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1. 发明授权

US6004810A Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes 失效
标题翻译：具有克隆生长能力的肝实质细胞，获得其的方法，传代培养方法，原代肝细胞传代培养系统
公开(公告)号：US6004810A
公开(公告)日：1999-12-21
申请号：US419982
申请日：1995-04-11
申请人： Chise Tateno , Katsutoshi Yoshizato
发明人： Chise Tateno , Katsutoshi Yoshizato
IPC分类号： C12N5/074 , C12N5/06
CPC分类号： C12N5/0672 , C12N2500/38 , C12N2501/11
摘要： The present invention provides liver parenchymal cells having a clonal growth ability, which possesses at least one of the cell biological properties such as: presence of peroxysome; being positive to hepatocyte-markers; being partially positive to neoplastic hepatocyte-markers or immature hepatocyte-markers; being positive to antibodies against the surface antigens of ovall cells; and being partially positive to bile duct cell-markers. The present invention also provides a method for obtaining such cells and a method for subculturing such cells.With the liver parenchymal cells above, it will be possible to research in detail the process of development and differentiation, the mechanisms of growth and functional expression of hepatic cells, and to open up a new way to clalification of mechanisms or hepatoma and various other diseases and to development of therapeutic method against these disseases.
摘要翻译：本发明提供具有克隆生长能力的肝实质细胞，其具有至少一种细胞生物学特性，例如：存在过氧化物酶体; 对肝细胞标志阳性; 对肿瘤性肝细胞标志物或未成熟肝细胞标志物部分阳性; 对抗卵巢细胞表面抗原的抗体呈阳性; 并且对胆管细胞标志物部分阳性。本发明还提供了获得这种细胞的方法以及传代这种细胞的方法。随着肝实质细胞的上游，有可能详细研究发育和分化过程，肝细胞生长和功能表达的机制，并开辟新的机制或肝癌和各种其他疾病的分离方式并开发针对这些疾病的治疗方法。

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