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1. 发明申请

US20200093884A1 STABLE INTRANASAL FORMULATIONS OF CARBETOCIN 审中-公开
公开(公告)号：US20200093884A1
公开(公告)日：2020-03-26
申请号：US16576940
申请日：2019-09-20
申请人： Mark C. MANNING , Ryan E. Holcomb , Derrick S. Katayama , Christopher Bryant
发明人： Mark C. MANNING , Ryan E. Holcomb , Derrick S. Katayama , Christopher Bryant
IPC分类号： A61K38/095 , A61K47/38 , A61K9/08 , A61K9/00 , A61K47/55
摘要： The application describes stable aqueous compositions comprising relatively high concentrations of carbetocin and a solubilizer and/or surface active agent. The disclosed carbetocin compositions are effective in the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin compositions show improved stability at room temperature and/or under accelerated conditions of stress.

2. 发明授权

US08602348B2 Flying-wing aircraft 有权
标题翻译：飞翼飞机
公开(公告)号：US08602348B2
公开(公告)日：2013-12-10
申请号：US12865429
申请日：2009-02-02
申请人： Ashley Christopher Bryant
发明人： Ashley Christopher Bryant
IPC分类号： B64C15/12 , B64C29/00 , B64C39/10
CPC分类号： B64C29/0033 , B64C39/024 , B64C39/10 , B64C2201/028 , B64C2201/088 , B64C2201/162 , B64C2201/165
摘要： A vertical take-off and landing flying-wing aircraft has a pair of thrust-vectoring propulsion units mounted fore and aft of the aircraft pitch axis on strakes at opposite extremities of the wing-structure, with the fore unit below, and the aft unit above, the wing-structure. The propulsion units are pivoted to the strakes, either directly or via arms, for individual angular displacement for thrust-vectored maneuvering of the aircraft in yaw, pitch and roll and for hover and forward and backward flight. When arms are employed, the arms of fore and aft propulsion units are intercoupled via chain drives or linkages. The wing-structure may have fins, slats and flaps and other aerodynamic control-surfaces, and enlarged strakes may incorporate rudder surfaces. Only one propulsion unit may be mounted at each extremity and additional fan units may be used.
摘要翻译：垂直起飞和着陆的飞翼飞机具有一对推力矢量推进装置，其在机翼结构的相对两端的前翼和后部单元的前后悬架的飞机俯仰轴上前后安装以上，翼结构。推进单元直接或经由臂枢转到斜面，用于单独的角位移，用于以偏航，俯仰和滚动以及用于悬停和向前和向后飞行的推力向导操纵飞行器。当使用武器时，前后推进单元的臂通过链条驱动器或连杆相互联接。机翼结构可以具有翅片，板条和翼片以及其它空气动力学控制表面，并且扩大的履带可以包括舵面。每个末端只能安装一个推进装置，也可以使用额外的风扇装置。

3. 发明申请

US20060294137A1 Database application including split views 有权
标题翻译：数据库应用程序包括拆分视图
公开(公告)号：US20060294137A1
公开(公告)日：2006-12-28
申请号：US11159763
申请日：2005-06-23
申请人： Christopher Bryant , George Fordham , Marcus Markiewicz , Michael McCormack , Theresa Naramore
发明人： Christopher Bryant , George Fordham , Marcus Markiewicz , Michael McCormack , Theresa Naramore
IPC分类号： G06F7/00
CPC分类号： G06F17/30554 , G06F2203/04803
摘要： A database application is provided which includes functionality for providing split views. The database application includes an object model having a number of objects, methods, and properties. The object model preferably includes a form object which includes a split view representation. A number of properties are associated with the split view which provides for the presentation of data to a user of the database application.
摘要翻译：提供了一个数据库应用程序，其中包括提供拆分视图的功能。数据库应用程序包括具有多个对象，方法和属性的对象模型。对象模型优选地包括包括分割视图表示的表单对象。许多属性与分割视图相关联，该视图提供数据呈现给数据库应用程序的用户。

