专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110059964A1 PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS 审中-公开
标题翻译：吡唑衍生物及其作为OREXIN受体拮抗剂的用途
公开(公告)号：US20110059964A1
公开(公告)日：2011-03-10
申请号：US12699231
申请日：2010-02-03
申请人： Michel Aletru , Peter Aranyi , Maria Balogh , Sandor Batori , Judit Bence , Philippe Bovy , Zoltan Kapui , Endre Mikus , Claudie Namane , Christophe Philippo , Tibor Szabo , Zsuzsanna Tomoskozi , Katalin Urban-Szabo
发明人： Michel Aletru , Peter Aranyi , Maria Balogh , Sandor Batori , Judit Bence , Philippe Bovy , Zoltan Kapui , Endre Mikus , Claudie Namane , Christophe Philippo , Tibor Szabo , Zsuzsanna Tomoskozi , Katalin Urban-Szabo
IPC分类号： A61K31/415 , C07D401/12 , C07D231/16 , C07D471/04 , C07D405/12 , C07D413/12 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/4709 , A61K31/4375 , A61K31/423 , A61K31/428 , A61K31/498 , A61K31/5377 , C07D401/04 , C07D413/06 , C07D409/04 , C07F9/54 , A61P3/04 , A61P3/10 , A61P25/00 , A61P25/24 , A61P25/22 , A61P15/00 , A61P29/00 , A61P11/00 , A61P9/00
CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
摘要翻译：本发明涉及食欲素受体拮抗剂通式（I）化合物及其异构体，盐和溶剂合物，其含有它们的药物组合物及其治疗应用。

2. 发明申请

US20100324084A1 UREA DERIVATIVES OF TROPANE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION 审中-公开
标题翻译： TROPANE的尿素衍生物及其制备及其治疗应用
公开(公告)号：US20100324084A1
公开(公告)日：2010-12-23
申请号：US12871403
申请日：2010-08-30
申请人： Michel ALETRU , Alain Jean BRAUN , Claudie NAMANE , Olivier VENIER , Christophe PHILIPPO , Patrick MOUGENOT , Eric NICOLAI , Stefan GUSSREGEN
发明人： Michel ALETRU , Alain Jean BRAUN , Claudie NAMANE , Olivier VENIER , Christophe PHILIPPO , Patrick MOUGENOT , Eric NICOLAI , Stefan GUSSREGEN
IPC分类号： A61K31/46 , C07D401/14 , A61P3/10 , A61P3/04 , A61P5/50 , A61P9/12 , A61P9/10 , A61P27/06 , A61P25/28 , A61P19/10
CPC分类号： C07D471/08
摘要： The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).
摘要翻译：本发明涉及式（I）化合物，其中R 1a，R 1b，R 1c，R 1d，R 2a，R 2b，R 3，R 4，p，r和如本文所定义，其制备，药物组合物和用作调节剂 11＆bgr-羟基类固醇脱氢酶1（11＆bgr; HSD1）的活性。

