mining framework for mining high-quality structured clinical information. The data mining framework includes a data miner that mines medical information from a computerized patient record (CPR) based on domain-specific knowledge contained in a knowledge base. The data miner includes components for extracting information from the CPR, combining all available evidence in a principled fashion over time, and drawing inferences from this combination process. The mined medical information is stored in a structured CPR which can be a data warehouse.
摘要翻译：本发明提供了用于挖掘高质量结构化临床信息的数据挖掘框架。数据挖掘框架包括一个数据挖掘机，该数据挖掘机基于知识库中包含的特定于领域的知识从计算机化的病历（CPR）中挖掘医疗信息。数据挖掘机包括从CPR中提取信息的组件，将所有可用证据以原则方式随时间结合，并从该组合过程中得出推论。开采的医疗信息存储在可以是数据仓库的结构化CPR中。

7. 发明授权

US08487269B2 Combined radiation therapy and magnetic resonance unit 有权
公开(公告)号：US08487269B2
公开(公告)日：2013-07-16
申请号：US13036202
申请日：2011-02-28
申请人： Christopher Jude Amies , Paul Beasley , Juan Carlos Celi , Oliver Heid , Francisco Miguel Hernandez-Guerra , Marcel Jan Marie Kruip , Markus Vester
发明人： Christopher Jude Amies , Paul Beasley , Juan Carlos Celi , Oliver Heid , Francisco Miguel Hernandez-Guerra , Marcel Jan Marie Kruip , Markus Vester
IPC分类号： G21K5/04
CPC分类号： A61N5/1049 , A61N2005/1055 , G01R33/3806 , G01R33/385 , G01R33/4215 , G01R33/4812
摘要： The invention relates to a combined radiation therapy and magnetic resonance unit. For this purpose, in accordance with the invention a combined radiation therapy and magnetic resonance unit is provided comprising a magnetic resonance diagnosis part with an interior, which is limited in radial direction by a main magnet, and a radiation therapy part for the irradiation of an irradiation area within the interior, wherein at least parts of the radiation therapy part, which comprise a beam deflection arrangement, are arranged within the interior.

8. 发明授权

US06853704B2 System providing multiple focused radiation beams 有权
标题翻译：提供多个聚焦辐射束的系统
公开(公告)号：US06853704B2
公开(公告)日：2005-02-08
申请号：US10252911
申请日：2002-09-23
申请人： William F. Collins , Christopher Jude Amies
发明人： William F. Collins , Christopher Jude Amies
IPC分类号： A61N5/10
CPC分类号： A61N5/1084 , A61N2005/1091 , A61N2005/1095
摘要： A system includes a plurality of treatment heads, each of the plurality of treatment heads including a radiation source and a radiation-focusing lens. The system also includes a plurality of voltage sources, each of the plurality of voltage sources associated with a respective one of the plurality of treatment heads, and a control device to control an intensity of radiation emitted from each radiation-focusing lens of the plurality of treatment heads in accordance with a treatment plan.
摘要翻译：一种系统包括多个处理头，所述多个处理头中的每一个包括辐射源和辐射聚焦透镜。所述系统还包括多个电压源，所述多个电压源中的每一个与所述多个治疗头中的相应治疗头相关联，以及控制装置，用于控制从所述多个治疗头中的每个辐射聚焦透镜发射的辐射的强度治疗头根据治疗计划。

9. 发明授权

US08958864B2 Combined radiation therapy and magnetic resonance unit 有权
标题翻译：联合放射治疗和磁共振单位
公开(公告)号：US08958864B2
公开(公告)日：2015-02-17
申请号：US12072851
申请日：2008-02-28
申请人： Christopher Jude Amies , Paul Beasley , Juan Carlos Celi , Oliver Heid , Francisco Miguel Hernandez-Guerra , Marcel Jan Marie Kruip , Markus Vester
发明人： Christopher Jude Amies , Paul Beasley , Juan Carlos Celi , Oliver Heid , Francisco Miguel Hernandez-Guerra , Marcel Jan Marie Kruip , Markus Vester
IPC分类号： A61B6/00 , A61B5/055
CPC分类号： A61N5/1049 , A61N2005/1055 , G01R33/3806 , G01R33/385 , G01R33/4215 , G01R33/4808
摘要： The invention relates to a combined radiation therapy and magnetic resonance unit. For this purpose, in accordance with the invention a combined radiation therapy and magnetic resonance unit is provided comprising a magnetic resonance diagnosis part with an interior, which is limited in radial direction by a main magnet, and a radiation therapy part for the irradiation of an irradiation area within the interior, wherein at least parts of the radiation therapy part, which comprise a beam deflection arrangement, are arranged within the interior.
摘要翻译：本发明涉及组合放射治疗和磁共振单元。为此，根据本发明，提供了一种组合的放射治疗和磁共振单元，其包括具有内部的磁共振诊断部分，所述磁共振诊断部分通过主磁体在径向上受到限制，并且辐射治疗部件用于照射内部的照射区域，其中包括光束偏转装置的放射治疗部分的至少一部分布置在内部。

10. 发明授权

US08579784B2 Personalized prognosis modeling in medical treatment planning 有权
标题翻译：医疗策划中的个性化预后建模
公开(公告)号：US08579784B2
公开(公告)日：2013-11-12
申请号：US12944288
申请日：2010-11-11
申请人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
发明人： Sriram Krishnan , R. Bharat Rao , Christopher Jude Amies
IPC分类号： A61N5/00
CPC分类号： A61N5/103 , A61N2005/1041 , G06F19/00 , G06F19/3481 , G16H50/30 , G16H50/50
摘要： Automated treatment planning is provided with individual specific consideration. One or more prognosis models indicate survivability as a function of patient specific information for a given dose. By determining survivability for a plurality of doses, the biological model represented by survivability as a function of dose is determined from the specific patient. Similarly, the chances of complications or side effects are determined. The chance of survivability and chance of complication are used as or instead of the tumor control probability and normal tissue complications probability, respectively. The desired tumor dosage and tolerance dosage are selected as a function of the patient specific dose distributions. The selected dosages are input to an inverse treatment planning system for establishing radiation treatment parameters.
摘要翻译：提供自动化治疗计划，具体考虑。一个或多个预后模型表明作为给定剂量的患者特异性信息的函数的存活率。通过确定多个剂量的存活率，从特定患者确定作为剂量的函数的存活率所表示的生物学模型。类似地，确定并发症或副作用的机会。生存能力和并发症的机会分别被用作肿瘤控制概率和正常组织并发症概率。选择所需的肿瘤剂量和耐受剂量作为患者具体剂量分布的函数。选择的剂量被输入到用于建立放射治疗参数的反向治疗计划系统。

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