4. 发明申请

US20110136492A1 INTELLIGENT ROUTING OF COMMUNICATIONS TO AN INTERNATIONAL NUMBER IN A MESSAGING SERVICE 有权
标题翻译：智能路由通信在消息传递服务中的国际号码
公开(公告)号：US20110136492A1
公开(公告)日：2011-06-09
申请号：US12634201
申请日：2009-12-09
申请人： Matthew James Bailey , Christopher Bryant , William Rosenberg
发明人： Matthew James Bailey , Christopher Bryant , William Rosenberg
IPC分类号： H04W40/00 , H04W4/12
CPC分类号： H04W40/34 , H04L51/066 , H04L51/14 , H04W4/06 , H04W4/12
摘要： System(s) and method(s) are provided for intelligent routing of communication(s) to international number(s) in a messaging service. To route a communication that includes an international number, format of the communication is established. A text-only communication is delivered through a messaging service transport protocol (MSTP) suitable for text. A media-based communication intended for a plurality of recipients, e.g., a group message, is ungrouped, the international number is identified, and a new message is generated for a group of recipients that excludes a recipient associated with the international number. The new message is delivered through a MSTP suitable for media, whereas an exception handling procedure is conducted for the international number. In addition, to route the communication that includes an international number, network interoperability of predetermined MSTP can be assessed. The communication is delivered through the predetermined MSTP if it is interoperable. Conversely, the communication is routed as a media-based group message.
摘要翻译：提供了系统和方法，用于智能路由通信到消息传递服务中的国际号码。为了路由包含国际号码的通信，建立通信的格式。纯文本通信通过适合于文本的消息传递服务传输协议（MSTP）传递。旨在用于多个接收者（例如，组消息）的基于媒体的通信被取消分组，识别国际号码，并且为排除与国际号码相关联的接收者的一组接收者生成新消息。新消息通过适合媒体的MSTP传递，而对国际号码进行异常处理程序。此外，为了路由包括国际号码的通信，可以评估预定MSTP的网络互操作性。通信是通过预定的MSTP交付的，如果它是可互操作的。相反，通信被路由为基于媒体的组消息。

5. 发明授权

US07734664B2 Database application including split views 有权
标题翻译：数据库应用程序包括拆分视图
公开(公告)号：US07734664B2
公开(公告)日：2010-06-08
申请号：US11159763
申请日：2005-06-23
申请人： Christopher Bryant , George R. Fordham , Marcus Markiewicz , Michael McCormack , Theresa Naramore
发明人： Christopher Bryant , George R. Fordham , Marcus Markiewicz , Michael McCormack , Theresa Naramore
IPC分类号： G06F7/00 , G06F17/30 , G06F3/048
CPC分类号： G06F17/30554 , G06F2203/04803
摘要： A database application is provided which includes functionality for providing split views. The database application includes an object model having a number of objects, methods, and properties. The object model preferably includes a form object which includes a split view representation. A number of properties are associated with the split view which provides for the presentation of data to a user of the database application.
摘要翻译：提供了一个数据库应用程序，其中包括提供拆分视图的功能。数据库应用程序包括具有多个对象，方法和属性的对象模型。对象模型优选地包括包括分割视图表示的表单对象。许多属性与分割视图相关联，该视图提供数据呈现给数据库应用程序的用户。

6. 发明申请

US20070005634A1 Templates in a schema editor 有权
标题翻译：模式编辑器中的模板
公开(公告)号：US20070005634A1
公开(公告)日：2007-01-04
申请号：US11231260
申请日：2005-09-20
申请人： Vitore Selca , Christopher Bryant , Clinton Covington , Dan Hough , Kelly Krout , Shane Groff , Timothy Getsch
发明人： Vitore Selca , Christopher Bryant , Clinton Covington , Dan Hough , Kelly Krout , Shane Groff , Timothy Getsch
IPC分类号： G06F7/00
CPC分类号： G06F17/30292 , G06F17/3056
摘要： A schema editor allows for definition, distribution, and use of schema templates. The schema editor allows schema to be edited and then saved in such a way that the saved file can be reimported into the schema editor.
摘要翻译：模式编辑器允许定义，分发和使用模式模板。模式编辑器允许编辑模式，然后以保存的文件可以重新导入模式编辑器的方式进行保存。

7. 发明申请

US20060156247A1 Floating action buttons 有权
标题翻译：浮动动作按钮
公开(公告)号：US20060156247A1
公开(公告)日：2006-07-13
申请号：US11026349
申请日：2004-12-30
申请人： Michael McCormack , Christopher Bryant , Andrew Miller , Robert Coggins , Scott Gardner
发明人： Michael McCormack , Christopher Bryant , Andrew Miller , Robert Coggins , Scott Gardner
IPC分类号： G06F17/00 , G06F3/00 , G06F9/00
CPC分类号： G06F3/048 , G06F3/0481
摘要： A user interface (UI) includes floating action buttons. Respective hot zones are established for associated respective UI elements. When a focus is targeting (e.g., located at) a given hot zone, one or more floating action buttons that are associated therewith are presented as part of the UI. Activation of a particular action button of the one or more floating action buttons causes an action corresponding to the particular action button to be implemented. In an example implementation, the actions available through the one or more floating action buttons may be context-sensitive such that the actions thereof are tailored to the type of item corresponding to the UI element (e.g., an icon, a graphical element, a text portion, a screen area, etc.).
摘要翻译：用户界面（UI）包括浮动操作按钮。针对相应的UI元素建立各个热区。当焦点瞄准（例如位于）给定的热区时，与其相关联的一个或多个浮动动作按钮被呈现为UI的一部分。激活一个或多个浮动动作按钮的特定动作按钮将导致与特定动作按钮对应的动作被实现。在示例实现中，通过一个或多个浮动动作按钮可用的动作可以是上下文相关的，使得其动作被定制为与UI元素相对应的项目的类型（例如，图标，图形元素，文本部分，屏幕区域等）。