3. 发明授权

US6060508A Benzylamine derivatives, their preparation and their application in therapeutics 失效
标题翻译：苄胺衍生物，其制备及其在治疗中的应用
公开(公告)号：US6060508A
公开(公告)日：2000-05-09
申请号：US254121
申请日：1999-02-26
申请人： Christophe Philippo , Marie Claire Orts , Olivier Crespin , Philippe R. Bovy
发明人： Christophe Philippo , Marie Claire Orts , Olivier Crespin , Philippe R. Bovy
IPC分类号： C07D333/54 , A61K31/343 , A61K31/381 , A61P1/00 , A61P9/00 , A61P13/00 , A61P25/06 , A61P27/16 , C07D307/79 , C07D307/85 , C07D307/91 , A61K31/34 , A61K31/38 , C07D307/78 , C07D333/52
CPC分类号： C07D307/79
摘要： Compounds of general formula (I) ##STR1## in which: A represents either a hydrogen atom, a hydroxyl, a C.sub.1-6 hydroxyalkyl group, a thiol, a C.sub.1-6 alkylsulphanyl group, an amino group, a C.sub.1-6 alkylamino group, a di(C.sub.1-6 alkyl)amino group, a C.sub.1-6 alkylhydroxylamine group, a C.sub.1-6 alkoxy group, a hydroxylamine group, an N,O-di(C.sub.1-6 alkyl)hydroxylamine group, an azido or a halogen such as fluorine, chlorine or bromine, B represents a hydrogen atom, a linear or branched C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.1-6 fluoroalkyl group, a C.sub.1-2 perfluoroalkyl group, a C.sub.1-6 alkoxy group, a phenyl group or an oxo group, X represents an oxygen or sulphur atom.Application in therapeutics.
摘要翻译： PCT No.PCT / FR97 / 01514 Sec。 371日期1999年2月26日 102（e）1999年2月26日PCT 1997年8月22日提交PCT公布。公开号WO98 / 08834 日期：1998年3月5日通式（I）的化合物，其中：A表示氢原子，羟基，C1-6羟基烷基，硫醇，C1-6烷基硫烷基，氨基，C1-6 烷基氨基，二（C 1-6烷基）氨基，C 1-6烷基羟胺基，C 1-6烷氧基，羟胺基，N，O-二（C 1-6烷基）羟胺基，叠氮基或卤素如氟，氯或溴，B表示氢原子，直链或支链C 1-6烷基，C 2-6烯基，C 1-6氟烷基，C 1-2全氟烷基，C 1〜 6烷氧基，苯基或氧代基，X表示氧或硫原子。在治疗中的应用。

4. 发明申请

US20120040984A1 THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 有权
标题翻译：噻唑和奥多唑衍生物，其制备方法及其治疗方法
公开(公告)号：US20120040984A1
公开(公告)日：2012-02-16
申请号：US13145665
申请日：2010-01-27
申请人： Eykmar Fett , Patrick Mougenot , Claudie Namane , Eric Nicolai , Christophe Philippo
发明人： Eykmar Fett , Patrick Mougenot , Claudie Namane , Eric Nicolai , Christophe Philippo
IPC分类号： A61K31/5377 , A61K31/433 , C07D417/04 , A61K31/4439 , C07D417/06 , C07D417/12 , C07D271/113 , A61K31/4245 , C07C69/612 , C07C69/757 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/00 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/14 , A61P17/00 , A61P25/28 , A61P37/00 , A61P31/18 , A61P1/00 , A61P35/00 , C07D285/135
CPC分类号： C07D271/06 , C07D285/12
摘要： The invention relates to compounds of the formula (I) either (i) in the state of a base or an acid addition salt, or (ii) in the state of an acid or a base addition salt, as well as to a method for preparing same and to the therapeutic applications thereof.
摘要翻译：本发明涉及式（I）的化合物：（i）以碱或酸加成盐的状态，或（ii）以酸或碱加成盐的状态，以及制备它们及其治疗应用。

5. 发明授权

US07897773B2 Urea derivatives of tropane, their preparation and their therapeutic application 有权
标题翻译：托烷的尿素衍生物及其制备及其治疗应用
公开(公告)号：US07897773B2
公开(公告)日：2011-03-01
申请号：US12332547
申请日：2008-12-11
申请人： Michel Aletru , Alain Jean Braun , Claudie Namane , Olivier Venier , Christophe Philippo , Patrick Mougenot , Eric Nicolai , Stefan Gussregen
发明人： Michel Aletru , Alain Jean Braun , Claudie Namane , Olivier Venier , Christophe Philippo , Patrick Mougenot , Eric Nicolai , Stefan Gussregen
IPC分类号： C07D401/00
CPC分类号： C07D471/08
摘要： The present invention is related to a compound of formula (I) wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R4, p, r and are as defined herein, its preparation, pharmaceutical composition and use as a modulator of the activity of the 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1).
摘要翻译：本发明涉及式（I）化合物，其中R 1a，R 1b，R 1c，R 1d，R 2a，R 2b，R 3，R 4，p，r和如本文所定义，其制备，药物组合物和用作调节剂 11＆bgr-羟基类固醇脱氢酶1（11＆bgr; HSD1）的活性。

