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1. 发明授权

US09096599B2 Spiroindoline compounds 有权
标题翻译：螺二氢吲哚化合物
公开(公告)号：US09096599B2
公开(公告)日：2015-08-04
申请号：US14236946
申请日：2012-08-03
申请人： Christophe Pierre Alain Chassaing , Sandra Koch , Jürgen Lutz
发明人： Christophe Pierre Alain Chassaing , Sandra Koch , Jürgen Lutz
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.
摘要翻译：本发明涉及通常可用作药物的式（I）的新型螺二氢吲哚化合物，更具体地说是作为动物的药物。药物可优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。本发明还涉及所述化合物的制备。此外，本发明涉及包含该化合物的药物组合物和试剂盒。

2. 发明授权

US08507474B2 Anthelmintic agents and their use 有权
标题翻译：驱虫剂及其用途
公开(公告)号：US08507474B2
公开(公告)日：2013-08-13
申请号：US13378377
申请日：2010-06-16
申请人： Christophe Pierre Alain Chassaing , Thorsten Meyer
发明人： Christophe Pierre Alain Chassaing , Thorsten Meyer
IPC分类号： C07D213/04 , C07D213/84 , C07D285/125 , C07D401/04 , C07D401/12 , C07D417/04 , A61K31/551 , A61K31/496 , A61K31/4545 , A61P33/10
CPC分类号： C07D213/74 , C07D213/84 , C07D285/125 , C07D401/04 , C07D401/12
摘要： This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds of this invention, pharmaceutical compositions and kits comprising the compounds of this invention, uses of the compounds of this invention to make medicaments, and treatments comprising the administration of the compounds of this invention to animals in need of the treatments.
摘要翻译：本发明涉及式（I）化合物及其盐，因此通常可用作驱肠剂或作为制备驱肠剂的方法中的中间体。本发明还涉及制备本发明化合物的方法，包含本发明化合物的药物组合物和试剂盒，本发明化合物的用途制备药物，以及包括将本发明化合物施用于动物的治疗需要治疗。

3. 发明申请

US20120295931A1 SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS 审中-公开
标题翻译：螺旋体化合物作为安全性使用
公开(公告)号：US20120295931A1
公开(公告)日：2012-11-22
申请号：US13574900
申请日：2011-02-04
申请人： Jürgen Lutz , Sandra Koch , Manfred Uphoff , Anja Regina Heckeroth , Britta von Oepen , Ulrich Sonderin , Christophe Pierre Alain Chassaing
发明人： Jürgen Lutz , Sandra Koch , Manfred Uphoff , Anja Regina Heckeroth , Britta von Oepen , Ulrich Sonderin , Christophe Pierre Alain Chassaing
IPC分类号： A61K31/438 , A61P33/00 , C07D471/10
CPC分类号： C07D471/10 , A61K31/438 , A61K31/444 , A61K45/06 , Y02A50/423
摘要： This invention relates to spiroindoline compounds for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.
摘要翻译：本发明涉及用于治疗蠕虫感染的螺二氢吲哚化合物和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。此外，本发明涉及包含该化合物的药物组合物和试剂盒。

4. 发明申请

US20120094981A1 ANTHELMINTIC AGENTS AND THEIR USE 有权
标题翻译： ANTHELMINIC代理及其使用
公开(公告)号：US20120094981A1
公开(公告)日：2012-04-19
申请号：US13378377
申请日：2010-06-16
申请人： Christophe Pierre Alain Chassaing , Thorsten Meyer
发明人： Christophe Pierre Alain Chassaing , Thorsten Meyer
IPC分类号： A61K31/551 , A61K31/496 , A61P33/10 , C07D401/12 , A61K31/4545 , C07D401/04 , C07D417/04
CPC分类号： C07D213/74 , C07D213/84 , C07D285/125 , C07D401/04 , C07D401/12
摘要： This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds of this invention, pharmaceutical compositions and kits comprising the compounds of this invention, uses of the compounds of this invention to make medicaments, and treatments comprising the administration of the compounds of this invention to animals in need of the treatments.
摘要翻译：本发明涉及式（I）化合物及其盐，因此通常可用作驱肠剂或作为制备驱肠剂的方法中的中间体。本发明还涉及制备本发明化合物的方法，包含本发明化合物的药物组合物和试剂盒，本发明化合物的用途制备药物，以及包括将本发明化合物施用于动物的治疗需要治疗。

