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1. 发明授权

US09248204B2 Gas-filled microvesicles composition for contrast imaging 有权
标题翻译：用于对比成像的充气微泡组合物
公开(公告)号：US09248204B2
公开(公告)日：2016-02-02
申请号：US11660188
申请日：2005-08-17
申请人： Philippe Bussat , Peter Frinking , Christian Guillot , Michel Schneider
发明人： Philippe Bussat , Peter Frinking , Christian Guillot , Michel Schneider
IPC分类号： A61K49/22 , A61K49/04
CPC分类号： A61K49/223
摘要： The present invention relates to a new composition comprising gas-filled microvesicles for contrast imaging which are particularly suitable for providing an effective echo response to at least two selected ultrasound waves having different frequencies. Said composition preferably comprises at least two different preparations of gas-filled microvesicles having respective peaks of non-liner echographic response differing by at least 2 MHz to each other, and preferably have respective size distributions with different mean sizes. In particular, said preparations preferably have size distributions with respective DV50 values differing from each other by at least 0.5 μm, more preferably at least 1.0 μm. Alternatively, said composition has a volume size distribution showing a value of Bowley skewness of 0.16 or higher. According to a preferred embodiment, at least 95% of the total volume of gas contained in said microvesicles, calculated on the population of microvesicles up to a diameter of 10 μm, is contained in microvesicles having a diameter of 8 micron or less.
摘要翻译：本发明涉及一种新的组合物，其包括用于对比成像的气体填充微泡，其特别适合于向至少两个具有不同频率的选定超声波提供有效的回波响应。所述组合物优选包含气相填充微泡的至少两种不同制剂，其具有彼此相差至少2MHz的非线性回波影响响应的各个峰，并且优选具有不同平均尺寸的相应尺寸分布。特别地，所述制剂优选具有各自的DV50值彼此相差至少0.5μm，更优选至少1.0μm的尺寸分布。或者，所述组合物具有显示Bowley偏度值为0.16或更高的体积大小分布。根据一个优选实施方案，所述微泡中包含的气体的总体积的至少95％是以直径为10μm的微泡总体计算的，包含在直径为8微米或更小的微泡中。

2. 发明申请

US20110248048A1 CLOSURE DEVICE COMPRISING A MEASURING CAP, INTENDED TO BE CONNECTED TO A FLEXIBLE CONTAINER 有权
标题翻译：包含测量帽的封闭装置，意在连接到灵活容器
公开(公告)号：US20110248048A1
公开(公告)日：2011-10-13
申请号：US13057887
申请日：2008-08-05
申请人： Javier Fernandez De Mendiola Quintana , Juan Ignacio Valpuesta Landa , Christian Guillot
发明人： Javier Fernandez De Mendiola Quintana , Juan Ignacio Valpuesta Landa , Christian Guillot
IPC分类号： G01F11/00 , B65D51/18
CPC分类号： B65D47/247 , B65D47/0838 , G01F11/288
摘要： Closure device, to be connected to a container (1), which comprises a measuring cap (2), a moving shutter (17) and a lid (24), where the moving shutter (17) is housed in a compartment (3) of the measuring cap (2) and presents a platform (18) provided with holes (19), two elastically deformable tongues (20) and a body with a cylindrical section (21, 22) held in place and guided by a chimney (27) in the lid (24), where the lid (24) comprises a central hole (29) that allows the product to exit. The moving shutter (17) is operated by pressing on the elastic container (1), which allows a dose of the product to come out, the moving shutter then being returned to its rest position by the tongues (20).
摘要翻译：封闭装置，其连接到容器（1），其包括测量帽（2），移动快门（17）和盖（24），其中移动快门（17）容纳在隔室（3）中，的测量帽（2），并且具有设置有孔（19）的平台（18），两个可弹性变形的舌片（20）和具有保持在适当位置并由烟囱（27）引导的圆柱形部分）在盖（24）中，其中盖（24）包括允许产品离开的中心孔（29）。活动快门（17）通过按压弹性容器（1）来操作，这允许产品的剂量出来，移动快门然后由舌片（20）返回到其静止位置。

