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1. 发明授权

US09474810B2 Superparamagnetic nanoparticles with PEG substituted α-hydroxy phosphonate shells 有权
标题翻译：具有PEG取代的α-羟基膦酸酯壳的超顺磁性纳米颗粒
公开(公告)号：US09474810B2
公开(公告)日：2016-10-25
申请号：US13411004
申请日：2012-03-02
申请人： Bruce Allan Hay , Daniel Eugene Meyer , Brian Christopher Bales , Michael Todd Luttrell
发明人： Bruce Allan Hay , Daniel Eugene Meyer , Brian Christopher Bales , Michael Todd Luttrell
IPC分类号： A61K49/18 , A61K47/48 , A61K33/26 , A61K33/28 , A61K33/24 , A61K33/32 , A61K33/34
CPC分类号： A61K49/186 , A61K33/24 , A61K33/26 , A61K33/32 , A61K33/34 , A61K47/548 , A61K47/60 , A61K47/6923 , A61K47/6929 , A61K49/1842 , Y10T428/2982
摘要： The present application discloses nanoparticles, particularly nanoparticles of superparamagnetic iron oxide, which find utility in iron therapy and diagnostic imaging such as magnetic resonance (MR). The disclosed nanoparticles have been treated with an α-hydroxyphosphonic acid conjugate containing polyethylene glycol as a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are polyethylene oxide-based polymers and have a molecular weight greater than 5,000 dalton and less than or equal to about 30,000 daltons. Surprisingly, these nanoparticles have a more rapid and complete processing in liver of retained nanoparticles when compared to similar nanoparticles in which the PEG-based hydrophilic moiety has a molecular weight less than 5,000.
摘要翻译：本申请公开了纳米颗粒，特别是超顺磁性氧化铁的纳米颗粒，其可用于铁疗法和诸如磁共振（MR）的诊断成像。所公开的纳米颗粒已经用含有聚乙二醇作为亲水部分的α-羟基膦酸缀合物进行处理，以使纳米颗粒充分亲水以发现在诊断成像中的应用。所公开的改性亲水性纳米粒子是其中改性缀合物的亲水部分是聚环氧乙烷基聚合物并具有大于5,000道尔顿且小于或等于约30,000道尔顿的分子量的那些。令人惊讶的是，与其中基于PEG的亲水部分具有小于5,000的分子量的类似纳米颗粒相比，这些纳米颗粒在保留的纳米颗粒的肝中具有更快速和完整的加工。

2. 发明授权

US09251937B2 Heat stable nanoparticle preparations and associated methods thereof 有权
标题翻译：热稳定纳米颗粒制剂及其相关方法
公开(公告)号：US09251937B2
公开(公告)日：2016-02-02
申请号：US13538493
申请日：2012-06-29
申请人： Brian Christopher Bales , Brian James Grimmond , Daniel Eugene Meyer , Bruce Allan Hay , Michael Todd Luttrell
发明人： Brian Christopher Bales , Brian James Grimmond , Daniel Eugene Meyer , Bruce Allan Hay , Michael Todd Luttrell
IPC分类号： A61K49/18 , H01F1/00 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00
CPC分类号： H01F1/0054 , A61K49/1842 , A61K49/186 , B82Y5/00 , B82Y15/00 , B82Y30/00 , B82Y40/00
摘要： A method of sterilizing a nanoparticle preparation at a high temperature is provided. A plurality of nanoparticles are purified to form the preparation, wherein the nanoparticles comprise at least a core and a shell and the shell comprises one or more ligand species attached to the core. The nanoparticle preparation is made by a purified nanoparticle composition, a carrier fluid and an excess of the one or more ligand species not attached to the core. The ligand species attached to the core and the excess ligand species added after purification are structurally identical. The nanoparticle preparation provided by the present invention may be used as contrast agents in medical imaging techniques such as X-ray and magnetic resonance imaging.
摘要翻译：提供了一种在高温下对纳米颗粒制剂进行灭菌的方法。纯化多个纳米颗粒以形成制剂，其中所述纳米颗粒至少包含核和壳，并且所述壳包含连接到核的一种或多种配体物质。纳米颗粒制备由纯化的纳米颗粒组合物，载体流体和过量的未连接到核的一种或多种配体物质制备。在核心附着的配体物质和纯化后加入的过量配体物质在结构上是相同的。本发明提供的纳米颗粒制剂可用作医学成像技术如X射线和磁共振成像中的造影剂。