5. 发明申请

US20090131369A1 Novel Benzimidazole(Thio)Carbamates with Antiparasitic Activity and the Synthesis Thereof 有权
标题翻译：具有抗寄生虫活性的新型苯并咪唑（Thio）氨基甲酸酯及其合成
公开(公告)号：US20090131369A1
公开(公告)日：2009-05-21
申请号：US11997057
申请日：2006-07-18
申请人： Christophe Pierre Alain Chassaing
发明人： Christophe Pierre Alain Chassaing
IPC分类号： A61K31/675 , C07F9/06
CPC分类号： C07F9/65068
摘要： This invention relates to benzimidazole carbamates and (thio)carbamates corresponding to Formula I: Here, X1 and X2 are independently O or S, wherein at least one of X1 and X2 is O; Y1 and Y2 are independently O or S, wherein at least one of Y1 and Y2 is O; R1 is alkyl having from 1-4 carbon atoms; R2, R3, and R4 are independently hydrogen or a cation; R5 and R6 are independently hydrogen, halogen, alkyl (having from 1-8 carbon atoms), —OR7, —SR8, —CO—R9, —OSO2—Ar, or —S(O)R10; R7 is alkyl having from 1-8 carbon atoms; R8 is alkyl (having from 1-8 carbon atoms) or aryl; R9 is alkyl (having from 1-8 carbon atoms), cycloalkyl (having from 3-6 carbon atoms), or aryl; Ar is aryl; and R10 is alkyl (having from 1-8 carbon atoms) or aryl. The compounds generally are soluble and stable in water, and have antiparasitic (particularly anthelmintic) activity in vivo that is comparable to known water-insoluble benzimidazole carbamates (e.g., albendazole and fenbendazole).
摘要翻译：本发明涉及对应于式I的苯并咪唑氨基甲酸酯和（硫代）氨基甲酸酯：这里，X 1和X 2独立地为O或S，其中X 1和X 2中的至少一个为O; Y1和Y2独立地为O或S，其中Y1和Y2中的至少一个为O; R1是具有1-4个碳原子的烷基; R2，R3和R4独立地为氢或阳离子; R5和R6独立地是氢，卤素，具有1-8个碳原子的烷基，-OR7，-SR8，-CO-R9，-OSO2-Ar或-S（O）R10; R7是具有1-8个碳原子的烷基; R8是烷基（具有1-8个碳原子）或芳基; R9是烷基（具有1-8个碳原子），环烷基（具有3-6个碳原子）或芳基; Ar为芳基; 和R 10是烷基（具有1-8个碳原子）或芳基。化合物通常在水中是可溶的和稳定的，并且在体内具有与已知的水不溶性苯并咪唑氨基甲酸酯（例如阿苯达唑和芬苯达唑）相当的抗寄生虫（特别是驱肠虫）活性。

6. 发明授权

US09096524B2 Anthelmintic agents and their use 有权
标题翻译：驱虫剂及其用途
公开(公告)号：US09096524B2
公开(公告)日：2015-08-04
申请号：US13256369
申请日：2010-03-17
申请人： Christophe Pierre Alain Chassaing , Thorsten Meyer
发明人： Christophe Pierre Alain Chassaing , Thorsten Meyer
IPC分类号： A01N43/66 , A01N43/60 , A01N43/40 , A01N43/54 , C07D239/42 , C07D401/04 , C07D213/74 , C07D207/14 , C07D211/46 , C07D211/58 , C07D295/185 , C07D401/12 , C07D401/14 , C07D417/12 , C07D487/04
CPC分类号： C07D213/74 , C07D207/14 , C07D211/46 , C07D211/58 , C07D295/185 , C07D401/04 , C07D401/12 , C07D401/14 , C07D417/12 , C07D487/04
摘要： This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration of the compounds and salts to animals in need of the treatments.
摘要翻译：本发明涉及通常用作驱肠虫剂或作为制备驱肠剂的方法中的中间体的化合物和盐。本发明还涉及制备化合物和盐的方法，包含化合物和盐的药物组合物和试剂盒，化合物和盐的用途来制备药物，以及包括将化合物和盐施用于需要治疗。

7. 发明申请

US20140163056A1 NOVEL SPIROINDOLINE COMPOUNDS 有权
标题翻译：新型螺旋体化合物
公开(公告)号：US20140163056A1
公开(公告)日：2014-06-12
申请号：US14236946
申请日：2012-08-03
申请人： Christophe Pierre Alain Chassaing , Sandra Koch , Jürgen LUTZ
发明人： Christophe Pierre Alain Chassaing , Sandra Koch , Jürgen LUTZ
IPC分类号： C07D471/10
CPC分类号： C07D471/10
摘要： This invention relates to novel spiroindoline compounds of formula (I) that are generally useful as medicaments, more specifically as medicaments for animals. The medicament can preferably be used for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. This invention also relates to the preparation of said compounds. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.
摘要翻译：本发明涉及通常可用作药物的式（I）的新型螺二氢吲哚化合物，更具体地说是作为动物的药物。药物可优选用于治疗蠕虫感染和寄生虫病的治疗，例如由蠕虫感染引起的寄生虫病。本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。本发明还涉及所述化合物的制备。此外，本发明涉及包含该化合物的药物组合物和试剂盒。