3. 发明申请

US20090263330A1 GAS-FILLED MICROVESICLES WITH POLYMER-MODIFIED LIPIDS 有权
标题翻译：气体填充微胶囊与聚合物修饰的脂肪
公开(公告)号：US20090263330A1
公开(公告)日：2009-10-22
申请号：US12440009
申请日：2007-09-04
申请人： Stephane Gorgerat , Christian Guillot , Feng Yan
发明人： Stephane Gorgerat , Christian Guillot , Feng Yan
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K49/1818 , A61K51/1251
摘要： Image enhancing contrast agents for use in diagnostic and/or therapeutic methods, particularly in the form of gas-filled microvesicles, with enhanced stability. The gas-filled microvesicles are stabilized by a layer of amphiphilic material and comprise from 0.15% to 1.0% by moles of a lipid bearing a hydrophilic polymer. The lipid bearing a hydrophilic polymer is preferably a phospholipid linked to polyethyleneglycol.
摘要翻译：用于诊断和/或治疗方法的图像增强造影剂，特别是以气体填充的微泡的形式，具有增强的稳定性。气体填充的微泡由一层两亲性材料稳定，并含有0.15％至1.0％（摩尔）含有亲水性聚合物的脂质。含有亲水性聚合物的脂质优选为与聚乙二醇连接的磷脂。

4. 发明申请

US20060034770A1 Ultrasound contrast agents and process for the preparation thereof 审中-公开
标题翻译：超声造影剂及其制备方法
公开(公告)号：US20060034770A1
公开(公告)日：2006-02-16
申请号：US11202008
申请日：2005-08-11
申请人： Michel Schneider , Philippe Bussat , Feng Yan , Christian Guillot
发明人： Michel Schneider , Philippe Bussat , Feng Yan , Christian Guillot
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： Injectable aqueous suspension of microbubbles filled with a biocompatible gas and a method of preparation thereof. At least 10% of the total volume of gas contained in the microbubbles is contained in microbububbles with a diameter of 1.5 μm or less. The microbubbles can be obtained by preparing an emulsion comprising an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and then reconstituted in an aqueous suspension of gas-filled microbubbles.
摘要翻译：填充有生物相容性气体的微泡的可注射水性悬浮液及其制备方法。包含在微泡中的气体的总体积的至少10％包含在直径为1.5μm或更小的微泡中。微泡可以通过制备包含水性介质，磷脂和与水不混溶的有机溶剂的乳液来获得。然后将乳液冷冻干燥，然后在气体填充的微泡的水性悬浮液中重构。

5. 发明授权

US5702722A Liposomes with enhanced entrapment capacity, method and use 失效
标题翻译：具有增强的捕获能力，方法和用途的脂质体
公开(公告)号：US5702722A
公开(公告)日：1997-12-30
申请号：US527087
申请日：1995-09-12
申请人： Herve Tournier , Michel Schneider , Christian Guillot
发明人： Herve Tournier , Michel Schneider , Christian Guillot
IPC分类号： A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
摘要翻译：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据的方法。