6. 发明申请

US20070021459A1 PYRAZOLE DERIVATIVES AND USE THEREOF AS OREXIN RECEPTOR ANTAGONISTS 有权
标题翻译：吡唑衍生物及其作为OREXIN受体拮抗剂的用途
公开(公告)号：US20070021459A1
公开(公告)日：2007-01-25
申请号：US11425583
申请日：2006-06-21
申请人： Michel ALETRU , Peter ARANYI , Maria BALOGH , Sandor BATORI , Judit BENCE , Philippe BOVY , Zoltan KAPUI , Endre MIKUS , Claudie NAMANE , Christophe PHILIPPO , Tibor SZABO , Zsuzsanna TOMOSKOZI , Katalin URBAN-SZABO
发明人： Michel ALETRU , Peter ARANYI , Maria BALOGH , Sandor BATORI , Judit BENCE , Philippe BOVY , Zoltan KAPUI , Endre MIKUS , Claudie NAMANE , Christophe PHILIPPO , Tibor SZABO , Zsuzsanna TOMOSKOZI , Katalin URBAN-SZABO
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/415 , C07D403/14 , C07D403/02 , C07D231/14
CPC分类号： C07D409/04 , C07D231/16 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing them and to the therapeutic application thereof.
摘要翻译：本发明涉及食欲素受体拮抗剂通式（I）化合物及其异构体，盐和溶剂合物，其含有它们的药物组合物及其治疗应用。

7. 发明授权

US06617336B1 2-arylquinoline derivatives, preparation and therapeutic use thereof 失效
标题翻译： 2-芳基喹啉衍生物，其制备和治疗用途
公开(公告)号：US06617336B1
公开(公告)日：2003-09-09
申请号：US10130875
申请日：2002-05-22
申请人： Philippe R Bovy , Alain Braun , Christophe Philippo
发明人： Philippe R Bovy , Alain Braun , Christophe Philippo
IPC分类号： A61K314706
CPC分类号： C07D401/04 , C07D215/12 , C07D215/14 , C07D409/04
摘要： Compounds of general formula (I) in which: A represents a hydrogen atom, a hydroxyl, a C1-3 alkoxy group, a hydroxy(C1-6 alkyl) group, a (C1-3 alkoxy)(C1-3 alkyl) group, a thiol, (C1-6 alkyl)sulfanyl or a halogen; B and D represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or B and D together from an oxo; R1 represents a phenyl, a naphthyl or a heteroaryl comprising 4 or 5 carbon atoms; R2 and R3 represent, independently of one another, a hydrogen atom, a halogen or a C1-6 alkyl group, R4 represents a hydrogen atom, a hydroxyl or a halogen, and R5 and R6 represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkenyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or R5 and R6 together form a C2-6 alkylene chain or a C3-6 alkenylene chain, to give, with the nitrogen to which they are attached, a heterocycle, this heterocycle optionally being substituted by a C1-4 alkyl group; and their salts.
摘要翻译：通式（I）的化合物，其中：A表示氢原子，羟基，C 1-3烷氧基，羟基（C 1-6烷基），（C 1-3烷氧基）（C 1-3烷基），硫醇，（C 1-6烷基）硫烷基或卤素; B和D彼此独立地表示氢原子，C 1-6烷基，氟（C 1-6烷基）或全氟（C 1 -C 6烷基） -2烷基）基团或B和D一起来自氧代; R 1表示苯基，萘基或含有4或5个碳原子的杂芳基; R 2和R 3彼此独立地表示氢原子，卤素或C 1 -6-烷基，R 4表示氢原子，羟基或卤素，R 5和R 6彼此独立地表示氢原子，C 1-6烷基，C 2-6烯基，C 3-6环烷基基团，C3-6环烯基，氟（C1-6烷基）基团或全氟（C1-2烷基）基团或R5和R6一起形成C 2-6亚烷基链或C 3-6亚烯基链，得到与它们相连的氮，杂环，t 他的杂环任选被C 1-4烷基取代; 和它们的盐。