8. 发明申请

US20110319393A1 ANTHELMINTIC AGENTS AND THEIR USE 有权
标题翻译： ANTHELMINIC代理及其使用
公开(公告)号：US20110319393A1
公开(公告)日：2011-12-29
申请号：US13256369
申请日：2010-03-17
申请人： Christophe Pierre Alain Chassaing , Thorsten Meyer
发明人： Christophe Pierre Alain Chassaing , Thorsten Meyer
IPC分类号： A61K31/5513 , A61P33/00 , C07D417/14 , C07D403/06 , C07D401/14 , C07D487/04 , A61K31/496 , A61K31/454
CPC分类号： C07D213/74 , C07D207/14 , C07D211/46 , C07D211/58 , C07D295/185 , C07D401/04 , C07D401/12 , C07D401/14 , C07D417/12 , C07D487/04
摘要： This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration of the compounds and salts to animals in need of the treatments.
摘要翻译：本发明涉及通常用作驱肠虫剂或作为制备驱肠剂的方法中的中间体的化合物和盐。本发明还涉及制备化合物和盐的方法，包含化合物和盐的药物组合物和试剂盒，化合物和盐的用途来制备药物，以及包括将化合物和盐施用于需要治疗。

9. 发明申请

US20110021506A1 ANTHELMINTIC AGENTS AND THEIR USE 有权
公开(公告)号：US20110021506A1
公开(公告)日：2011-01-27
申请号：US12808897
申请日：2008-12-16
申请人： Christophe Pierre Alain Chassaing , Jörg Schröder , Thomas Simon Ilg , Manfred Uphoff , Thorsten Meyer
发明人： Christophe Pierre Alain Chassaing , Jörg Schröder , Thomas Simon Ilg , Manfred Uphoff , Thorsten Meyer
IPC分类号： A61K31/551 , C07D241/04 , C07D211/16 , C07D401/12 , C07D487/06 , C07D243/08 , C07C237/20 , C07D241/08 , A61K31/496 , A61K31/451 , A61K31/407 , A61K31/165 , A61P33/00 , A61P33/10
CPC分类号： C07D211/60 , C07D211/26 , C07D295/108 , C07D487/08
摘要： This invention is directed to compounds and salts that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents. This invention also is directed to processes for making the compounds and salts, pharmaceutical compositions and kits comprising the compounds and salts, uses of the compounds and salts to make medicaments, and treatments comprising the administration of the compounds and salts to animals in need of the treatments.

10. 发明申请

US20150057302A1 SPIROINDOLINE COMPOUNDS FOR USE AS ANTHELMINTHICS 审中-公开
标题翻译：螺旋体化合物作为安全性使用
公开(公告)号：US20150057302A1
公开(公告)日：2015-02-26
申请号：US14513929
申请日：2014-10-14
申请人： Jürgen LUTZ , Sandra KOCH , Manfred UPHOFF , Anja Regina HECKEROTH , Britta von OEPEN , Ulrich SONDERN , Christophe Pierre Alain CHASSAING
发明人： Jürgen LUTZ , Sandra KOCH , Manfred UPHOFF , Anja Regina HECKEROTH , Britta von OEPEN , Ulrich SONDERN , Christophe Pierre Alain CHASSAING
IPC分类号： C07D471/10 , A61K45/06 , A61K31/444
CPC分类号： C07D471/10 , A61K31/438 , A61K31/444 , A61K45/06 , Y02A50/423
摘要： This invention relates to spiroindoline compounds for the treatment of helminth infections and the treatment of parasitosis, such as caused by helminth infections. This invention also relates to uses of the compounds to make medicaments and treatments comprising the administration of the compounds to animals in need of the treatments. Moreover this invention relates to pharmaceutical compositions and kits comprising the compounds.
摘要翻译：本发明涉及用于治疗蠕虫感染的螺二氢吲哚化合物和由蠕虫感染引起的寄生虫病的治疗。本发明还涉及该化合物制备药物和治疗方法的用途，其包括将化合物施用于需要治疗的动物。此外，本发明涉及包含该化合物的药物组合物和试剂盒。

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