8. 发明申请

US20060149768A1 Database interaction 有权
标题翻译：数据库交互
公开(公告)号：US20060149768A1
公开(公告)日：2006-07-06
申请号：US11027301
申请日：2004-12-30
申请人： Michael McCormack , Christopher Bryant , Robert Coggins , Scott Gardner , Theresa Naramore , Daniel Hough , Kelly Krout , Clinton Covington
发明人： Michael McCormack , Christopher Bryant , Robert Coggins , Scott Gardner , Theresa Naramore , Daniel Hough , Kelly Krout , Clinton Covington
IPC分类号： G06F17/00
CPC分类号： G06F17/30554 , G06F3/0482 , G06F17/30389 , G06F17/30873
摘要： Database interaction is facilitated by graphically presenting database objects in groups that are not necessarily dictated by object types of the database objects. In an example implementation, database navigation is facilitated by determining object dependency groups for a database in which each object dependency group corresponds to a database source object and includes at least those database objects that depend directly or indirectly from the corresponding database source object. When these data source object-based dependency groups are graphically displayed, selecting a database object thereof provides access thereto. In another example implementation, a user can designate an attribute associated with database objects by which the database objects are to be grouped. Thus, the database objects are grouped by various values that the user-designated associated attribute takes. These designated attribute-based value-driven groups may also be graphically displayed to enable navigation of and access to the different database objects assigned to them.
摘要翻译：通过图形化地呈现不一定由数据库对象的对象类型指定的组中的数据库对象来促进数据库交互。在示例实现中，通过确定数据库的对象依赖性组来促进数据库导航，其中每个对象依赖组对应于数据库源对象，并且至少包括那些直接或间接依赖于对应的数据库源对象的数据库对象。当这些基于数据源的基于对象的依赖组被图形显示时，选择其数据库对象提供对其的访问。在另一示例实现中，用户可以指定与要对数据库对象进行分组的数据库对象相关联的属性。因此，数据库对象按照用户指定的关联属性所采用的各种值进行分组。这些指定的基于属性的价值驱动组也可以以图形方式显示，以便导航和访问分配给它们的不同数据库对象。

9. 发明申请

US20210087233A1 DEUTERATED FORMS OF CARBETOCIN AND ANALOGS THEREOF 有权
公开(公告)号：US20210087233A1
公开(公告)日：2021-03-25
申请号：US16952251
申请日：2020-11-19
申请人： Christopher Bryant , Joseph William Cormier , Daniel G. Welch
发明人： Christopher Bryant , Joseph William Cormier , Daniel G. Welch
IPC分类号： C07K7/56 , C07B59/00 , A61K9/00
摘要： The present disclosure relates to deuterated forms of oxytocin, carbetocin and analogs thereof. The disclosed deuterated compounds may have similar biochemical potency and selectivity as the parent compound, and, in select instances, the selective deuteration may enable substantial benefits to their overall therapeutic profile, such as reduced adverse side effects with a decreased metabolic liability, extended pharmacological effective life, enhanced subject compliance, and/or may also decrease population pharmacokinetic variability. The present disclosure also includes pharmaceutical compositions of deuterated compounds, which may be used to treat various diseases and conditions.

10. 发明申请

US20200093885A1 CARBETOCIN DRUG PRODUCT AND PROCESS FOR PREPARING THE SAME 审中-公开
公开(公告)号：US20200093885A1
公开(公告)日：2020-03-26
申请号：US16576961
申请日：2019-09-20
申请人： Christopher BRYANT , Mark C. Manning , Ryan E. Holcomb
发明人： Christopher BRYANT , Mark C. Manning , Ryan E. Holcomb
IPC分类号： A61K38/095 , A61K47/38 , A61K9/08 , A61K47/22 , A61K47/26
摘要： The present disclosure includes a method of making an improved carbetocin drug product. The disclosed method for making an improved carbetocin drug product comprises agitating a carbetocin preparation containing an aqueous solution of carbetocin and one or more excipients for a period of time to initiate the formation of aggregate-forming solids and filtering off the aggregates that form before further processing the remaining carbetocin into a final drug product. The present disclosure also relates to an improved carbetocin drug product, wherein the drug product is substantially free of aggregate-forming solids. The disclosed carbetocin drug product can be used for the treatment of a neurodevelopmental disorder, such as Präder-Willi syndrome. Additionally, the disclosed carbetocin drug product shows content uniformity of carbetocin over long periods of time before and after one or more freeze/thaw cycles, provides enhanced convenience and patient compliance, and/or are highly concentrated.

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