6. 发明授权

US4824578A Method of purifying bioactive substances by biospecific adsorption 失效
标题翻译：通过生物特异性吸附纯化生物活性物质的方法
公开(公告)号：US4824578A
公开(公告)日：1989-04-25
申请号：US23861
申请日：1987-02-05
申请人： Michel Schneider , Christian Guillot , Bernard Lamy
发明人： Michel Schneider , Christian Guillot , Bernard Lamy
IPC分类号： G01N33/48 , B01D15/08 , B01J20/02 , B01J20/22 , B01J20/281 , B01J20/32 , C07F7/18 , C12N9/00 , C12N11/14 , G01N30/88 , B01D15/00
CPC分类号： B01D15/3804 , B01J20/08 , B01J20/103 , B01J20/28004 , B01J20/28057 , B01J20/286 , B01J20/3204 , B01J20/3219 , B01J20/3246 , B01J20/3257 , B01J20/3259 , B01J20/3261 , B01J20/3263 , B01J20/3274 , B01J2220/54 , Y10S977/773 , Y10S977/775 , Y10S977/888
摘要： A ligand specific to a bioactive substance to be purified is fixed, through a connecting silane, to a mineral particulate carrier chosen from among SiO.sub.2, Al.sub.2 O.sub.3, ZrO.sub.2 and TiO.sub.2, the particles of the carrier being submicronic, non-porous and having a large specific surface. The carrier is contacted with an aqueous extract containing the bioactive substances, for the time required for the substance to become specifically fixed to the carrier. The carrier is then separated and the desired bioactive substance is isolated by desorption.
摘要翻译： PCT No.PCT / CH86 / 00081 Sec。 371日期：1987年2月5日 102（e）1987年2月5日PCT PCT 1986年6月4日PCT公布。公开号WO86 / 07281 1986年12月18日。对于待纯化生物活性物质的配体，通过连接硅烷固定到选自SiO 2，Al 2 O 3，ZrO 2和TiO 2中的矿物颗粒载体上，载体的颗粒是亚微米级，非具有大的比表面积。载体与含有生物活性物质的含水提取物接触，使物质特异性固定在载体上所需的时间。然后分离载体，通过解吸分离所需的生物活性物质。

7. 发明授权

US4451568A Composition for binding bioactive substances 失效
标题翻译：用于结合生物活性物质的组合物
公开(公告)号：US4451568A
公开(公告)日：1984-05-29
申请号：US285182
申请日：1981-07-13
申请人： Michel Schneider , Pierre Chevreux , Christian Guillot
发明人： Michel Schneider , Pierre Chevreux , Christian Guillot
IPC分类号： C08F2/50 , C12N11/08 , C12N11/06
CPC分类号： C12N11/08 , Y10T428/31536
摘要： An acrylic-acid- based photopolymerizable composition is prepared which is capable of binding bioactive substances after being photopolymerized. The composition may be applied as a coating on a carrier substrate, photopolymerized and a bioactive substance fixed thereto. The composition adheres well to any usual carrier substrates, and its degree of hydrophilicity and permeability can be adapted to needs. The composition contains acrylic acid, a photoinitiator which is an aromatic ketone compound, a photopolymerization activator and adhesion promotor which is an amino-alcohol, acrylate or methacrylate, and a copolymerizable olefinic monomer which contains a reactive functional group capable of binding bioactive substances. The olefinic monomer is preferably N-hydroxysuccinimide acrylate, N-hydroxysuccinninimde amidocaproate, epoxypropyl acrylate or 2-isocyanato-ethyl acrylate.
摘要翻译： PCT No.PCT / CH80 / 00138 Sec。 371日期1981年7月13日 102（e）日期1981年7月13日PCT提交1980年11月13日PCT公布。出版物WO81 / 0141200 日期：1981年5月28日。制备能够在光聚合后结合生物活性物质的丙烯酸类光聚合组合物。组合物可以涂覆在载体基材上，光聚合和固定在其上的生物活性物质。该组合物很好地粘附到任何通常的载体基底上，并且其亲水性和渗透性的程度可以适应需要。该组合物含有丙烯酸，作为芳族酮化合物的光引发剂，光聚合活化剂和作为氨基醇，丙烯酸酯或甲基丙烯酸酯的粘合促进剂和含有能够结合生物活性物质的反应性官能团的可共聚烯烃单体。烯属单体优选为N-羟基琥珀酰亚胺丙烯酸酯，N-羟基琥珀酰亚胺酰胺，丙烯酸环氧丙酯或丙烯酸-2-异氰酸酯基乙酯。

8. 发明授权

US09364569B2 Ultrasound contrast agents and process for the preparation thereof 有权
公开(公告)号：US09364569B2
公开(公告)日：2016-06-14
申请号：US10544123
申请日：2004-02-03
申请人： Michel Schneider , Philippe Bussat , Feng Yan , Christian Guillot
发明人： Michel Schneider , Philippe Bussat , Feng Yan , Christian Guillot
IPC分类号： A61K49/22
CPC分类号： A61K49/223
摘要： Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.