8. 发明授权

US08546391B2 Thiadiazole and oxadiazole derivatives, preparation thereof and therapeutic use thereof 有权
标题翻译：噻二唑和恶二唑衍生物，其制备及其治疗用途
公开(公告)号：US08546391B2
公开(公告)日：2013-10-01
申请号：US13145665
申请日：2010-01-27
申请人： Eykmar Fett , Patrick Mougenot , Claudie Namane , Eric Nicolai , Christophe Philippo
发明人： Eykmar Fett , Patrick Mougenot , Claudie Namane , Eric Nicolai , Christophe Philippo
IPC分类号： A61K31/5377 , A61K31/433 , A61K31/4439 , A61K31/4245 , C07D417/06 , C07D417/12 , C07D271/113 , C07D285/135
CPC分类号： C07D271/06 , C07D285/12
摘要： The invention relates to compounds of the formula (I) either (i) in the state of a base or an acid addition salt, or (ii) in the state of an acid or a base addition salt, as well as to a method for preparing same and to the therapeutic applications thereof.
摘要翻译：本发明涉及式（I）的化合物：（i）以碱或酸加成盐的状态，或（ii）以酸或碱加成盐的状态，以及制备它们及其治疗应用。

9. 发明授权

US08530657B2 Substituted adamantanes and their therapeutic application 有权
标题翻译：取代金刚烷及其治疗应用
公开(公告)号：US08530657B2
公开(公告)日：2013-09-10
申请号：US13483710
申请日：2012-05-30
申请人： Alain Jean Braun , Olivier Crespin , Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Christophe Philippo , Olivier Venier
发明人： Alain Jean Braun , Olivier Crespin , Claudie Namane , Eric Nicolai , Francois Pacquet , Cecile Pascal , Christophe Philippo , Olivier Venier
IPC分类号： C07D497/00
CPC分类号： C07D239/26 , C07D241/44 , C07D401/10 , C07D401/12
摘要： The present invention relates to tetrahydroquinoxaline urea derivatives of formula (I) as defined herein, and, to their preparation and to their therapeutic application.
摘要翻译：本发明涉及本文定义的式（I）的四氢喹喔aline脲衍生物，以及它们的制备及其治疗应用。

10. 发明授权

US07947834B2 Substituted quinoxalines, their preparation and their therapeutical use as 11βHSD1 modulators 有权
标题翻译：取代喹喔啉，其制备及其治疗用途为11＆amp; HSD1调节剂
公开(公告)号：US07947834B2
公开(公告)日：2011-05-24
申请号：US12337967
申请日：2008-12-18
申请人： Alain Braun , Patrick Mougenot , Claudie Namane , Eric Nicolai , Francois Pacquet , Christophe Philippo , Olivier Venier , Olivier Crespin , Cecile Pascal , Michel Aletru , Stefan Gussregen
发明人： Alain Braun , Patrick Mougenot , Claudie Namane , Eric Nicolai , Francois Pacquet , Christophe Philippo , Olivier Venier , Olivier Crespin , Cecile Pascal , Michel Aletru , Stefan Gussregen
IPC分类号： C07D241/36
CPC分类号： C07D401/14 , C07D401/06 , C07D403/06 , C07D403/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要： The present invention is related to a compound of formula (I): wherein i, j, n, o, p, q, r, R1a, R1b, R1c, R1d, R2a, R2b, R2c, R2d, R3a, R3b and R4 are as defined herein, or an addition salt with an acid thereof, or a hydrate or solvate thereof, its preparation, pharmaceutical composition, and uses for treating a disease in which the enzyme 11β-HSD1 is involved.
摘要翻译：本发明涉及式（I）化合物：其中i，j，n，o，p，q，r，R1a，R1b，R1c，R1d，R2a，R2b，R2c，R2d，R3a，R3b和R4 或其与酸或其水合物或溶剂合物的加成盐，其制备，药物组合物和用于治疗其中涉及酶11和bgr-HSD1的疾病的用途。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式