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    • 1. 发明申请
    • Production Of Isoprenoids
    • 异戊二烯的生产
    • US20070202579A1
    • 2007-08-30
    • US11632280
    • 2005-08-11
    • Alan BerryChristian ManhartPetra Simic
    • Alan BerryChristian ManhartPetra Simic
    • C12P7/66C12P7/04C12N9/10C12N15/74C07H21/04
    • C12P23/00C12N15/52
    • The present invention relates to a process for the production of isoprenoids Coenzyme Q-10 by microorganisms. More particularly, the present invention relates to a process for increased production of Coenzyme Q-10 by microorganisms of the genus Rhodobacter, preferably of the species R. sphaeroides which have been transformed with one or more gene(s) of the mevalonate (mev) operon from a different microorganism, preferably of the genus Paracoccus, more preferably of the species P. zeaxanthinifaciens, whereby the mev operon is mutated leading to an increased coenzyme Q-10 production. Sequences carrying such a mutation as well as a microorganism carrying such a mutated mev operon are also included.
    • 本发明涉及通过微生物生产类异戊二烯辅酶Q-10的方法。 更具体地说,本发明涉及通过红细菌属的微生物增加辅酶Q-10的生产的方法,优选使用已经用甲羟戊酸(mev)的一个或多个基因转化的球形芽孢杆菌 操纵子来自不同的微生物,优选副球菌属,更优选种类玉米黄质裂解物,由此使操纵子突变,导致增加的辅酶Q-10生产。 携带这种突变的序列以及携带这种突变的mev操纵子的微生物也被包括在内。
    • 2. 发明授权
    • Production of isoprenoids
    • 生产类异戊二烯
    • US07572609B2
    • 2009-08-11
    • US11632280
    • 2005-08-11
    • Alan BerryChristian ManhartPetra Simic
    • Alan BerryChristian ManhartPetra Simic
    • C12P7/66C12N15/74C07H21/04
    • C12P23/00C12N15/52
    • The present invention relates to a process for the production of isoprenoids Coenzyme Q-10 by microorganisms. More particularly, the present invention relates to a process for increased production of Coenzyme Q-10 by microorganisms of the genus Rhodobacter, preferably of the species R. sphaeroides which have been transformed with one or more gene(s) of the mevalonate (mev) operon from a different microorganism, preferably of the genus Paracoccus, more preferably of the species P. zeaxanthinifaciens, whereby the mev operon is mutated leading to an increased coenzyme Q-10 production. Sequences carrying such a mutation as well as a microorganism carrying such a mutated mev operon are also included.
    • 本发明涉及通过微生物生产类异戊二烯辅酶Q-10的方法。 更具体地说,本发明涉及通过红细菌属的微生物增加辅酶Q-10的生产的方法,优选使用已经用甲羟戊酸(mev)的一个或多个基因转化的球形芽孢杆菌 操纵子来自不同的微生物,优选副球菌属,更优选种类玉米黄质裂解物,由此使操纵子突变,导致增加的辅酶Q-10生产。 携带这种突变的序列以及携带这种突变的mev操纵子的微生物也被包括在内。