9. 发明授权

US09107671B2 Compressive hemostatic device 有权
标题翻译：压缩式止血装置
公开(公告)号：US09107671B2
公开(公告)日：2015-08-18
申请号：US13387516
申请日：2010-07-26
申请人： Romain Christian Guillot
发明人： Romain Christian Guillot
IPC分类号： A61B17/00 , A61B17/132
CPC分类号： A61B17/1325 , A61B17/1327
摘要： The invention relates to a device capable of stopping the bleeding caused by the withdrawal of an introducer stuck into an introduction area of a patient. The device comprises: a base; a supporting means capable of temporarily attaching the base to the patient; an applicator supported by the base and provided with a transparent pad; and a screw-and-nut adjustment means capable of moving the applicator toward the introduction area so that the applicator moves to a position where the pad exerts pressure on the introduction area. The screw-and-nut system is located completely outside the diameter of the transparent pad. The invention can be used for angiography and angioplasty operations.
摘要翻译：本发明涉及一种能够阻止引入器抽出而导致的渗血的装置，该导引器卡在病人的导入区域中。该装置包括：基座; 支撑装置，能够临时将基座附接到病人身上; 由基座支撑并具有透明垫的施加器; 以及螺旋螺母调节装置，其能够将施加器移动到引入区域，使得施加器移动到垫在引入区域上施加压力的位置。螺母和螺母系统完全位于透明垫的直径之外。本发明可用于血管造影和血管成形术操作。

10. 发明授权

US5980937A Liposomes with enhanced entrapment capacity and their use in imaging 失效
标题翻译：具有增强的捕获能力的脂质体及其在成像中的应用
公开(公告)号：US5980937A
公开(公告)日：1999-11-09
申请号：US909827
申请日：1997-08-12
申请人： Herve Tournier , Michel Schneider , Christian Guillot
发明人： Herve Tournier , Michel Schneider , Christian Guillot
IPC分类号： A61K9/127 , A61K49/04 , B01J13/02
CPC分类号： A61K9/1277 , Y10S514/945 , Y10T428/2984
摘要： The invention relates to a dry deposit as a precursor to liposome vesicles, the precursor being a three dimensional expanded structure with bulk density between 0.01 and 0.001 g/cm.sup.3. The invention also concerns a method of making liposome vesicles with an enhanced entrapment capacity by dissolving one or more film forming lipids in at least one organic solvent to form a solution in a reaction vessel, evaporating the solvent to form an expanded three dimensional porous lipid structure, contacting the lipid deposit with an aqueous carrier phase, and producing liposome vesicles entrapping the carrier phase as well as an apparatus comprising an array of tubing or an inert packing which serves as a material support or a matrix surface for the deposition of lipids produced according to the method.
摘要翻译：本发明涉及作为脂质体囊泡前体的干沉积物，该前体是体积密度在0.01至0.001g / cm 3之间的三维膨胀结构。本发明还涉及通过将一种或多种成膜脂质溶解在至少一种有机溶剂中以形成溶液在反应容器中，使溶剂蒸发以形成扩展的三维多孔脂质结构，从而制备具有增强的捕获能力的脂质体囊泡的方法使脂质沉积物与水性载体相接触，并产生包裹载体相的脂质体囊泡，以及包含管阵列或惰性填料的装置，其用作材料载体或基质表面，用于沉积根据的方法。

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