3. 发明申请

US20110104072A1 TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS 有权
标题翻译：用水解ALPHA-羟基磷酸共聚物处理水不溶性纳米颗粒，该改性纳米粒子及其作为对比剂的用途
公开(公告)号：US20110104072A1
公开(公告)日：2011-05-05
申请号：US12609799
申请日：2009-10-30
申请人： Brian Christopher Bales , Bruce Allan Hay , Binil Itty Ipe Kandapallil
发明人： Brian Christopher Bales , Bruce Allan Hay , Binil Itty Ipe Kandapallil
IPC分类号： A61K49/08 , C07F9/38 , C08G61/04 , A61K49/04
CPC分类号： A61K49/1857 , A61K49/0428 , A61K49/1842 , A61K49/186 , B82Y5/00
摘要： The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.
摘要翻译：本申请公开了处理水不溶性纳米颗粒，特别是金属和金属化合物的纳米颗粒，其在诊断成像如MR和X射线成像中具有与亲水部分的α-羟基膦酸缀合物的效用，以使纳米颗粒充分亲水以发现在诊断成像中的应用。所公开的改性亲水性纳米粒子中的那些是其中改性缀合物的亲水部分是环氧乙烷基聚合物和共聚物和两性离子，并且纳米颗粒由过渡金属氧化物如超顺磁性氧化铁和氧化钽组成。公开了足够亲水以形成稳定的水性胶体悬浮液的纳米颗粒。还公开了使用修饰的亲水性纳米颗粒作为造影剂的诊断成像如MR和X射线。

4. 发明申请

US20100278748A1 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
公开(公告)号：US20100278748A1
公开(公告)日：2010-11-04
申请号：US12431892
申请日：2009-04-29
申请人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Peter John Bonitatibus, JR. , Matthew David Butts , Robert Edgar Colborn , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
IPC分类号： A61K49/18 , A61K49/06
CPC分类号： A61K49/1848 , A61K49/0428 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one net positively charged group and at least one net negatively charged group, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core and a shell. The shell comprises a plurality of silane moieties; at least one silane moiety of the plurality is functionalized with a net positively charged group and at least one silane moiety of the plurality is functionalized with a net negatively charged group.

5. 发明申请

US20100166664A1 NANOPARTICLE CONTRAST AGENTS FOR DIAGNOSTIC IMAGING 审中-公开
公开(公告)号：US20100166664A1
公开(公告)日：2010-07-01
申请号：US12344604
申请日：2008-12-29
申请人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
发明人： Matthew David Butts , Robert Edgar Colborn , Peter John Bonitatibus, JR. , Amit Mohan Kulkarni , Bruce Allan Hay , Andrew Soliz Torres , Brian Christopher Bales , Michael Ernest Marino
IPC分类号： A61K49/18 , A61K49/04 , B82B1/00 , B82B3/00
CPC分类号： A61K49/0428 , A61K49/1848 , B82Y5/00
摘要： Compositions of nanoparticles functionalized with at least one zwitterionic moiety, methods for making a plurality of nanoparticles, and methods of their use as diagnostic agents are provided. The nanoparticles have characteristics that result in minimal retention of the particles in the body compared to other nanoparticles. The nanoparticle comprises a core, having a core surface essentially free of silica, and a shell attached to the core surface. The shell comprises at least one silane-functionalized zwitterionic moiety.

