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1. 发明授权

US08524752B2 Thiazolidin-4-one derivatives 有权
公开(公告)号：US08524752B2
公开(公告)日：2013-09-03
申请号：US13570956
申请日：2012-08-09
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A01N43/78 , A61K31/425 , C07D277/00 , C07D327/04 , C07D343/00
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.

2. 发明申请

US20090018641A1 LARGE VESSEL STENTS 审中-公开
标题翻译：大型水龙头
公开(公告)号：US20090018641A1
公开(公告)日：2009-01-15
申请号：US11909537
申请日：2006-03-24
申请人： Christoph Binkert
发明人： Christoph Binkert
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2230/0054
摘要： Large cell stents can be made having a plurality of cylindrical segments; and a plurality of connectors that join the segments to form a hollow tube, in which each segment comprises a series of support elements joined end to end at turning points in a zig-zag pattern to form a cylinder; a first segment is joined to a second segment by a plurality of connectors, each connector connecting a turning point of a first segment to a corresponding turning point of a second segment; and cells of the stent comprise two support elements in a first segment, one connector, two support elements in a second adjacent segment, and a second connector, all connected in series to form a continuous line. In some embodiments, each turning point in the first segment is longitudinally aligned with turning point in the second segment.
摘要翻译：可以制造具有多个圆柱形段的大型细胞支架; 以及多个连接器，其连接所述段以形成中空管，其中每个段包括在Z字形图案的转折点处端对端连接以形成圆柱体的一系列支撑元件; 第一段通过多个连接器连接到第二段，每个连接器将第一段的转折点连接到第二段的相应转折点; 并且支架的细胞包括第一段中的两个支撑元件，一个连接器，第二相邻区段中的两个支撑元件和全部连续串联连接形成连续线的第二连接器。在一些实施例中，第一段中的每个转折点与第二段中的转折点纵向对准。

3. 再颁专利

USRE43728E1 Thiazolidin-4-one derivatives 有权
标题翻译：噻唑烷-4-酮衍生物
公开(公告)号：USRE43728E1
公开(公告)日：2012-10-09
申请号：US13194172
申请日：2004-11-16
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译：本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。所述化合物还特别用作免疫抑制剂。

4. 发明授权

US07435828B2 Thiazolidin-4-one derivatives 有权
标题翻译：噻唑烷-4-酮衍生物
公开(公告)号：US07435828B2
公开(公告)日：2008-10-14
申请号：US10580169
申请日：2004-11-16
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4- one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译：本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。所述化合物还特别用作免疫抑制剂。

5. 发明申请

US20050043535A1 4-(Piperidyl-and pyrrolidyl-alkyl-ureido)-quinolines as urotensin II receptor antagonists 失效
标题翻译： 4-（哌啶基和吡咯烷基 - 烷基 - 脲基） - 喹啉作为尿素转运蛋白II受体拮抗剂
公开(公告)号：US20050043535A1
公开(公告)日：2005-02-24
申请号：US10501054
申请日：2002-12-02
申请人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
发明人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
IPC分类号： A61K31/4709 , A61P9/02 , C07D20060101 , C07D401/12 , C07D401/14 , C07D471/04 , C07D471/02 , C07D41/02
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译：本发明涉及新颖的1-吡啶-4-基脲衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。

6. 发明授权

US06815451B2 1,2,3,4-Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists 失效
标题翻译： 1,2,3,4-四氢异喹啉衍生物作为尿素转运蛋白II受体拮抗剂
公开(公告)号：US06815451B2
公开(公告)日：2004-11-09
申请号：US10471724
申请日：2003-09-15
申请人： Jörg Velker , Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller
发明人： Jörg Velker , Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller
IPC分类号： C07D40312
CPC分类号： C07D401/12 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists especially urotensin II antagonists.

7. 发明申请

US20120302612A1 NOVEL THIAZOLIDIN-4-ONE DERIVATIVES 有权
标题翻译：新型噻唑烷-4-酮衍生物
公开(公告)号：US20120302612A1
公开(公告)日：2012-11-29
申请号：US13570956
申请日：2012-08-09
申请人： Christoph BINKERT , Martin BOLLI , Boris MATHYS , Claus MUELLER , Michael SCHERZ , Oliver NAYLER
发明人： Christoph BINKERT , Martin BOLLI , Boris MATHYS , Claus MUELLER , Michael SCHERZ , Oliver NAYLER
IPC分类号： A61K31/426 , A61P17/06
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译：本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。所述化合物还特别用作免疫抑制剂。

8. 发明授权

US08067419B2 Piperazines as antimalarial agents 有权
标题翻译：哌嗪作为抗疟剂
公开(公告)号：US08067419B2
公开(公告)日：2011-11-29
申请号：US12090816
申请日：2006-10-20
申请人： Christoph Binkert , Christoph Boss , Olivier Corminboeuf , Corinna Grisostomi , Solange Meyer
发明人： Christoph Binkert , Christoph Boss , Olivier Corminboeuf , Corinna Grisostomi , Solange Meyer
IPC分类号： A61K31/4965 , C07D487/00
CPC分类号： C07D295/185 , C07D209/04 , C07D209/16 , C07D213/26 , C07D213/38 , C07D213/40 , C07D213/60 , C07D213/74 , C07D217/04 , C07D217/14 , C07D233/64 , C07D239/42 , C07D277/28 , C07D307/14 , C07D317/58 , C07D333/20 , C07D333/28 , C07D333/58
摘要： The invention relates to novel piperazine derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including pharmaceutical compositions containing one or more of those compounds and their use as medicaments for the treatment or prevention of protozoal infections, especially malaria.
摘要翻译：本发明涉及新型哌嗪衍生物及其在制备药物组合物中作为活性成分的用途。本发明还涉及包括含有一种或多种这些化合物的药物组合物及其用作治疗或预防原生动物感染，特别是疟疾的药物的相关方面。

9. 发明授权

US07875726B2 Thiazolidin-4-one derivatives 有权
标题翻译：噻唑烷-4-酮衍生物
公开(公告)号：US07875726B2
公开(公告)日：2011-01-25
申请号：US12132443
申请日：2008-06-03
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A61K31/426 , C07D277/54
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译：本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。所述化合物还特别用作免疫抑制剂。

10. 发明申请

US20080146629A1 NOVEL THIAZOLIDIN-4-ONE DERIVATIVES 有权
标题翻译：新型噻唑烷-4-酮衍生物
公开(公告)号：US20080146629A1
公开(公告)日：2008-06-19
申请号：US12026277
申请日：2008-02-05
申请人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
发明人： Christoph Binkert , Martin Bolli , Boris Mathys , Claus Mueller , Michael Scherz , Oliver Nayler
IPC分类号： A61K31/426 , C07D277/38
CPC分类号： C07D277/54 , A61K31/426 , C07D277/20 , C07D277/42 , C07D417/06
摘要： The invention relates to pharmaceutical compositions containing at least one thiazolidin-4-one derivative to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically active compounds. Said compounds particularly act also as immunosuppressive agents.
摘要翻译：本发明涉及含有至少一种噻唑烷-4-酮衍生物以预防或治疗与活化的免疫系统相关的疾病的药物组合物。此外，本发明涉及特别用作药物活性化合物的新型噻唑烷-4-酮衍生物。所述化合物还特别用作免疫抑制剂。

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