6. 发明申请

US20070113188A1 System and method for providing dynamic content in a communities framework 审中-公开
标题翻译：在社区框架中提供动态内容的系统和方法
公开(公告)号：US20070113188A1
公开(公告)日：2007-05-17
申请号：US11371305
申请日：2006-03-08
申请人： Christopher Bales , Nathan Olson , Charles Coates , Petri Pellinen , Richard Feit , Edward O'Neil
发明人： Christopher Bales , Nathan Olson , Charles Coates , Petri Pellinen , Richard Feit , Edward O'Neil
IPC分类号： G06F17/00 , G06F15/16 , G06F15/173
CPC分类号： G06F16/958
摘要： A client and server computers can be provided in the context of a community framework. Portions of the client's user interface can be updated dynamically and granularly via communicating with the server and without reposting the entire page upon each communication. A dynamic content tag library can be provided to add dynamic update functionality to the client's user interface. The developer can use tags contained in the tag library when customizing the user interface for various community members. For example, a dynamic container tag can specify a target area on the client's user interface to be updated dynamically. This target area can be a portlet, portion or a portlet, value or some granular piece of data on the user interface. An action script tag can specify a particular update request to be executed by the server, the results of which replace the old contents of the dynamic container.
摘要翻译：可以在社区框架的上下文中提供客户端和服务器计算机。客户端用户界面的部分可以通过与服务器进行通信，并且在每次通信时都不会重新整理整个页面时，可以动态和细粒度地进行更新。可以提供动态内容标签库，以向客户端的用户界面添加动态更新功能。当定制各种社区成员的用户界面时，开发人员可以使用标签库中包含的标签。例如，动态容器标签可以指定客户端用户界面上的目标区域，以便动态更新。该目标区域可以是用户界面上的Portlet，部分或Portlet，值或一些细粒度的数据。动作脚本标签可以指定要由服务器执行的特定更新请求，其结果将替换动态容器的旧内容。

7. 发明申请

US20070110233A1 System and method for providing extensible controls in a communities framework 审中-公开
标题翻译：在社区框架中提供可扩展控件的系统和方法
公开(公告)号：US20070110233A1
公开(公告)日：2007-05-17
申请号：US11601553
申请日：2006-11-17
申请人： Ray Polk , Cindy McMullen , Christopher Bales , Nathan Olson
发明人： Ray Polk , Cindy McMullen , Christopher Bales , Nathan Olson
IPC分类号： H04L9/30
CPC分类号： G06Q10/10 , G06F21/6218
摘要： A communities framework is disclosed which contains resources in a repository. The repository contains data stored in nodes wherein each node has data associated with a collaboration resource and each resource has a set of properties or attributes. A server can provide a content object for wrapping the node wherein the content object defines the type of resource contained by the data in the node. An extensible control is provided that performs operations on the node thereby providing an interface to manipulating the node's data. The extensible controls can allow developers to easily create new resources. A generic control can further wrap the extensible control and be adapted to provide an abstracted interface to the content object. An extensible portlet can implement the extensible controls in order to provide users with the ability to add new properties and edit existing properties of the resource.
摘要翻译：公开了一个包含存储库中的资源的社区框架。存储库包含存储在节点中的数据，其中每个节点具有与协作资源相关联的数据，并且每个资源具有一组属性或属性。服务器可以提供用于包裹节点的内容对象，其中内容对象定义节点中的数据所包含的资源的类型。提供了一种可扩展的控制，其执行节点上的操作，从而提供操纵节点数据的接口。可扩展控件可以让开发人员轻松创建新的资源。通用控件可以进一步包装可扩展控件并适于向内容对象提供抽象界面。可扩展的portlet可以实现可扩展控件，以便为用户提供添加新属性和编辑资源的现有属性的功能。

8. 发明申请

US20070110231A1 System and method for providing notifications in a communities framework 有权
标题翻译：在社区框架中提供通知的系统和方法
公开(公告)号：US20070110231A1
公开(公告)日：2007-05-17
申请号：US11368865
申请日：2006-03-06
申请人： Christopher Bales , Stephen Pepper , Brodi Beartusk , Kevin Frender , Edward O'Neil , Daryl Olander , Richard Feit
发明人： Christopher Bales , Stephen Pepper , Brodi Beartusk , Kevin Frender , Edward O'Neil , Daryl Olander , Richard Feit
IPC分类号： H04L9/30
CPC分类号： H04L63/10 , H04L67/26 , H04L67/325 , Y10S707/99952
摘要： A community enables user membership in a distributed collaborative computing environment. The members can have access to a repository of resources. Dynamic notifications between client and server can be provided. A member can be logged onto a client which pings the server computer through no interaction of the user. A notifications manager located on the server can retrieve updates available for the member in response to each ping. The notifications manager can look up any changes to the resources that the member has subscribed to. The server can subsequently notify the client of the available updates. The client's user interface can be updated to reflect the relevant changes. A dynamic and granular interaction between the server and the client can be enabled instead of updating the entire portal page. Each ping can carry an id of the member and community, which the server can use to determine the relevant updates.
摘要翻译：社区使用户能够在分布式协作计算环境中成为会员。成员可以访问资源库。可以提供客户端和服务器之间的动态通知。成员可以登录到通过用户的互动来ping服务器计算机的客户端。位于服务器上的通知管理器可以检索针对每个ping的成员可用的更新。通知管理器可以查看成员已订阅的资源的任何更改。服务器随后可以通知客户可用的更新。可以更新客户端的用户界面以反映相关更改。可以启用服务器和客户端之间的动态和细粒度的交互，而不是更新整个门户页面。每个ping可以携带成员和社区的id，服务器可以使用该标识来确定相关更新。

9. 发明申请

US20060294457A1 System and method for configuring a document 有权
标题翻译：用于配置文档的系统和方法
公开(公告)号：US20060294457A1
公开(公告)日：2006-12-28
申请号：US11167697
申请日：2005-06-27
申请人： Christopher Bales , Nathan Olson
发明人： Christopher Bales , Nathan Olson
IPC分类号： G06F15/00
CPC分类号： G06F17/30873 , G06F17/3089
摘要： Embodiments of the present invention enable efficient presentation of user information. A user identifier is presented on a page. In response to a selection of a user identifier, one or more user information modules are utilized to return information relating to the user. The user information modules are modules that maintain user information in association with a user. In one embodiment, a configurable java server tag function generates the presentation of the user identifier, which can then be selected and utilized to request information from one or more information sources.
摘要翻译：本发明的实施例能够有效地呈现用户信息。用户标识符显示在页面上。响应于用户标识符的选择，使用一个或多个用户信息模块来返回与用户有关的信息。用户信息模块是维护与用户相关联的用户信息的模块。在一个实施例中，可配置的java服务器标签功能产生用户标识符的呈现，然后可以选择并使用用户标识符来从一个或多个信息源请求信息。

10. 发明申请

US20060294160A1 System and method for improved user information management 有权
标题翻译：改进用户信息管理的系统和方法
公开(公告)号：US20060294160A1
公开(公告)日：2006-12-28
申请号：US11167702
申请日：2005-06-27
申请人： Christopher Bales , Nathan Olson
发明人： Christopher Bales , Nathan Olson
IPC分类号： G06F17/30 , G06F17/00
CPC分类号： G06F17/3089
摘要： Embodiments of the present invention enable efficient presentation of user information. A user identifier is presented on a page. In response to a selection of a user identifier, one or more user information modules are utilized to return information relating to the user. The user information modules are modules that maintain user information in association with a user. In one embodiment, a configurable java server tag function generates the presentation of the user identifier, which can then be selected and utilized to request information from one or more information sources.
摘要翻译：本发明的实施例能够有效地呈现用户信息。用户标识符显示在页面上。响应于用户标识符的选择，使用一个或多个用户信息模块来返回与用户有关的信息。用户信息模块是维护与用户相关联的用户信息的模块。在一个实施例中，可配置的java服务器标签功能生成用户标识符的呈现，然后可以选择并使用用户标识符来从一个或多个信息源请求信息。

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